EP3405484A4 - A method for producing insulin and insulin derivatives, and hybrid peptide used in this method - Google Patents

A method for producing insulin and insulin derivatives, and hybrid peptide used in this method Download PDF

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Publication number
EP3405484A4
EP3405484A4 EP17741726.8A EP17741726A EP3405484A4 EP 3405484 A4 EP3405484 A4 EP 3405484A4 EP 17741726 A EP17741726 A EP 17741726A EP 3405484 A4 EP3405484 A4 EP 3405484A4
Authority
EP
European Patent Office
Prior art keywords
insulin
peptide used
hybrid peptide
producing
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17741726.8A
Other languages
German (de)
French (fr)
Other versions
EP3405484A1 (en
Inventor
Piotr Borowicz
Andrzej Plucienniczak
Grazyna Plucienniczak
Iwona Sokolowska
Agnieszka ROMANIK-CHRUSCIELEWSKA
Natalia Lukasiewicz
Marcin Zielinski
Jaroslaw Antosik
Agnieszka SOBOLEWSKA
Diana MIKIEWICZ
Anna WÓJTOWICZ-KRAWIEC
Piotr BARAN
Anna BIERCZYNSKA-KRZYSIK
Michal Odrowaz-Sypniewski
Bozena Tejchman-Malecka
Dorota Stadnik
Jacek STADNIK
Weronika SURMACZ-CHWEDORUK
Joanna ZIELINSKA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siec Badawcza Lukasiewicz Instytut Chemii Przemyslowej Imienia Profesora Ignacego Moscickiego
Original Assignee
Instytut Biotechnologii i Antybiotykow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Biotechnologii i Antybiotykow filed Critical Instytut Biotechnologii i Antybiotykow
Publication of EP3405484A1 publication Critical patent/EP3405484A1/en
Publication of EP3405484A4 publication Critical patent/EP3405484A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP17741726.8A 2016-01-22 2017-01-22 A method for producing insulin and insulin derivatives, and hybrid peptide used in this method Pending EP3405484A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL415888A PL239062B1 (en) 2016-01-22 2016-01-22 Method for producing insulin and its derivatives and the hybrid peptide used in this method
PCT/PL2017/050003 WO2017126984A1 (en) 2016-01-22 2017-01-22 A method for producing insulin and insulin derivatives, and hybrid peptide used in this method

Publications (2)

Publication Number Publication Date
EP3405484A1 EP3405484A1 (en) 2018-11-28
EP3405484A4 true EP3405484A4 (en) 2019-11-06

Family

ID=59361950

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17741726.8A Pending EP3405484A4 (en) 2016-01-22 2017-01-22 A method for producing insulin and insulin derivatives, and hybrid peptide used in this method

Country Status (3)

Country Link
EP (1) EP3405484A4 (en)
PL (1) PL239062B1 (en)
WO (1) WO2017126984A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105635A (en) * 2018-06-18 2020-12-18 联合化学实验室有限公司 Leader sequences for higher expression of recombinant proteins
TW202039539A (en) 2018-12-11 2020-11-01 法商賽諾菲公司 Insulin analogs having reduced insulin receptor binding affinity
US10799564B1 (en) 2019-05-06 2020-10-13 Baxter International Inc. Insulin premix formulation and product, methods of preparing same, and methods of using same
WO2021116243A1 (en) * 2019-12-10 2021-06-17 Sanofi A method of forming a conjugate of a sulfonamide and a polypeptide
CN113527506A (en) * 2020-04-15 2021-10-22 博锐生物科技有限公司 Fusion protein and application thereof
CN113527505A (en) * 2020-04-15 2021-10-22 博锐生物科技有限公司 Polypeptide, pharmaceutical composition containing polypeptide and application of polypeptide and pharmaceutical composition
CN113801236A (en) * 2020-06-11 2021-12-17 宁波鲲鹏生物科技有限公司 Preparation method of insulin lispro
CN113105536B (en) * 2020-09-11 2023-07-18 美药星（南京）制药有限公司 New proinsulin glargine and method for preparing insulin glargine by using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
WO2014122653A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK129385A (en) * 1985-03-22 1986-09-23 Novo Industri As PEPTIDES AND PREPARATION THEREOF
DE59409816D1 (en) * 1993-04-27 2001-09-13 Hoechst Ag Amorphous monospheric forms of insulin derivatives
NZ279002A (en) * 1994-12-29 1999-02-25 Bio Technology General Corp Production of recombinant human insulin by folding a proinsulin hybrid polypeptide obtained from a bacterial cell
WO2009104199A1 (en) * 2008-02-19 2009-08-27 Biocon Limited A method of obtaining purified heterologous insulins expressed in yeast
PL219335B1 (en) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków New slow-release insulin analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
WO2014122653A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017126984A1 *

Also Published As

Publication number Publication date
WO2017126984A1 (en) 2017-07-27
EP3405484A1 (en) 2018-11-28
PL239062B1 (en) 2021-11-02
PL415888A1 (en) 2017-07-31

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