EP3324990A4 - Identification of immunogenic mhc class ii peptides for immune-based therapy - Google Patents

Identification of immunogenic mhc class ii peptides for immune-based therapy Download PDF

Info

Publication number
EP3324990A4
EP3324990A4 EP16828163.2A EP16828163A EP3324990A4 EP 3324990 A4 EP3324990 A4 EP 3324990A4 EP 16828163 A EP16828163 A EP 16828163A EP 3324990 A4 EP3324990 A4 EP 3324990A4
Authority
EP
European Patent Office
Prior art keywords
peptides
immune
identification
mhc class
based therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16828163.2A
Other languages
German (de)
French (fr)
Other versions
EP3324990A1 (en
Inventor
Gary K. Koski
Brian J. Czerniecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRIAN J. CZERNIECKI
Original Assignee
Brian J Czerniecki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/041034 external-priority patent/WO2016011432A2/en
Application filed by Brian J Czerniecki filed Critical Brian J Czerniecki
Publication of EP3324990A1 publication Critical patent/EP3324990A1/en
Publication of EP3324990A4 publication Critical patent/EP3324990A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464403—Receptors for growth factors
    • A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/812—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/828—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
EP16828163.2A 2015-07-17 2016-04-07 Identification of immunogenic mhc class ii peptides for immune-based therapy Withdrawn EP3324990A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2015/041034 WO2016011432A2 (en) 2014-07-17 2015-07-17 Identification of immunogenic mhc class ii peptides for immune-based therapy
PCT/US2016/021042 WO2017014810A1 (en) 2015-07-17 2016-03-04 Identification of immunogenic mhc class ii peptides for immune-based therapy
PCT/US2016/026542 WO2017014816A1 (en) 2015-07-17 2016-04-07 Identification of immunogenic mhc class ii peptides for immune-based therapy

Publications (2)

Publication Number Publication Date
EP3324990A1 EP3324990A1 (en) 2018-05-30
EP3324990A4 true EP3324990A4 (en) 2019-04-03

Family

ID=57835029

Family Applications (2)

Application Number Title Priority Date Filing Date
EP16828158.2A Withdrawn EP3325005A4 (en) 2015-07-17 2016-03-04 Identification of immunogenic mhc class ii peptides for immune-based therapy
EP16828163.2A Withdrawn EP3324990A4 (en) 2015-07-17 2016-04-07 Identification of immunogenic mhc class ii peptides for immune-based therapy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP16828158.2A Withdrawn EP3325005A4 (en) 2015-07-17 2016-03-04 Identification of immunogenic mhc class ii peptides for immune-based therapy

Country Status (5)

Country Link
EP (2) EP3325005A4 (en)
JP (3) JP2018527286A (en)
CN (1) CN107206045A (en)
CA (2) CA2992925A1 (en)
WO (2) WO2017014810A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017014810A1 (en) * 2015-07-17 2017-01-26 Czerniecki Brian J Identification of immunogenic mhc class ii peptides for immune-based therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016011343A1 (en) * 2014-07-17 2016-01-21 The Trustees Of The University Of Pennsylvania Her3 peptides and dendritic cell vaccines

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
IL145926A0 (en) * 2001-10-15 2002-07-25 Mor Research Applic Ltd Peptide epitopes of mimotopes useful in immunomodulation
EP2258712A3 (en) * 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
JP4660094B2 (en) * 2002-03-26 2011-03-30 ゼンサン （シャンハイ） サイ−テク． リミテッド ErbB3-based methods and compositions for treating neoplasms
US7700299B2 (en) * 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
US7897723B2 (en) * 2006-04-07 2011-03-01 Københavns Universitet ErbB receptor-derived peptide fragments
BRPI0713150A8 (en) * 2006-06-15 2017-08-22 Novartis Ag ADJUVANT-SPARING INFLUENZA VACCINATION MULTIDOSE REGIME
EP2401621B1 (en) * 2009-02-24 2013-08-14 Roche Diagnostics GmbH Use of s-erbb-3 as a marker for cancer
JP2010200693A (en) * 2009-03-04 2010-09-16 Chiyoda Kako Kensetsu Kk Culture device for producing dendritic cell vaccine and method for producing the dendritic cell
US8765383B2 (en) * 2009-04-07 2014-07-01 Genomic Health, Inc. Methods of predicting cancer risk using gene expression in premalignant tissue
AU2010278702C1 (en) * 2009-07-31 2016-07-14 Forsyth Dental Infirmary For Children Programming of cells for tolerogenic therapies
AU2011227447B2 (en) * 2010-03-15 2016-04-14 The Trustees Of The University Of Pennsylvania System and method of preparing and storing activated mature dendritic cells
KR102101806B1 (en) * 2011-05-19 2020-04-20 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) Anti-human-her3 antibodies and uses thereof
EA036739B1 (en) * 2011-12-05 2020-12-15 Новартис Аг Antibodies for epidermal growth factor receptor 3 (her3)
JP2016535079A (en) * 2013-09-30 2016-11-10 第一三共株式会社 Nucleic acid biomarkers and uses thereof
WO2017014810A1 (en) * 2015-07-17 2017-01-26 Czerniecki Brian J Identification of immunogenic mhc class ii peptides for immune-based therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016011343A1 (en) * 2014-07-17 2016-01-21 The Trustees Of The University Of Pennsylvania Her3 peptides and dendritic cell vaccines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATTA JASHODEEP ET AL: "Progressive loss of anti-HER2 CD4(+) T-helper type 1 response in breast tumorigenesis and the potential for immune restoration", ONCOIMMUNOLOGY, LANDES BIOSCIENCE, US, vol. 4, no. 10, 1 April 2015 (2015-04-01), XP002782236, ISSN: 2162-402X, DOI: 10.1080/2162402X.2015.1022301 *
FRACOL MEGAN ET AL: "Loss of Anti-HER-3 CD4+ T-Helper Type 1 Immunity Occurs in Breast Tumorigenesis and is Negatively Associated with Outcomes", ANNALS OF SURGICAL ONCOLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 24, no. 2, 23 September 2016 (2016-09-23), pages 407 - 417, XP036125796, ISSN: 1068-9265, [retrieved on 20160923], DOI: 10.1245/S10434-016-5584-6 *
JASHODEEP DATTA ET AL: "Association of Depressed Anti-HER2 T-Helper Type 1 Response With Recurrence in Patients With Completely Treated HER2-Positive Breast Cancer : Role for Immune Monitoring", JAMA ONCOLOGY, vol. 2, no. 2, 1 February 2016 (2016-02-01), US, pages 242, XP055556159, ISSN: 2374-2437, DOI: 10.1001/jamaoncol.2015.5482 *
See also references of WO2017014816A1 *

Also Published As

Publication number Publication date
EP3325005A4 (en) 2019-03-27
CA2992925A1 (en) 2017-01-26
EP3324990A1 (en) 2018-05-30
EP3325005A1 (en) 2018-05-30
CA2992937A1 (en) 2017-01-26
WO2017014816A1 (en) 2017-01-26
CN107206045A (en) 2017-09-26
WO2017014810A1 (en) 2017-01-26
JP2021043204A (en) 2021-03-18
JP2018521953A (en) 2018-08-09
JP2018527286A (en) 2018-09-20

Similar Documents

Publication Publication Date Title
EP3291842A4 (en) Variant survivin vaccine for treatment of cancer
PL3207053T3 (en) Novel immunogenic peptides
ZA201806860B (en) Novel immunogenic cd1d binding peptides
EP3646883A4 (en) Novel tumor vaccine and use thereof
EP3220953A4 (en) COMPOSITIONS AND METHODS OF USING THERAPEUTIC p53 PEPTIDES AND ANALOGUES
ZA201808246B (en) Improvement of hpv l2 peptide immunogenicity
EP3523274A4 (en) Formulations for administration of eflornithine
EP3315599A4 (en) Oral tumor vaccine
EP3199627A4 (en) Tumor antigen peptides
EP3152236A4 (en) Method for decreasing immunogenicity of protein and peptide
IL265805A (en) Immunogenic arginase peptides
HK1250662A1 (en) Immunogenic fusion proteins for the treatment of cancer
EP3178491A4 (en) Composition for enhancing induction of humoral immunity, and vaccine pharmaceutical composition
EP3283095A4 (en) Therapeutic peptides for cerebrovascular diseases
EP3107450A4 (en) Cosmetic base matching system
EP3231867A4 (en) Tumor antigen peptide
EP3223016A4 (en) Peptides for targeting gastric cancer, and medical use thereof
EP3331544A4 (en) Identification of class i mhc associated glycopertides as targets for cancer immunotherapy
EP3169354A4 (en) Identification of immunogenic mhc class ii peptides for immune-based therapy
EP3336186A4 (en) Depdc1-derived peptide and vaccine containing same
AU2015300256B2 (en) KOC1-Derived peptide and vaccine including same
EP3189852A4 (en) Bisphosphonate-containing pharmaceutical vaccine composition for humoral immunity
EP3162378A4 (en) Influenza vaccine nasal vaccination system
EP3324990A4 (en) Identification of immunogenic mhc class ii peptides for immune-based therapy
EP3222289A4 (en) Dna-peptide combination vaccine

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170217

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BRIAN J. CZERNIECKI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CZERNIECKI, BRIAN J.

Inventor name: KOSKI, GARY K.

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20190301

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 2/00 20060101ALI20190225BHEP

Ipc: A61K 38/16 20060101ALI20190225BHEP

Ipc: G01N 33/574 20060101ALI20190225BHEP

Ipc: G01N 33/569 20060101ALI20190225BHEP

Ipc: A61K 38/00 20060101ALI20190225BHEP

Ipc: A61K 39/00 20060101AFI20190225BHEP

Ipc: C07K 16/28 20060101ALI20190225BHEP

Ipc: A61P 35/00 20060101ALI20190225BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20211103