EP3823559A1 - Heart valve prosthesis, particularly suitable for transcatheter implantation - Google Patents

Heart valve prosthesis, particularly suitable for transcatheter implantation

Info

Publication number
EP3823559A1
EP3823559A1 EP19759745.3A EP19759745A EP3823559A1 EP 3823559 A1 EP3823559 A1 EP 3823559A1 EP 19759745 A EP19759745 A EP 19759745A EP 3823559 A1 EP3823559 A1 EP 3823559A1
Authority
EP
European Patent Office
Prior art keywords
armature
valve
radially
flaps
armature according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19759745.3A
Other languages
German (de)
French (fr)
Inventor
Franco Vallana
Maria Curcio
Matteo Antoniotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret AS
Original Assignee
Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret AS filed Critical Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret AS
Publication of EP3823559A1 publication Critical patent/EP3823559A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents

Definitions

  • Heart valve prosthesis particularly suitable for transcatheter implantation
  • the present invention is generally in the field of heart valve prostheses; in particular, the invention refers to a heart valve prosthesis, particularly suitable for transcatheter implantation.
  • Armatures for prosthetic heart valves are known, which comprise a tubular or annular portion suitable to accommodate the valve, and a structure (cup-shaped, mushroom- shaped, globe-shaped, etc.), which is insertable into one of the cavities of a patient’s heart and helps to hold the tubular portion in place.
  • An example of an armature for a prosthetic valve of this type is known from the document EP 2 982 336 Al , wherein the drum or annular element which houses the prosthetic valve is insertable into the annulus , so as to prevent the closure of the flaps of the native valve.
  • the flaps of the native valve may compress the annular element, with the risk that the resulting crushing will induce a deformation of the same annular element, such as to affect the operation of the prosthetic valve contained therein (which may, for example, not close properly).
  • a prosthesis configured to hold the flaps of the native valve is known from the document WO 2018/099484, which describes an armature equipped with a tubular structure (suitable to house the prosthetic valve) from which radial formations branch off which hold the flaps of the native valve in the open position.
  • radial formations are configured to clamp the annulus so that the armature is anchored thereto and held in place.
  • the effects of clamping the annulus and spreading the native valve flaps are achieved by the radial formations being essentially in the form of a horizontal S, with an ascending portion (which, at its apex, engages the lower side of the annulus ), and a descending portion (which engages the native valve flaps).
  • An object of the present invention is to remedy the aforementioned problems.
  • an armature for a prosthetic heart valve includes, in addition to the tubular drum (suitable to house the prosthetic valve) and the cup structure (or similar), a plurality of radially expandable formations which, branching off from the body of the armature, spread apart in such a way as to push the flaps of the native valve outwards (when the armature is inserted in the biological implantation site), so as to prevent or hinder the movement thereof and avoid direct contact with this tubular drum, where, however, the armature is configured in such a way as to avoid anchoring to the annulus of the native heart valve.
  • the flaps of the native valve are held in an open position by the radial formations, without directly compressing the annular element that houses the prosthetic valve (and, therefore, without inducing deformations or crushing) and limiting or completely inhibiting the contact between the flaps and this annular element, so as to avoid further damage to the former, leading to lacerations or ruptures that could cause calcification and/or embolization of the tissue.
  • the armature is not fixed to the annulus, there is no risk that the deterioration of the anatomical structure of the implant will compromise the anchoring of the armature and the functionality of the radial formations.
  • Figure 1 is a schematic perspective view of an armature inserted in a mitral implant site, according to an embodiment of the present invention
  • Figures 2 and 3 are respectively a schematic perspective view and a schematic view orthogonal to the longitudinal axis of an armature, wherein are visible the radially projecting formations, suitable to counteract the closure of the native valve, and the prosthetic valve housed in the annular element, according to an embodiment of the present invention
  • Figures 4 A to 4C are schematic views of an armature in three alternative embodiments, wherein the radial formations branch off respectively from the globe structure, from the interface edge between the globe structure and the tubular drum, and from an edge of that drum which is distal relative to the globe structure;
  • Figures 5A to 5D are schematic views of a plurality of shapes that the cross section of the annular element may assume in a radially expanded configuration.
  • an armature 1 for a prosthetic valve 13 (preferably a mitral valve) is expandable and collapsible radially so as to be insertable into a cavity in a patient’s heart and extends along a longitudinal axis x.
  • this longitudinal axis x is configured in such a way that the armature 1, when placed in the anatomical implant site, is essentially coaxial with respect to the native valve.
  • the armature 1 comprises an annular or tubular element 10, suitable to support the mitral prosthetic valve 13, and an anchoring frame 12, suitable to be inserted into the left atrium of a patient’s heart (to help anchor the same valve prosthesis in place)' and is connected to an upper edge lOa of the annular element 10, proximal to such anchoring frame 12.
  • the anchoring frame 12, known per se, is preferably configured as a cup (but other shapes are possible, such as a globe, a dome, a mushroom, a ball, a half-sphere, etc.).
  • the armature 1 further comprises a plurality of radial formations 14, radially spreadable relative to the body 9 so as to present a greater radial extension relative to the annular element 10 (in other words, the radial formations 14 protrude radially on the outside of the annular element 10).
  • These radial formations 14 are suitable to hold the flaps 15 of the native valve in the open position, so as to prevent or limit the movements thereof and to avoid direct contact between these flaps 15 and the annular element 10, but are further configured so as to avoid an anchoring of the armature 1 to the annulus of a native heart valve by means of said radial formations 14.
  • the radial formations 14 are configured in such a way as to engage the flaps of the native valve (and, according to an embodiment, the connection portion between the two radially extended sides of the annulus), avoiding the engagement of this second side of the annulus that faces the ventricle.
  • the portion of the radial formations 14 suitable to enter into contact with the annulus and the flaps of the native heart valve has a monotonic trend (more specifically, a decreasing monotonic trend, when the armature 1 is placed in the anatomical implant site).
  • the radial formations 14 do not have portions folded upwards, which allow the annulus to tighten and anchor the armature 1 there (as contemplated in the prior art).
  • the radial formations 14 have a curved profile, having a concavity turned towards a direction radially external with respect to the armature 1, so as to adapt to the profile of the annulus and to fold radially towards the outside of the body 9.
  • At least part of the radial formations 14 are configured in the shape of elongated elements spaced circumferentially and having a first end l4a fixed to the body 9, and a second free end l4b, outermost radially, which is capable of pushing the flaps 15 of the native valve outwards radially.
  • the radial formations 14 are configured in the shape of a collar or circumferential collar sections, having a first edge !4a fixed to the body 9, and a second free edge l4b, and outermost radially, suitable to press radially on the flaps 15 of the native valve.
  • the collar or collar portion may be described as an element which, in the collapsed configuration of the armature 1 , extends longitudinally and circumferentially, and then radially spreads into the expanded configuration of the armature 1.
  • the collar may extend continuously along an entire circumference, or it may extend along circumferential sectors (so as to form, for example, petals in the expanded configuration).
  • the anchoring function of the armature 1 in the anatomical implant site is performed by the anchoring frame 12, which may have an at least partially spherical or globular shape.
  • the anchoring frame 12 is configured to face a majority portion of the inner surface of the left atrium of a patient’s heart so as to engage this atrium with a higher anchoring force.
  • the anchoring frame 12 may be configured to extend along the meridians of the sphere from the annulus to above this equator.
  • At least part of the radial formations 14 are fixed to the anchoring frame 12.
  • At least part of the radial formations 14 are fixed to the upper edge lOa of interconnection between the annular element 10 and the anchoring frame 12.
  • At least part of the radial formations 14 are fixed to an edge lOb of the annular element 10, distal relative to the anchoring frame 12. This lower edge lOb faces the left ventricle of the heart when the armature 1 is inserted into the anatomical mitral implantation site.
  • the armature 1 may comprise radial formations 14 of even more types.
  • it may simultaneously include radial formations 14 configured as elongated elements or collar portions, and/or fixed at different points of the body 9.
  • the armature 1 is configured so as to be implantable by means of a transcatheter.
  • the annular element 10 assumes, in the radially expanded condition, a cylindrical shape (as schematically illustrated in Figure 5A).
  • the annular element 10 may take an elliptical configuration (as schematically illustrated in Figure 5B), or a“bean” configuration (as schematically illustrated in Figures 5C and 5D).
  • FIGS. 5A-5D are shown, merely by way of example, the relationships that bind some geometric elements approximately indicative of the shape that the cross section of the annular element 10 may assume.

Abstract

An armature (1) for a prosthetic heart valve (13), extended along a longitudinal axis (x) and radially expandable and collapsible, comprises a body (9) which includes an annular element (10), supporting the prosthetic valve (13), an anchoring frame (12), which is inserted into a cavity in a patient's heart, and a plurality of radial formations (14), radially spreadable with respect to the body (9) to hold the flaps (15) of the native valve in open position, where the armature (1) is configured in such a way as to avoid anchoring to the annulus of a native heart valve.

Description

Heart valve prosthesis, particularly suitable for transcatheter implantation
Technical Field
The present invention is generally in the field of heart valve prostheses; in particular, the invention refers to a heart valve prosthesis, particularly suitable for transcatheter implantation.
Prior art
Armatures for prosthetic heart valves are known, which comprise a tubular or annular portion suitable to accommodate the valve, and a structure (cup-shaped, mushroom- shaped, globe-shaped, etc.), which is insertable into one of the cavities of a patient’s heart and helps to hold the tubular portion in place.
Examples of such armatures are known from the documents WO 2016/134239 Al and WO 2018/031855 Al . In these solutions, which specifically concern prosthetic mitral valves, the armature is shaped so as to be accommodated entirely in the left atrium of the heart, that is, placing itself above the so-called annulus, and avoiding interaction with the flaps of the native valve. In this case, therefore, the prosthesis is added and superimposed on the native valve, without controlling or inhibiting the motility thereof.
Although similar solutions may appear functional and minimally invasive, in practice they have many disadvantages, such as the fact that the freedom of movement of the native valve may in turn lead to uncontrolled interaction with the armature of the prosthesis, causing further damage over time, or even affecting (at least partially) the functionality of the prosthetic valve itself.
In light of this, it may therefore be appropriate to replace the native valve entirely with the prosthetic one, effectively inhibiting the functionality of the former.
An example of an armature for a prosthetic valve of this type is known from the document EP 2 982 336 Al , wherein the drum or annular element which houses the prosthetic valve is insertable into the annulus , so as to prevent the closure of the flaps of the native valve.
In such a configuration, however, the flaps of the native valve may compress the annular element, with the risk that the resulting crushing will induce a deformation of the same annular element, such as to affect the operation of the prosthetic valve contained therein (which may, for example, not close properly).
A prosthesis configured to hold the flaps of the native valve is known from the document WO 2018/099484, which describes an armature equipped with a tubular structure (suitable to house the prosthetic valve) from which radial formations branch off which hold the flaps of the native valve in the open position.
These radial formations are configured to clamp the annulus so that the armature is anchored thereto and held in place. In particular, the effects of clamping the annulus and spreading the native valve flaps are achieved by the radial formations being essentially in the form of a horizontal S, with an ascending portion (which, at its apex, engages the lower side of the annulus ), and a descending portion (which engages the native valve flaps).
However, this attachment method is disadvantageous, as the anatomical structure of the annulus degrades over time, weakening the anchorage to the point where it is possible to impair the operation of the radial formations, in the event, for example, of the armature becoming detached from the annulus.
Summary of the invention
An object of the present invention is to remedy the aforementioned problems.
To achieve this result, an armature for a prosthetic heart valve includes, in addition to the tubular drum (suitable to house the prosthetic valve) and the cup structure (or similar), a plurality of radially expandable formations which, branching off from the body of the armature, spread apart in such a way as to push the flaps of the native valve outwards (when the armature is inserted in the biological implantation site), so as to prevent or hinder the movement thereof and avoid direct contact with this tubular drum, where, however, the armature is configured in such a way as to avoid anchoring to the annulus of the native heart valve.
In this way, the flaps of the native valve are held in an open position by the radial formations, without directly compressing the annular element that houses the prosthetic valve (and, therefore, without inducing deformations or crushing) and limiting or completely inhibiting the contact between the flaps and this annular element, so as to avoid further damage to the former, leading to lacerations or ruptures that could cause calcification and/or embolization of the tissue. Furthermore, as the armature is not fixed to the annulus, there is no risk that the deterioration of the anatomical structure of the implant will compromise the anchoring of the armature and the functionality of the radial formations.
The aforesaid and other objects and advantages are achieved, according to an aspect of the invention, via a heart valve prosthesis having the features defined in claim 1. Preferred embodiments of the invention are defined in the dependent claims.
Brief description of the drawings
The functional and structural features of some preferred embodiments of a heart valve prosthesis according to the invention will now be described: Reference is made to the accompanying drawings, which are representative of a preferred application (specifically, a mitral site application) of a valve prosthesis according to the invention, wherein:
Figure 1 is a schematic perspective view of an armature inserted in a mitral implant site, according to an embodiment of the present invention;
Figures 2 and 3 are respectively a schematic perspective view and a schematic view orthogonal to the longitudinal axis of an armature, wherein are visible the radially projecting formations, suitable to counteract the closure of the native valve, and the prosthetic valve housed in the annular element, according to an embodiment of the present invention; Figures 4 A to 4C are schematic views of an armature in three alternative embodiments, wherein the radial formations branch off respectively from the globe structure, from the interface edge between the globe structure and the tubular drum, and from an edge of that drum which is distal relative to the globe structure; and
Figures 5A to 5D are schematic views of a plurality of shapes that the cross section of the annular element may assume in a radially expanded configuration.
Detailed description
Before explaining in detail a plurality of embodiments of the invention, it should be clarified that the invention is not limited in its application to the constructive details and to the configuration of the components presented in the following description or illustrated in the drawings. The invention may assume other embodiments and may in practice be implemented or achieved in different ways. It should also be understood that the phraseology and terminology have descriptive purposes and should not be construed as restrictive.
By way of example, referring to the figures, an armature 1 for a prosthetic valve 13 (preferably a mitral valve) is expandable and collapsible radially so as to be insertable into a cavity in a patient’s heart and extends along a longitudinal axis x. Conveniently, this longitudinal axis x is configured in such a way that the armature 1, when placed in the anatomical implant site, is essentially coaxial with respect to the native valve.
The armature 1 comprises an annular or tubular element 10, suitable to support the mitral prosthetic valve 13, and an anchoring frame 12, suitable to be inserted into the left atrium of a patient’s heart (to help anchor the same valve prosthesis in place)' and is connected to an upper edge lOa of the annular element 10, proximal to such anchoring frame 12. The anchoring frame 12, known per se, is preferably configured as a cup (but other shapes are possible, such as a globe, a dome, a mushroom, a ball, a half-sphere, etc.).
The armature 1 further comprises a plurality of radial formations 14, radially spreadable relative to the body 9 so as to present a greater radial extension relative to the annular element 10 (in other words, the radial formations 14 protrude radially on the outside of the annular element 10). These radial formations 14 are suitable to hold the flaps 15 of the native valve in the open position, so as to prevent or limit the movements thereof and to avoid direct contact between these flaps 15 and the annular element 10, but are further configured so as to avoid an anchoring of the armature 1 to the annulus of a native heart valve by means of said radial formations 14. In other words, considering the annulus of the native valve as a formation protruding radially between the atrium and the ventricle of the patient’s heart, and having two radially extended sides (i.e. a first side facing the atrium and a second side, opposite the first, facing the ventricle) connected together in an axial direction, the radial formations 14 are configured in such a way as to engage the flaps of the native valve (and, according to an embodiment, the connection portion between the two radially extended sides of the annulus), avoiding the engagement of this second side of the annulus that faces the ventricle.
Appropriately, the portion of the radial formations 14 suitable to enter into contact with the annulus and the flaps of the native heart valve has a monotonic trend (more specifically, a decreasing monotonic trend, when the armature 1 is placed in the anatomical implant site). In other words, the radial formations 14 do not have portions folded upwards, which allow the annulus to tighten and anchor the armature 1 there (as contemplated in the prior art).
According to a preferred embodiment (illustrated schematically in Figures 1 and 2), the radial formations 14 have a curved profile, having a concavity turned towards a direction radially external with respect to the armature 1, so as to adapt to the profile of the annulus and to fold radially towards the outside of the body 9.
According to an embodiment, illustrated merely by way of example in Figures 2 and 3, at least part of the radial formations 14 are configured in the shape of elongated elements spaced circumferentially and having a first end l4a fixed to the body 9, and a second free end l4b, outermost radially, which is capable of pushing the flaps 15 of the native valve outwards radially.
According to a non-illustrated embodiment, at least part of the radial formations 14 are configured in the shape of a collar or circumferential collar sections, having a first edge !4a fixed to the body 9, and a second free edge l4b, and outermost radially, suitable to press radially on the flaps 15 of the native valve. Merely by way of example, the collar or collar portion may be described as an element which, in the collapsed configuration of the armature 1 , extends longitudinally and circumferentially, and then radially spreads into the expanded configuration of the armature 1. The collar may extend continuously along an entire circumference, or it may extend along circumferential sectors (so as to form, for example, petals in the expanded configuration).
In the entire present description and in the claims, the terms and expressions indicating positions and orientations, such as“longitudinal”,“radial”,“circumferential” etc., refer to the longitudinal axis x.
Conveniently, the anchoring function of the armature 1 in the anatomical implant site is performed by the anchoring frame 12, which may have an at least partially spherical or globular shape.
Appropriately, the anchoring frame 12 is configured to face a majority portion of the inner surface of the left atrium of a patient’s heart so as to engage this atrium with a higher anchoring force. For example, considering the shape of the left atrium of the heart as a sort of sphere, having an equator in the radially most expanded section, the anchoring frame 12 may be configured to extend along the meridians of the sphere from the annulus to above this equator.
According to an embodiment, illustrated merely by way of example in Figure 4 A, at least part of the radial formations 14 are fixed to the anchoring frame 12.
According to a further embodiment, illustrated merely by way of example in Figure 4B, at least part of the radial formations 14 are fixed to the upper edge lOa of interconnection between the annular element 10 and the anchoring frame 12.
According to a further embodiment, illustrated merely by way of example in Figure 4C, at least part of the radial formations 14 are fixed to an edge lOb of the annular element 10, distal relative to the anchoring frame 12. This lower edge lOb faces the left ventricle of the heart when the armature 1 is inserted into the anatomical mitral implantation site.
It is understood that the armature 1 may comprise radial formations 14 of even more types. For example, it may simultaneously include radial formations 14 configured as elongated elements or collar portions, and/or fixed at different points of the body 9.
Conveniently, the armature 1 is configured so as to be implantable by means of a transcatheter.
Preferably, the annular element 10 assumes, in the radially expanded condition, a cylindrical shape (as schematically illustrated in Figure 5A).
Alternatively, the annular element 10 may take an elliptical configuration (as schematically illustrated in Figure 5B), or a“bean” configuration (as schematically illustrated in Figures 5C and 5D).
Next to Figures 5A-5D are shown, merely by way of example, the relationships that bind some geometric elements approximately indicative of the shape that the cross section of the annular element 10 may assume. In this case, one takes as reference two perpendicular segments AA’ and BB’, which intersect at a point C, where these segments extend respectively along the direction of minimum and maximum extension of the cross section (in the case wherein the annular element 10 is cylindrical, then the cross section would be circular, and the two segments would have equal length).
Different aspects and embodiments of a heart valve prosthesis have been described according to the invention. It is understood that each embodiment may be combined with any other embodiment. The invention, moreover, is not limited to the described embodiments, but may vary within the scope defined by the accompanying claims.

Claims

1. An armature (1) for a prosthetic heart valve (13), extended along a longitudinal axis (x) and radially expandable and collapsible, said armature comprising a body (9) which includes:
- an annular element (10), suitable to support the prosthetic valve (13); and
- an anchoring frame (12), suitable to fit into a cavity of the heart of a patient, said anchoring frame (12) being connected to an upper edge (lOa) of the annular element (10); the armature (1) comprising a plurality of radial formations (14), radially spreadable with respect to the body (9) so as to have a greater radial extension with respect to the annular element (10), said radial formations (14) being suitable to hold the flaps (15) of the native valve in an open position, so as to prevent or limit the movements of said flaps and avoid direct contact between said flaps (15) and said annular element (10),
characterized in that said armature (1) is configured in such a way as to avoid anchoring itself to the annulus of a native heart valve by means of said radial formations (14).
2. An armature according to claim 1, wherein the portion of the radial formations (14) suitable to come into contact with the annulus and the flaps of the native heart valve has a monotonic trend.
3. An armature according to claim 1 or 2, wherein the radial formations (14) have a curved profile, having a concavity turned towards a direction radially external with respect to the armature (1), so as to adapt to the profile of the annulus and fold radially towards the outside of the body (9).
4. An armature according to any one of the preceding claims, wherein at least part of the radial formations (14) are configured in the shape of elongated elements spaced circumferentially and having a first end (l4a) fixed to the body (9), and a second free end (l4b), radially outermost, which is suitable to radially press on the flaps (15) of the native valve.
5. An armature according to any one of the preceding claims, wherein the anchoring frame (12) is configured to face a majority portion of the inner surface of the left atrium of a patient’s heart.
6. An armature according to any one of the preceding claims, wherein at least part of the radial formations (14) are configured in the shape of a collar or circumferential collar sections, having a first edge (l4a) fixed to the body (9), and a second free edge (l4b), radially outermost, which is suitable to press radially on the flaps (15) of the native valve.
7. An armature according to any one of the preceding claims, wherein at least part of the radial formations (14) are fixed to the anchoring frame (12).
8. An armature according to any one of the preceding claims, wherein at least part of the radial formations (14) are fixed to the upper edge (lOa) of interconnection (lOa) between the annular element (10) and the anchoring frame (12).
9. An armature according to any one of the preceding claims, wherein at least part of the radial formations (14) are fixed to a lower edge (lOb) of the annular element (10), distal with respect to the upper edge (lOa).
10. An armature according to any one of the preceding claims, wherein the anchoring frame (12) is configured in the shape of a cup.
1 1. An armature according to any one of the preceding claims, wherein the anchoring frame (12) is configured in the shape of a globe.
12. An armature according to any one of the preceding claims, wherein said armature (1) is configured to support a prosthetic valve (13) suitable to replace functionally a native mitral valve.
13. An armature according to any one of the preceding claims, implantable via transcatheter.
EP19759745.3A 2018-07-20 2019-07-19 Heart valve prosthesis, particularly suitable for transcatheter implantation Pending EP3823559A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102018000007382A IT201800007382A1 (en) 2018-07-20 2018-07-20 Heart valve prosthesis, especially suitable for transcatheter implantation.
PCT/IB2019/056188 WO2020016842A1 (en) 2018-07-20 2019-07-19 Heart valve prothesis, particularly suitable for transcatheter implantation

Publications (1)

Publication Number Publication Date
EP3823559A1 true EP3823559A1 (en) 2021-05-26

Family

ID=63896512

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19759745.3A Pending EP3823559A1 (en) 2018-07-20 2019-07-19 Heart valve prosthesis, particularly suitable for transcatheter implantation

Country Status (3)

Country Link
EP (1) EP3823559A1 (en)
IT (1) IT201800007382A1 (en)
WO (1) WO2020016842A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016134239A1 (en) * 2015-02-20 2016-08-25 4C Medical Technologies, Inc. Devices, systems and methods for cardiac treatment
CN108992207B (en) * 2015-11-06 2021-10-26 麦克尔有限公司 Mitral valve prosthesis
JP7057350B2 (en) * 2016-12-02 2022-04-19 シノメド カーディオヴィータ テクノロジー インク Thin heart valve system

Also Published As

Publication number Publication date
WO2020016842A8 (en) 2021-02-18
WO2020016842A1 (en) 2020-01-23
IT201800007382A1 (en) 2020-01-20

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