EP3528773A1

EP3528773A1 - Oral care composition

Info

Publication number: EP3528773A1
Application number: EP17780135.4A
Authority: EP
Inventors: Xiaoke Li; Jinfang Wang; Huaiyong XING
Original assignee: Unilever PLC; Unilever NV
Current assignee: Unilever Global IP Ltd; Unilever IP Holdings BV
Priority date: 2016-10-18
Filing date: 2017-10-11
Publication date: 2019-08-28
Also published as: CN109890350A; WO2018073062A1; CL2019001038A1; CN109890350B; BR112019006087B1; PH12019500690A1; BR112019006087A2

Abstract

An oral care composition is disclosed comprising from 3 to 80% by weight of calcium silicate, a soluble calcium source, a phosphate source, a benefit agent and a physiologically acceptable carrier, wherein the calcium silicate and the soluble calcium source is present in a weight ratio from 1:3 to 20:1.

Description

ORAL CARE COMPOSITION

Technical Field of the Invention

The present invention relates to oral care compositions such as tooth pastes, powders, gums, mouthwashes and the like. In particular the present invention relates to an oral care composition comprising calcium silicate, a soluble calcium source and benefit agents. The invention also relates to the use of such compositions for benefiting teeth of an individual.

Background of the Invention

Many products we consume have a negative impact on our teeth and mouth. Acidic drinks and sweets, for example, can result in tooth erosion by attacking enamel which is the outer coating that protects the teeth. Moreover, tobacco based products as well as beverages like coffee and tea can stain or reduce the whiteness of one's teeth. These staining and discoloring substances are often able to permeate the enamel layer. This problem occurs gradually over many years, but imparts a noticeable discoloration of the enamel of one's teeth.

Consumers have always had a strong desire for healthy and white teeth. Benefit agents such as coloring agents, biomineralization agents and antibacterial agents are commonly incorporated in oral care compositions to be delivered to teeth to provide benefits such as whitening, remineralization and better oral hygiene. Therefore, it is always desired to improve the delivery efficiencies of benefit agents to maximize the effectiveness of such benefit agents.

However, it is usually difficult to achieve high delivery of benefit agents from oral care compositions. Those benefit agents do not strongly adhere to the tooth surfaces which makes them easy to be rinsed off during daily oral hygiene routine like brushing teeth. There is continuing need for enhancing the delivery efficiency of benefit agents. The present inventors have now found unexpectedly that the deposition of benefit agents on tooth surfaces can be enhanced by using calcium silicate in combination with soluble calcium sources and a phosphate source. Additionally, it has been further found that such compositions can also enhance the binding affinity of benefit agents to tooth surfaces.

Additional Information

WO 2008/068149 A (Unilever) discloses an oral care product comprising a first

composition comprising an insoluble calcium salt that is not a calcium phosphate salt, a second independent composition comprising a source of phosphate ions, and a means for delivering each of the compositions to the surface of the teeth. The preferred insoluble calcium salt is calcium silicate.

The additional information above does not describe an oral care composition comprising from 3 to 80% by weight of calcium silicate, a soluble calcium source, a benefit agent and a phosphate source, wherein the calcium silicate and the soluble calcium source is present in a weight ratio from 1 :3 to 20:1 , and especially such oral care composition can enhance the deposition of benefit agents on tooth surfaces. Tests and Definitions

Dentifrice

"Dentifrice" for the purposes of the present invention means a paste, powder, liquid, gum or other preparation for cleaning the teeth or other surfaces in the oral cavity. Tooth Paste

"Tooth paste" for the purpose of the present invention means a paste or gel dentifrice for use with a toothbrush. Especially preferred are tooth pastes suitable for cleaning teeth by brushing for about two minutes. Mouth Wash

"Mouth wash" for the purpose of the present invention means liquid dentifrice for use in rinsing the mouth. Especially preferred are mouth washes suitable for rinsing the mouth by swishing and/or gargling for about half a minute before expectorating.

Particle Size

"Particle size" for the purpose of the present invention means D50 particle size. The D50 particle size of a particulate material is the particle size diameter at which 50 wt% of the particles are larger in diameter and 50 wt% are smaller in diameter. For the purpose of the present invention, particle sizes and distribution are measured using Malvern Mastersizer 2000 and Malvern ZetaSizer Nano series.

Composite Particle

"Composite particle" for the purpose of the present invention means a particle comprising a first component core and a second component coating wherein the core and coating are composed of different materials.

Refractive Index

Refractive index is quoted at a temperature of 25°C and a wavelength of 589 nm. pH

pH is quoted at atmospheric pressure and a temperature of 25°C. When referring to the pH of an oral care composition, this means the pH measured when 5 parts by weight of the composition is unifomnly dispersed and/or dissolved in 20 parts by weight pure water at 25°C. In particular the pH may be measured by manually mixing 5 g oral care composition with 20 ml_ water for 30 s, then immediately testing the pH with indicator or a pH meter.

Solubility

"Soluble" and "insoluble", as used herein, refers to the solubility of a source (e.g., like calcium salts) in water at 25°C and atmospheric pressure. "Soluble" means a source that dissolves in water to give a solution with a concentration of at least 0.1 moles per litre. "Insoluble" means a source that dissolves in water to give a solution with a concentration of less than 0.001 moles per litre. "Sparingly soluble", therefore, is defined to mean a source that dissolves in water to give a solution with a concentration of greater than 0.001 moles per litre and less than 0.1 moles per litre. Water of Hydration

"Water of hydration" for the purpose of the present invention means water chemically combined with a substance in a way that it can be removed by heating without substantially changing the chemical composition of the substance. In particular, water which could only be removed when heated above 200°C. The water loss is measured using thermo gravimetric analysis (TGA) with a Netzsch TG instrument. The TGA is conducted under an N2 atmosphere with heating rate of 10 degree/min in the range of 30 to 900°C.

Substantially Free

"Substantially free of for the purpose of the present invention means less than 1.5%, and preferably less than 1.0%, and more preferably less than 0.75% and more preferably still less than 0.5%, and even more preferably less than 0.1 % and most preferably from 0.0 to 0.01 % by weight, based on total weight of the oral care composition, including all ranges subsumed therein.

Dual-Phase

"Dual-Phase" for the purpose of the present invention means a composition having two independent phases which are physically separate. Viscosity

Viscosity of a tooth paste is the value taken at room temperature (25°C) with a Brookfield Viscometer, Spindle No.4 and at a speed of 5 rpm. Values are quoted in centipoises (cP=mPa.s) unless otherwise specified. Remineralization

"Remineralization" for the purpose of the present invention means in situ (i.e. in the oral cavity) generation of calcium phosphate on teeth (including layers on teeth from 10 nm to 20 microns, and preferably from 75 nm to 10 microns, and most preferably, from 150 nm to 5 microns thick including all ranges subsumed therein) to reduce the likelihood of tooth sensitivity, tooth decay, regenerate enamel and/or improve the appearance of teeth by whitening through the generation of such new calcium phosphate.

Miscellaneous

Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use may optionally be understood as modified by the word "about". All amounts are by weight of the final oral care composition, unless otherwise specified. It should be noted that in specifying any ranges of values, any particular upper value can be associated with any particular lower value.

For the avoidance of doubt, the word "comprising" is intended to mean "including" but not necessarily "consisting of or "composed of. In other words, the listed steps or options need not be exhaustive.

The disclosure of the invention as found herein is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy.

Where a feature is disclosed with respect to a particular aspect of the invention (for example a composition of the invention), such disclosure is also to be considered to apply to any other aspect of the invention (for example a method of the invention) mutatis mutandis.

Summary of the Invention

In a first aspect, the present invention is directed to an oral care composition comprising: a) from 3 to 80% by weight of calcium silicate;

b) a soluble calcium source;

c) a phosphate source;

d) a benefit agent; and

e) a physiologically acceptable carrier;

wherein the calcium silicate and the soluble calcium source is present in a weight ratio from 1 :3 to 20:1.

In a second aspect, the present invention is directed to a packaged oral care product comprising the oral care composition of the first aspect of this invention.

In a third aspect, the present invention is directed to a method of benefiting teeth of an individual comprising the step of applying the oral care composition of any embodiment of the first aspect to at least one surface of the teeth of the individual. Particularly, the present invention is directed to a method of remineralizing and/or whitening of teeth of an individual.

All other aspects of the present invention will more readily become apparent upon considering the detailed description and examples which follow.

Detailed Description

Now it has been found that an oral care composition comprising calcium silicate, a soluble calcium source and a phosphate source can enhance the delivery efficiency of benefit agents to tooth surfaces, providing improved tooth benefits. Additionally, it has also been found that such compositions can also enhance the binding affinity of benefit agents to tooth surfaces. Delivery efficiency, as used herein, means the ability to deliver and deposit benefit agents to tooth surfaces of an individual. CALCIUM SILICATE

In a preferred embodiment, the calcium silicate used is one which has low water solubility and is made commercially available under the name Sorbosil CA40 by PQ Corporation. In another preferred embodiment, the calcium silicate is insoluble, present as the composite material calcium oxide-silica (CaO-SiO2), which is described, for example, in international patent application published as WO 2008/01517(Unilever) which is hereby incorporated by reference in its entirety. For a calcium silicate composite material, the atom ratio of calcium to silicon (Ca:Si) may be from 1 :30 to 3:1. The Ca:Si ratio is preferably 1 :20 to 3:1 , and more preferably, from 1 :10 to 3:1 , and most preferably, from about 1 :7 to 3:1. The calcium silicate may comprise mono-calcium silicate, bi-calcium silicate, or tri-calcium silicate. The calcium silicate may be in a crystalline or amorphous state or even in a mesoporous state.

In addition to calcium oxide, silica, the particles comprising the calcium silicate which is not hydrated may comprise other components, such as metal cations, anions (such as phosphate) and the like. However, it is preferred that the particles comprise calcium oxide, silica in an amount of at least 70% by weight of the particles, more preferably at least 80%, more preferably still at least 90% and even more preferably at least 95%. Most preferably the particles consist of (or at least consist essentially of) calcium oxide, silica. In another preferred embodiment, the calcium silicate is calcium silicate hydrate. The calcium silicate hydrate for use in the present invention comprises at least calcium oxide (CaO), silica (S1O2) and water. Compared with conventional calcium silicate which are not hydrated, the calcium silicate hydrate comprises the water of hydration in an amount of at least 5% by weight of the calcium silicate hydrate, preferably at least 10%, more preferably at least 15%, even more preferably at least 20% and most preferably at least 25%. The water content is typically no greater than 50% by weight of the calcium silicate hydrate, more preferably no greater than 40%, even more preferably no greater than 35% and most preferably no greater than 30%. The calcium silicate hydrate preferably comprises at least 20% silica by weight of the calcium silicate hydrate, more preferably at least 30%, more preferably still at least 40% and most preferably at least 55%. The silica content is preferably no greater than 70% by weight of the calcium silicate hydrate, more preferably no greater than 65% and most preferably no greater than 60%.

To provide calcium necessary for remineralization, the calcium silicate hydrate preferably comprises calcium oxide in an amount of at least 5% by weight of the calcium silicate hydrate, more preferably at least 7%, more preferably still at least 10%, even more preferably at least 12% and most preferably at least 15%. The calcium oxide content is typically no greater than 50% by weight of the calcium silicate hydrate, more preferably no greater than 40%, even more preferably no greater than 30% and most preferably no greater than 25%.

The calcium silicate hydrate preferably comprises Ca and Si in an atom ratio (Ca:Si) less than 1 :1 , more preferably less than 1 :1.2, more preferably still from 1 :1.5 to 1 :4 and most preferably from 1 :1.7 to 1 :3.

The calcium silicate may be amorphous or at least partly crystalline or mesoporous. The calcium silicate is preferably particulate as this allows for maximum surface area for contact with dental tissue. Thus preferably the composition comprises particles comprising the calcium silicate. Preferably from 10 to 100%, and especially, from 25 to 100%, and most especially, from 70% to 100% by weight of the particles comprising calcium silicate used in this invention have a particle size from 100 nm to less than 50 microns, preferably from 500 nm to 30 microns, more preferably from 1 micron to 20 microns, most preferably from 1 micron to 10 microns. In addition to calcium oxide, silica and water, the particles which comprise the calcium silicate hydrate may comprise other components, such as metal cations, anions (such as phosphate) and the like. However, it is preferred that the particles comprise CaO, S1O2 and water in an amount of at least 70% by weight of the particles, more preferably at least 80%, more preferably still at least 90% and even more preferably at least 95%. Most preferably the particles consist of (or at least consist essentially of) CaO, S1O2 and water. Typically, the oral care composition of the present invention comprises from 3 to 80% by weight of the calcium silicate, more preferably from 3 to 50%, most preferably from 5 to 30%, based on the total weight of the oral care composition and including all ranges subsumed therein.

SOLUBLE CALCIUM SOURCE

The soluble calcium source suitable for use in this invention is limited only to the extent that the same may be used in the mouth. Illustrative yet non-limiting examples of the types of soluble calcium source that may be used in this invention include, for example, calcium chloride, calcium nitrate, calcium acetate, calcium lactate, calcium gluconate, calcium formate, calcium malate, calcium propionate, calcium butyrate, calcium bicarbonate, mixtures thereof or the like. In a preferred embodiment, the calcium source is calcium chloride, calcium nitrate or mixtures thereof.

Typically, the oral care composition of the present invention comprises from 0.1 to 20% by weight of the soluble calcium source, more preferably from 1 to 15%, most preferably from 2 to 10%, based on the total weight of the oral care composition and including all ranges subsumed therein.

The oral care composition preferably comprises the calcium silicate and the soluble calcium source in a weight ratio from 1 :3 to 20:1 , more preferably from 1 :3 to 10:1 , most preferably from 1 :3 to 7:1.

PHOSPHATE SOURCE

The phosphate source that may be used in this invention is limited only to the extent that the same may be used in a composition suitable for use in the mouth. Illustrative examples of the types of phosphate source suitable for use in this invention include trisodium phosphate, monosodium dihydrogen phosphate, disodium hydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, tripotassium phosphate, monopotassium dihydrogen phosphate, dipotassium hydrogen phosphate, mixtures thereof or the like. The phosphate source is preferably one which is water soluble.

When used, the phosphate source typically makes up from 0.5 to 40%, and more preferably, from 1 to 30%, and most preferably, from 2 to 20% by weight of the oral care composition, based on total weight of the oral care composition and including all ranges subsumed therein. In a preferred embodiment, the phosphate source used is trisodium phosphate and monosodium dihydrogen phosphate at a trisodium phosphate to monosodium dihydrogen phosphate weight ratio of 1 :4 to 4:1 , preferably 1 :3 to 3:1 , and most preferably, from 1 :2 to 2:1 , including all ratios subsumed therein. In another preferred embodiment, the phosphate source used is or at least comprises monosodium dihydrogen phosphate.

The oral care composition preferably comprises the calcium silicate and the phosphate source in a weight ratio from 10:1 to 1 :5, more preferably from 5:1 to 1 :3, most preferably from 3:1 to 1 :1.

BENEFIT AGENT

Benefit agents as used herein means an active typically delivered to human teeth and/or the oral cavity including the gums to enhance or improve a characteristic of those dental tissues. The only limitation with respect to the benefit agents that may be used in this invention is that the same is suitable for use in the mouth. Typically the benefit agent is selected from optical agents, biomineralization agents, antibacterial agents, gum health agents, desensitizing agents, anti-calculus agents, freshness agents or mixtures thereof. Preferably, the benefit agent is selected from optical agents, biomineralization agents, antibacterial agents, gum health agents, freshness agents or mixtures thereof.

For example, optical agents such as coloring agents like whitening agents and pigments. Preferably, the pigment, when used, is violet or blue having a hue angle, h, in the CIELAB system of from 220 to 320 degrees. These pigments may be selected from one or more of those listed in the Colour Index International, listed as pigment blue 1 through to pigment blue 83, and pigment violet 1 through to pigment violet 56. In another preferred embodiment, the optical agents may be selected from one or more of mica, interference mica, boron nitride, poly(methyl methacrylate) flake, composite microspheres, titanium dioxide coated glass flake, inverse opal, cholesteric liquid crystal, photonic sphere, hollow sphere and zinc oxide, biomineralization agents for tooth enamel remineralization may be selected from one or more of fluoride sources, biomolecules, proteinaceous materials, amorphous calcium phosphate, a-tricalcium phosphate, β-tricalcium phosphate; calcium carbonate, calcium deficient hydroxyapatite Caio-x(HPO4)x(PO4)6-x(OH)2-x, 0 < x < 1 ), dicalcium phosphate (CaHPO4), dicalcium phosphate dihydrate (CaHPO4-2H2O), hydroxyapatite (Caio(PO4)6(OH)2), monocalcium phosphate monohydrate

(Ca(H2PO4)2-H2O), octacalcium phosphate (Ca8H2(PO4)6-5H2O) and tetracalcium phosphate (Ca4(PO4)2O); antibacterial agents may be selected from one or more of metal salts where the metal is selected from zinc, copper, silver or a mixture thereof, triclosan, triclosan monophosphate, triclocarban, curcumin, quaternary ammonium compounds, bisbiguanides and long chain tertiary amines, preferably zinc salts including zinc oxide, zinc chloride, zinc acetate, zinc ascorbate, zinc sulphate, zinc nitrate, zinc citrate, zinc lactate, zinc peroxide, zinc fluoride, zinc ammonium sulfate, zinc bromide, zinc iodide, zinc gluconate, zinc tartarate, zinc succinate, zinc formate, zinc phenol sulfonate, zinc salicylate, zinc glycerophosphate or a mixture thereof. Gum health agents may be selected from one or more of anti-inflammatory agents, plaque buffers, biomolecules, proteinaceous materials, vitamin, plant extracts and curcumin. Freshness agents may be flavors selected from one or more of peppemnint, spearmint, menthol, flora oil, clove oil and citrus oil.

The benefit agent is preferably particulate as this allows for maximum surface area for contact with dental tissue.

In a preferred embodiment, the benefit agent is a particulate whitening agent for tooth whitening. Typically, the particulate whitening agent comprises a material suitable to physically and immediately improve characteristics of teeth and especially whiten teeth. In order to provide excellent whitening effect, the material is preferred to have a high refractive index of at least 1.9, more preferably at least 2.0, even more preferably at least 2.2, even more preferably still at least 2.4 and most preferably at least 2.5. The maximum refractive index of the material is not particularly limited but preferably up to 4.0. Preferably, the material has a refractive index ranging from 1.9 to 4.0.

Particularly suitable materials are metal compounds and preferred are compounds where the metal is selected from zinc (Zn), titanium (Ti), zirconium (Zr) or a combination thereof. Preferably, the metal compound is (or at least comprises) a metal oxide such as titanium dioxide (ΤΊΟ2), zinc oxide (ZnO), zirconium dioxide (ZrO2) or a combination thereof. In addition, the particulate whitening agent can also comprise non-metal oxides such as silicon monoxide (SiO).

In a preferred embodiment, the particulate whitening agent comprises metal oxides, non- metal oxides or a combination thereof in an amount of at least 50% by weight of the whitening agent and more preferably at least 70%, more preferably still from 80 to 100% and most preferably from 85 to 95%. In an especially preferred embodiment, the particulate whitening agent is at least 50% by weight titanium dioxide, and most preferably, from 60 to 100% by weight titanium dioxide, based on total weight of the whitening agent and including all ranges subsumed therein. In another especially preferred embodiment, the particulate whitening agents are slightly soluble or insoluble in water, but most preferably, insoluble in water.

In a preferred embodiment, the particulate whitening agents are composite particles. The refractive index of a composite particle comprising more than one material can be calculated based on the refractive indices and volume fractions of the constituents using effective medium theory, as is described for example in WO 2009/023353.

The composite particle comprises a first component core and a second component coating. Typically, the core of the composite particle comprises a material suitable to physically and immediately improve characteristics of teeth and especially whiten teeth. In order to provide excellent whitening effect, the material is preferred to have a high refractive index of at least 1.9, more preferably at least 2.0, even more preferably at least 2.2, even more preferably still at least 2.4 and most preferably at least 2.5. The maximum refractive index of the material is not particularly limited but preferably up to 4.0. Preferably, the material has a refractive index ranging from 1.9 to 4.0. Particular suitable materials are metal compounds and preferred are compounds where the metal is selected from zinc (Zn), titanium (Ti), zirconium (Zr) or a combination thereof. Preferably, the metal compound is (or at least comprises) a metal oxide such as titanium dioxide (T1O2), zinc oxide (ZnO), zirconium dioxide (ZrO2) or a combination thereof. In addition, the core of the composite particle can also comprise non-metal oxides such as silicon monoxide (SiO).

The core of the composite particle typically makes up from 3 to 98%, and preferably from 6 to 65%, and most preferably from 10 to 55% by weight of the composite particle, based on total weight of the composite particle and including all ranges subsumed therein. In a preferred embodiment, the core comprises metal oxides, non-metal oxides or a

combination thereof in an amount of at least 50% by weight of the core and more preferably at least 70%, more preferably still from 80 to 100% and most preferably from 85 to 95%. In an especially preferred embodiment, the core is at least 50% by weight titanium dioxide, and most preferably, from 60 to 100% by weight titanium dioxide, based on total weight of the first component core.

The second component coating comprises material suitable to adhere to tooth enamel, dentin or both. Typically the coating material comprises the element calcium, and optionally, other metals like potassium, sodium, aluminium, magnesium as well as mixtures thereof whereby such optional metals are provided as, for example, sulphates, lactates, oxides, carbonates or silicates. Optionally, the coating material may be aluminium oxide or silica. In a preferred embodiment, the coating material is suitable to provide a biological or chemical improvement to teeth which is long term (e.g., results in

hydroxyapatite formation). Preferably, the coating employed comprises at least 50% by weight elemental calcium, and most preferably, at least 65% by weight elemental calcium based on total weight of metal in the coating. In an especially preferred embodiment, the metal in the coating is from 80 to 100% by weight of elemental calcium, based on total weight of metal in the second component coating and including all ranges subsumed therein. In another especially preferred embodiment, the core and the coating are slightly soluble or insoluble in water, but most preferably, insoluble in water. In an especially desired embodiment, the second component coating can comprise, for example, calcium phosphate, calcium gluconate, calcium oxide, calcium lactate, calcium carbonate, calcium hydroxide, calcium sulphate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate, mixture thereof or the like. In another desired embodiment, the calcium source in the coating comprises calcium silicate.

In yet another preferred embodiment, the coating can comprise the element calcium which originates from insoluble calcium silicate, present as the composite material calcium oxide- silica (CaO-SiO2) as described in international patent applications published as WO 2008/015117 and WO 2008/068248.

When a calcium silicate composite material is employed as coating, the ratio of calcium to silicon (Ca:Si) may be from 1 :10 to 3:1. The Ca:Si ratio is preferably from 1 :5 to 3:1 , and more preferably, from 1 :3 to 3:1 , and most preferably, from about 1 :2 to 3:1. The calcium silicate may comprise mono-calcium silicate, bi-calcium silicate, or tri-calcium silicate whereby ratios of calcium to silicon (Ca:Si) should be understood to be atom ratios.

Usually, at least 30% of the outer surface area of the first component core is coated with the second component coating, preferably at least 50% of the core is coated with the coating, most preferably, from 70 to 100% of the outer surface area of the first component core is coated with the second component coating.

In an especially preferred embodiment, the particulate whitening agent is titanium dioxide coated with calcium silicate.

The particulate whitening agent according to the present invention can be of different sizes and shapes. The particles may be of spherical, platelet or irregular shape form. The diameter of the particulate whitening agent is often from 10 nm to less than 50 microns, and preferably, from 75 nm to less than 10 microns. In an especially preferred embodinnent, the diameter of particles is from 100 nm to 5 microns, including all ranges subsumed therein. For composite particles, in a preferred embodiment, at least 40%, and preferably, at least 60%, and most preferably, from 75 to 99.5% of the diameter of the composite particle is the core, including all ranges subsumed therein.

The oral care composition of the present invention may comprise a single benefit agent or a mixture of two or more benefit agents. Typically, the benefit agent is present in an amount from 0.25 to 60%, and more preferably, from 0.5 to 40%, and most preferably, from 1 to 30% by total weight of the oral care composition and including all ranges subsumed therein.

The relative weight ratio of calcium silicate to benefit agent may range from 1 :10 to 20:1 , preferably from 1 :5 to 10:1 , most preferably from 1 :3 to 5:1.

CARRIER

The composition of the present invention is an oral care composition and typically comprises a physiologically acceptable carrier. The carrier preferably comprises at least surfactant, thickener, humectant or a combination thereof.

Preferably the oral care composition comprises a surfactant. Preferably the composition comprises at least 0.01 % surfactant by weight of the composition, more preferably at least 0.1 % and most preferably from 0.5 to 7%. Suitable surfactants include anionic surfactants, such as the sodium, magnesium, ammonium or ethanolamine salts of Cs to Cie alkyl sulphates (for example sodium lauryl sulphate), Cs to Cie alkyl sulphosuccinates (for example dioctyl sodium sulphosuccinate), Cs to Cie alkyl sulphoacetates (such as sodium lauryl sulphoacetate), Cs to Cie alkyl sarcosinates (such as sodium lauryl sarcosinate), Cs to Cie alkyl phosphates (which can optionally comprise up to 10 ethylene oxide and/or propylene oxide units) and sulphated monoglycerides. Other suitable surfactants include nonionic surfactants, such as optionally polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid

monoglycerides and diglycerides, and ethylene oxide/propylene oxide block polymers. Other suitable surfactants include amphoteric surfactants, such as betaines or

sulphobetaines. Mixtures of any of the above described materials may also be used. More preferably the surfactant comprises or is anionic surfactant. The preferred anionic surfactants are sodium lauryl sulphate and/or sodium dodecylbenzene sulfonate. Most preferably the surfactant is sodium lauryl sulphate, sodium coco sulfate, cocamidopropyl betaine, sodium methyl cocoyl taurate or mixtures thereof.

Thickener may also be used in this invention and is limited only to the extent that the same may be added to a composition suitable for use in the mouth. Illustrative examples of the types of thickeners that may be used in this invention include, sodium carboxymethyl cellulose (SCMC), hydroxyl ethyl cellulose, methyl cellulose, ethyl cellulose, gum tragacanth, gum arabic, gum karaya, sodium alginate, carrageenan, guar, xanthan gum, Irish moss, starch, modified starch, silica based thickeners including silica aerogels, magnesium aluminum silicate (e.g., Veegum), Carbomers (cross-linked acrylates) and mixtures thereof.

Typically, xanthan gum and/or sodium carboxymethyl cellulose and/or a Carbomer is/are preferred. When a Carbomer is employed, those having a weight-average molecular weight of at least 700,000 are desired, and preferably, those having a molecular weight of at least 1 ,200,000, and most preferably, those having a molecular weight of at least about 2,500,000 are desired. Mixtures of Carbomers may also be used herein.

In an especially preferred embodiment, the Carbomer is Synthalen PNC, Synthalen KP or a mixture thereof. It has been described as a high molecular weight and cross-linked polyacrylic acid and identified via CAS number 9063-87-0. These types of materials are available commercially from suppliers like Sigma.

In another especially preferred embodiment, the sodium carboxymethyl cellulose (SCMC) used is SCMC 9H. It has been described as a sodium salt of a cellulose derivative with carboxymethyl groups bound to hydroxy groups of glucopyranose backbone monomers and identified via CAS number 9004-32-4. The same is available from suppliers like Alfa Chem. ln another especially preferred embodinnent, the thickener is xanthan gum.

Thickener typically makes up from 0.01 to about 10%, more preferably from 0.1 to 9%, and most preferably, from 0.1 to 5% by weight of the oral care composition, based on total weight of the composition and including all ranges subsumed therein.

When the oral care composition of this invention is a toothpaste or gel, the same typically has a viscosity from about 30,000 to 180,000 centipoise, and preferably, from 60,000 to 170,000 centipoise, and most preferably, from 65,000 to 165,000 centipoise.

Suitable humectants are preferably used in the oral care composition of the present invention and they include, for example, glycerin, sorbitol, propylene glycol, dipropylene glycol, diglycerol, triacetin, mineral oil, polyethylene glycol (preferably, PEG-400), alkane diols like butane diol and hexanediol, ethanol, pentylene glycol, or a mixture thereof.

Glycerin, polyethylene glycol, sorbitol or mixtures thereof are the preferred humectants. The humectant may be present in the range of from 10 to 90% by weight of the oral care composition. More preferably, the carrier humectant makes up from 25 to 80%, and most preferably, from 30 to 60% by weight of the composition, based on total weight of the composition and including all ranges subsumed therein.

OPTIONAL COMPONENTS

The oral care composition of the present invention is found to be effective in enhancing the delivery efficiency of benefit agents to tooth surfaces. Without wishing to be bound by theory, the present inventors believe that the presence of soluble calcium source increases the calcium ion concentration in the oral composition, which enhances the reaction between the calcium salts and phosphate source in the mouth to form calcium phosphate. The calcium phosphate precipitation can help the deposition of calcium silicate and/or benefit agents onto the tooth surfaces. The remineralization of calcium silicate around the benefit agents further helps the retention of those benefit agents on tooth surfaces by enhancing their resistance to shear force. The oral care composition of the present invention may further comprise a deposition aid. The deposition aid suitable for use in this invention is limited only to the extent that the same may be used in the mouth. In a preferred embodiment, the deposition aid provides plenty of calcium ions in the mouth and is inexpensive and abundant. In an especially preferred embodiment, the deposition aid is calcium salts in addition to the soluble calcium source which is included in the composition.

Illustrative yet non-limiting examples of the types of deposition aid that may be used in this invention include, for example, calcium sulfate hemihydrates, calcium dihydrogen phosphate, calcium aluminate, calcium monohydrogen phosphate or mixtures thereof or the like. In a preferred embodiment, the deposition aid is calcium dihydrogen phosphate, calcium sulfate hemihydrates or mixtures thereof.

It has been discovered that the materials used as deposition aids in this invention is biocompatible, and undergoes rapid reaction with water and complete resorption onto the tooth surface, therefore it can be used to aid the deposition of oral care actives such as calcium silicate and/or other benefit agents onto the tooth surface.

Typically, the oral care composition of the present invention comprises from 0.1 to 20% by weight of the deposition aid, more preferably from 0.2 to 15%, more preferably still from 0.5 to 10%, most preferably from 1 to 5%, based on the total weight of the oral care composition and including all ranges subsumed therein.

The oral care composition preferably comprises the calcium silicate and the deposition aid in a weight ratio from 20:1 to 1 :5, more preferably from 15:1 to 1 :3, most preferably from

10:1 to 1 :1.

The oral care composition of the present invention may contain a variety of other ingredients which are common in the art to enhance physical properties and performance. These ingredients include preservatives, pH-adjusting agents, sweetening agents, particulate abrasive materials, polymeric compounds, buffers and salts to buffer the pH and ionic strength of the compositions, and mixtures thereof. Such ingredients typically and collectively make-up less than 20% by weight of the composition, and preferably, from 0.0 to 15% by weight, and most preferably, from 0.01 to 12% by weight of the composition, including all ranges subsumed therein. The oral care composition of this invention can be used in a method of benefiting teeth of an individual comprising applying the composition to at least one surface of the teeth of an individual. The oral care composition of this invention may additionally or alternatively be for use as a medicament and/or used in the manufacture of a medicament for providing an oral care benefit as described herein, such as for remineralizing and/or whitening of the teeth of an individual. Alternatively and preferably, the use is non-therapeutic.

Preferably, the oral care composition is substantially free of water to prevent the premature reaction between the calcium salts and the phosphate source. In a preferred embodiment, the oral care composition is a monophase anhydrous composition.

In another preferred embodiment, the oral care composition is a dual-phase composition comprising a calcium phase and a phosphate phase, wherein the calcium silicate and the soluble calcium source are present in the calcium phase and the phosphate source is present in the phosphate phase. The benefit agent can be present in either of the two phases. The two phases are physically separate from one another by being in

independent phases. The delivery of the two independent phases to the teeth may be simultaneous or sequential. In a preferred embodiment, the phases are delivered simultaneously.

Typically, the dual-phase composition is delivered by a dual-tube having a first

compartment for calcium phase and a second compartment for phosphate phase, which allows for co-extrusion of the two phases.

In a preferred embodiment, such a dual-tube has one of the compartments surrounding the other. In such embodiments, one phase is present as a sheath, surrounding the other phase in the core. In an especially preferred embodiment, the core is the calcium phase and the sheath is the phosphate phase.

In another preferred embodiment, such a dual-tube has the two compartments side by side within the same tube. In such embodiments, the two phases are extruded from the tube as one, such extrusion being termed "contact extrusion". A pump head may be used in such a dual-tube for squeezing the two phases from the tube as one.

The dual-phase oral care composition may be a gel composition that comprises two independent gel phases, the first is the calcium phase and the second is the phosphate phase. The means of delivery may involve a cotton rod, or a tray, onto which the calcium phase and the phosphate phase are applied, prior to the tray being placed in contact with the teeth. Typically the composition will be packaged. In tooth paste or gel form, the composition may be packaged in a conventional plastic laminate, metal tube or a single compartment dispenser. The same may be applied to dental surfaces by any physical means, such as a toothbrush, fingertip or by an applicator directly to the sensitive area. The composition can be effective even when used in an individual's daily oral hygiene routine. For example, the composition may be brushed onto the teeth. The composition may, for example, be contacted with the teeth for a time period of one second to 20 hours. More preferably from 1 s to 10 hours, more preferably still from 10 s to 1 hour and most preferably from 30 s to 5 minutes. The composition may be used daily, for example for use by an individual once, twice or three times per day. When the oral care composition is a dual-phase composition, the two phases of the composition are mixed during application. The mixed phases are typically left on the teeth for from 3 minutes to 10 hours, more preferably from 3 minutes to 8 hours. The application may be carried out daily. The following examples are provided to facilitate an understanding of the present invention. The examples are not provided to limit the scope of the claims. Examples

Example 1

This example demonstrates the improved deposition of particles on tooth surfaces by using soluble calcium source in combination with calcium silicate. All ingredients are expressed by weight percent of the total formulation, and as level of active ingredient.

TABLE 1

a. Commercially available calcium silicate (CaSiCb) under the trade name Sorbosil CA40 from PQ Corporation.

b. Commercially available titanium dioxide coated with calcium silicate from KOBO Products Inc.

c. Commercially available silica under the trade name Sorbosil AC77 from PQ Corporation.

Methods

To evaluate deposition of particles on tooth surface, the test samples was mixed with water at a ratio of 4 g to 8 ml_ de-ionized water (Dl water) to make a slurry. Sample 1 comprising only composite particles was used as control.

The bovine enamel blocks were treated with different slurries via brushing following the same protocol. The enamel blocks were brushed with the slurry under a tooth brushing machine equipped with toothbrushes. The load of the tooth brushing was 170 g +/-5 g and the automatic brushing operated at a speed of 150 rpm. After brushing for 1 min, the enamel blocks were soaked in toothpaste slurry for 1 min. Then the enamel blocks were rinsed with Dl water and placed in simulated oral fluid (SOF) under the condition of a shaking water bath at 37°C and 60.0 rpm. After soaking for about 3 to 4 hours, the enamel blocks were brushed with the slurry by machine using the same procedure as in the first step. The brushing was repeated three times for one day, then the enamel blocks were kept in SOF overnight(>12 hours) in a shaking water bath at 37°C to mimic oral environment. The enamel samples were brushed for 14 times. Simulated oral fluid was made by combining the ingredients in Table 2:

TABLE 2

Results

After 14 brushings, SEM (Scanning Electron Microscopy) images of the enamel blocks were taken. From the top view of the SEM images, it showed that composite particles were randomly deposited onto the enamel surfaces for Samples 1 , 2 and 5. But for Samples 3 and 4 comprising soluble calcium source, it showed the formation of a new layer on the enamel surface and the particles or particle aggregates were evenly embedded in the newly fomned layer.

The corresponding cross-section SEM images showed that a new layer with a thickness around 3 to 5 microns was fomned on the surface of the enamel blocks after treatment with Sample 3 and the particles were embedded in the new layer, while the enamel blocks treated with Sample 1 did not have a new layer formed on their surfaces. The cross- section SEM images also showed that a new layer with a thickness around 2 microns was fomned on the surface of the enamel blocks after treatment with Sample 4 and the particles were embedded in the new layer.

The enamel blocks treated with Sample 2 and Sample 5 also did not have a new layer fomned on their surfaces due to the short treatment period. Analysis using EDX (Energy Dispersive X-ray Spectroscopy) further identified the elements of Si, Ca, P and Ti within the new layer, indicating the deposition of particles on enamel surfaces.

Example 2

This example demonstrates the affinity of the newly formed layer comprising embedded particles to tooth surfaces. Samples used here was Sample 3 in Example 1. Methods

To evaluate the affinity of the newly formed layer to tooth surfaces, the test sample was mixed with Dl water at a ratio of 4 g to 8 ml_ water to make a toothpaste slurry.

The bovine enamel blocks were treated with the slurry via brushing following the same protocol. The enamel blocks were brushed with the slurry under a tooth brushing machine equipped with toothbrushes. The load of the tooth brushing was 170 g +/-5 g and the automatic brushing operated at a speed of 150 rpm. After brushing for 1 min, the enamel blocks were soaked in toothpaste slurry for 1 min. Then the enamel blocks were rinsed with Dl water and placed in SOF under the condition of a shaking water bath at 37°C and 60.0 rpm. After soaking for at least 3 hours, the enamel blocks were brushed with Dl water using the tooth brushing machine. The load of the tooth brushing was 170 g +/-5 g and the automatic brushing operated at a speed of 150 rpm. After brushing for 1 min, the enamel blocks were placed in SOF under the condition of a shaking water bath at 37°C and 60.0 rpm. After soaking for at least 3 hours, the enamel blocks were brushed with Dl water again using the tooth brushing machine for 1 min (170 g +/-5 g load, 150 rpm). Then the enamel blocks were brushed with fresh toothpaste slurry using the tooth brushing machine for 1 min (170 g +/-5 g load, 150 rpm) and soaked in toothpaste slurry for 1 min. Then the enamel blocks were rinsed with Dl water and kept in SOF overnight (>12 hours) in a shaking water bath at 37°C to mimic oral environment. The enamel blocks were then brushed with Dl water using the tooth brushing machine for 1 min (170 g +/-5 g load, 150 rpm). These steps are considered as a whole treatment cycle for one day. The enamel blocks were treated for 14 days.

Results

After 14 days of treatments, SEM images of the enamel block surfaces were taken. From the top view of the SEM images, it can be seen that there were still many particles or particle aggregates evenly embedded in the new layer formed on the enamel surface. The corresponding cross-section SEM images further showed that a new layer was fomned on the surfaces of the enamel blocks after treatment with Sample 3 and the particles were evenly embedded in the new layer. The results clearly showed that the newly fomned layer was not brushed away by water brushing, indicating enhanced affinity of the newly formed layer to enamel surfaces. Analysis using EDX further identified the elements of Si, Ca, P and Ti within the new layer, indicating the deposition of particles on enamel surfaces.

Claims

1. An oral care composition comprising:

a) from 3 to 80% by weight of calcium silicate;

b) a soluble calcium source;

c) a phosphate source;

d) a benefit agent; and

e) a physiologically acceptable carrier;

2. The oral care composition according to claim 1 , wherein the soluble calcium source is calcium chloride, calcium nitrate, calcium acetate, calcium lactate, calcium gluconate, calcium formate, calcium malate, calcium propionate, calcium butyrate, calcium bicarbonate or mixtures thereof, preferably calcium chloride, calcium nitrate or mixtures thereof.

3. The oral care composition according to claim 1 or claim 2, wherein the calcium

silicate is present in an amount from 3 to 50% by weight of the composition, preferably from 5 to 30%.

4. The oral care composition according to any of the preceding claims, wherein the calcium silicate and the soluble calcium source are present in a weight ratio from 1 :3 to 10:1 , preferably from 1 :3 to 7:1.

5. The oral care composition according to any of the preceding claims, wherein the phosphate source is trisodium phosphate, monosodium dihydrogen phosphate, disodium hydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, tripotassium phosphate, monopotassium dihydrogen phosphate, dipotassium hydrogen phosphate or a mixture thereof, preferably trisodium phosphate, monosodium dihydrogen phosphate or a mixture thereof.

6. The oral care composition according to any of the preceding claims, wherein the composition comprises the calcium silicate and the phosphate source in a weight ratio from 10:1 to 1 :5, preferably from 5:1 to 1 :3.

7. The oral care composition according to any of the preceding claims, wherein the benefit agent is selected from optical agents, biomineralization agents, antibacterial agents, gum health agents, desensitizing agents, anti-calculus agents, freshness agents or mixtures thereof.

8. The oral care composition according to any of the preceding claims, wherein the benefit agent is a particulate whitening agent comprising a material having a refractive index ranging from 1.9 to 4.0.

9. The oral care composition according to claim 8, wherein the particulate whitening agent is a composite particle, preferably the composite particle is titanium dioxide coated with calcium silicate.

10. The oral care composition according to any of the preceding claims, wherein the relative weight ratio of the calcium silicate to the benefit agent ranges from 1 :10 to 20:1 , preferably from 1 :5 to 10:1.

11. The oral care composition according to any of the preceding claims, wherein the composition further comprises a deposition aid selected from calcium dihydrogen phosphate, calcium sulfate hemihydrate, calcium aluminate, calcium monohydrogen phosphate or a mixture thereof, preferably calcium dihydrogen phosphate.

12. The oral care composition according to claim 11 , wherein the calcium silicate and the deposition aid are present in a weight ratio from 20:1 to 1 :5, preferably from 15:1 to 1 :3.

13. The oral care composition according to any of the preceding claims, wherein the oral care composition is a monophase anhydrous composition.

The oral care composition according to any of the preceding claims 1 to 12, wherein the composition is a dual-phase composition comprising a calcium phase and a phosphate phase, wherein the calcium silicate and the soluble calcium source is present in the calcium phase and the phosphate source is present in the phosphate phase.

15. A method for benefiting teeth of an individual comprising the step of applying the composition as claimed in any one of claims 1 to 14 to at least one surface of the teeth of the individual.