EP3784241A4 - Tricyclic heterocycle compounds useful as hiv integrase inhibitors - Google Patents

Tricyclic heterocycle compounds useful as hiv integrase inhibitors Download PDF

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Publication number
EP3784241A4
EP3784241A4 EP19793407.8A EP19793407A EP3784241A4 EP 3784241 A4 EP3784241 A4 EP 3784241A4 EP 19793407 A EP19793407 A EP 19793407A EP 3784241 A4 EP3784241 A4 EP 3784241A4
Authority
EP
European Patent Office
Prior art keywords
compounds useful
hiv integrase
integrase inhibitors
tricyclic heterocycle
heterocycle compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19793407.8A
Other languages
German (de)
French (fr)
Other versions
EP3784241A1 (en
Inventor
Tao Yu
James M. Apgar
Alan Whitehead
Yonglian Zhang
Zhiyong Hu
Valerie W. SHURTLEFF
John A. Mccauley
Izzat T. Raheem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of EP3784241A1 publication Critical patent/EP3784241A1/en
Publication of EP3784241A4 publication Critical patent/EP3784241A4/en
Withdrawn legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP19793407.8A 2018-04-27 2019-04-22 Tricyclic heterocycle compounds useful as hiv integrase inhibitors Withdrawn EP3784241A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862663377P 2018-04-27 2018-04-27
US201862664527P 2018-04-30 2018-04-30
PCT/US2019/028432 WO2019209667A1 (en) 2018-04-27 2019-04-22 Tricyclic heterocycle compounds useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
EP3784241A1 EP3784241A1 (en) 2021-03-03
EP3784241A4 true EP3784241A4 (en) 2022-01-19

Family

ID=68294232

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19793407.8A Withdrawn EP3784241A4 (en) 2018-04-27 2019-04-22 Tricyclic heterocycle compounds useful as hiv integrase inhibitors

Country Status (10)

Country Link
EP (1) EP3784241A4 (en)
JP (1) JP2021522254A (en)
KR (1) KR20210005139A (en)
CN (1) CN112088005A (en)
AU (1) AU2019260608A1 (en)
BR (1) BR112020021768A2 (en)
CA (1) CA3101180A1 (en)
MA (1) MA52367A (en)
MX (1) MX2020011317A (en)
WO (1) WO2019209667A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202011386QA (en) 2018-05-31 2020-12-30 Shionogi & Co Polycyclic pyridone derivative
AR115455A1 (en) 2018-05-31 2021-01-20 Shionogi & Co POLYCLIC PYRIDOTRIAZINE DERIVATIVE
EP3801543B1 (en) 2018-06-05 2024-09-11 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
TWI745900B (en) 2019-03-22 2021-11-11 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
AU2020391106B2 (en) * 2019-11-26 2024-03-21 Gilead Sciences, Inc. Processes and intermediates for preparing MCL1 inhibitors
PE20221569A1 (en) * 2020-02-24 2022-10-06 Gilead Sciences Inc TETRACYCLIC COMPOUNDS FOR THE TREATMENT OF HIV INFECTIONS
ES2968058T3 (en) 2021-01-19 2024-05-07 Gilead Sciences Inc Substituted pyridotriazine compounds and uses thereof
TWI843506B (en) 2022-04-06 2024-05-21 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014183532A1 (en) * 2013-05-17 2014-11-20 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
WO2017113288A1 (en) * 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002334205B2 (en) * 2001-10-26 2007-07-05 Istituto Di Ricerche Di Biologia Molecolara P. Angeletti Spa Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014183532A1 (en) * 2013-05-17 2014-11-20 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
WO2017113288A1 (en) * 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019209667A1 *
ZUO XIAOFANG ET AL: "Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014-2017)", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 28, no. 4, 3 April 2018 (2018-04-03), GB, pages 299 - 316, XP055870040, ISSN: 1354-3776, Retrieved from the Internet <URL:http://dx.doi.org/10.1080/13543776.2018.1438410> DOI: 10.1080/13543776.2018.1438410 *

Also Published As

Publication number Publication date
MX2020011317A (en) 2020-11-18
EP3784241A1 (en) 2021-03-03
WO2019209667A1 (en) 2019-10-31
JP2021522254A (en) 2021-08-30
AU2019260608A1 (en) 2020-10-29
KR20210005139A (en) 2021-01-13
BR112020021768A2 (en) 2021-01-26
MA52367A (en) 2021-03-03
CN112088005A (en) 2020-12-15
CA3101180A1 (en) 2019-10-31

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