EP3597639A4 - Deuterated benzimidazole compound and medicinal use thereof - Google Patents
Deuterated benzimidazole compound and medicinal use thereof Download PDFInfo
- Publication number
- EP3597639A4 EP3597639A4 EP18768085.5A EP18768085A EP3597639A4 EP 3597639 A4 EP3597639 A4 EP 3597639A4 EP 18768085 A EP18768085 A EP 18768085A EP 3597639 A4 EP3597639 A4 EP 3597639A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- benzimidazole compound
- medicinal use
- deuterated
- deuterated benzimidazole
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Deuterated benzimidazole compound Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017050334 | 2017-03-15 | ||
| PCT/JP2018/009873 WO2018168894A1 (en) | 2017-03-15 | 2018-03-14 | Deuterated benzimidazole compound and medicinal use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3597639A1 EP3597639A1 (en) | 2020-01-22 |
| EP3597639A4 true EP3597639A4 (en) | 2020-09-16 |
Family
ID=63522186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18768085.5A Pending EP3597639A4 (en) | 2017-03-15 | 2018-03-14 | Deuterated benzimidazole compound and medicinal use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11066372B2 (en) |
| EP (1) | EP3597639A4 (en) |
| JP (1) | JP7090069B2 (en) |
| KR (1) | KR102614535B1 (en) |
| CN (1) | CN110612289B (en) |
| AU (1) | AU2018236530B2 (en) |
| CA (1) | CA3055510A1 (en) |
| WO (1) | WO2018168894A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11242332B2 (en) * | 2017-03-15 | 2022-02-08 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing benzimidazole derivative |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250554A (en) | 1989-10-24 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives useful as angiotensin II inhibitors |
| IL95975A (en) | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
| JP2009536918A (en) * | 2006-03-06 | 2009-10-22 | ファイザー株式会社 | Sulfonylbenzimidazole derivatives |
| RU2013124395A (en) | 2010-10-28 | 2014-12-10 | Ниппон Синяку Ко., Лтд. | PYRIDINE DERIVATIVE AND MEDICINE |
| EP2858983B1 (en) | 2012-06-11 | 2018-04-18 | UCB Biopharma SPRL | Tnf-alpha modulating benzimidazoles |
| JP2014114221A (en) | 2012-12-06 | 2014-06-26 | Dainippon Sumitomo Pharma Co Ltd | Method for producing benzimidazole derivative and intermediate thereof |
| JP2018052817A (en) | 2015-01-21 | 2018-04-05 | 大日本住友製薬株式会社 | Novel benzimidazole derivative and medical application thereof |
| WO2017043636A1 (en) | 2015-09-11 | 2017-03-16 | 大日本住友製薬株式会社 | Novel benzimidazole compound and pharmaceutical use of same |
-
2018
- 2018-03-14 CA CA3055510A patent/CA3055510A1/en active Pending
- 2018-03-14 EP EP18768085.5A patent/EP3597639A4/en active Pending
- 2018-03-14 KR KR1020197029381A patent/KR102614535B1/en active IP Right Grant
- 2018-03-14 JP JP2019506065A patent/JP7090069B2/en active Active
- 2018-03-14 CN CN201880032361.0A patent/CN110612289B/en active Active
- 2018-03-14 AU AU2018236530A patent/AU2018236530B2/en active Active
- 2018-03-14 US US16/494,128 patent/US11066372B2/en active Active
- 2018-03-14 WO PCT/JP2018/009873 patent/WO2018168894A1/en unknown
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11066372B2 (en) | 2021-07-20 |
| EP3597639A1 (en) | 2020-01-22 |
| CA3055510A1 (en) | 2018-09-20 |
| AU2018236530A1 (en) | 2019-10-03 |
| KR102614535B1 (en) | 2023-12-14 |
| JP7090069B2 (en) | 2022-06-23 |
| JPWO2018168894A1 (en) | 2020-01-23 |
| CN110612289A (en) | 2019-12-24 |
| US20200017450A1 (en) | 2020-01-16 |
| KR20190128671A (en) | 2019-11-18 |
| WO2018168894A1 (en) | 2018-09-20 |
| AU2018236530B2 (en) | 2022-05-19 |
| CN110612289B (en) | 2023-06-30 |
| RU2019132047A3 (en) | 2021-07-02 |
| RU2019132047A (en) | 2021-04-15 |
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Legal Events
| Date | Code | Title | Description |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20200813 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 235/08 20060101AFI20200807BHEP Ipc: A61P 29/00 20060101ALI20200807BHEP Ipc: A61P 25/04 20060101ALI20200807BHEP Ipc: A61P 13/02 20060101ALI20200807BHEP Ipc: A61P 25/00 20060101ALI20200807BHEP Ipc: A61K 31/4184 20060101ALI20200807BHEP Ipc: C07D 405/06 20060101ALI20200807BHEP Ipc: A61K 45/00 20060101ALI20200807BHEP |
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| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40019705 Country of ref document: HK |
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| STAA | Information on the status of an ep patent application or granted ep patent |
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| RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SUMITOMO PHARMA CO., LTD. |
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| 17Q | First examination report despatched |
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| GRAP | Despatch of communication of intention to grant a patent |
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