EP3863615A4 - Procédés de traitement de cancers à tumeur solide à l'aide d'illudines et de biomarqueurs - Google Patents
Procédés de traitement de cancers à tumeur solide à l'aide d'illudines et de biomarqueurs Download PDFInfo
- Publication number
- EP3863615A4 EP3863615A4 EP19872565.7A EP19872565A EP3863615A4 EP 3863615 A4 EP3863615 A4 EP 3863615A4 EP 19872565 A EP19872565 A EP 19872565A EP 3863615 A4 EP3863615 A4 EP 3863615A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- illudins
- biomarkers
- treatment
- methods
- solid tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862745382P | 2018-10-14 | 2018-10-14 | |
PCT/US2019/056039 WO2020081414A1 (fr) | 2018-10-14 | 2019-10-14 | Procédés de traitement de cancers à tumeur solide à l'aide d'illudines et de biomarqueurs |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3863615A1 EP3863615A1 (fr) | 2021-08-18 |
EP3863615A4 true EP3863615A4 (fr) | 2022-08-03 |
Family
ID=70284107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19872565.7A Pending EP3863615A4 (fr) | 2018-10-14 | 2019-10-14 | Procédés de traitement de cancers à tumeur solide à l'aide d'illudines et de biomarqueurs |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3863615A4 (fr) |
JP (1) | JP2022513349A (fr) |
CN (1) | CN113194934A (fr) |
AU (1) | AU2019361781A1 (fr) |
CA (1) | CA3116552A1 (fr) |
WO (1) | WO2020081414A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230109696A (ko) * | 2020-11-18 | 2023-07-20 | 랜턴 파마 인코포레이티드 | 암 약물 민감도 결정 마커 |
EP4274662A2 (fr) * | 2021-01-08 | 2023-11-15 | Lantern Pharma Inc. | Traitement de métastases cérébrales et de métastases du système nerveux central à l'aide d'illudines ou d'hydroxyluréeméthyl acylfulvène |
EP4376821A1 (fr) * | 2021-07-29 | 2024-06-05 | Lantern Pharma Inc. | Traitement de cancers avec des combinaisons de spironolactone et d'acylfulvènes |
WO2023010119A1 (fr) * | 2021-07-29 | 2023-02-02 | Lantern Pharma Inc. | Traitement de cancers avec des associations d'inhibiteur de parp et d'acylfulvènes |
WO2024016014A2 (fr) * | 2022-07-15 | 2024-01-18 | Lantern Pharma Inc. | Méthode de traitement de cancers du sein et de cancers du sein résistant à parp |
CN116287275B (zh) * | 2023-04-10 | 2024-04-05 | 广州市第一人民医院(广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院) | Ptgr1作为cdk4/6抑制剂与二甲双胍联合用药指导标志物的应用 |
CN117233391A (zh) * | 2023-08-28 | 2023-12-15 | 南方医科大学南方医院 | 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007019308A2 (fr) * | 2005-08-03 | 2007-02-15 | The Regents Of The University Of California | Analogues d'illudine utiles en tant qu'agents anticancereux |
US9725769B1 (en) * | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
WO2018170230A1 (fr) * | 2017-03-15 | 2018-09-20 | Memorial Sloan Kettering Cancer Center | Diagnostic et traitement du cancer à mutant ercc3 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10285955B2 (en) * | 2014-04-10 | 2019-05-14 | Af Chemicals, Llc | Affinity medicant conjugate |
EP3129357B1 (fr) * | 2014-04-10 | 2023-08-23 | AF Chemicals LLC | Conjugués de médicament et d'élément d'affinité |
-
2019
- 2019-10-14 CN CN201980067429.3A patent/CN113194934A/zh active Pending
- 2019-10-14 WO PCT/US2019/056039 patent/WO2020081414A1/fr unknown
- 2019-10-14 EP EP19872565.7A patent/EP3863615A4/fr active Pending
- 2019-10-14 AU AU2019361781A patent/AU2019361781A1/en active Pending
- 2019-10-14 JP JP2021545268A patent/JP2022513349A/ja active Pending
- 2019-10-14 CA CA3116552A patent/CA3116552A1/fr active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007019308A2 (fr) * | 2005-08-03 | 2007-02-15 | The Regents Of The University Of California | Analogues d'illudine utiles en tant qu'agents anticancereux |
US9725769B1 (en) * | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
WO2018170230A1 (fr) * | 2017-03-15 | 2018-09-20 | Memorial Sloan Kettering Cancer Center | Diagnostic et traitement du cancer à mutant ercc3 |
Non-Patent Citations (3)
Title |
---|
MARINA TANASOVA ET AL: "Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents", CHEMICAL REVIEWS, vol. 112, no. 6, 6 April 2012 (2012-04-06), US, pages 3578 - 3610, XP055665990, ISSN: 0009-2665, DOI: 10.1021/cr2001367 * |
See also references of WO2020081414A1 * |
STAAKE MICHAEL D ET AL: "Hydroxyurea derivatives of irofulven with improved antitumor efficacy", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 7, 13 February 2016 (2016-02-13), pages 1836 - 1838, XP029453930, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2016.02.028 * |
Also Published As
Publication number | Publication date |
---|---|
CN113194934A (zh) | 2021-07-30 |
AU2019361781A1 (en) | 2021-06-03 |
JP2022513349A (ja) | 2022-02-07 |
EP3863615A1 (fr) | 2021-08-18 |
WO2020081414A1 (fr) | 2020-04-23 |
CA3116552A1 (fr) | 2020-04-23 |
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Legal Events
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STAA | Information on the status of an ep patent application or granted ep patent |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Effective date: 20220630 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/6886 20180101ALI20220627BHEP Ipc: A61P 35/00 20060101ALI20220627BHEP Ipc: A61K 31/17 20060101ALI20220627BHEP Ipc: C12Q 1/686 20180101ALI20220627BHEP Ipc: C07C 239/14 20060101ALI20220627BHEP Ipc: A61K 31/122 20060101AFI20220627BHEP |