EP3334289B1 - Hochdurchsatzverfahren zur lieferung eines halbfesten gels für geflügel - Google Patents

Hochdurchsatzverfahren zur lieferung eines halbfesten gels für geflügel Download PDF

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Publication number
EP3334289B1
EP3334289B1 EP16837534.3A EP16837534A EP3334289B1 EP 3334289 B1 EP3334289 B1 EP 3334289B1 EP 16837534 A EP16837534 A EP 16837534A EP 3334289 B1 EP3334289 B1 EP 3334289B1
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EP
European Patent Office
Prior art keywords
gel
semi
chicks
alginic acid
firm gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16837534.3A
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English (en)
French (fr)
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EP3334289A1 (de
EP3334289A4 (de
Inventor
Jay Palmer
Paul DIOLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clearh2o Inc
Original Assignee
Clearh2o Inc
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Publication date
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Application filed by Clearh2o Inc filed Critical Clearh2o Inc
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Publication of EP3334289A4 publication Critical patent/EP3334289A4/de
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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K13/00—Devices for grooming or caring of animals, e.g. curry-combs; Fetlock rings; Tail-holders; Devices for preventing crib-biting; Washing devices; Protection against weather conditions or insects
    • A01K13/003—Devices for applying insecticides or medication
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K39/00—Feeding or drinking appliances for poultry or other birds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K45/00—Other aviculture appliances, e.g. devices for determining whether a bird is about to lay
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Definitions

  • the invention relates to a high throughput process of delivering non-smearing, semi-firm gel to poultry chicks.
  • the use of gels and water spray to deliver hydration, vaccination, medication, and nutrition to poultry chicks is known in the industry.
  • the common process is as follows: 1) a large number of chicks are placed in a box that is sent down a conveyor line; 2) along the line, the box of chicks passes under a series of spray cabinets where the chicks are sprayed with vaccines and other substances that are dispersed in water and/or gel; and 3) once fully vaccinated, the box is removed from the conveyor and delivered to a farm or poultry-raising facility.
  • the vaccines and other substances that are dispersed in the water and/or gel are delivered as a coarse spray or small gel droplets which the chicks consume off of one another by preening.
  • chicks It is common for the chicks to be sprayed with a number of separate solutions as they travel along the conveyor. This process is a high throughput process, typically taking 1 second or less to spray the box of chicks. Up to 500,000 chicks can be processed daily.
  • Conventional gels are soft, lack durability and often smear when applied to chicks. As the chicks are repeatedly sprayed, their downs become wet and some of the vaccine or deliverable substance is absorbed into the down or dissipates to the point where it cannot be consumed. The gel continues to smear to the point where it is difficult or impossible for a chick to consume. The wetness can also cause illness and cause the chicks to stress, which leads to further health issues.
  • microencapsulation In other settings the process of microencapsulation is used to deliver substances to animals.
  • the creation of microencapsulated particles is well known for the delivery of substances, such as medications, nutrients and enzymes, to animals and humans alike.
  • Microencapsulation methods include techniques such as spray drying, extrusion, air and electrostatic atomization, and using aerosol atomizers, all within a closed system or reactor where the reaction process can be easily controlled.
  • the reaction process requires a great deal of control, is expensive, and not practical for high throughput applications, such as delivering vaccines and substances to poultry traveling in open containers along a conveyor.
  • the invention is a high throughput process for delivering vaccines, medications, nutrients, such as vitamins, protein, fat, hydration, probiotics, prebiotics and other similar such substances in the form of a semi-firm gel pieces.
  • the gel is non-absorbent, non-smearing, durable and easily consumed by poultry chicks, which results in better uptake and healthier chicks.
  • the semi-firm gel is created by spraying the chicks with a solution containing an alginic acid crosslinking agent and a gel containing alginic acid.
  • the deliverable substance can be added to either the gel or the solution.
  • the deliverable substance, after the chicks are sprayed may be located on the outside of the gel, within the gel or may move between the inside and outside of the gel due to the semi-firm nature of the resultant gel.
  • the invention relates to a process for delivering a substance in the form of consumable semi-firm gel pieces for use with animals, and in particular with poultry chicks.
  • the deliverable substance may be vaccines, medications, nutrients, such as vitamins, protein, fat, hydration, probiotics, prebiotics and other similar such substances.
  • the disclosure discusses the invention in terms of its use with poultry chicks and turkey poults, or simply "chicks", however, it is understood that it is not limited to use with poultry chicks and turkey poults and may be used with any number of other animals.
  • An apparatus that includes at least one conveyor belt and at least one spray cabinet that is used to spray chicks with various solutions is provided.
  • a number of chicks usually around 100, are placed in an open top container that is placed on the conveyor and transported through one or more spray cabinets.
  • the chicks are commonly processed up to rates of 100,000 chicks/1,000 boxes per hour.
  • the spray cabinets include a plurality of nozzles, which are typically mounted within one or more manifolds, to spray the chicks as they pass through the spray cabinets.
  • the consumable semi-firm gel is created by providing a combination of two solutions that are sequentially or simultaneously sprayed onto the chicks.
  • the first solution is a solution containing an alginic acid crosslinking agent, such as the divalent cation Ca2+ or a trivalent cation.
  • the solution may be water or a low to high viscosity gel.
  • the first solution may be a mixture of water and powdered calcium, the mixture preferably containing 5% or less of the powdered calcium.
  • the second solution is a gel containing an alginic acid.
  • the second solution may be mixture of a gel and an alginic acid, the mixture preferably containing 5% or less of the alginic acid.
  • the deliverable substance is added to either or both solutions.
  • Both solutions are applied to the chicks, and crosslinking between the crosslinking agent and the alginic acid creates a semi-firm gel that is firmer than traditional gels and is not absorbable. More specifically, the area of the gel that comes into contact with the first solution initially experiences the crosslinking, which increases the firmness of the gel at that point of contact. For several minutes following the initial contact, the two solutions continue to interact with one another, continuing to increase the firmness of the gel over that period of time. For example, spraying the chicks with the first solution and then applying the gel creates a gel that is firmer on the bottom where it is in contact with the chick. Alternatively, spraying the gel first followed by the first solution creates a gel that is firmer on the top than it is on the bottom.
  • the semi-firm gel remains generally as a fully consumable irregular piece on a chick's down and greatly reduces the amount the chicks are wetted in the delivery process.
  • the irregular piece of gel may be in many shapes, including streaks or strings.
  • the semi-firm gel pieces are readily consumed by the chicks, resulting in improved vaccine uptake and healthier chicks.
  • the semi-firm gel is created by applying the two solutions sequentially.
  • an open-top container is sized to hold approximately 100 chicks relatively closely packed, so that their downs touch one another.
  • the container is placed on a conveyor, which transports the container through a spray cabinet.
  • the spray cabinet includes at least two manifolds, each of which includes a plurality of nozzles, and a plurality of nozzles that are independent of the manifolds.
  • the independent nozzles spray the chicks with the alginic acid crosslinking solution.
  • the alginic crosslinking solution is preferably sprayed at a rate up to 30 ml per container.
  • the nozzles on the manifolds spray the chicks with the alginic acid gel at rates up to 60 ml per container of chicks.
  • the crosslinking solution reacts with the alginic acid gel, forming a semi-firm gel according to the invention, which is then consumed by the chicks.
  • the sprays may be applied in any sequence such that the crosslinking occurs after being applied to the chicks.
  • the same process may also be used to create consumable gels that are consumed in, for example, an incubator at a chick hatchery.
  • the eggs When the eggs are placed in the incubator, they typically hatch within a 72 hour period although some hatch sooner than others. Within that timeframe, chicks typically have access to hydration and nutrition. Water and food can be messy, and in many cases is incompatible for use in incubators. Nutrition/hydration gels are occasionally provided, however, the conventional gel is only consumable for approximately 24 hours before it evaporates.
  • a nutrition/hydration gel containing alginic acid is deposited in a container, such as a food or water trough, located inside incubator and then sprayed with a solution containing the alginic cross-linking agent.
  • a container such as a food or water trough
  • the result is a semi-firm surface on the gel that acts as a layer to protect against evaporation. This allows the gel to remain hydrated and consumable for a longer period of time, typically 72 hours or longer.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Inorganic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Fodder In General (AREA)

Claims (9)

  1. Nicht-medizinisches Verfahren zur Abgabe eines halbfesten Gels, das eine abgebbare Substanz enthält,
    wobei das Verfahren Folgendes umfasst:
    (a) Besprühen einer Gruppe von Küken mit einer Lösung, die ein Alginsäurevernetzungsmittel enthält;
    (b) Besprühen der Küken mit einem Gel, das Alginsäure enthält; und
    (c) Aufnehmen der abgebbaren Substanz in das Alginsäurevernetzungsmittel und/oder die Alginsäure.
  2. Halbfestes Gel, das ein Arzneimittel zur Verwendung in der Medizin in einem Verfahren enthält, umfassend:
    (a) Besprühen einer Gruppe von Küken mit einer Lösung, die ein Alginsäurevernetzungsmittel enthält;
    (b) Besprühen der Küken mit einem Gel, das Alginsäure enthält; und
    (c) Aufnehmen des abgebbaren Arzneimittels in das Alginsäurevernetzungsmittel und/oder die Alginsäure.
  3. Halbfestes Gel, das einen Impfstoff zur Verwendung bei Impfungen in einem Verfahren enthält, umfassend:
    (a) Besprühen einer Gruppe von Küken mit einer Lösung, die ein Alginsäurevernetzungsmittel enthält;
    (b) Besprühen der Küken mit einem Gel, das Alginsäure enthält; und
    (c) Aufnehmen des Impfstoffs in das Alginsäurevernetzungsmittel und/oder die Alginsäure.
  4. Nicht-medizinisches Verfahren nach Anspruch 1, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 2 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 3, wobei die Sprühmittel nacheinander angewendet werden.
  5. Nicht-medizinisches Verfahren nach Anspruch 1, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 2 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 3, wobei die Sprühmittel gleichzeitig angewendet werden.
  6. Nicht-medizinisches Verfahren nach Anspruch 4, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 4 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 4, wobei die Küken mit der Lösung, die ein Alginsäurevernetzungsmittel enthält, besprüht werden und dann mit dem Alginsäuregel besprüht werden.
  7. Nicht-medizinisches Verfahren nach Anspruch 4, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 4 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 4, wobei die Küken mit dem Alginsäuregel besprüht werden und dann mit der Lösung, die ein Alginsäurevernetzungsmittel enthält, besprüht werden.
  8. Nicht-medizinisches Verfahren nach Anspruch 1, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 2 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 3, wobei das Alginsäurevernetzungsmittel ein zweiwertiges Kation ist.
  9. Nicht-medizinisches Verfahren nach Anspruch 1, halbfestes Gel zur Verwendung in der Medizin nach Anspruch 2 oder halbfestes Gel zur Verwendung bei Impfungen nach Anspruch 3, wobei das Alginsäurevernetzungsmittel ein dreiwertiges Kation ist.
EP16837534.3A 2015-08-14 2016-08-11 Hochdurchsatzverfahren zur lieferung eines halbfesten gels für geflügel Active EP3334289B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562205324P 2015-08-14 2015-08-14
US201562222345P 2015-09-23 2015-09-23
PCT/US2016/046443 WO2017030876A1 (en) 2015-08-14 2016-08-11 High throughput process for delivering semi-firm gel for poultry

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Publication Number Publication Date
EP3334289A1 EP3334289A1 (de) 2018-06-20
EP3334289A4 EP3334289A4 (de) 2018-07-11
EP3334289B1 true EP3334289B1 (de) 2019-10-02

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US (2) US10905136B2 (de)
EP (1) EP3334289B1 (de)
CA (1) CA2994970A1 (de)
WO (1) WO2017030876A1 (de)

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US10905136B2 (en) 2015-08-14 2021-02-02 Clear H2O, Inc. High throughput process for delivering semi-firm gel for poultry
US11805794B2 (en) 2015-08-14 2023-11-07 Clearh2O, Inc. High throughput process for delivering semi-firm gel for poultry

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US20210127714A1 (en) 2021-05-06
EP3334289A1 (de) 2018-06-20
WO2017030876A1 (en) 2017-02-23
EP3334289A4 (de) 2018-07-11
US11805794B2 (en) 2023-11-07
US20170208839A1 (en) 2017-07-27
US10905136B2 (en) 2021-02-02

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