EP3866981A4 - Methods for generating therapeutic delivery platforms - Google Patents

Methods for generating therapeutic delivery platforms Download PDF

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Publication number
EP3866981A4
EP3866981A4 EP19875362.6A EP19875362A EP3866981A4 EP 3866981 A4 EP3866981 A4 EP 3866981A4 EP 19875362 A EP19875362 A EP 19875362A EP 3866981 A4 EP3866981 A4 EP 3866981A4
Authority
EP
European Patent Office
Prior art keywords
methods
therapeutic delivery
delivery platforms
generating therapeutic
generating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19875362.6A
Other languages
German (de)
French (fr)
Other versions
EP3866981A1 (en
Inventor
Mei He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Kansas State University
Original Assignee
University of Kansas
Kansas State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas, Kansas State University filed Critical University of Kansas
Publication of EP3866981A1 publication Critical patent/EP3866981A1/en
Publication of EP3866981A4 publication Critical patent/EP3866981A4/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP19875362.6A 2018-10-21 2019-10-21 Methods for generating therapeutic delivery platforms Withdrawn EP3866981A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862748470P 2018-10-21 2018-10-21
PCT/US2019/057237 WO2020086471A1 (en) 2018-10-21 2019-10-21 Methods for generating therapeutic delivery platforms

Publications (2)

Publication Number Publication Date
EP3866981A1 EP3866981A1 (en) 2021-08-25
EP3866981A4 true EP3866981A4 (en) 2022-09-07

Family

ID=70331909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19875362.6A Withdrawn EP3866981A4 (en) 2018-10-21 2019-10-21 Methods for generating therapeutic delivery platforms

Country Status (9)

Country Link
EP (1) EP3866981A4 (en)
JP (1) JP2022512762A (en)
KR (1) KR20210088594A (en)
CN (1) CN113195103A (en)
AU (1) AU2019368213A1 (en)
BR (1) BR112021007508A2 (en)
CA (1) CA3117030A1 (en)
IL (1) IL282538A (en)
WO (1) WO2020086471A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11162143B2 (en) 2018-10-21 2021-11-02 The University Of Kansas Methods for generating therapeutic delivery platforms
WO2021226589A1 (en) * 2020-05-08 2021-11-11 The University Of Kansas Immunomagnetic compositions for the ph-specific capture of extracellular vesicles
CN113005021B (en) * 2020-06-17 2023-12-08 山东大学 Microfluidic chip and method for exosome cracking and detection
WO2022076413A1 (en) * 2020-10-05 2022-04-14 Clara Biotech, Inc. Apparatus, system, and method for analyte release
KR20230026261A (en) 2021-08-17 2023-02-24 한국과학기술원 Multi-layered vesicles for induction of immunity, pharmaceutical composition for inducing immunity comprising same, and method of manufacturing multi-layered vesicles for induction of immunity

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US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
WO2002014290A1 (en) * 2000-08-18 2002-02-21 Sense Proteomic Limited Lipo- or amphiphilic scintillators and their use in assays
GB0318096D0 (en) * 2003-08-01 2003-09-03 Queen Mary & Westfield College Vaccine
US20080255004A1 (en) * 2006-11-15 2008-10-16 Invitrogen Dynal As Methods of reversibly binding a biotin compound to a support
WO2008147530A1 (en) * 2007-05-24 2008-12-04 The Regents Of The University Of California Integrated fluidics devices with magnetic sorting
US10359425B2 (en) * 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
KR20110111449A (en) * 2008-12-31 2011-10-11 인터젠엑스 인크. Instrument with microfluidic chip
KR20120081972A (en) * 2009-07-02 2012-07-20 아이티에이치 임뮨 세라피 홀딩스 에이비 Exosome based treatment of cancer
CN107315086B (en) * 2011-06-29 2019-09-10 中央研究院 Capture, purifying and release using surface covering to biological substance
CN103278628A (en) * 2013-06-12 2013-09-04 齐齐哈尔医学院 Method and device for detecting and separating HP (helicobacter pylori) ELISA (enzyme-linked immuno sorbent assay)
US20150111777A1 (en) * 2013-09-24 2015-04-23 Kansas City University Of Medicine And Biosciences Biomarker for early neurodegeneration detection
WO2015139019A1 (en) * 2014-03-14 2015-09-17 Mei He Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
US10350599B2 (en) * 2014-03-14 2019-07-16 University Of Kansas Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
US10788486B2 (en) * 2016-10-09 2020-09-29 The University Of Kansas Graphene oxide-based nanolab and methods of detecting of exosomes
CN107764804B (en) * 2017-10-09 2020-02-07 郑州大学 Self-assembled poly HRP probe, preparation method, kit and application thereof
CN107723338B (en) * 2017-10-27 2020-03-27 山东师范大学 Fluorescent chemical sensor for simultaneously detecting multiple DNA glycosylases at single-molecule level and detection method and application thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GISS D ET AL: "MICROFLUIDICS TO ISOLATE UNTAGGED PROTEINS FROM CELL EXTRACTS FOF VISUAL ANALYSIS BY ELECTRON MICROSCOPY", 17TH MICROAFFINITY PURIFICATION OF PROTEINS BASED ON PHOTOLYTIC ELUTION: TOWARD AN EFFICIENT MICROBEAD AFFINITY CHROMATOGRAPHY ON A CHIP ELECTROPHORESIS 27-31 OCTOBER 2013, FREIBURG, GERMANY, 31 October 2013 (2013-10-31), pages 1785 - 1787, XP055947895, Retrieved from the Internet <URL:https://www.rsc.org/images/loc/2013/PDFs/Papers/597_0776.pdf> *
MIN-SOO KIM ET AL: "Study on bead-based micro biochip and analytical system for protein detection", TRANSDUCERS, SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS, 12TH INN ATIONAL CONFERENCE ON, 2003, PISCATAWAY, NJ, USA,IEEE, 8 June 2003 (2003-06-08), pages 1267, XP032377732, ISBN: 978-0-7803-7731-8, DOI: 10.1109/SENSOR.2003.1217003 *
QINGFU ZHU ET AL: "Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics", LAB ON A CHIP, vol. 18, no. 12, 1 January 2018 (2018-01-01), UK, pages 1690 - 1703, XP055709479, ISSN: 1473-0197, DOI: 10.1039/C8LC00246K *
See also references of WO2020086471A1 *
Z. ZHAO, J. SIBBITT; M. HE: "On-Chip Harvesting and Photo-Release of Immunogenic Extracellular Vesicles for Cancer Immunotherapy", MICROTAS 2017; 21ST INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES (MICROTAS 2017), SAVANNAH, GEORGIA, USA, 22-26 OCTOBER 2017, vol. 2, 22 October 2017 (2017-10-22) - 26 October 2017 (2017-10-26), pages 898 - 899, XP009537868, ISBN: 978-1-7138-0272-3, Retrieved from the Internet <URL:https://www.proceedings.com/52575.html> *
ZHENG ZHAO ET AL: "Microfluidic on-demand engineering of exosomes towards cancer immunotherapy", LAB ON A CHIP, vol. 19, no. 10, 1 January 2019 (2019-01-01), UK, pages 1877 - 1886, XP055754271, ISSN: 1473-0197, DOI: 10.1039/C8LC01279B *

Also Published As

Publication number Publication date
KR20210088594A (en) 2021-07-14
CA3117030A1 (en) 2020-04-30
WO2020086471A1 (en) 2020-04-30
BR112021007508A2 (en) 2021-08-10
IL282538A (en) 2021-06-30
JP2022512762A (en) 2022-02-07
AU2019368213A1 (en) 2021-06-03
EP3866981A1 (en) 2021-08-25
CN113195103A (en) 2021-07-30

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