EP3733198A4 - Composition for regeneration of human fibrous cartilage or elastic cartilage - Google Patents

Composition for regeneration of human fibrous cartilage or elastic cartilage Download PDF

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Publication number
EP3733198A4
EP3733198A4 EP18895486.1A EP18895486A EP3733198A4 EP 3733198 A4 EP3733198 A4 EP 3733198A4 EP 18895486 A EP18895486 A EP 18895486A EP 3733198 A4 EP3733198 A4 EP 3733198A4
Authority
EP
European Patent Office
Prior art keywords
cartilage
regeneration
composition
elastic
human fibrous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18895486.1A
Other languages
German (de)
French (fr)
Other versions
EP3733198C0 (en
EP3733198B1 (en
EP3733198A2 (en
Inventor
Seung Uk An
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bef Medical Inc
Original Assignee
Bef Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bef Medical Inc filed Critical Bef Medical Inc
Publication of EP3733198A2 publication Critical patent/EP3733198A2/en
Publication of EP3733198A4 publication Critical patent/EP3733198A4/en
Application granted granted Critical
Publication of EP3733198C0 publication Critical patent/EP3733198C0/en
Publication of EP3733198B1 publication Critical patent/EP3733198B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP18895486.1A 2017-12-29 2018-12-28 Composition for regeneration of human fibrous cartilage or elastic cartilage Active EP3733198B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170183688 2017-12-29
PCT/KR2018/016892 WO2019132604A2 (en) 2017-12-29 2018-12-28 Composition for regeneration of human fibrous cartilage or elastic cartilage

Publications (4)

Publication Number Publication Date
EP3733198A2 EP3733198A2 (en) 2020-11-04
EP3733198A4 true EP3733198A4 (en) 2021-06-23
EP3733198C0 EP3733198C0 (en) 2023-06-07
EP3733198B1 EP3733198B1 (en) 2023-06-07

Family

ID=67067882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18895486.1A Active EP3733198B1 (en) 2017-12-29 2018-12-28 Composition for regeneration of human fibrous cartilage or elastic cartilage

Country Status (6)

Country Link
US (1) US20210069376A1 (en)
EP (1) EP3733198B1 (en)
JP (1) JP7221297B2 (en)
KR (1) KR102216008B1 (en)
CN (1) CN111587121B (en)
WO (1) WO2019132604A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116392639B (en) * 2023-02-17 2024-02-13 无锡市中医医院 Full-layer repair double-layer bracket and preparation method and application thereof
KR102565364B1 (en) * 2023-04-04 2023-08-09 김재열 Sustained-release topical drug delivery system containing a composition for accelerating autogenous bone recovery and pharmaceutical composition containing the same

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005170816A (en) * 2003-12-09 2005-06-30 Naoki Ishiguro Material for restoring cartilage, and method for producing the same
WO2007028258A2 (en) * 2005-09-09 2007-03-15 Ottawa Health Research Institute Interpenetrating networks, and related methods and compositions
US20070134291A1 (en) * 1999-10-05 2007-06-14 Kang Ting Composition for cartilage
US20100010114A1 (en) * 2008-07-07 2010-01-14 David Myung Hydrophilic Interpenetrating Polymer Networks Derived From Hydrophobic Polymers
WO2011005974A2 (en) * 2009-07-08 2011-01-13 Northwestern University Interpenetrating biomaterial matrices and uses thereof
US20120288564A1 (en) * 2011-05-11 2012-11-15 Agency For Science, Technology And Research Interpenetrating polymer network comprising fibrin
US20150166735A1 (en) * 2013-12-18 2015-06-18 Universite Cergy-Pontoise Method Of Production Of New Polymeric Material
ES2544763T3 (en) * 2008-11-20 2015-09-03 Université de Cergy-Pontoise Materials in the form of interpenetrating polymer networks that combine a fibrin gel and a polyethylene glycol network
WO2016112176A1 (en) * 2015-01-08 2016-07-14 University Of Iowa Research Foundation Methods for the regeneration of articular cartilage in vivo
WO2017027590A1 (en) * 2015-08-10 2017-02-16 Hyale Surgical, Inc. Interpenetrating polymer networks
WO2017168428A1 (en) * 2016-03-30 2017-10-05 Regentis Biomaterials Ltd. Treatments utilizing a polymer-protein conjugate
EP3498309A1 (en) * 2017-12-15 2019-06-19 HRA Pharma Rare Diseases Interpenetrating polymer networks, and their methods of manufacturing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
KR101340458B1 (en) * 2010-11-02 2013-12-11 서울대학교산학협력단 Composition Comprising Hydrogel for Transplant to Cartilage
WO2014093836A1 (en) * 2012-12-13 2014-06-19 University Of Georgia Research Foundation, Inc. Ossification-inducing composition and methods of use thereof
EP4159248A1 (en) * 2013-12-10 2023-04-05 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for adhering tissue surfaces and materials and biomedical uses thereof
KR101844878B1 (en) * 2016-04-12 2018-04-04 아주대학교산학협력단 Injectable double network hydrogels and biomedical use thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070134291A1 (en) * 1999-10-05 2007-06-14 Kang Ting Composition for cartilage
JP2005170816A (en) * 2003-12-09 2005-06-30 Naoki Ishiguro Material for restoring cartilage, and method for producing the same
WO2007028258A2 (en) * 2005-09-09 2007-03-15 Ottawa Health Research Institute Interpenetrating networks, and related methods and compositions
US20100010114A1 (en) * 2008-07-07 2010-01-14 David Myung Hydrophilic Interpenetrating Polymer Networks Derived From Hydrophobic Polymers
ES2544763T3 (en) * 2008-11-20 2015-09-03 Université de Cergy-Pontoise Materials in the form of interpenetrating polymer networks that combine a fibrin gel and a polyethylene glycol network
WO2011005974A2 (en) * 2009-07-08 2011-01-13 Northwestern University Interpenetrating biomaterial matrices and uses thereof
US20120288564A1 (en) * 2011-05-11 2012-11-15 Agency For Science, Technology And Research Interpenetrating polymer network comprising fibrin
US20150166735A1 (en) * 2013-12-18 2015-06-18 Universite Cergy-Pontoise Method Of Production Of New Polymeric Material
WO2016112176A1 (en) * 2015-01-08 2016-07-14 University Of Iowa Research Foundation Methods for the regeneration of articular cartilage in vivo
WO2017027590A1 (en) * 2015-08-10 2017-02-16 Hyale Surgical, Inc. Interpenetrating polymer networks
WO2017168428A1 (en) * 2016-03-30 2017-10-05 Regentis Biomaterials Ltd. Treatments utilizing a polymer-protein conjugate
EP3498309A1 (en) * 2017-12-15 2019-06-19 HRA Pharma Rare Diseases Interpenetrating polymer networks, and their methods of manufacturing

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AKPALO E ET AL: "Fibrinpolyethylene oxide interpenetrating polymer networks: New self-supported biomaterials combining the properties of both protein gel and synthetic polymer", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 6, 2 March 2011 (2011-03-02), pages 2418 - 2427, XP028199359, ISSN: 1742-7061, [retrieved on 20110305], DOI: 10.1016/J.ACTBIO.2011.03.002 *
BIDAULT L ET AL: "Fibrin-based interpenetrating polymer network biomaterials with tunable biodegradability", POLYMER, vol. 62, 2015, pages 19 - 27, XP029209207, ISSN: 0032-3861, DOI: 10.1016/J.POLYMER.2015.02.014 *
RAMPICHOVÁ MICHALA ET AL: "Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation", ASAIO JOURNAL., vol. 56, no. 6, 1 November 2010 (2010-11-01), US, pages 563 - 568, XP055799392, ISSN: 1058-2916, DOI: 10.1097/MAT.0b013e3181fcbe24 *
SHANEEN L. ROWE ET AL: "Interpenetrating Collagen-Fibrin Composite Matrices with Varying Protein Contents and Ratios", BIOMACROMOLECULES, vol. 7, no. 11, 1 November 2006 (2006-11-01), US, pages 2942 - 2948, XP055690321, ISSN: 1525-7797, DOI: 10.1021/bm0602233 *
YAN GUO ET AL: "Hydrogels of collagen/chondroitin sulfate/hyaluronan interpenetrating polymer network for cartilage tissue engineering", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, KLUWER ACADEMIC PUBLISHERS, BO, vol. 23, no. 9, 26 May 2012 (2012-05-26), pages 2267 - 2279, XP035105472, ISSN: 1573-4838, DOI: 10.1007/S10856-012-4684-5 *

Also Published As

Publication number Publication date
CN111587121B (en) 2024-02-20
EP3733198C0 (en) 2023-06-07
JP7221297B2 (en) 2023-02-13
WO2019132604A2 (en) 2019-07-04
CN111587121A (en) 2020-08-25
KR102216008B1 (en) 2021-02-16
WO2019132604A3 (en) 2019-08-22
JP2021509350A (en) 2021-03-25
EP3733198B1 (en) 2023-06-07
US20210069376A1 (en) 2021-03-11
KR20190082138A (en) 2019-07-09
KR102216008B9 (en) 2023-12-08
EP3733198A2 (en) 2020-11-04

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