EP3487531A4 - Zusammensetzungen und verfahren zur behandlung von frontotemporaler demenz - Google Patents

Zusammensetzungen und verfahren zur behandlung von frontotemporaler demenz Download PDF

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Publication number
EP3487531A4
EP3487531A4 EP17831788.9A EP17831788A EP3487531A4 EP 3487531 A4 EP3487531 A4 EP 3487531A4 EP 17831788 A EP17831788 A EP 17831788A EP 3487531 A4 EP3487531 A4 EP 3487531A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
frontotemporal dementia
treating frontotemporal
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17831788.9A
Other languages
English (en)
French (fr)
Other versions
EP3487531A1 (de
Inventor
Sethu SANKARANARAYANAN
Ted Yednock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Annexon Inc
Original Assignee
Annexon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annexon Inc filed Critical Annexon Inc
Publication of EP3487531A1 publication Critical patent/EP3487531A1/de
Publication of EP3487531A4 publication Critical patent/EP3487531A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP17831788.9A 2016-07-19 2017-07-19 Zusammensetzungen und verfahren zur behandlung von frontotemporaler demenz Withdrawn EP3487531A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662364013P 2016-07-19 2016-07-19
PCT/US2017/042846 WO2018017711A1 (en) 2016-07-19 2017-07-19 Compositions and methods for treating frontotemporal dementia

Publications (2)

Publication Number Publication Date
EP3487531A1 EP3487531A1 (de) 2019-05-29
EP3487531A4 true EP3487531A4 (de) 2020-03-25

Family

ID=60992917

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17831788.9A Withdrawn EP3487531A4 (de) 2016-07-19 2017-07-19 Zusammensetzungen und verfahren zur behandlung von frontotemporaler demenz

Country Status (6)

Country Link
EP (1) EP3487531A4 (de)
AU (1) AU2017299579A1 (de)
CA (1) CA3030872A1 (de)
IL (1) IL264167A (de)
SG (1) SG11201900123TA (de)
WO (1) WO2018017711A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6462680B2 (ja) 2013-07-09 2019-01-30 アネクソン，インコーポレーテッド 抗補体因子Ｃ１ｑ抗体及びその使用
BR112018010360A2 (pt) * 2015-11-24 2018-12-04 Annexon Inc fragmentos fab de fator de complemento anti-c1q e utilizações dos mesmos
CN108159421B (zh) * 2018-02-05 2021-05-18 苏州大学 磷脂酰丝氨酸阻断剂在制备治疗血小板数量减少相关疾病药物中的用途
US20200140533A1 (en) * 2018-11-02 2020-05-07 Annexon, Inc. Compositions and methods for treating brain injury
WO2021242493A2 (en) * 2020-05-05 2021-12-02 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Compositions and methods for treating epilepsy
AU2021310926A1 (en) 2020-07-23 2023-03-23 Othair Prothena Limited Anti-abeta antibodies
EP4337332A2 (de) 2021-07-13 2024-03-20 Mabwell Therapeutics Inc. Anti-c1s-antikörper und verwendungen davon

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014066744A2 (en) * 2012-10-25 2014-05-01 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
WO2016073685A1 (en) * 2014-11-05 2016-05-12 Annexon, Inc. Humanized anti-complement factor c1q antibodies and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148330B2 (en) * 2005-12-09 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptic maintenance
US9480658B2 (en) * 2005-12-09 2016-11-01 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptic maintenance
JP6462680B2 (ja) * 2013-07-09 2019-01-30 アネクソン，インコーポレーテッド 抗補体因子Ｃ１ｑ抗体及びその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014066744A2 (en) * 2012-10-25 2014-05-01 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
WO2016073685A1 (en) * 2014-11-05 2016-05-12 Annexon, Inc. Humanized anti-complement factor c1q antibodies and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LUI HANSEN ET AL: "Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation", CELL, ELSEVIER, AMSTERDAM, NL, vol. 165, no. 4, 21 April 2016 (2016-04-21), pages 921 - 935, XP029530775, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2016.04.001 *
S. K. SINGHRAO ET AL: "Role of complement in the aetiology of Pick's disease?", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1 May 1996 (1996-05-01), pages 578 - 593, XP055665408, Retrieved from the Internet <URL:https://academic.oup.com/jnen/article-pdf/55/5/578/8276203/55-5-578.pdf> [retrieved on 20200205] *
See also references of WO2018017711A1 *
TSAI RICHARD M ET AL: "Treatment of Frontotemporal Dementia", CURRENT TREATMENT OPTIONS IN NEUROLOGY, SPRINGER US, BOSTON, vol. 16, no. 11, 21 September 2014 (2014-09-21), pages 1 - 14, XP035395075, ISSN: 1092-8480, [retrieved on 20140921], DOI: 10.1007/S11940-014-0319-0 *

Also Published As

Publication number Publication date
SG11201900123TA (en) 2019-02-27
AU2017299579A1 (en) 2019-01-24
IL264167A (en) 2019-02-28
EP3487531A1 (de) 2019-05-29
CA3030872A1 (en) 2018-01-25
WO2018017711A1 (en) 2018-01-25

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