EP3538147A4 - Covalently fused viral coat proteins for the display of target molecules - Google Patents
Covalently fused viral coat proteins for the display of target molecules Download PDFInfo
- Publication number
- EP3538147A4 EP3538147A4 EP17868629.1A EP17868629A EP3538147A4 EP 3538147 A4 EP3538147 A4 EP 3538147A4 EP 17868629 A EP17868629 A EP 17868629A EP 3538147 A4 EP3538147 A4 EP 3538147A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- display
- target molecules
- coat proteins
- viral coat
- covalently fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000565 Capsid Proteins Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/14011—Bromoviridae
- C12N2770/14023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/14011—Bromoviridae
- C12N2770/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/14011—Bromoviridae
- C12N2770/14041—Use of virus, viral particle or viral elements as a vector
- C12N2770/14042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662420993P | 2016-11-11 | 2016-11-11 | |
PCT/US2017/061134 WO2018089814A1 (en) | 2016-11-11 | 2017-11-10 | Covalently fused viral coat proteins for the display of target molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3538147A1 EP3538147A1 (en) | 2019-09-18 |
EP3538147A4 true EP3538147A4 (en) | 2020-07-08 |
Family
ID=62110075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17868629.1A Withdrawn EP3538147A4 (en) | 2016-11-11 | 2017-11-10 | Covalently fused viral coat proteins for the display of target molecules |
Country Status (6)
Country | Link |
---|---|
US (2) | US11078240B2 (en) |
EP (1) | EP3538147A4 (en) |
CN (1) | CN109937052A (en) |
BR (1) | BR112019009221A2 (en) |
CA (1) | CA3041888A1 (en) |
WO (1) | WO2018089814A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102696265B1 (en) * | 2021-02-25 | 2024-08-21 | 주식회사 바이오앱 | Method for manufacturing alfalfa mosaic virus-like particles using plant expression system and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001077158A1 (en) * | 2000-04-07 | 2001-10-18 | University Of Leeds Innovations Limited | Hepatitis b core antigen fusion proteins |
US20120219579A1 (en) * | 2009-09-18 | 2012-08-30 | Fraunhofer Usa Inc. | Virus like particles comprising target proteins fused to plant viral coat proteins |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3004173B1 (en) | 2013-06-06 | 2018-05-30 | iQur Limited | Single domain antibody display |
US20160185826A1 (en) * | 2014-08-07 | 2016-06-30 | Medigen Biotechnology Corp. | Virus-like particle vaccines |
-
2017
- 2017-11-10 WO PCT/US2017/061134 patent/WO2018089814A1/en unknown
- 2017-11-10 CN CN201780069666.4A patent/CN109937052A/en active Pending
- 2017-11-10 US US16/346,315 patent/US11078240B2/en active Active
- 2017-11-10 CA CA3041888A patent/CA3041888A1/en active Pending
- 2017-11-10 EP EP17868629.1A patent/EP3538147A4/en not_active Withdrawn
- 2017-11-10 BR BR112019009221A patent/BR112019009221A2/en not_active Application Discontinuation
-
2021
- 2021-06-29 US US17/361,835 patent/US11618771B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001077158A1 (en) * | 2000-04-07 | 2001-10-18 | University Of Leeds Innovations Limited | Hepatitis b core antigen fusion proteins |
US20120219579A1 (en) * | 2009-09-18 | 2012-08-30 | Fraunhofer Usa Inc. | Virus like particles comprising target proteins fused to plant viral coat proteins |
Non-Patent Citations (5)
Title |
---|
"Advances in Virus Research", vol. 97, 8 November 2016, ACADEMIC PRESS, US, ISSN: 0065-3527, article B. SCHWARZ ET AL: "Biomedical and Catalytic Opportunities of Virus-Like Particles in Nanotechnology", pages: 1 - 60, XP055698542, DOI: 10.1016/bs.aivir.2016.09.002 * |
HADRIEN PEYRET ET AL: "Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins", PLOS ONE, vol. 10, no. 4, 1 April 2015 (2015-04-01), pages e0120751, XP055251306, DOI: 10.1371/journal.pone.0120751 * |
R. MARK JONES ET AL: "A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice", PLOS ONE, vol. 8, no. 11, 18 November 2013 (2013-11-18), pages e79538, XP055155019, DOI: 10.1371/journal.pone.0079538 * |
See also references of WO2018089814A1 * |
YUSIBOV V ET AL: "ANTIGENS PRODUCED IN PLANTS BY INFECTION WITH CHIMERIC PLANT VIRUSES IMMUNIZE AGAINST RABIES VIRUS AND HIV-1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 94, 1 May 1997 (1997-05-01), pages 5784 - 5788, XP002952177, ISSN: 0027-8424, DOI: 10.1073/PNAS.94.11.5784 * |
Also Published As
Publication number | Publication date |
---|---|
US20210324015A1 (en) | 2021-10-21 |
WO2018089814A1 (en) | 2018-05-17 |
US11078240B2 (en) | 2021-08-03 |
US20200181203A1 (en) | 2020-06-11 |
BR112019009221A2 (en) | 2019-07-16 |
CN109937052A (en) | 2019-06-25 |
US11618771B2 (en) | 2023-04-04 |
EP3538147A1 (en) | 2019-09-18 |
CA3041888A1 (en) | 2018-05-17 |
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Legal Events
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Effective date: 20190513 |
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AK | Designated contracting states |
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Extension state: BA ME |
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DAV | Request for validation of the european patent (deleted) | ||
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20200605 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 39/39 20060101AFI20200529BHEP Ipc: A61P 31/12 20060101ALI20200529BHEP Ipc: A61K 39/12 20060101ALI20200529BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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Effective date: 20210820 |
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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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Effective date: 20240601 |