EP3794139A4 - Enrichissement et détection de méthylation spécifique à une séquence - Google Patents

Enrichissement et détection de méthylation spécifique à une séquence Download PDF

Info

Publication number
EP3794139A4
EP3794139A4 EP18919343.6A EP18919343A EP3794139A4 EP 3794139 A4 EP3794139 A4 EP 3794139A4 EP 18919343 A EP18919343 A EP 18919343A EP 3794139 A4 EP3794139 A4 EP 3794139A4
Authority
EP
European Patent Office
Prior art keywords
detection
sequence specific
specific methylation
methylation enrichment
enrichment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18919343.6A
Other languages
German (de)
English (en)
Other versions
EP3794139A1 (fr
Inventor
Anthony P. Shuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Research LLC
Original Assignee
Genetics Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/018,926 external-priority patent/US20190002964A1/en
Application filed by Genetics Research LLC filed Critical Genetics Research LLC
Publication of EP3794139A1 publication Critical patent/EP3794139A1/fr
Publication of EP3794139A4 publication Critical patent/EP3794139A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP18919343.6A 2018-05-16 2018-10-03 Enrichissement et détection de méthylation spécifique à une séquence Withdrawn EP3794139A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862672217P 2018-05-16 2018-05-16
US16/018,926 US20190002964A1 (en) 2017-06-28 2018-06-26 Bodily fluid target enrichment
PCT/US2018/054188 WO2019221769A1 (fr) 2018-05-16 2018-10-03 Enrichissement et détection de méthylation spécifique à une séquence

Publications (2)

Publication Number Publication Date
EP3794139A1 EP3794139A1 (fr) 2021-03-24
EP3794139A4 true EP3794139A4 (fr) 2022-06-01

Family

ID=68540705

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18919343.6A Withdrawn EP3794139A4 (fr) 2018-05-16 2018-10-03 Enrichissement et détection de méthylation spécifique à une séquence
EP18918562.2A Withdrawn EP3655546A4 (fr) 2018-05-16 2018-10-12 Détection et surveillance de tumeur

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18918562.2A Withdrawn EP3655546A4 (fr) 2018-05-16 2018-10-12 Détection et surveillance de tumeur

Country Status (3)

Country Link
EP (2) EP3794139A4 (fr)
CA (2) CA3100492A1 (fr)
WO (2) WO2019221769A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10081829B1 (en) 2017-06-13 2018-09-25 Genetics Research, Llc Detection of targeted sequence regions
WO2021108366A1 (fr) * 2019-11-27 2021-06-03 Genetics Research, Llc Enrichissement de crispr d'allèle rare ciblé
WO2024006908A1 (fr) * 2022-06-30 2024-01-04 Guardant Health, Inc. Enrichissement d'adn méthylé de manière aberrante

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016028887A1 (fr) * 2014-08-19 2016-02-25 Pacific Biosciences Of California, Inc. Compositions et méthodes pour l'enrichissement d'acides nucléiques

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047787A2 (fr) * 2004-10-27 2006-05-04 Exact Sciences Corporation Methode de surveillance de la progression ou la recurrence d'une maladie
US8916530B2 (en) * 2005-11-18 2014-12-23 Gradalis, Inc. Individualized cancer therapy
CA3176503A1 (fr) * 2014-07-21 2016-01-28 Illumina, Inc Enrichissement de polynucleotides a l'aide de systemes crispr-cas
CA2985506A1 (fr) * 2015-05-15 2016-11-24 Pioneer Hi-Bred International, Inc. Systemes arn guide/endonuclease cas
US20170014449A1 (en) * 2015-07-13 2017-01-19 Elwha LLC, a limited liability company of the State of Delaware Site-specific epigenetic editing
US10081829B1 (en) * 2017-06-13 2018-09-25 Genetics Research, Llc Detection of targeted sequence regions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016028887A1 (fr) * 2014-08-19 2016-02-25 Pacific Biosciences Of California, Inc. Compositions et méthodes pour l'enrichissement d'acides nucléiques

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LIANG GANGNING ET AL: "DNA methylation aberrancies as a guide for surveillance and treatment of human cancers", EPIGENETICS, vol. 12, no. 6, 28 April 2017 (2017-04-28), US, pages 416 - 432, XP055914021, ISSN: 1559-2294, Retrieved from the Internet <URL:https://www.tandfonline.com/doi/pdf/10.1080/15592294.2017.1311434?needAccess=true> DOI: 10.1080/15592294.2017.1311434 *
MENGQI HUANG ET AL: "Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Triggered Isothermal Amplification for Site-Specific Nucleic Acid Detection", ANALYTICAL CHEMISTRY, vol. 90, no. 3, 5 January 2018 (2018-01-05), US, pages 2193 - 2200, XP055611061, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b04542 *
PFEIFER GERD: "Defining Driver DNA Methylation Changes in Human Cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 4, 1 January 2018 (2018-01-01), Basel, CH, pages 1166, XP055914018, ISSN: 1661-6596, DOI: 10.3390/ijms19041166 *
RICHARD C. STEVENS ET AL: "A novel CRISPR/Cas9 associated technology for sequence-specific nucleic acid enrichment", PLOS ONE, vol. 14, no. 4, 18 April 2019 (2019-04-18), pages e0215441, XP055751103, DOI: 10.1371/journal.pone.0215441 *
See also references of WO2019221769A1 *
YOTANI TAKUYA ET AL: "A novel CRISPR/Cas9 associated technology for sequence-specific nucleic acid enrichment", CANCER SCIENCE, vol. 109, no. 5, 17 April 2018 (2018-04-17), JP, pages 1690 - 1700, XP055792834, ISSN: 1347-9032, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.13566> DOI: 10.1111/cas.13566 *

Also Published As

Publication number Publication date
EP3794139A1 (fr) 2021-03-24
WO2019221773A1 (fr) 2019-11-21
EP3655546A4 (fr) 2021-04-07
WO2019221769A1 (fr) 2019-11-21
EP3655546A1 (fr) 2020-05-27
CA3100492A1 (fr) 2019-11-21
CA3069939A1 (fr) 2019-11-21

Similar Documents

Publication Publication Date Title
EP3624752A4 (fr) Systèmes à redressement automatique, et composants et procédés associés
EP3543663A4 (fr) Système d&#39;inspection et système de registre
EP3565885A4 (fr) Nouveaux systèmes et procédés de fermentation
EP3886737A4 (fr) Systèmes et procédés d&#39;histotrypsie
EP3548456A4 (fr) Systèmes et procédés de conversion d&#39;éthylène en liquides
EP3497245A4 (fr) Compositions et procédés permettant de détecter des variants de séquences rares
EP3810182A4 (fr) Néoantigènes et leurs utilisations
EP3284070A4 (fr) Système et procédés de détection audio
EP3810180A4 (fr) Néoantigènes et leurs utilisations
GB201805479D0 (en) Microorganism separation and detection
EP3367360A4 (fr) Repère magnétique et système de détection de repère magnétique
EP3703838A4 (fr) Procédés et systèmes d&#39;enrichissement de terpène
EP3672443A4 (fr) Valise et sytème de valise
EP3497436A4 (fr) Élution et détection
EP3806061A4 (fr) Dispositif de détection et système de détection
EP3806062A4 (fr) Dispositif et système de détection
EP3476932A4 (fr) Nouveau microorganisme appartenant à la famille des sporichthyaceae et son utilisation
AU2018283983B2 (en) Index sorting systems and methods
EP3829734A4 (fr) Procédés d&#39;appauvrissement et d&#39;enrichissement
EP3743525A4 (fr) Procédés et compositions de détection de proximité
EP3692008A4 (fr) Procédés et systèmes de biocimentation
EP3617699A4 (fr) Système de détection et procédé de détection
EP3794139A4 (fr) Enrichissement et détection de méthylation spécifique à une séquence
EP3524554A4 (fr) Système d&#39;alimentation en feuilles et procédé d&#39;alimentation en feuilles
EP3457163A4 (fr) Système de détection de position et récepteur

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20201216

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20220429

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/6827 20180101ALI20220422BHEP

Ipc: C12Q 1/6804 20180101ALI20220422BHEP

Ipc: G01N 33/50 20060101ALI20220422BHEP

Ipc: C12N 15/10 20060101ALI20220422BHEP

Ipc: C12N 15/11 20060101ALI20220422BHEP

Ipc: C12N 9/22 20060101ALI20220422BHEP

Ipc: C12Q 1/68 20180101AFI20220422BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20221129