EP3478270A4 - Semi-solid and viscous liquid nasal formulations of cannabinoids - Google Patents

Semi-solid and viscous liquid nasal formulations of cannabinoids Download PDF

Info

Publication number
EP3478270A4
EP3478270A4 EP17805945.7A EP17805945A EP3478270A4 EP 3478270 A4 EP3478270 A4 EP 3478270A4 EP 17805945 A EP17805945 A EP 17805945A EP 3478270 A4 EP3478270 A4 EP 3478270A4
Authority
EP
European Patent Office
Prior art keywords
cannabinoids
semi
solid
viscous liquid
nasal formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17805945.7A
Other languages
German (de)
French (fr)
Other versions
EP3478270A2 (en
Inventor
Nathan Bryson
Avinash Chander Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acerus Labs Inc
Original Assignee
Acerus Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60478110&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3478270(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Acerus Labs Inc filed Critical Acerus Labs Inc
Publication of EP3478270A2 publication Critical patent/EP3478270A2/en
Publication of EP3478270A4 publication Critical patent/EP3478270A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
EP17805945.7A 2016-06-02 2017-06-02 Semi-solid and viscous liquid nasal formulations of cannabinoids Pending EP3478270A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344486P 2016-06-02 2016-06-02
US201662426403P 2016-11-25 2016-11-25
PCT/IB2017/000759 WO2017208072A2 (en) 2016-06-02 2017-06-02 Nasal cannabidiol compositions

Publications (2)

Publication Number Publication Date
EP3478270A2 EP3478270A2 (en) 2019-05-08
EP3478270A4 true EP3478270A4 (en) 2019-11-27

Family

ID=60478110

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17805945.7A Pending EP3478270A4 (en) 2016-06-02 2017-06-02 Semi-solid and viscous liquid nasal formulations of cannabinoids

Country Status (12)

Country Link
US (1) US20170348276A1 (en)
EP (1) EP3478270A4 (en)
KR (1) KR102433459B1 (en)
CN (1) CN109789090A (en)
BR (1) BR112018075073A2 (en)
CA (1) CA3026274A1 (en)
CL (1) CL2018003452A1 (en)
CO (1) CO2018013654A2 (en)
MX (1) MX2018014978A (en)
TW (1) TWI790204B (en)
UY (1) UY37271A (en)
WO (1) WO2017208072A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907823B1 (en) 2014-11-07 2018-03-06 Eric H. Kuhrts Water-soluble phytocannabinoid formulations
WO2019064234A1 (en) 2017-09-28 2019-04-04 Zynerba Pharmaceuticals, Inc. Treatment of fragile x syndrome with cannabidiol
US20190240148A1 (en) * 2018-02-07 2019-08-08 Tarukino Holdings, Inc. Lubricant composition and method for preparing the composition
US20210008026A1 (en) * 2018-03-05 2021-01-14 Solva, Llc Water-soluble phytocannabinoid formulations
US11020357B2 (en) * 2018-03-19 2021-06-01 Alexandra Yerike Compound for use in relief of pain and method to produce thereof
EP3856172A4 (en) * 2018-09-28 2022-10-05 Visceral Therapeutics Inc. Pharmaceutically active cannabis-based compositions and methods of use for treating gastrointestinal conditions
US20200170962A1 (en) * 2018-11-30 2020-06-04 F. Markus Leweke Nasal cannabidiol compositions
JP2022517724A (en) * 2018-12-14 2022-03-10 アセラス バイオファーマ インコーポレーテッド Active ester derivatives of testosterone, compositions, and their use
WO2020121260A1 (en) 2018-12-14 2020-06-18 Zynerba Pharmaceuticals, Inc. Treatment of 22q11.2 deletion syndrome with cannabidiol
BR102018076973A2 (en) * 2018-12-21 2020-09-15 Entourage Participações S.A. PHARMACEUTICAL COMPOSITION UNDERSTANDING CANNABIS EXTRACT, PHARMACEUTICAL PRODUCT, PROCESS OF PREPARATION OF SUCH COMPOSITION
WO2020142692A1 (en) * 2019-01-04 2020-07-09 Columbia Care Llc Topical formulations having cannabinoid
WO2020146478A1 (en) * 2019-01-08 2020-07-16 Replennabis LLC Cannabinoid formulations for treating alcohol hangover
US20220110887A1 (en) * 2019-02-08 2022-04-14 Schedule 1 Therapeutics, Inc. Compositions comprising cannabinoids and methods of use thereof
US10993928B2 (en) * 2019-04-26 2021-05-04 Natural Extraction Systems, LLC Compositions comprising non-crystalline forms of cannabidiol
CN110433133A (en) * 2019-08-19 2019-11-12 中国人民解放军军事科学院军事医学研究院 The cannabidiol nasal formulations for treating posttraumatic stress disorder
CA3151691A1 (en) 2019-08-30 2021-03-04 Sakso Loaded granules, their process of production and their uses
GB2588455B (en) * 2019-10-25 2022-12-21 Gw Res Ltd Cannabinoid compound
CA3163788A1 (en) * 2019-12-06 2021-06-10 JLABS Beauty LLC Topical compositions containing rose oil and cannabidiol and methods of making and using the same
TWI708835B (en) * 2020-01-17 2020-11-01 和協工程股份有限公司 Slow release type carbon-releasing gel substrate and soil treatment method
CH717205A1 (en) * 2020-03-11 2021-09-15 Jk Holding Gmbh Use of cannabinoids in therapy and wellness devices.
US20210322343A1 (en) * 2020-04-15 2021-10-21 Farzana Shaheen Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders
EP3984522A1 (en) * 2020-10-19 2022-04-20 Shima Khaki Composition, device and use
IT202100014909A1 (en) * 2021-06-08 2022-12-08 Velleja Res S R L OILY FORMULATIONS OF CANNABINOIDS
CN113304109A (en) * 2021-06-08 2021-08-27 内蒙古大唐药业股份有限公司 A flavone acetylsalicylate solid lipid nanoparticle dispersion and its preparation method
WO2023028708A1 (en) * 2021-09-02 2023-03-09 Canopy Growth Corporation Water-soluble cannabinoid compositions, methods of making and use
US11471905B1 (en) 2021-09-23 2022-10-18 Apackaging Group Llc All plastic airless pump dispenser
EP4186490A1 (en) 2021-11-29 2023-05-31 Sanity Group GmbH Kit for preparing a medicament, cannabinoid composition, and preparation method
WO2023177675A1 (en) * 2022-03-15 2023-09-21 Milehigh Repro Solutions, Llc Methods and systems to reduce injury in treated tissues
US11666543B1 (en) * 2022-07-05 2023-06-06 Poviva Corp. Pharmaceutical compositions and methods for treating hypertension
WO2024010628A1 (en) * 2022-07-05 2024-01-11 Poviva Corp Pharmaceutical compositions and methods for treating hypertension

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070060639A1 (en) * 2005-09-09 2007-03-15 University Of Kentucky Compositions and methods for intranasal delivery of tricyclic cannabinoids

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
WO2002064109A2 (en) * 2001-02-14 2002-08-22 Gw Pharma Limited Mucoadhesive pharmaceutical formulations
GB0103638D0 (en) * 2001-02-14 2001-03-28 Gw Pharmaceuticals Ltd Pharmaceutical formulations
GB2392093B (en) * 2002-08-14 2006-03-08 Gw Pharma Ltd Pharmaceutical formulations
KR20070118069A (en) * 2004-12-09 2007-12-13 인시스 테라퓨틱스, 인코포레이티드 Room-temperature stable dronabinol formulations
CA2836405C (en) * 2011-05-15 2021-09-07 Trimel Biopharma Srl Controlled release nasal testosterone gels, methods and pre-filled multi-dose applicator systems for pernasal administration

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20070060639A1 (en) * 2005-09-09 2007-03-15 University Of Kentucky Compositions and methods for intranasal delivery of tricyclic cannabinoids

Also Published As

Publication number Publication date
BR112018075073A2 (en) 2019-04-30
CA3026274A1 (en) 2017-12-07
UY37271A (en) 2017-11-30
TW201801721A (en) 2018-01-16
WO2017208072A2 (en) 2017-12-07
US20170348276A1 (en) 2017-12-07
KR102433459B1 (en) 2022-08-17
KR20190034506A (en) 2019-04-02
CO2018013654A2 (en) 2019-08-30
CN109789090A (en) 2019-05-21
EP3478270A2 (en) 2019-05-08
WO2017208072A3 (en) 2018-01-11
CL2018003452A1 (en) 2019-06-21
TWI790204B (en) 2023-01-21
MX2018014978A (en) 2019-09-04

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