EP3498716A4 - Thienopyrimidine compound, preparation method therefor, pharmaceutical composition, and applications - Google Patents

Thienopyrimidine compound, preparation method therefor, pharmaceutical composition, and applications Download PDF

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Publication number
EP3498716A4
EP3498716A4 EP17838851.8A EP17838851A EP3498716A4 EP 3498716 A4 EP3498716 A4 EP 3498716A4 EP 17838851 A EP17838851 A EP 17838851A EP 3498716 A4 EP3498716 A4 EP 3498716A4
Authority
EP
European Patent Office
Prior art keywords
applications
preparation
pharmaceutical composition
method therefor
thienopyrimidine compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17838851.8A
Other languages
German (de)
French (fr)
Other versions
EP3498716B1 (en
EP3498716A1 (en
Inventor
Xianming Deng
Baoding ZHANG
Shuang Liu
Chao Dong
Xihuan SUN
Xiaoxing HUANG
Zhou DENG
Yunzhan LI
Yue Lu
Li Li
Zhiyu Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xiamen University
Original Assignee
Hongyun Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hongyun Biotech Co Ltd filed Critical Hongyun Biotech Co Ltd
Publication of EP3498716A1 publication Critical patent/EP3498716A1/en
Publication of EP3498716A4 publication Critical patent/EP3498716A4/en
Application granted granted Critical
Publication of EP3498716B1 publication Critical patent/EP3498716B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP17838851.8A 2016-08-09 2017-09-28 Sulfonyl bearing thienopyrimidine compound, preparation method therefor, pharmaceutical composition, and application as anti-cancer agent Active EP3498716B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610646949.8A CN107698603B (en) 2016-08-09 2016-08-09 Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof
PCT/CN2017/103983 WO2018028721A1 (en) 2016-08-09 2017-09-28 Thienopyrimidine compound, preparation method therefor, pharmaceutical composition, and applications

Publications (3)

Publication Number Publication Date
EP3498716A1 EP3498716A1 (en) 2019-06-19
EP3498716A4 true EP3498716A4 (en) 2020-03-25
EP3498716B1 EP3498716B1 (en) 2024-04-17

Family

ID=61162766

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17838851.8A Active EP3498716B1 (en) 2016-08-09 2017-09-28 Sulfonyl bearing thienopyrimidine compound, preparation method therefor, pharmaceutical composition, and application as anti-cancer agent

Country Status (8)

Country Link
US (1) US11078213B2 (en)
EP (1) EP3498716B1 (en)
JP (1) JP6963598B2 (en)
KR (1) KR102429355B1 (en)
CN (1) CN107698603B (en)
AU (1) AU2017311168B2 (en)
CA (1) CA3033459C (en)
WO (1) WO2018028721A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107698603B (en) 2016-08-09 2022-04-08 南京红云生物科技有限公司 Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof
US11279703B2 (en) * 2016-12-01 2022-03-22 Aptose Biosciences Inc. Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
KR102577824B1 (en) 2017-01-22 2023-09-13 선샤인 레이크 파르마 컴퍼니 리미티드 Thienopyrimidine derivatives and their uses in medicine
CN109575045B (en) * 2017-09-28 2021-02-12 南京红云生物科技有限公司 Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof
WO2019154091A1 (en) * 2018-02-07 2019-08-15 深圳市塔吉瑞生物医药有限公司 Substituted diaminopyrimidine compound
EP3912976A4 (en) * 2019-01-18 2022-11-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Salt of egfr inhibitor, crystal form, and preparation method therefor
AU2020385527B2 (en) * 2019-11-21 2023-04-13 Tyk Medicines, Inc. Compound used as EGFR kinase inhibitor and use thereof
WO2022146027A1 (en) * 2020-12-29 2022-07-07 주식회사 비투에스바이오 Heteroaryl derivative compound and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009062258A1 (en) * 2007-11-15 2009-05-22 Cytopia Research Pty Ltd N-containing heterocyclic compounds
CN106083742A (en) * 2016-05-31 2016-11-09 广东工业大学 A kind of 2,4 2 amido quinazoline derivants and its preparation method and application

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470356A1 (en) 1964-01-15 1970-04-30 Thomae Gmbh Dr K New thieno [3,2-d] pyrimidines and process for their preparation
AU2002364211A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
WO2006105056A2 (en) 2005-03-28 2006-10-05 Fmc Corporation Insecticidal 2,4-diaminoquinazolines and related derivatives
ES2562428T3 (en) 2005-12-15 2016-03-04 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
JP2008013527A (en) * 2006-07-10 2008-01-24 Sankyo Co Ltd THIENO[3,2-d]PYRIMIDINE-2,4-DIAMINE DERIVATIVE
DK2300013T3 (en) * 2008-05-21 2017-12-04 Ariad Pharma Inc PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS
NZ627709A (en) * 2010-06-23 2014-12-24 Hanmi Science Co Ltd Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity
EP2670401B1 (en) * 2011-02-02 2015-06-10 Novartis AG Methods of using alk inhibitors
KR20140011773A (en) * 2012-07-19 2014-01-29 한미약품 주식회사 Heterocyclic derivatives with dual inhibitory activity
KR20140118575A (en) 2013-03-29 2014-10-08 한미약품 주식회사 Novel hydroxamate derivative
CN103242341B (en) * 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 Thieno-2,4 substituted pyrimidines compounds and pharmaceutical composition thereof and application
WO2015039612A1 (en) * 2013-09-18 2015-03-26 北京韩美药品有限公司 Compound inhibiting kinase activities of btk and/or jak3
JP2018522867A (en) * 2015-06-26 2018-08-16 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Fused bicyclic pyrimidine derivatives and their use
CN107698603B (en) 2016-08-09 2022-04-08 南京红云生物科技有限公司 Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009062258A1 (en) * 2007-11-15 2009-05-22 Cytopia Research Pty Ltd N-containing heterocyclic compounds
CN106083742A (en) * 2016-05-31 2016-11-09 广东工业大学 A kind of 2,4 2 amido quinazoline derivants and its preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES T METZ ET AL: "Navigating the kinome", NATURE CHEMICAL BIOLOGY, vol. 7, no. 4, 1 April 2011 (2011-04-01), pages 200 - 202, XP055101166, ISSN: 1552-4450, DOI: 10.1038/nchembio.530 *

Also Published As

Publication number Publication date
EP3498716B1 (en) 2024-04-17
EP3498716A1 (en) 2019-06-19
WO2018028721A1 (en) 2018-02-15
CN107698603B (en) 2022-04-08
JP6963598B2 (en) 2021-11-10
KR20200026782A (en) 2020-03-11
CA3033459C (en) 2023-10-24
JP2019524790A (en) 2019-09-05
US11078213B2 (en) 2021-08-03
US20200207779A2 (en) 2020-07-02
AU2017311168B2 (en) 2021-03-04
AU2017311168A1 (en) 2019-02-28
CA3033459A1 (en) 2018-02-15
CN107698603A (en) 2018-02-16
KR102429355B1 (en) 2022-08-04
US20190211030A1 (en) 2019-07-11

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