EP3809866A1 - Vitamin c-containing chewing gum - Google Patents

Vitamin c-containing chewing gum

Info

Publication number
EP3809866A1
EP3809866A1 EP19742123.3A EP19742123A EP3809866A1 EP 3809866 A1 EP3809866 A1 EP 3809866A1 EP 19742123 A EP19742123 A EP 19742123A EP 3809866 A1 EP3809866 A1 EP 3809866A1
Authority
EP
European Patent Office
Prior art keywords
chewing gum
vitamin
nausea
treatment
amounts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19742123.3A
Other languages
German (de)
French (fr)
Inventor
Reinhart Jarisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP3809866A1 publication Critical patent/EP3809866A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums

Definitions

  • the present invention relates to a chewing gum containing vitamin C for use in the treatment of
  • Nausea in people for example when traveling by sea, on a coach or car trip in the back seat and when
  • the present invention is therefore based on the object, the antiemetic effect of vitamin C by providing a new and inventive
  • the object of the invention is achieved by providing a chewing gum containing vitamin C for use in the treatment of nausea in humans.
  • Chewing gum has a strong antiemetic effect by stimulating salivation (Chewing gum for the treatment of nausea andvomiting: a pilot randomized controlled trial. Br.J. Anaesth. Jan., 118 (1): 83-89 ) and strengthens this effect of vitamin C, so that a highly effective preparation that is easy and enjoyable to consume can be provided.
  • the vitamin C chewing gum according to the invention unlike when taken in the form of effervescent tablets or dragees, the active substance is taken up to a substantial extent sublingually, which leads to particularly rapid and complete absorption of the
  • the dosage form as chewing gum is extremely durable, can be easily carried on trips and taken discreetly.
  • the chewing gum according to the present invention is intended for use in the treatment of nausea associated with early pregnancy.
  • the chewing gum of the present invention is for use in the treatment of seasickness associated
  • a piece of chewing gum preferably contains vitamin C in amounts of 50 mg to 300 mg, preferably in amounts of 100 mg to 250 mg, particularly preferably in amounts of 150 mg to 200 mg.
  • the chewing gum is coated.
  • vitamin C includes related to the
  • This invention not only L- (+) -asorbic acid but also their derivatives with the same effect and thus substances that can be converted in the body to L- (+) -ascorbic acid, such as dehydroascorbic acid.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a vitamin C-containing chewing gum for use in the treatment of nauseas in humans.

Description

Kaugummi enthaltend Vitamin C  Chewing gum containing vitamin C.
Die vorliegende Erfindung betrifft einen Kaugummi enthaltend Vitamin C zur Verwendung bei der Behandlung von The present invention relates to a chewing gum containing vitamin C for use in the treatment of
Übelkeitszuständen beim Menschen.  Nausea in humans.
Übelkeit beim Menschen, beispielsweise bei der Seefahrt, auf Äutobusreisen oder Autoreisen auf dem Rücksitz und beim Nausea in people, for example when traveling by sea, on a coach or car trip in the back seat and when
autonomen Fahren, im Flugzeug sowie in der Raumfahrt) ist mitunter auf einen Mangel von Vitamin C im Blut zurückzuführen. Der Mangel ist mit erhöhten Histaminwerten assoziiert, was wiederum mit Übelkeitszuständen in Zusammenhang steht. Die Gabe von Vitamin C ist daher zur Behandlung von Übelkeitszuständen, beispielsweise im Zusammenhang mit Seekrankheit untersucht und für wirksam befunden worden (Impact of oral vitamin C on histamine levels and seasickness . ; J Vestib Res.  autonomous driving, in airplanes as well as in space travel) is sometimes due to a lack of vitamin C in the blood. The deficiency is associated with increased histamine levels, which in turn is related to nausea. The administration of vitamin C has therefore been investigated for the treatment of nausea, for example in connection with seasickness, and has been found to be effective (Impact of oral vitamin C on histamine levels and seasickness.; J Vestib Res.
2014 ; 24 (4) :281-8) .  2014; 24 (4): 281-8).
Gleichzeitig haben diese Untersuchungen gezeigt, dass die At the same time, these studies have shown that the
Wirkung der alleinigen Gabe von Vitamin C nicht bei allen Effect of vitamin C alone does not affect all
Probanden zuverlässig das Auftreten der Übelkeitszustände verhindern konnte. Der vorliegenden Erfindung liegt daher die Aufgabe zugrunde, die antiemetische Wirkung von Vitamin C durch die Bereitstellung einer neuen und erfinderischen  Subjects could reliably prevent the occurrence of nausea. The present invention is therefore based on the object, the antiemetic effect of vitamin C by providing a new and inventive
Darreichungsform zu verbessern. Dosage form to improve.
Die erfindungsgemäße Aufgabe wird durch die Bereitstellung eines Kaugummis enthaltend Vitamin C zur Verwendung bei der Behandlung von Übelkeitszuständen beim Menschen gelöst. Das Kauen von Kaugummi hat durch die Anregung des Speichelflusses für sich gesehen einen stark antiemetischen Effekt (Chewing gum for the treatment of nausea andvomiting: a pilot randomized controlled trial. Br.J. Anaesth. Jan., 118 ( 1 ) : 83-89 ) und verstärkt diese Wirkung des Vitamin C, sodass ein hochwirksames sowie einfach und genussvoll zu konsumierendes Präparat zur Verfügung gestellt werden kann. Darüber hinaus wird bei der Anwendung des erfindungsgemäßen Vitamin C Kaugummis anders als bei der Einnahme in Form von Brausetabletten oder Dragees der Wirkstoff in wesentlichem Ausmaß sublingual aufgenommen, was zu einer besonders raschen und vollständigen Resorption des The object of the invention is achieved by providing a chewing gum containing vitamin C for use in the treatment of nausea in humans. Chewing gum has a strong antiemetic effect by stimulating salivation (Chewing gum for the treatment of nausea andvomiting: a pilot randomized controlled trial. Br.J. Anaesth. Jan., 118 (1): 83-89 ) and strengthens this effect of vitamin C, so that a highly effective preparation that is easy and enjoyable to consume can be provided. In addition, when using the vitamin C chewing gum according to the invention, unlike when taken in the form of effervescent tablets or dragees, the active substance is taken up to a substantial extent sublingually, which leads to particularly rapid and complete absorption of the
Wirkstoffs führt. Die Darreichungsform als Kaugummi ist überaus haltbar, kann leicht auch auf Reisen mitgeführt und diskret eingenommen werden.  Active ingredient leads. The dosage form as chewing gum is extremely durable, can be easily carried on trips and taken discreetly.
Bevorzugt ist der Kaugummi gemäß der vorliegenden Erfindung zur Verwendung bei der Behandlung von mit der Frühschwangerschaft assoziierten Übelkeitszuständen vorgesehen. Ein hoher Preferably, the chewing gum according to the present invention is intended for use in the treatment of nausea associated with early pregnancy. A high one
Histaminspiegel wurde auch bereits mit einem erhöhten  Histamine levels have also been increased
Abortrisiko in Verbindung gebracht, sodass ein Vitamin Öl haltiger Kaugummi auch diesbezüglich zu einer Verbesserung der Umstände in der Frühschwangerschaft führt.  Abortion risk associated, so that a chewing gum containing vitamin oil leads to an improvement of the circumstances in early pregnancy.
Gemäß einer alternativen bevorzugten Ausführungsform ist der Kaugummi gemäß dem vorliegenden Erfindung zur Verwendung bei der Behandlung von mit Seekrankheit assoziierten In an alternative preferred embodiment, the chewing gum of the present invention is for use in the treatment of seasickness associated
Übelkeitszuständen vorgesehen. Nausea conditions provided.
Bevorzugt enthält ein Stück Kaugummi Vitamin C in Mengen von 50 mg bis 300 mg, bevorzugt in Mengen von 100 mg bis 250 mg, insbesondere bevorzugt in Mengen von 150 mg bis 200 mg. A piece of chewing gum preferably contains vitamin C in amounts of 50 mg to 300 mg, preferably in amounts of 100 mg to 250 mg, particularly preferably in amounts of 150 mg to 200 mg.
Derartige Konzentrationen können als sehr hoch angesehen  Such concentrations can be considered very high
werden, wobei jedoch noch keine Nebenwirkungen auftreten. but there are still no side effects.
Um die Eignung des Kaugummi gemäß dem vorliegenden To the suitability of the chewing gum according to the present
Gebrauchsmuster hinsichtlich einer langen Haltbarkeit und Utility models for a long shelf life and
Transportfähigkeit zu optimieren, ist es bevorzugt vorgesehen, dass der Kaugummi dragiert ist. To optimize transportability, it is preferably provided that the chewing gum is coated.
Der Begriff Vitamin C umfasst im Zusammenhang mit der The term vitamin C includes related to the
vorliegenden Erfindung nicht nur L- (+) -Ascorbinsäure sondern auch ihre Derivate mit gleicher Wirkung und somit Stoffe, die im Körper zu L- (+) -Ascorbinsäure umgesetzt werden können, wie beispielsweise Dehydroascorbinsäure . This invention not only L- (+) -asorbic acid but also their derivatives with the same effect and thus substances that can be converted in the body to L- (+) -ascorbic acid, such as dehydroascorbic acid.

Claims

Ansprüche : Expectations :
1. Kaugummi enthaltend Vitamin C zur Verwendung bei der Behandlung von Übelkeitszuständen beim Menschen. 1. Chewing gum containing vitamin C for use in the treatment of nausea in humans.
2. Kaugummi nach Anspruch 1, zur Verwendung bei der 2. Chewing gum according to claim 1, for use in the
Behandlung von mit der Frühschwangerschaft assoziierten  Treatment of early pregnancy
Übelkeitszuständen .  States of nausea.
3. Kaugummi nach Anspruch 1 zur Verwendung bei der Behandlung von mit Seekrankheit assoziierten Übelkeitszuständen. 3. Chewing gum according to claim 1 for use in the treatment of nausea associated with seasickness.
4. Kaugummi nach einem der Anspruch 1, 2 oder 3, dadurch gekennzeichnet, dass ein Stück Kaugummi Vitamin C in Mengen von 50 mg bis 300 mg, bevorzugt in Mengen von 100 mg bis 250 mg, insbesondere bevorzugt in Mengen von 150 mg bis 200 mg enthält. 4. chewing gum according to one of claims 1, 2 or 3, characterized in that a piece of chewing gum vitamin C in amounts of 50 mg to 300 mg, preferably in amounts of 100 mg to 250 mg, particularly preferably in amounts of 150 mg to 200 mg contains.
5. Kaugummi nach einem der Ansprüche 1 bis 4, dadurch 5. chewing gum according to any one of claims 1 to 4, characterized
gekennzeichnet, dass der Kaugummi dragiert ist. characterized that the chewing gum is coated.
EP19742123.3A 2018-06-21 2019-06-17 Vitamin c-containing chewing gum Pending EP3809866A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATGM131/2018U AT16235U1 (en) 2018-06-21 2018-06-21 Chewing gum containing vitamin C.
PCT/AT2019/000017 WO2019241810A1 (en) 2018-06-21 2019-06-17 Vitamin c-containing chewing gum

Publications (1)

Publication Number Publication Date
EP3809866A1 true EP3809866A1 (en) 2021-04-28

Family

ID=66087631

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19742123.3A Pending EP3809866A1 (en) 2018-06-21 2019-06-17 Vitamin c-containing chewing gum

Country Status (4)

Country Link
US (1) US20210259278A1 (en)
EP (1) EP3809866A1 (en)
AT (1) AT16235U1 (en)
WO (1) WO2019241810A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197510B (en) * 1986-12-19 1989-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing phenyl-alkyl-amine derivatives, against motion-sick
DE19941221A1 (en) * 1999-08-30 2001-08-16 Joachim Steuer Chewing gum contains - in the role of additives - hydrophilic vitamins and/or mineral substances and/or trace elements
DE202013001426U1 (en) * 2013-02-14 2013-04-10 Sandro Raisun Vitamin-containing chewing gum

Also Published As

Publication number Publication date
AT16235U1 (en) 2019-04-15
US20210259278A1 (en) 2021-08-26
WO2019241810A1 (en) 2019-12-26

Similar Documents

Publication Publication Date Title
EP2613793A1 (en) Nasal spray
DE4342568A1 (en) Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine
EP0037488B1 (en) Pharmaceutical composition for healing inflammatory and/or degenerative and/or atrophic mucous membranes
EP3809866A1 (en) Vitamin c-containing chewing gum
DE2060601B2 (en) Food supplements
Engel Migrations-und Integrationspotenziale im ländlichen Raum Deutschlands
Позднев Warum Phemios?(Pl. Ion 533b5-c3)
DE2325809A1 (en) Skin agents contg. vitamin B-12 and folic acid - having cosmetic, anti-acne, deodorant and cholesterol-lowering effects
Kuldkepp Besprechung. The Great War in Lithuania and Lithuanians in the Great War: Experiences and Memories (Acta Historica Universitatis Klaipedensis, Vol. XXXIV). Hrsg. von Vasilijus Safronovas. Institute of Baltic Region History and Archaeology, Klaipėda University. Klaipėda 2017. 239 S.
DE672662C (en) Germ killing method
Somek Rechtsverhältnis und aufrechter Gang. Rechtsethik im zweiten Versuch
Stefou Zwischen traditioneller Rhetorik und sokratischer (Anti-) Rhetorik. Einige neue Βemerkungen über das Proömium von Platons" Apologie des Sokrates"(17a1-18a6)
DE2749618B2 (en) Prevention of endogenous oxalate urinary stone formation
Alexander Pentosurie und Darmstörung
ARNEGGER et al. EINIGE BEMERKUNGEN ZUM SPANISCHEN ERBFOLGE KRIEG (1701-1714).
Frauen BMI=
DE10103692A1 (en) Use of zeolite substances that are non-astringent and develop antiperspirant and/or deodorant activity only in the presence of acidic components, to prepare antiperspirants and/or deodorants
Müller et al. Arzneimittel-und Wirkstoffherstellungsverordnung (AMWHV): Wieviel Arzneimittelrecht braucht die Transfusionsmedizin noch?
Appel et al. Potenzial, Herausforderungen und Grenzen des G-20 Agricultural Market Information System (AMIS)
Biersack Italian Renaissance Humanism in the Mirror (Ideas in Context)
Stephan Till my Tale is Told. Women's Memoirs of the Gulag. Indiana-Michigan Series in Russian and East European Studies
Faes et al. The family as an essential partner in the care of dementia patients
Schallert Studies on Old High German Syntax. Left sentence periphery, verb placement and verb-second
Fanai Verlauf und Prognose der Verwahrlosung
DE202017006288U1 (en) Cosmetic agent for the reduction of skin pores

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210120

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)