EP3801221A4 - Methods of delaying and reversing alzheimer's disease progression - Google Patents

Methods of delaying and reversing alzheimer's disease progression Download PDF

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Publication number
EP3801221A4
EP3801221A4 EP19819198.3A EP19819198A EP3801221A4 EP 3801221 A4 EP3801221 A4 EP 3801221A4 EP 19819198 A EP19819198 A EP 19819198A EP 3801221 A4 EP3801221 A4 EP 3801221A4
Authority
EP
European Patent Office
Prior art keywords
delaying
methods
disease progression
reversing alzheimer
alzheimer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19819198.3A
Other languages
German (de)
French (fr)
Other versions
EP3801221A1 (en
Inventor
Salvador Soriano
Dong Kyu Shin
Karina MAYAGOITIA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loma Linda University
Original Assignee
Loma Linda University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loma Linda University filed Critical Loma Linda University
Publication of EP3801221A1 publication Critical patent/EP3801221A1/en
Publication of EP3801221A4 publication Critical patent/EP3801221A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
EP19819198.3A 2018-06-11 2019-06-10 Methods of delaying and reversing alzheimer's disease progression Withdrawn EP3801221A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862683587P 2018-06-11 2018-06-11
PCT/US2019/036395 WO2019241156A1 (en) 2018-06-11 2019-06-10 Methods of delaying and reversing alzheimer's disease progression

Publications (2)

Publication Number Publication Date
EP3801221A1 EP3801221A1 (en) 2021-04-14
EP3801221A4 true EP3801221A4 (en) 2022-03-30

Family

ID=68842290

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19819198.3A Withdrawn EP3801221A4 (en) 2018-06-11 2019-06-10 Methods of delaying and reversing alzheimer's disease progression

Country Status (3)

Country Link
US (1) US20210322386A1 (en)
EP (1) EP3801221A4 (en)
WO (1) WO2019241156A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024400A1 (en) * 1997-11-10 1999-05-20 Vyrex Corporation Probucol esters and uses thereof
WO2005058842A1 (en) * 2003-12-15 2005-06-30 Laboratoire Theramex 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150031655A1 (en) * 2011-04-15 2015-01-29 University Of North Dakota Combination of liver x receptor modulator and estrogen receptor modulator for the treatment of age-related diseases
US20150005351A1 (en) * 2013-06-26 2015-01-01 Loma Linda University Methods and kits for determining risk for developing alzheimer's disease and prevention or treatment thereof
AU2017371071B2 (en) * 2016-12-09 2023-06-15 Loma Linda University Health Methods of diagnosing Alzheimer's disease and risk of progression to Alzheimer's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024400A1 (en) * 1997-11-10 1999-05-20 Vyrex Corporation Probucol esters and uses thereof
WO2005058842A1 (en) * 2003-12-15 2005-06-30 Laboratoire Theramex 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CATHERINE M BENDER ET AL: "Patterns of change in cognitive function with anastrozole therapy", CANCER, AMERICAN CANCER SOCIETY , PHILADELPHIA , PA, US, vol. 121, no. 15, 23 April 2015 (2015-04-23), pages 2627 - 2636, XP071127891, ISSN: 0008-543X, DOI: 10.1002/CNCR.29393 *
GABRIELLA TESTA ET AL: "Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation", REDOX BIOLOGY, vol. 10, 16 September 2016 (2016-09-16), NL, pages 24 - 33, XP055423027, ISSN: 2213-2317, DOI: 10.1016/j.redox.2016.09.001 *
See also references of WO2019241156A1 *
ZHANG XIAONA ET AL: "Increased Levels of 27-Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 62, no. 3, 2 January 2018 (2018-01-02), DE, pages 1700531, XP055891689, ISSN: 1613-4125, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700531> DOI: 10.1002/mnfr.201700531 *

Also Published As

Publication number Publication date
EP3801221A1 (en) 2021-04-14
US20210322386A1 (en) 2021-10-21
WO2019241156A1 (en) 2019-12-19

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