EP3429510A1 - Prothèse acétabulaire servant à une arthroplastie de la hanche - Google Patents

Prothèse acétabulaire servant à une arthroplastie de la hanche

Info

Publication number
EP3429510A1
EP3429510A1 EP17710270.4A EP17710270A EP3429510A1 EP 3429510 A1 EP3429510 A1 EP 3429510A1 EP 17710270 A EP17710270 A EP 17710270A EP 3429510 A1 EP3429510 A1 EP 3429510A1
Authority
EP
European Patent Office
Prior art keywords
acetabular prosthesis
insert
metal
cavity
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17710270.4A
Other languages
German (de)
English (en)
Inventor
Bohic J. YVES
Jacques Lovet
Khaled BOUACIDA
Olivier MAY
Nicolas FOUILLERON
Philippe Massin
Julien HENRY
Benoit LEBEL
Matthieu TURCAT
Christophe Besson
Stephen Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adler Ortho SpA
Original Assignee
Adler Ortho SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adler Ortho SpA filed Critical Adler Ortho SpA
Publication of EP3429510A1 publication Critical patent/EP3429510A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
    • A61F2002/30354—Cylindrically-shaped protrusion and recess, e.g. cylinder of circular basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30769—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth madreporic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2002/3208—Bipolar or multipolar joints, e.g. having a femoral head articulating within an intermediate acetabular shell whilst said shell articulates within the natural acetabular socket or within an artificial outer shell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2002/3233—Joints for the hip having anti-luxation means for preventing complete dislocation of the femoral head from the acetabular cup
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A61F2002/3429—Acetabular cups with an integral peripheral collar or flange, e.g. oriented away from the shell centre line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A61F2002/3443—Acetabular cups with an anti-luxation elevated rim portion, e.g. on the inner shell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A61F2002/3453—Acetabular cups having a non-hemispherical convex outer surface, e.g. quadric-shaped
    • A61F2002/3466—Acetabular cups having a non-hemispherical convex outer surface, e.g. quadric-shaped having a cylindrical external shape, e.g. entirely cylindrical

Definitions

  • the present invention relates to an acetabular prosthesis for hip arthroplasty.
  • acetabular prosthesis also known as acetabular cup prosthesis, is used in orthopedic surgery for the full replacement of the hip by coupling with a femoral stem.
  • the hip joint is constituted by two articulation surfaces: the acetabulum of the iliac bone (concave surface) and the head of the femur (convex surface).
  • This joint has great mobility and withstands very high loads, and for this very reason it is also a joint that is often subject to degenerative pathologies, such as arthrosis, rheumatoid arthritis, cephalic necrosis, and traumas and dislocations. In all these situations a surgical procedure for replacement of the hip joint with an artificial joint may be necessary.
  • hip prostheses are constituted by a femoral stem made of metallic material, on which the femoral head made of ceramic or metal is fitted.
  • the acetabular prosthesis commonly known as cotyloid element, is inserted in the acetabular cavity.
  • the cotyloid element is constituted by a metallic component known as metal-back, which usually is hemispherical and inside which an insert is arranged which will be articulated to the femoral head.
  • the metal-back of a cotyloid element can be implanted with a press- fit method or with a cemented method, by using acrylic cement.
  • Cotyloid elements implanted with the press-fit method of the known type are inserted by forcing in the appropriately prepared cavity, giving the joint so-called primary stability.
  • the metal-back is commonly made of titanium alloy and has such an external surface as to facilitate bone regrowth and stabilize the prosthesis in the medium-long term, giving the joint so-called secondary stability.
  • Cotyloid elements implanted with the cemented method instead have such an external surface as to facilitate the adhesion of the cement, which will be interposed between the prosthetic component and the bone.
  • the insert, arranged within the metal-back can be made of ceramic, metal or polyethylene.
  • the latter is a low-cost material but can give rise to dislocations or wear depending on whether it is coupled to heads having a small or large diameter respectively.
  • a dual mobility acetabular prosthesis of a known type consists of a metal-back and a polyethylene insert which rotates freely in the metal-back.
  • Said insert has, in the equatorial part, an opening in which a femoral head made of metal or ceramic, having small dimensions, generally 22 or 28 mm in diameter, is to be inserted by forcing.
  • the aim of the present invention is to provide an acetabular prosthesis that overcomes the limitations of the background art, improving its primary and secondary stability.
  • an object of the present invention is to provide an acetabular prosthesis that ensures higher stability, even in the case of a press-fit method, which minimizes wear phenomena and therefore extends the survival of the system.
  • Another object of the present invention is to provide an acetabular prosthesis that prevents the escape of the insert from the metal-back.
  • Another object of the invention is to provide an acetabular prosthesis that prevents the escape of the prosthetic femoral head from the insert.
  • a further object of the invention is to provide an acetabular prosthesis that is capable of giving the greatest assurances of reliability and safety in use.
  • Another object of the invention is to provide an acetabular prosthesis that is easy to provide and economically competitive if compared with the background art.
  • an acetabular prosthesis for hip arthroplasty comprising a metal-back in which a cavity is formed which is adapted to accommodate an insert, characterized in that said cavity comprises a first region having a substantially hemispherical internal surface from which a second region extends which has a substantially cylindrical internal surface, the height of said second region being comprised in the interval between 1 and 5 millimeters and being adapted to help to retain said insert in said cavity.
  • Figure 1 is a perspective view of an embodiment of a metal-back of an acetabular prosthesis, according to the invention
  • Figure 2 is a top plan view of the metal-back of Figure 1 , according to the invention.
  • Figure 3 is a front elevation view of the metal-back of Figure 1, according to the invention.
  • Figure 4 is a sectional view of the metal-back shown in Figure 2, taken along the line IV-IV;
  • Figure 5 is an enlarged- scale view of a portion of Figure 4.
  • Figure 6 is a front elevation view of the metal-back of Figure 1, according to the invention, provided with an outer layer of porous metal;
  • Figure 7 is a perspective view of an embodiment of an insert of an acetabular prosthesis, according to the invention.
  • Figure 8 is a top plan view of the insert of Figure 7, according to the invention.
  • Figure 9 is a front elevation view of the insert of Figure 7, according to the invention.
  • Figure 10 is a sectional view of the insert shown in Figure 8, taken along the line X-X.
  • the acetabular prosthesis generally- designated by the reference numeral 1 , comprises a metal-back 3, in which a cavity 5 adapted to accommodate an insert 7 is formed.
  • the cavity 5 comprises a first region 50 provided with a substantially hemispherical internal surface 52 from which a second region 54 extends which has a substantially cylindrical internal surface 56, the height of the second region 54 being comprised in the interval between 1 and 5 millimeters and being adapted to contribute to the retention of the insert 7 inside the cavity 5.
  • the height of the second region 54 is comprised between 2 and 4 millimeters and is preferably substantially equal to 3 millimeters.
  • the metal-back 3 is made of a material such as chromium-cobalt, and preferably of the type of the chromium-cobalt- molybdenum alloy, using additive powder technology.
  • the metal-back 3 is provided by using exclusively additive powder technology. Starting from metal powders, a high-precision finished product is obtained advantageously, reducing considerably both production times and process waste material.
  • chromium-cobalt offers the advantage that it can be worked easily in order to obtain inside the metal-back 3 a particularly smooth surface without any roughness, thus reducing the phenomenon of wear of the polyethylene of which the insert 7 is generally made.
  • the metal-back 3 can comprise a layer of porous metal 30 which comprises a plurality of protruding elements 32.
  • a layer of porous metal 30 which comprises a plurality of protruding elements 32.
  • the layer of porous metal 30 can have a three- dimensional porous structure with a thickness comprised between 0.2 and 1 millimeters; even more preferably, such thickness is substantially equal to 0.8 millimeters.
  • the external surface of the layer of porous metal 30 advantageously comprises a plurality of protruding cusps, which have a substantially triangular shape and protrude from the external surface of the metal-back 3 with an inclination preferably comprised between 3° and 20°, even more preferably substantially equal to 7°, with respect to directions that are tangential to the metal-back 3.
  • these cusps are particularly sharp and such as to ensure effective primary stability and consequently, also by virtue of a hydroxyapatite coating, excellent secondary stability.
  • the insert 7 has a cavity 9 adapted to accommodate a femoral head.
  • the cavity 9 of the insert 7 comprises a first region
  • the insert 7 is advantageously made of a material selected from the group constituted by ultra high molecular weight polyethylene (UHMWPE), crosslinked ultra high molecular weight polyethylene (UHMWPE), ultra high molecular weight polyethylene (UHMWPE) with the addition of an antioxidant, and crosslinked ultra high molecular weight polyethylene (UHMWPE) with the addition of an antioxidant.
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE crosslinked ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • UHMWPE ultra high molecular weight polyethylene
  • the insert 7 is articulated to the metal-back 3, advantageously made of chromium-cobalt, and to the femoral head, made of metal or ceramic.
  • the internal surface 52, 56 of the metal-back 3 is polished to a mirror finish. In this manner, the wear phenomena that can occur following contact between the internal surfaces 52, 56 and the insert 7 are minimized.
  • the metal-back 3 comprises, at its peripheral edge, a radially protruding perimetric collar 36, which is also polished to a mirror finish. In this manner any damage to soft tissues located at the collar 36 are also minimized.
  • the substantially cylindrical internal surface 96 of the second region 94 of the insert 7 eliminates the risk that the prosthetic femoral head can escape from the cavity 9, acting in practice as its retention collar.
  • Another advantage of the acetabular prosthesis according to the invention resides in that it has a metal-back that can be manufactured completely by using additive powder technology and therefore ensuring modest costs and simplicity in production.
  • a further advantage of the acetabular prosthesis according to the invention resides in that it is a dual mobility prosthesis and therefore is exceptionally durable and smooth.
  • Another advantage of the acetabular prosthesis according to the invention resides in that the metal-back, by virtue of the use of chromium- cobalt or chromium- cobalt-molybdenum, has an internal surface that is absolutely smooth and without roughness, therefore capable of reducing drastically the phenomenon of wear of the polyethylene of which the insert is made.
  • the materials used may be any according to the requirements.

Abstract

La présente invention concerne une prothèse acétabulaire (1) servant à une arthroplastie de la hanche, comprenant une partie arrière métallique (3) dans laquelle est formée une cavité (5) qui est conçue pour loger un insert (7) et qui comprend une première zone (50) présentant une surface interne sensiblement hémisphérique (52) depuis laquelle s'étend une seconde zone (54) qui présente une surface interne sensiblement cylindrique (56), la hauteur de la seconde zone (54) étant comprise dans l'intervalle entre 1 et 5 millimètres et étant conçue pour aider à retenir l'insert (7) dans la cavité (5).
EP17710270.4A 2016-03-15 2017-03-13 Prothèse acétabulaire servant à une arthroplastie de la hanche Withdrawn EP3429510A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUA2016A001662A ITUA20161662A1 (it) 2016-03-15 2016-03-15 Protesi cotiloidea perfezionata per artroprotesi d'anca.
PCT/EP2017/055821 WO2017157842A1 (fr) 2016-03-15 2017-03-13 Prothèse acétabulaire servant à une arthroplastie de la hanche

Publications (1)

Publication Number Publication Date
EP3429510A1 true EP3429510A1 (fr) 2019-01-23

Family

ID=56203709

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17710270.4A Withdrawn EP3429510A1 (fr) 2016-03-15 2017-03-13 Prothèse acétabulaire servant à une arthroplastie de la hanche

Country Status (3)

Country Link
EP (1) EP3429510A1 (fr)
IT (1) ITUA20161662A1 (fr)
WO (1) WO2017157842A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437199A2 (fr) * 1978-09-29 1980-04-25 Rambert Andre Prothese partielle pour articulation
FR2770769B1 (fr) * 1997-11-07 2000-02-18 Orthotechnique Composant acetabulaire
FR2779341B1 (fr) * 1998-06-09 2000-07-28 Merck Biomaterial France Cotyle pour prothese de hanche
FR2856585B1 (fr) * 2003-06-26 2005-08-19 Jean Louis Dore Implant cotyloidien de prothese de hanche
FR2858760B1 (fr) * 2003-08-14 2006-05-05 Philippe Lapresle Cupule pour implant cotyloidien de prothese totale de hanche, implant cotyloidien et prothese totale de hanche la comprenant
US8163029B2 (en) * 2004-06-30 2012-04-24 Depuy Products, Inc. Extended radius prosthesis and associated method
FR2958533B1 (fr) * 2010-04-08 2012-03-23 Jean Claude Cartillier Gamme d?implants cotyloidiens de differentes tailles

Also Published As

Publication number Publication date
WO2017157842A1 (fr) 2017-09-21
ITUA20161662A1 (it) 2017-09-15

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