EP3288585A4 - Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants - Google Patents

Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants Download PDF

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Publication number
EP3288585A4
EP3288585A4 EP16787110.2A EP16787110A EP3288585A4 EP 3288585 A4 EP3288585 A4 EP 3288585A4 EP 16787110 A EP16787110 A EP 16787110A EP 3288585 A4 EP3288585 A4 EP 3288585A4
Authority
EP
European Patent Office
Prior art keywords
immunotherapies
methods
small molecule
novel compositions
integrin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP16787110.2A
Other languages
German (de)
French (fr)
Other versions
EP3288585A2 (en
Inventor
Darren G. Woodside
Peter Vanderslice
Upendra K. Marathi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas Heart Institute
7 Hills Interests LLC
Original Assignee
Texas Heart Institute
7 Hills Interests LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Heart Institute, 7 Hills Interests LLC filed Critical Texas Heart Institute
Priority claimed from PCT/US2016/029683 external-priority patent/WO2016176400A2/en
Publication of EP3288585A2 publication Critical patent/EP3288585A2/en
Publication of EP3288585A4 publication Critical patent/EP3288585A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
EP16787110.2A 2015-04-29 2016-04-28 Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants Pending EP3288585A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562154554P 2015-04-29 2015-04-29
PCT/US2016/029683 WO2016176400A2 (en) 2015-04-29 2016-04-28 Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants

Publications (2)

Publication Number Publication Date
EP3288585A2 EP3288585A2 (en) 2018-03-07
EP3288585A4 true EP3288585A4 (en) 2019-05-01

Family

ID=61024178

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16787110.2A Pending EP3288585A4 (en) 2015-04-29 2016-04-28 Novel compositions and methods for immunotherapies comprising small molecule integrin receptor-ligand agonist adjuvants

Country Status (1)

Country Link
EP (1) EP3288585A4 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068251A2 (en) * 2010-11-16 2012-05-24 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068251A2 (en) * 2010-11-16 2012-05-24 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALESSANDRA TOLOMELLI ET AL: "Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators", CANCERS, vol. 9, no. 12, 5 July 2017 (2017-07-05), pages 78, XP055531258, DOI: 10.3390/cancers9070078 *
ANDREW M. SCOTT ET AL: "Antibody therapy of cancer", NATURE REVIEWS. CANCER, vol. 12, no. 4, 1 April 2012 (2012-04-01), GB, pages 278 - 287, XP055531673, ISSN: 1474-175X, DOI: 10.1038/nrc3236 *
M. A. SCHWARTZ ET AL: "Integrin Agonists as Adjuvants in Chemotherapy for Melanoma", CLINICAL CANCER RESEARCH, vol. 14, no. 19, 1 October 2008 (2008-10-01), US, pages 6193 - 6197, XP055531739, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-08-1285 *
SIMON L GOODMAN ET AL: "Integrins as therapeutic targets", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 33, no. 7, 1 July 2012 (2012-07-01), pages 405 - 412, XP028495741, ISSN: 0165-6147, [retrieved on 20120412], DOI: 10.1016/J.TIPS.2012.04.002 *

Also Published As

Publication number Publication date
EP3288585A2 (en) 2018-03-07

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