EP3911447A1

EP3911447A1 - Dispenser for discharging fluid, in particular for discharging a pharmaceutical fluid, and set comprising a dispenser of this type

Info

Publication number: EP3911447A1
Application number: EP19817712.3A
Authority: EP
Inventors: Frank Keppner
Original assignee: Aptar Radolfzell GmbH
Current assignee: Aptar Radolfzell GmbH
Priority date: 2019-01-17
Filing date: 2019-12-11
Publication date: 2021-11-24
Also published as: CN113286662A; WO2020148032A1; CN113286662B; JP7313448B2; CN116871078A; EP3682972B1; US20220097087A1; US11583879B2; JP2022516327A; JP2023093431A; EP3682972A1

Abstract

Dispensers for discharging fluid are known, in particular for discharging a pharmaceutical fluid, comprising a housing (20) having a discharge opening (22) and a fluid store (30) for storing the fluid before discharge. These dispensers also comprise a ventilation channel (40), by means of which an ambient atmosphere is connected to the fluid store (30), in order to allow an inflow of air from the atmosphere into the fluid store (30) after the discharge of fluid. It is proposed that the dispensers are provided with a detection device (50) for detecting a discharge process, which is designed for detecting the air flowing in through the ventilation channel (40). Likewise, is is proposed that the dispenser (10) has a protective cap (14) for covering the discharge opening (22), which can be placed onto the housing (20) and removed from the housing (20). The dispenser (10) has a switch valve (42) in the ventilation channel (40), which can be opened by actuating a button (43) provided on the outer side of the housing. The protective cap (14) is designed to act on the button (43) when the protective cap (14) is placed on/being placed onto the housing (20), thereby opening the switch valve (42).

Description

Dispenser for dispensing liquid, in particular for dispensing a pharmaceutical liquid.

as well as set comprising such a donor

APPLICATION AREA AND PRIOR ART

The invention relates to a dispenser for dispensing liquid, in particular for dispensing a pharmaceutical liquid, and to a set comprising such a dispenser.

Like a dispenser according to the invention, a dispenser of the generic type has a housing with a discharge opening through which liquid can be dispensed from a liquid reservoir of the dispenser. This can be done, for example, by designing the liquid reservoir as a squeeze bottle and compressing it manually for the purpose of discharge.

In the case of dispensers of the generic type or according to the invention, a discharge is generated in the liquid reservoir by the dispensed liquid volume. To compensate for this volume of liquid, the dispenser has a ventilation channel through which air can be drawn into the liquid storage device. The ventilation duct can be provided with a filter arrangement for the purpose of avoiding contamination.

Depending on the design of such a dispenser, it can be designed to discharge a structurally defined liquid dose per actuation or a quantity of liquid that can be freely determined by the type of actuation by the user.

In the case of a dispenser of the generic type or of the type according to the invention, it may be desirable to record the quantity of liquid discharged or the number of liquid doses discharged, in particular by electronic measuring means. This can be desired both in the normal operation of such a donor at the end customer and in a trial phase using special product testers. The purpose can be, for example, to estimate the remaining amount of liquid in the liquid store or to enable the user to be reminded if a planned discharge has not taken place.

Various measuring systems for liquid dispensers are already known from the prior art, in which the actuation itself is recorded and processed in particular in the form of a count. It is in such systems, however, it does not always guarantee that a correct discharge has actually taken place, for example not if the donor was not oriented as intended when it was actuated.

It has also already been considered to detect the liquid flow itself, that is to say to measure a suitable measuring device in a discharge channel between the liquid reservoir and the discharge opening. However, this is often difficult to achieve structurally and leads to a significant change in the design of a dispenser. Also, depending on the materials used, a corresponding sensor system, the liquid contact with this sensor system is disadvantageous for the sensor system and / or the liquid.

TASK AND SOLUTION

The object of the invention is to provide a dispenser which allows the detection of the liquid discharge in an advantageous manner and in this way, thereby avoiding or reducing the above-mentioned problems of the prior art.

According to the invention, a dispenser for discharging liquid, in particular for discharging a pharmaceutical liquid, is proposed for this.

In accordance with dispensers of the generic type, such dispensers according to the invention have a housing with a discharge opening for the discharge of liquid and a liquid store for storing the liquid before the discharge. The dispensers according to the invention are portable dispensers for the end customer and in particular for patients, collectively referred to below as the user. The maximum volume of the liquid reservoir is therefore usually between 5 ml and 500 ml, in particular between 5 ml and 50 ml.

The liquid in the liquid reservoir is conveyed through a discharge channel to the discharge opening when actuated by the user. The discharge opening is preferably preceded by an outlet valve which only opens at a defined limit pressure. The discharge form can in particular be that of a liquid stream, an atomized spray jet mixed with air or the form of an individual drop. In the case of a drop dispenser, the discharge opening is surrounded by a drop formation surface, to which the liquid to be dispensed adheres until the amount of liquid is sufficient to detach from the drop formation surface in drop form. The drop formation area is preferably delimited on the outside by a tear-off edge in order to ensure a particularly uniform drop size.

In order to convey the liquid from the liquid store to the discharge opening, in particular a manually operable pump device with a pump chamber and pump valves on the inlet and outlet sides can be provided. A particularly important alternative to this is the design of the dispenser as a squeeze bottle dispenser. In this case, the liquid reservoir or a surrounding actuating body can be compressed elastically, so that an overpressure is generated in the liquid, which causes a conveyance in the direction of the discharge opening.

In a dispenser according to the invention it is provided that after discharge and resetting the liquid reservoir or the surrounding actuating body, air is drawn into the liquid reservoir from the surroundings in order to equalize the previously discharged liquid volume and to adjust the pressure in the liquid reservoir to the ambient pressure again.

For this purpose, a dispenser according to the invention has an aeration channel, by means of which a surrounding atmosphere is connected to the liquid reservoir in order to allow the air to flow in from the atmosphere after the discharge of liquid.

According to the main aspect of the invention, the dispenser also has a detection device for detecting a discharge process, wherein the detection device is designed for detecting the air flowing in through the ventilation duct.

It is therefore proposed according to the main aspect of the invention to use neither the actuation of the dispenser as such nor a direct detection of the discharged liquid volume for the detection of the discharge, but instead the ventilation process following the discharge, within the scope of which air, in particular from a surrounding one Atmosphere into which liquid storage or a surrounding actuating body flows.

It has been shown that a discharge can be reliably identified with this, depending on the embodiment, only the discharge taking place as such or the discharged liquid being indirectly detectable. Liquid contact of a corresponding sensor system can be avoided. Actuating the dispenser, which has not led to liquid discharge and therefore does not lead to the inflow of air, does not correctly lead to detection. In its most general form, a detection device is a mechanism that reproducibly changes its state when an event, in the present case the intake of air, takes place. Although purely mechanical designs also appear conceivable here, an electronic detection device is preferably provided in a dispenser according to the invention, that is to say a detection device with a sensor and a memory, which changes its storage state as a result of the indirectly sensed discharge process. A sensor according to the invention is arranged in or on the edge of the ventilation duct and detects the air stream thereby directed into the liquid reservoir directly and thus indirectly the previously carried out discharge of liquid.

Various sensors can be used to detect the inflow of air.

Thus, the detection device can have a sensor arrangement for detecting the air flowing in through the ventilation channel, which is designed to detect a differential pressure between two locally spaced reference points of the ventilation channel. This can be done in particular by providing a bypass piece in the ventilation duct or a special part thereof (measuring duct) which is closed by means of a deflectable surface section. Depending on the differential pressure, this membrane is deflected, which can be detected electronically. A deflectable surface section can also directly form a wall part of the ventilation duct and can be deflected depending on the pressure prevailing therein. A further design which can be used in the context of the invention provides that the sensor arrangement comprises at least two temperature sensors and at least one heating element which are arranged in the ventilation duct, the two temperature sensors being provided upstream and downstream of the heating element. From the temperature difference of the temperature sensors and the power of the heating element, the detection device can draw conclusions about the inflow of air.

A possible design of the dispenser according to the invention and its detection device provide that the detection device determines the amount of the previously discharged liquid indirectly via the air flowing in through the ventilation duct and displays the determined amount of liquid discharged or the calculated amount of liquid remaining in the liquid storage device on a display device. The display device can be configured as a display, for example as an LC display. However, depending on the application, a simple LED can suffice, in particular if the display device is only intended to indicate whether the determined amount of liquid discharged corresponds to a predetermined amount of liquid or exceeds or remains behind this. Another design provides that the detection device is designed to recognize discharge processes as such indirectly via the air flowing in through the ventilation duct, it not being necessary for the quantity of liquid discharged to be detected. Such a design of a detection device and its sensors are technically simpler, but sufficient depending on the field of application.

In the case of a dispenser that dispenses liquid cans of the same size for structural reasons, the information that a discharge has taken place can be sufficient for a count. Such a detection device in connection with an integrated clock can also be designed to compare planned times of use and carried out discharge processes and, in the event of no discharge times at planned times of use, to emit a preferably acoustic warning signal via a signaling device.

The detection device described can be integrated directly into a discharge head of a dispenser according to the invention. For disposable dispensers, however, this is usually avoidable for ecological and economic reasons. Instead, the arrangement in an external module and the arrangement in a protective cap are preferred, as will be explained below.

First of all, to arrange the detection device in an external detection module, this detection module being encompassed by the invention both in combination with a dispenser (set) to which it is attached, and alone.

Such an external detection module can preferably be attached to the housing of the dispenser without tools and can preferably be detached therefrom without tools. Depending on the application, however, an attachability that is only possible with a tool may be sufficient. However, the module does not constitute an integral part of the dispenser even when it is firmly attached to the dispenser. This means that the module can be removed without preventing the functionality of the dispenser for dispensing liquid.

The external acquisition module can be attached to the dispenser housing in such a way that it sits firmly there and can no longer unintentionally detach. If the external module is to be handled by end customers, simple handling is an advantage. In this case, the external module is preferably pushed onto the housing in a force-fitting manner or secured in a form-fitting manner against removal, in particular by means of a thread. The detection module is formed for external coupling at that point in the dispenser housing at which an inflow opening is provided in the dispenser-side part of the ventilation channel.

The detection module itself has a measuring channel and at the end of a coupling output, the coupling output being positioned such that the measuring channel is communicatively coupled to the inflow opening on the housing of the ventilation channel of the donor after the detection module has been attached. Preferably, an outside of the housing and an inside of the detection module jointly delimit a circumferential channel, with which both the inflow opening and the coupling outlet are communicatively connected. After coupling, the measuring duct forms part of the ventilation duct.

The detection module preferably, but not necessarily, has an annular module housing which surrounds a central recess, so that it can be pushed onto the housing in a surrounding manner.

The design of the detection device as part of an external detection module is structurally usually advantageous over an integrated solution in the dispenser housing. It allows the manufacture and / or use of the dispenser in a design with and a design without a detection device, without the components required for the liquid discharge and in particular the housing having to be specially designed. In addition, dispensers already on the market can even be retrofitted with a detection module, provided that the inflow opening is provided at a point on the housing which is suitable for coupling a detection module.

Furthermore, an external recording module can be removed easily and in particular preferably without tools from an emptied disposable dispenser and placed on a new dispenser, which is economically and ecologically advantageous. A special embodiment of the detection module can therefore be designed with sensors in order to register such a donor change and to use this information for a reset process. For example, a counter can be reset to zero.

As already mentioned above, the design of a protective cap with an integrated detection device is also advantageous. Before going into this in detail, the design of a dispenser according to the invention according to a second aspect of the invention is first explained, this design serves in particular as the basis for the use of a protective cap with a detection device.

In this second design, a dispenser of the generic type is equipped with a protective cap for covering the discharge opening in the attached state. The protective cap is removed by the user before using the dispenser and then replaced. This can in particular be a plug cap or a screw cap.

The dispenser according to this second aspect of the invention has a switching valve in the ventilation channel, which can be opened by actuating a button provided on the outside of the housing. The ventilation duct is thus closed when the switching valve is not actuated. Sucking in air is prevented. The switching valve is preferably provided in the area of an outside surface of the dispenser housing, so that it prevents the entry of air into the ventilation duct.

To actuate the button mentioned, it is provided that the housing and the protective cap are coordinated with one another in such a way that the protective cap acts in the state placed on the housing or when the button is placed on it, and thus opens the switching valve. This means that the process of putting on the protective cap at least in the meantime causes the switching valve to open and thus allows air to flow in.

With such a design of the dispenser, it is therefore not provided that the liquid discharge alone and the resulting negative pressure in the liquid storage device enable air to be sucked in. Instead, the suppression is initially maintained and may be increased by repeated actuation of the dispenser and, accordingly, multiple discharge of liquid. Ventilation can only take place when the protective cap is put back on the housing.

This has several advantages. Irrespective of the presence of a detection device, a tendency towards greater suppression and a resulting larger air flow of the inflowing air can be advantageous, for example in order to detach liquid residues from a liquid filter at the end of the ventilation duct.

Such a configuration of a dispenser is particularly advantageous, however, if the dispenser has a detection device of the type described above. Such a detection device With regard to its sensor technology, it can be made technically simpler if a larger air flow is detected, as can be achieved by blocking the ventilation duct by means of the switching valve.

It is particularly advantageous if the detection device is integrated in the protective cap. This results in the advantages already discussed above with regard to the external recording module, in particular the reusability and the possibility of being able to offer donors with and without a recording device with a high degree of structural agreement.

In the case of integration of the detection device into the protective cap, this is preferably configured, as is also described for the external detection module, that is to say with a measuring channel in or on which the sensor system is provided, and which becomes part of the ventilation channel by fitting the protective cap. The actuating surface provided on the protective cap for actuating the button of the switching valve is preferably arranged in such a way that the measuring channel of the protective cap and the ventilation channel in the housing are communicating and are connected in the transition area in a sealed manner to an environment, so that the cap-side detection device directly detects the air flow can, as soon as the switching valve is opened using the protective cap.

The detection of the inflowing air in the course of putting on the protective cap can also be advantageous because it only requires a brief phase in which the electronics of the detection device is activated. It is therefore particularly advantageous if the detection device has a switch which can be actuated by placing the protective cap on the housing.

The triggering of this switch, which can form a common structural unit with the switching valve in a detection device within the housing of the dispenser, activates the detection device. As soon as the then sensed air flow has been completed and evaluated, the detection direction can be deactivated again. Little electrical energy is thus consumed. A battery as part of the detection device can therefore provide energy for the operation of the detection device for a long time, possibly for several years. BRIEF DESCRIPTION OF THE DRAWINGS

Further advantages and aspects of the invention result from the claims and from the following description of preferred exemplary embodiments of the invention, which are explained below with reference to the figures.

Fig. 1 and 2A and 2B show a known donor as a starting point for the subsequently described designs according to the invention and the basic operation of this dispenser.

Fig. 3 shows a first embodiment of the invention with the detection device integrated in the dispenser.

4A and 4B show a second embodiment of the invention with an external detection module.

5A and 5B show a third exemplary embodiment of the invention with a detection module integrated in a protective cap.

DETAILED DESCRIPTION OF THE EMBODIMENTS

1 and 2A and 2B first show a generic liquid dispenser, which is further developed by modifying or supplementing a liquid dispenser according to the invention.

The liquid dispenser 10 has a discharge device 12 which is the main component of the liquid dispenser 10 and in turn has a housing 20 which is penetrated by a discharge opening 22 at the distal end. To protect this discharge opening 22, the dispenser 10 comprises a protective cap 14, which in the present case is designed as a vented protective cap in order to allow liquid residues remaining on the discharge opening 22 to escape quickly through ventilation holes 16 in the attached state.

The discharge device 12 has a liquid reservoir 30, the walls of which represent a squeeze bottle, as will be explained below. A discharge head is placed on the liquid reservoir 30 and, in addition to the discharge opening 22 already mentioned, a discharge provides 24 that connects the liquid reservoir 30 to the discharge opening 22. The discharge opening 22 is preceded by an outlet valve 26 which opens with sufficient liquid pressure in a valve chamber and thus permits the escape of liquid through the discharge opening 22. In the present case, the dispenser 10 is designed as a pot dispenser and has a drop-forming surface 23 beyond the discharge opening 22, which is delimited on the outside by a tear-off edge.

As already mentioned, the liquid reservoir 30 is a liquid reservoir 30 designed in the manner of a squeeze bottle. This means that in the manner illustrated by FIG. 2A, the dispenser is actuated by squeezing the bottle in the direction of the arrows 6 becomes. This creates an overpressure in the liquid reservoir 30, which causes liquid to be conveyed along the exit path 7 to the discharge opening 22 and the drop formation surface 23 and is dispensed here in drop form. If the force applied to the squeeze bottle is omitted, then this assumes its initial shape again in the manner illustrated by the arrows 8 in FIG. 2B, as a result of which a suppression in the liquid reservoir 30 occurs. This causes air to be drawn in along ventilation path 9 through a ventilation duct 40. The sucked-in air is cleaned at the end of the ventilation duct 40 in the area of a filter arrangement 48 of impurities such as germs and bacteria. The inflowing air ensures pressure equalization in the liquid storage 30, so that the meanwhile existing negative pressure is reduced.

FIG. 3 shows a modification of the dispenser of FIG. 1, in the present case in particular a modification of the discharge device 12. The modification consists in that the housing 20 is of a different type and surrounds a detection device 50 which detects air flowing in through the ventilation duct 40 is designed. The detection device 50 has an acoustic signal generator 67 in the form of a loudspeaker, a microprocessor 64 and an energy source in the form of a battery 62.

Furthermore, the detection device 50 has a sensor arrangement 52 in the ventilation duct 40, which is provided in particular on its wall. This sensor arrangement 52 comprises two temperature sensors 56 and a heating element 58 arranged therebetween. If air now flows through the ventilation duct 40 in accordance with the phase of FIG. 2B when air is sucked in, the temperature in front of the heating element 58 can be detected by the first temperature sensor 56 are and by the second temperature sensor 56 downstream of the heating element 58, the air heated by the heating element 58 is measured with respect to its temperature. The temperature difference is a Indicator of whether and how much air has flowed through the ventilation duct 40. A high temperature difference occurs with a low air flow. A small temperature difference occurs with a large air flow.

The result of the measurements of this can be evaluated by the microprocessor 64. For example, if the air flow is too low and the liquid discharge through the loudspeaker 67 is previously too low, the microprocessor 64 can indicate that the discharge did not take place properly. The microprocessor 64 can also indicate via the loudspeaker 67 if a scheduled discharge has not taken place if stored in its memory prior to the given delivery times. The user is therefore reminded to make up for this discharge.

The arrangement of the sensor arrangement 52 in the ventilation duct 40 means that a discharge can be reliably recognized without the sensor arrangement having to be in direct contact with the liquid for this purpose.

4A and 4B, the basic principle is similar to that of FIG. 3. As can be seen from FIG. 4A, the detection device 50 is, however, configured here as part of a detection module 80 which has an annular module housing 82 which is provided for being pushed onto the housing 20 of the discharge device 12. Fig. 4B shows the pushed-up state.

The detection module 80 also includes a battery 62 and a microprocessor 64. In this design, however, an LC display 66 is additionally provided, which enables the transmission of more complex information to the user than is usually the case with a loudspeaker corresponding to FIG. 3 is. 3 and the integration of the detection device 50 into the housing 20 instead of the loudspeaker or a display can also be provided in the design of FIG. 3.

The sensor arrangement 52 in the exemplary embodiment of FIGS. 4A and 4B is similar to that of FIG. 3 and in turn is based on the presence of two temperature sensors 56 and a heating element 58. In this case, however, the sensor arrangement 52 is not an integral part of the discharge device according to FIG. 3 12, but part of the mentioned detection module 80. Referring to FIG. 4A, it can be seen that on the inside of the annular module housing 82 of the detection module 80, a switch 69, only shown schematically, is provided. The detection module can use this switch to recognize when it is pushed onto the housing 20 of the discharge device 12. This can be used, for example, to reset an integrated counter to an initial value. When mounting the detection module 80, this switch 69 is triggered.

4B shows the assembled state. This shows that a coupling output 45 of the measuring channel 44 of the detection module 80 is in communicating connection with an inflow opening 41 of the part of the ventilation channel 40 on the discharge device side. In order to also allow a non-aligned direction, the housing 20 of the discharge device 12 and the module housing 82 of the detection module 80 are designed to define an annular space 84 in the coupled state. This allows the detection module to be pushed onto the housing 20 in any position.

As already mentioned, the sensor arrangement 52 is shown in the same manner as in the embodiment in FIG. 3. However, the presence of the LC display 66 allows the values recorded via this sensor arrangement 52 to be evaluated in an even more extensive manner and made available to the user. In particular, by detecting the air flow and the duration of the air flow when air is sucked in through the measuring channel 44 and the ventilation channel 40, it is possible to estimate which amount of air has entered the bottle and, consequently, which amount of liquid has previously been discharged. Accordingly, the total amount of liquid already discharged or, in the event that the detection module 80 knows the initial amount, the remaining amount of liquid in the liquid reservoir 30 can be shown on the LC display 66.

5A and 5B is similar to that of FIGS. 4A and 4B with regard to the fact that here too the detection device 50 is not an integral part of the discharge device 12. However, the detection device 50 is provided in the protective cap 14 in this case. This detection device also has a battery 62, a microprocessor 64 and an LC display 66. The sensor arrangement 52, which is provided on a measuring channel 44 of the cap 14, is designed differently in the present case, it being basically arbitrary which of the exemplary embodiments with which type of sensor arrangement 52 is designed. The sensor arrangement 52 of FIGS. 5A and 5B has a two-part side channel 46 which extends from the measuring channel 44 and in which a membrane 54 is arranged. Depending on the air flow that flows through the measuring channel 44, this membrane 54 is deflected to different degrees, which can be detected, for example, by means of a piezo sensor and further processed by the microprocessor 64. The protective cap 14 also has a switch 69, which, however, has a slightly different technical meaning than the switch 69 in the case of FIGS. 4A and 4B, as will be explained further below.

Since the protective cap is naturally not attached to the discharge device 12 during the discharge of liquid, the discharge device 12 has a switching valve 42 which covers the flow opening of the ventilation duct 40 in the state of FIG. 5A and thus the inflow of air at this time not allowed. If the dispenser of FIG. 5A is thus actuated as shown in FIG. 2A, liquid is discharged, but initially there is no pressure compensation by inflowing air. Rather, in the case of multiple discharges, an ever increasing negative pressure builds up in the liquid reservoir 30, which cannot be compensated for at this point in time.

Only when the protective cap 14 is placed on the discharge device 12 in the manner illustrated by FIG. 5B can a detection occur. First, the switch 69 is triggered, which leads to an activation of the detection device 50. If the cap is pressed down into its end position of FIG. 5B, actuating surfaces 15, which are provided all around at the lower end of ribs on the protective cap 14, can press a button 43 of the switching valve 42 and thereby illustrate this in FIG. 5B Press down wise. As a result, the ventilation channel 40 is opened, but only after the protective cap 14 has been placed so far that neither along its lower edge nor through the ventilation openings on the end face of the cap can air flow. This means that the pressure compensation through the measuring channel 44 of the cap-side detection device 50 previously activated by switch 69 is quite sudden at high negative pressure.

The microprocessor 64 of the detection device 50 can then display data on the LC display 66, in particular the total amount of liquid that has been discharged to date or the amount of liquid still remaining in the liquid storage device 30. The sudden pressure equalization is also advantageous, in order to possibly still be on the Filter arrangement 48 liquid residues to separate from this.

As soon as the sensor arrangement 52 no longer senses air flow in the measuring channel 44, it can switch to a power saving mode or deactivate itself completely until the switch 69 is turned off for the next time. is solved. Even with only a small battery 62, the protective cap 14 can thus take over its function as the protective protocolling discharge.

Claims

1. Dispenser (10) for the discharge of liquid, in particular for the discharge of a pharmaceutical

Liquid, with the following characteristics: a. the dispenser (10) has a housing (20) with a discharge opening (22) for the discharge of liquid, and b. the dispenser (10) has a liquid reservoir (30) for storing the liquid before the discharge, and c. the dispenser has a ventilation channel (40), by means of which a surrounding atmosphere is connected to the liquid reservoir (30) in order to allow air to flow in from the atmosphere into the liquid reservoir (30) after the discharge of liquid by the following features: d. the dispenser (10) has a detection device (50) for detecting a discharge process, and e. the detection device (50) is designed to detect the air flowing through the ventilation duct (40).

2. Dispenser (10) according to claim 1 with the following additional feature: a. the detection device (50) has a sensor arrangement (52) for detecting the air flowing in through the ventilation duct (40), the sensor arrangement (52) being designed for detecting a differential pressure between two spatially spaced reference points of the ventilation duct, and / or the sensor arrangement (52) has at least one deflectable surface section (54) which can be deflected by air flowing through the ventilation duct, and / or the sensor arrangement (52) comprises at least two temperature sensors (56) and at least one heating element (58) which are arranged in the ventilation duct (40), the two temperature sensors (56) being provided upstream and downstream of the heating element (58).

3. Dispenser (10) according to one of the preceding claims with the following additional Merkma len: a. the detection device (50) is designed to determine the amount of the previously discharged liquid indirectly via the air flowing in through the ventilation duct (40), and b. the detection device (50) has a display device (66) and is designed to bring the determined discharged amount of liquid or the amount of liquid calculated therefrom in the liquid reservoir (30) to a user via the display device (66).

4. Dispenser (10) according to one of the preceding claims with the following further feature: a. the detection device (50) is designed to detect discharge processes indirectly via the air flowing in through the ventilation duct (40), preferably with the additional feature: b. The detection device (50) has an internal clock and is designed to compare planned times of use and carried out discharge processes and to issue a warning signal when there are no discharge processes at planned times of use via a signaling device (67).

5. Dispenser (10) according to one of the preceding claims with at least one of the following further features: a. the dispenser (10) is designed as a squeeze bottle dispenser and has a liquid reservoir (30) that can be compressed manually from the outside for the purpose of liquid discharge, and / or b. the liquid reservoir (30) has a maximum volume between 5 ml and 500 ml, preferably between 5 ml and 50 ml, and / or c. the dispenser (10) is designed as a drop dispenser (10) and has in the region of the discharge opening (22) a drop formation surface (23), which is particularly preferably delimited on the outside by a tear-off edge, and / or d. the dispenser is designed as a pharmaceutical dispenser (10) and has a liquid reservoir (30) filled with a pharmaceutical liquid, in particular with a pharmaceutical liquid for ophthalmic application.

6. Dispenser (10) according to one of the preceding claims with the following additional feature: a. the detection device (50) is designed in the form of an external detection module (80), which is preferably attached to the housing (20) of the dispenser (10) without tools and can preferably be detached therefrom without tools, in particular preferably with the additional feature: b. the detection module (80) has a switch (69) which can be actuated by fastening the detection module (80) to the housing (20).

7. Dispenser (10) for the discharge of liquid, in particular for the discharge of a pharmaceutical liquid, with the following features: a. the dispenser (10) has a housing (20) with a discharge opening (22) for the discharge of liquid, and b. the dispenser (10) has a liquid reservoir (30) for storing the liquid before the discharge, and c. the dispenser (10) has a ventilation channel (40), by means of which a surrounding atmosphere is connected to the liquid reservoir (30) in order to allow air to flow into the liquid reservoir (30) after the discharge of liquid, characterized by the following features: d. the dispenser (10) has a protective cap (14) for covering the discharge opening (22), which can be placed on the housing (20) and removed from the housing (20), and e. the dispenser (10) has a switching valve (42) in the ventilation duct (40), which can be opened by actuating a button (43) provided on the outside of the housing, and f. the housing (20) and the protective cap (14) are matched to one another in such a way that the protective cap (14) acts on the button (43) when the protective cap (14) is placed on the housing (20) or when the protective cap (14) is fitted, and thus the switching valve (42) opens.

8. Dispenser (10) for the discharge of liquid according to claim 7 with the following further feature: a. the dispenser (10) is designed according to one of claims 1 to 6, and

9. Dispenser (10) for the discharge of liquid according to claim 8 with the following further feature: a. the detection device (50) is integrated in the protective cap (14).

10. Dispenser (10) for discharging liquid according to one of claims 7 to 9 with the following further feature: a. the detection device (50) has a switch (69) which can be actuated by placing the protective cap (14) on the housing (20).

11. Dispenser for dispensing liquid according to one of claims 7 to 10 with the following further feature: a. the detection device (50) is designed to determine the air flow in the ventilation duct (40) in response to a fitting of the protective cap (14).

12. Detection module (80) for a dispenser (10) according to one of the preceding claims with the following features: a. the detection module (80) is designed for external coupling to the housing (20) of the dispenser (10), which has a ventilation channel (40) with an inflow opening (41) arranged on an outside of the housing, and b. the detection module (80) has a measuring channel (44) and is designed to detect the air flowing through the measuring channel (44), and c. the measuring channel (44) has a coupling output (45) which, when communicating with the detection module (80) coupled to the housing (20), is coupled to the inflow opening (41) of the ventilation channel (40) of the dispenser (10).

13. Detection module (80) according to claim 12 with the following additional feature: a. the detection module (80) has an annular module housing (82) which surrounds a central recess, so that it can be pushed onto the dispenser housing surrounding it.

14. Dispenser set with the following features: a. The set comprises a dispenser (10) with a housing (20) and a discharge opening (22) for the discharge of liquid, a liquid reservoir (30) for storing the liquid in front of the discharge and a ventilation channel (40), by means of which a surrounding atmosphere is connected to the liquid reservoir (30) to allow air to flow into the liquid reservoir (30) after the discharge of liquid, and b. the ventilation channel (40) of the dispenser has an inflow opening (41) on an outside of the housing (20), and c. the set comprises a detection module (80) according to claim 12 or 13, and d. the detection module (80) and the housing (20) of the dispenser (10) are matched to one another in such a way that the coupling output (45) of the measuring channel (44) of the detection module (80) is coupled to the housing (20) of the dispenser (10) Detection module communicating with the ventilation opening of the ventilation channel of the dispenser is coupled.