EP3440054A4 - Pyrrole derivatives - Google Patents
Pyrrole derivatives Download PDFInfo
- Publication number
- EP3440054A4 EP3440054A4 EP16897539.9A EP16897539A EP3440054A4 EP 3440054 A4 EP3440054 A4 EP 3440054A4 EP 16897539 A EP16897539 A EP 16897539A EP 3440054 A4 EP3440054 A4 EP 3440054A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyrrole derivatives
- pyrrole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003233 pyrroles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2016/078548 WO2017173604A1 (en) | 2016-04-06 | 2016-04-06 | Pyrrole derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3440054A1 EP3440054A1 (en) | 2019-02-13 |
EP3440054A4 true EP3440054A4 (en) | 2019-10-09 |
EP3440054B1 EP3440054B1 (en) | 2021-12-01 |
Family
ID=60000825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16897539.9A Active EP3440054B1 (en) | 2016-04-06 | 2016-04-06 | Pyrrole derivatives useful as mglur5 modulators |
Country Status (3)
Country | Link |
---|---|
US (1) | US10669255B2 (en) |
EP (1) | EP3440054B1 (en) |
WO (1) | WO2017173604A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113254586B (en) * | 2021-05-31 | 2021-11-05 | 中国科学院深圳先进技术研究院 | Unsupervised text retrieval method based on deep learning |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002046166A1 (en) * | 2000-12-04 | 2002-06-13 | F. Hoffmann-La Roche Ag | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
WO2003059904A1 (en) * | 2001-12-21 | 2003-07-24 | Merck & Co., Inc. | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 |
WO2006089700A1 (en) * | 2005-02-22 | 2006-08-31 | Novartis Ag | Pyrrolidine and piperidine acetylene derivatives for use as mglur5 antagonists |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6397897B2 (en) * | 2013-05-14 | 2018-09-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation and their use as kinase inhibitors |
CN105061286B (en) * | 2015-09-08 | 2017-11-24 | 上海蓝木化工有限公司 | A kind of synthetic method of alkynyl substituted azoles |
-
2016
- 2016-04-06 US US16/091,781 patent/US10669255B2/en active Active
- 2016-04-06 EP EP16897539.9A patent/EP3440054B1/en active Active
- 2016-04-06 WO PCT/CN2016/078548 patent/WO2017173604A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002046166A1 (en) * | 2000-12-04 | 2002-06-13 | F. Hoffmann-La Roche Ag | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
WO2003059904A1 (en) * | 2001-12-21 | 2003-07-24 | Merck & Co., Inc. | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 |
WO2006089700A1 (en) * | 2005-02-22 | 2006-08-31 | Novartis Ag | Pyrrolidine and piperidine acetylene derivatives for use as mglur5 antagonists |
Non-Patent Citations (2)
Title |
---|
See also references of WO2017173604A1 * |
SHILPA A. WORLIKAR ET AL: "Highly Substituted Indole Library Synthesis by Palladium-Catalyzed Coupling Reactions in Solution and on a Solid Support", JOURNAL OF COMBINATORIAL CHEMISTRY., vol. 11, no. 5, 14 September 2009 (2009-09-14), US, pages 875 - 879, XP055615485, ISSN: 1520-4766, DOI: 10.1021/cc900057n * |
Also Published As
Publication number | Publication date |
---|---|
EP3440054A1 (en) | 2019-02-13 |
WO2017173604A1 (en) | 2017-10-12 |
EP3440054B1 (en) | 2021-12-01 |
US10669255B2 (en) | 2020-06-02 |
US20190100506A1 (en) | 2019-04-04 |
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