EP3762103A4 - Radiotherapy seeds and applicators - Google Patents

Radiotherapy seeds and applicators Download PDF

Info

Publication number
EP3762103A4
EP3762103A4 EP19763461.1A EP19763461A EP3762103A4 EP 3762103 A4 EP3762103 A4 EP 3762103A4 EP 19763461 A EP19763461 A EP 19763461A EP 3762103 A4 EP3762103 A4 EP 3762103A4
Authority
EP
European Patent Office
Prior art keywords
applicators
radiotherapy seeds
radiotherapy
seeds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19763461.1A
Other languages
German (de)
French (fr)
Other versions
EP3762103A1 (en
Inventor
Itzhak Kelson
Yona Keisari
Michael Schmidt
Ofer MAGEN
Amitai SOSNOVITCH
Guy KERET
Amnon GAT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Tau Medical Ltd
Original Assignee
Alpha Tau Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Tau Medical Ltd filed Critical Alpha Tau Medical Ltd
Publication of EP3762103A1 publication Critical patent/EP3762103A1/en
Publication of EP3762103A4 publication Critical patent/EP3762103A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1785—Syringes comprising radioactive shield means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A61N2005/1009—Apparatus for loading seeds into magazines or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A61N2005/101—Magazines or cartridges for seeds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A61N2005/1011—Apparatus for permanent insertion of sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027—Interstitial radiation therapy
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F5/00—Transportable or portable shielded containers
    • G21F5/02—Transportable or portable shielded containers with provision for restricted exposure of a radiation source within the container
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP19763461.1A 2018-03-08 2019-03-07 Radiotherapy seeds and applicators Pending EP3762103A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862640077P 2018-03-08 2018-03-08
PCT/IB2019/051834 WO2019171308A1 (en) 2018-03-08 2019-03-07 Radiotherapy seeds and applicators

Publications (2)

Publication Number Publication Date
EP3762103A1 EP3762103A1 (en) 2021-01-13
EP3762103A4 true EP3762103A4 (en) 2021-12-01

Family

ID=67847049

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19763461.1A Pending EP3762103A4 (en) 2018-03-08 2019-03-07 Radiotherapy seeds and applicators

Country Status (11)

Country Link
US (1) US20200406059A1 (en)
EP (1) EP3762103A4 (en)
JP (2) JP2021516081A (en)
KR (1) KR20200130307A (en)
CN (4) CN111818970B (en)
AU (6) AU2019229849B2 (en)
CA (1) CA3091560A1 (en)
MX (1) MX2020008829A (en)
SG (1) SG11202007645TA (en)
WO (1) WO2019171308A1 (en)
ZA (1) ZA202004966B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9821174B1 (en) 2015-02-06 2017-11-21 Gammatile Llc Radioactive implant planning system and placement guide system
US10888710B1 (en) 2016-11-29 2021-01-12 Gt Medical Technologies, Inc. Transparent loading apparatus
EP4041386A4 (en) * 2019-10-10 2023-11-22 Alpha Tau Medical Ltd. Wet preparation of radiotherapy sources
US11872409B2 (en) 2020-11-12 2024-01-16 Alpha Tau Medical Ltd. Radiotherapy template assembly
AU2021400142A1 (en) 2020-12-16 2023-06-22 Alpha Tau Medical Ltd. Diffusing alpha-emitters radiation therapy with enhanced beta treatment
KR20230156328A (en) * 2021-03-11 2023-11-14 알파 타우 메디컬 리미티드 Radiation therapy applicator
US12076583B2 (en) 2021-06-10 2024-09-03 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for melanoma
US11964168B2 (en) 2021-06-10 2024-04-23 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for prostate cancer
US12076581B2 (en) 2021-06-10 2024-09-03 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for glioblastoma
US12042668B2 (en) 2021-06-10 2024-07-23 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for squamous cell carcinoma
US12064643B2 (en) 2021-06-10 2024-08-20 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for breast cancer
US12070620B2 (en) 2021-06-10 2024-08-27 Alpha Tau Medical Ltd. Activity levels for diffusing alpha-emitter radiation therapy
US12076582B2 (en) 2021-06-10 2024-09-03 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for colorectal cancer
US12070621B2 (en) 2021-06-10 2024-08-27 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for pancreatic cancer
CA3222415A1 (en) 2021-06-30 2023-01-05 Alpha Tau Medical Ltd. Radiotherapy applicator with perpendicular or angled radial dispensing
US12053644B2 (en) 2021-12-30 2024-08-06 Gt Medical Technologies, Inc. Radiation shielding apparatus for implantable radioactive seeds

Citations (5)

* Cited by examiner, † Cited by third party
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US5899882A (en) * 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
WO2000004953A2 (en) * 1998-07-20 2000-02-03 Cook Urological Inc. Brachytherapy device including an anti-static handle
WO2005087274A1 (en) * 2004-03-05 2005-09-22 Xl Sci-Tech, Inc. Particulate materials and compositions for radio therapy
WO2017157880A1 (en) * 2016-03-16 2017-09-21 Koninklijke Philips N.V. Electromagnetic drivable inserts
WO2017173352A1 (en) * 2016-03-31 2017-10-05 Thomas Jefferson University Tumor bed implant for multimodality treatment of at risk tissue surrounding a resection cavity

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US2075508A (en) 1934-07-18 1937-03-30 Edward W Davidson Suture retainer
US6086942A (en) * 1998-05-27 2000-07-11 International Brachytherapy S.A. Fluid-jet deposition of radioactive material for brachytherapy devices
ES2259480T3 (en) * 1998-11-06 2006-10-01 Ge Healthcare Limited BRAQUITERAPIA PRODUCTS AND METHODS.
AU8026600A (en) 1999-10-15 2001-04-30 Deschutes Medical Products, Inc. Brachytherapy instrument and methods
US6949064B2 (en) * 2000-10-20 2005-09-27 Bard Brachytherapy, Inc. Brachytherapy seed deployment system
WO2002041762A2 (en) * 2000-11-10 2002-05-30 Mentor Corporation Automated implantation system for radioisotope seeds
US7074291B2 (en) * 2001-11-02 2006-07-11 Worldwide Medical Technologies, L.L.C. Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6786858B2 (en) * 2001-11-02 2004-09-07 Ideamatrix, Inc. Delivery system and method for interstitial radiotherapy using hollow seeds
US20030191355A1 (en) 2002-04-04 2003-10-09 Ferguson Patrick J. Hollow bioabsorbable elements for positioning material in living tissue
US7749151B2 (en) * 2002-04-04 2010-07-06 Cp Medical, Inc. Brachytherapy spacer
AU2003274960C1 (en) * 2002-09-10 2010-04-01 Cianna Medical, Inc. Brachytherapy apparatus
US7322928B2 (en) * 2003-03-17 2008-01-29 Medi-Physics, Inc. Products and methods for brachytherapy
ATE424221T1 (en) 2003-04-30 2009-03-15 Univ Ramot METHOD AND APPARATUS FOR RADIATION THERAPY
CN1816369A (en) * 2003-07-02 2006-08-09 医疗物理有限公司 Methods and systems of preparing preloaded needles for brachytherapy
US20050245785A1 (en) * 2003-10-29 2005-11-03 Tarone Theodore T Biodegradable seed placement device and method
CA2615589A1 (en) 2005-07-26 2007-02-01 Ramot At Tel Aviv University Ltd. A radioactive surface source and a method for producing the same
WO2007053823A2 (en) 2005-10-31 2007-05-10 Biolucent, Inc. Brachytherapy apparatus and methods of using same
US20080269540A1 (en) 2007-04-27 2008-10-30 Worldwide Medical Technologies Llc Seed cartridge adaptor and methods for use therewith
WO2009156893A1 (en) * 2008-06-25 2009-12-30 Koninklijke Philips Electronics N.V. Method and system for brachytherapy
US8764619B2 (en) 2009-04-21 2014-07-01 Breast Microseed Llc Brachytherapy fiducial needle fixation system and method
WO2012024085A2 (en) 2010-08-20 2012-02-23 Wake Forest University Health Sciences Tethered and/or visually coded brachytherapy devices and related methods
US8742383B2 (en) 2011-10-04 2014-06-03 Surikat S.A. Radiation protection device
ES2660572T3 (en) 2013-03-14 2018-03-23 C. R. Bard, Inc. Brachytherapy seed insertion and fixation system
US20140296612A1 (en) 2013-03-26 2014-10-02 David Schwartz Brachytherapy Assist Device
CN104162226B (en) * 2014-07-10 2017-01-11 北京理工大学 Automation device capable of implanting radioactive particles continuously
JP5936754B1 (en) * 2015-06-09 2016-06-22 株式会社林寺メディノール Stylet stopper
US10262763B2 (en) 2016-09-19 2019-04-16 Radium Incorporated Systems, devices, and/or methods for managing radiation shielding

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5899882A (en) * 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
WO2000004953A2 (en) * 1998-07-20 2000-02-03 Cook Urological Inc. Brachytherapy device including an anti-static handle
WO2005087274A1 (en) * 2004-03-05 2005-09-22 Xl Sci-Tech, Inc. Particulate materials and compositions for radio therapy
WO2017157880A1 (en) * 2016-03-16 2017-09-21 Koninklijke Philips N.V. Electromagnetic drivable inserts
WO2017173352A1 (en) * 2016-03-31 2017-10-05 Thomas Jefferson University Tumor bed implant for multimodality treatment of at risk tissue surrounding a resection cavity

Also Published As

Publication number Publication date
EP3762103A1 (en) 2021-01-13
MX2020008829A (en) 2020-10-05
CN116531683A (en) 2023-08-04
AU2023201498A1 (en) 2023-04-13
AU2019229849B2 (en) 2021-07-15
JP2024003142A (en) 2024-01-11
AU2021236575A1 (en) 2021-10-28
CN111818970A (en) 2020-10-23
AU2021236578B2 (en) 2022-12-15
CA3091560A1 (en) 2019-09-12
AU2021236578A1 (en) 2021-10-28
AU2021236577A1 (en) 2021-10-28
AU2021236575B2 (en) 2023-02-02
WO2019171308A1 (en) 2019-09-12
AU2021236577B2 (en) 2022-12-15
CN111818970B (en) 2023-06-27
AU2024213162A1 (en) 2024-09-12
SG11202007645TA (en) 2020-09-29
RU2020127039A (en) 2022-04-08
KR20200130307A (en) 2020-11-18
ZA202004966B (en) 2022-06-29
AU2019229849A1 (en) 2020-09-03
CN116531682A (en) 2023-08-04
US20200406059A1 (en) 2020-12-31
JP2021516081A (en) 2021-07-01
CN116585625A (en) 2023-08-15
AU2023201498B2 (en) 2024-05-23

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