EP3846780A4 - Enzymatic assays for quantifying therapy in subjects with mucopolysaccharidosis type i or ii - Google Patents
Enzymatic assays for quantifying therapy in subjects with mucopolysaccharidosis type i or ii Download PDFInfo
- Publication number
- EP3846780A4 EP3846780A4 EP19857764.5A EP19857764A EP3846780A4 EP 3846780 A4 EP3846780 A4 EP 3846780A4 EP 19857764 A EP19857764 A EP 19857764A EP 3846780 A4 EP3846780 A4 EP 3846780A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- quantifying
- subjects
- therapy
- enzymatic assays
- mucopolysaccharidosis type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102100035028 Alpha-L-iduronidase Human genes 0.000 title 1
- 101001019502 Homo sapiens Alpha-L-iduronidase Proteins 0.000 title 1
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 title 1
- 208000028781 Mucopolysaccharidosis type 1 Diseases 0.000 title 1
- 238000007824 enzymatic assay Methods 0.000 title 1
- 201000002273 mucopolysaccharidosis II Diseases 0.000 title 1
- 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862727465P | 2018-09-05 | 2018-09-05 | |
| US201962802104P | 2019-02-06 | 2019-02-06 | |
| US201962801110P | 2019-02-06 | 2019-02-06 | |
| US201962802558P | 2019-02-07 | 2019-02-07 | |
| US201962802568P | 2019-02-07 | 2019-02-07 | |
| US201962812592P | 2019-03-01 | 2019-03-01 | |
| PCT/US2019/045491 WO2020050947A2 (en) | 2018-09-05 | 2019-08-07 | Enzymatic assays for quantifying therapy in subjects with mucopolysaccharidosis type i or ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3846780A2 EP3846780A2 (en) | 2021-07-14 |
| EP3846780A4 true EP3846780A4 (en) | 2022-11-30 |
Family
ID=69721876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19857764.5A Withdrawn EP3846780A4 (en) | 2018-09-05 | 2019-08-07 | Enzymatic assays for quantifying therapy in subjects with mucopolysaccharidosis type i or ii |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3846780A4 (en) |
| JP (1) | JP2022512542A (en) |
| WO (1) | WO2020050947A2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100603A1 (en) * | 2014-12-18 | 2016-06-23 | Shire Human Genetic Therapies, Inc. | Enzymatic activity assays for i2s |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101158673B1 (en) * | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| EP3218000A2 (en) * | 2014-11-10 | 2017-09-20 | Alexion Pharmaceuticals, Inc. | Therapeutic compositions of alpha-l-iduronidase, iduronate-2-sulfatase, and alpha-galactosidase a and methods of use thereof |
-
2019
- 2019-08-07 EP EP19857764.5A patent/EP3846780A4/en not_active Withdrawn
- 2019-08-07 JP JP2021512419A patent/JP2022512542A/en active Pending
- 2019-08-07 WO PCT/US2019/045491 patent/WO2020050947A2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100603A1 (en) * | 2014-12-18 | 2016-06-23 | Shire Human Genetic Therapies, Inc. | Enzymatic activity assays for i2s |
Non-Patent Citations (1)
| Title |
|---|
| "JIMD Reports - Volume 11", vol. 38, 1 January 2017, SPRINGER BERLIN HEIDELBERG, Berlin, Heidelberg, ISBN: 978-3-642-37328-2, ISSN: 2192-8304, article AZADEH MITRA ET AL: "A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment", pages: 89 - 95, XP055970626, DOI: 10.1007/8904_2017_34 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022512542A (en) | 2022-02-07 |
| WO2020050947A2 (en) | 2020-03-12 |
| EP3846780A2 (en) | 2021-07-14 |
| WO2020050947A3 (en) | 2020-07-23 |
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Legal Events
| Date | Code | Title | Description |
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| STAA | Information on the status of an ep patent application or granted ep patent |
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| STAA | Information on the status of an ep patent application or granted ep patent |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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| STAA | Information on the status of an ep patent application or granted ep patent |
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| 17P | Request for examination filed |
Effective date: 20210223 |
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| DAX | Request for extension of the european patent (deleted) | ||
| REG | Reference to a national code |
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| A4 | Supplementary search report drawn up and despatched |
Effective date: 20221031 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 9/40 20060101ALI20221025BHEP Ipc: C12N 9/24 20060101ALI20221025BHEP Ipc: C12N 9/16 20060101ALI20221025BHEP Ipc: A61K 47/42 20170101ALI20221025BHEP Ipc: A61K 38/46 20060101ALI20221025BHEP Ipc: A61K 9/00 20060101AFI20221025BHEP |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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| 18D | Application deemed to be withdrawn |
Effective date: 20230531 |