EP3416646A4 - PEMETXED FORMULATIONS - Google Patents

PEMETXED FORMULATIONS Download PDF

Info

Publication number
EP3416646A4
EP3416646A4 EP16890851.5A EP16890851A EP3416646A4 EP 3416646 A4 EP3416646 A4 EP 3416646A4 EP 16890851 A EP16890851 A EP 16890851A EP 3416646 A4 EP3416646 A4 EP 3416646A4
Authority
EP
European Patent Office
Prior art keywords
pemetxed
formulations
pemetxed formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP16890851.5A
Other languages
German (de)
French (fr)
Other versions
EP3416646A1 (en
Inventor
Feng-Jing Chen
Steven L. Krill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eagle Pharmaceuticals Inc
Original Assignee
Eagle Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eagle Pharmaceuticals Inc filed Critical Eagle Pharmaceuticals Inc
Publication of EP3416646A1 publication Critical patent/EP3416646A1/en
Publication of EP3416646A4 publication Critical patent/EP3416646A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP16890851.5A 2016-02-19 2016-02-19 PEMETXED FORMULATIONS Pending EP3416646A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/018703 WO2017142556A1 (en) 2016-02-19 2016-02-19 Pemetrexed formulations

Publications (2)

Publication Number Publication Date
EP3416646A1 EP3416646A1 (en) 2018-12-26
EP3416646A4 true EP3416646A4 (en) 2019-09-04

Family

ID=59625349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16890851.5A Pending EP3416646A4 (en) 2016-02-19 2016-02-19 PEMETXED FORMULATIONS

Country Status (9)

Country Link
EP (1) EP3416646A4 (en)
JP (1) JP2019505561A (en)
KR (2) KR20240049356A (en)
CN (1) CN109152778B (en)
AU (2) AU2016393213B2 (en)
CA (1) CA3014755C (en)
IL (4) IL301291A (en)
MX (2) MX2018010037A (en)
WO (1) WO2017142556A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012015810A2 (en) * 2010-07-28 2012-02-02 Eagle Pharmaceuticals, Inc. Pharmaceutical compositions containing pemetrexed having extended storage stability
EP2666463A1 (en) * 2012-05-21 2013-11-27 Synthon BV Stabilized liquid composition comprising pemetrexed
WO2013179248A1 (en) * 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
WO2015193517A2 (en) * 2014-10-16 2015-12-23 Synthon B.V. Liquid pharmaceutical composition comprising pemetrexed

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
JP2008543976A (en) * 2006-08-14 2008-12-04 シコール インコーポレイティド Method for preparing pharmaceutically acceptable lyophilized salt of pemetrexed diacid
US20150073000A1 (en) * 2012-03-27 2015-03-12 Fresenius Kabi Oncology Limited Stable ready-to-use pharmaceutical composition of pemetrexed
WO2013179310A1 (en) * 2012-05-31 2013-12-05 Mylan Laboratories Limited Stable aqueous compositions of pemetrexed
JP6099557B2 (en) * 2013-12-27 2017-03-22 富士フイルム株式会社 Injection solution preparation and method for producing the same
KR101703980B1 (en) * 2013-12-30 2017-02-08 주식회사 삼양바이오팜 Antioxidant-free pharmaceutical composition and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012015810A2 (en) * 2010-07-28 2012-02-02 Eagle Pharmaceuticals, Inc. Pharmaceutical compositions containing pemetrexed having extended storage stability
EP2666463A1 (en) * 2012-05-21 2013-11-27 Synthon BV Stabilized liquid composition comprising pemetrexed
WO2013179248A1 (en) * 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
WO2015193517A2 (en) * 2014-10-16 2015-12-23 Synthon B.V. Liquid pharmaceutical composition comprising pemetrexed

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017142556A1 *

Also Published As

Publication number Publication date
MX2022009547A (en) 2022-09-09
AU2016393213A1 (en) 2018-10-04
CA3014755A1 (en) 2017-08-24
MX2018010037A (en) 2019-07-04
KR20180132643A (en) 2018-12-12
CN109152778B (en) 2021-08-10
EP3416646A1 (en) 2018-12-26
CN109152778A (en) 2019-01-04
IL290647B2 (en) 2023-08-01
IL261179A (en) 2018-10-31
IL290647B1 (en) 2023-04-01
CA3014755C (en) 2023-11-14
IL290647A (en) 2022-04-01
WO2017142556A1 (en) 2017-08-24
IL312427A (en) 2024-06-01
IL301291A (en) 2023-05-01
JP2019505561A (en) 2019-02-28
AU2016393213B2 (en) 2022-03-31
IL261179B (en) 2022-03-01
KR20240049356A (en) 2024-04-16
AU2023202089A1 (en) 2023-06-01

Similar Documents

Publication Publication Date Title
DK3688162T3 (en) FORMULATIONS
EP3454634A4 (en) SAATGRUBENSCHLIESSSENSOREN
DK3405050T3 (en) CHILD-PROTECTED SNUCKER
EP3466394A4 (en) GEHBEWEGUNGASSISTENZVORRICHTUNG
MA50657A (en) NIRAPARIB FORMULATIONS
EP3440949A4 (en) GESCHMACKSINHALATOR
DK3436823T3 (en) ANTIGEN-ARRAY
DK3335532T3 (en) Tandsharve
DK3445708T3 (en) STIRBØJLE
DK3402792T3 (en) QUINOLIN-2-ON DERIVATORS
EP3402022A4 (en) CLAMP-WIRE
EP3364945C0 (en) FIXED FORMULATIONS
EP3402021A4 (en) CLAMP-WIRE
DK3509963T3 (en) PALLECONTAINER
EP3454847A4 (en) IMPROVED DRUG FORMULATIONS
MA50068A (en) COPANLISIB FORMULATIONS
DK3528829T3 (en) BACITRACIN-ALGINATE-OLIGOMER-CONJUGATES
EP3466246A4 (en) ERNTEGUTMANAGEMENTSYSTEM
DK3575238T3 (en) PALLECONTAINER
EP3468396A4 (en) SHISHA-MELASSEKAPSELN
EP3477092A4 (en) ENDKAPPE
EP3402421A4 (en) UTERINMANIPULATORANORDNUNG
DE112017006386A5 (en) Schraubarbeitszylinder
EP3455282A4 (en) POLYSILOXANHYDRAULIKFLÜSSIGKEITEN
DK3452590T3 (en) PLADEMAGNET

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20180918

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61K0031505000

Ipc: A61K0047100000

A4 Supplementary search report drawn up and despatched

Effective date: 20190807

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 47/10 20170101AFI20190801BHEP

Ipc: A61K 47/18 20170101ALI20190801BHEP

Ipc: A61K 31/519 20060101ALI20190801BHEP

Ipc: A61K 47/02 20060101ALI20190801BHEP

Ipc: A61K 9/00 20060101ALI20190801BHEP

Ipc: A61K 47/12 20060101ALI20190801BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40003128

Country of ref document: HK

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230503

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230717