EP3242671A4 - Ex vivo-verfahren zur minimierung der risiken und maximierung der vorteile von allogener blut- und knochenmarktransplantation - Google Patents
Ex vivo-verfahren zur minimierung der risiken und maximierung der vorteile von allogener blut- und knochenmarktransplantation Download PDFInfo
- Publication number
- EP3242671A4 EP3242671A4 EP16735447.1A EP16735447A EP3242671A4 EP 3242671 A4 EP3242671 A4 EP 3242671A4 EP 16735447 A EP16735447 A EP 16735447A EP 3242671 A4 EP3242671 A4 EP 3242671A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- marrow transplantation
- vivo methods
- allogeneic blood
- minimizing risks
- maximizing benefits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000735 allogeneic effect Effects 0.000 title 1
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002054 transplantation Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562101181P | 2015-01-08 | 2015-01-08 | |
PCT/US2016/012573 WO2016112245A1 (en) | 2015-01-08 | 2016-01-08 | Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3242671A1 EP3242671A1 (de) | 2017-11-15 |
EP3242671A4 true EP3242671A4 (de) | 2018-08-08 |
Family
ID=56356448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16735447.1A Withdrawn EP3242671A4 (de) | 2015-01-08 | 2016-01-08 | Ex vivo-verfahren zur minimierung der risiken und maximierung der vorteile von allogener blut- und knochenmarktransplantation |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3242671A4 (de) |
CA (1) | CA2972846A1 (de) |
WO (1) | WO2016112245A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
CN109401971B (zh) * | 2018-12-28 | 2024-01-30 | 江苏省人民医院(南京医科大学第一附属医院) | 一种多功能自动化独立/联合共培养装置 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827642A (en) * | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US20040259177A1 (en) * | 2003-05-06 | 2004-12-23 | Lowery Robert G. | Three dimensional cell cultures in a microscale fluid handling system |
WO2008060449A2 (en) * | 2006-11-09 | 2008-05-22 | President And Fellows Of Harvard College | Microfluidic detector |
US20110027804A1 (en) * | 2008-01-10 | 2011-02-03 | Hurel Corporation | Immune system modeling devices and methods |
US20140038279A1 (en) * | 2011-02-28 | 2014-02-06 | President And Fellows Of Harvard College | Cell culture system |
-
2016
- 2016-01-08 EP EP16735447.1A patent/EP3242671A4/de not_active Withdrawn
- 2016-01-08 WO PCT/US2016/012573 patent/WO2016112245A1/en active Application Filing
- 2016-01-08 CA CA2972846A patent/CA2972846A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827642A (en) * | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US20040259177A1 (en) * | 2003-05-06 | 2004-12-23 | Lowery Robert G. | Three dimensional cell cultures in a microscale fluid handling system |
WO2008060449A2 (en) * | 2006-11-09 | 2008-05-22 | President And Fellows Of Harvard College | Microfluidic detector |
US20110027804A1 (en) * | 2008-01-10 | 2011-02-03 | Hurel Corporation | Immune system modeling devices and methods |
US20140038279A1 (en) * | 2011-02-28 | 2014-02-06 | President And Fellows Of Harvard College | Cell culture system |
Non-Patent Citations (5)
Title |
---|
CARLENS STEFAN ET AL: "Ex vivo T lymphocyte expansion for retroviral transduction: Influence of serum-free media on variations in cell expansion rates and lymphocyte subset distribution", EXPERIMENTAL HEMATO, ELSEVIER INC, US, vol. 28, no. 10, 1 October 2000 (2000-10-01), pages 1137 - 1146, XP009165868, ISSN: 0301-472X, DOI: 10.1016/S0301-472X(00)00526-9 * |
DMITRY SAMSONOV ET AL: "Differential activation of human T cells to allogeneic endothelial cells, epithelial cells and fibroblasts in vitro", TRANSPLANTATION RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 24 April 2012 (2012-04-24), pages 4, XP021124468, ISSN: 2047-1440, DOI: 10.1186/2047-1440-1-4 * |
See also references of WO2016112245A1 * |
STYBAYEVA G ET AL: "Micropatterned co-cultures of T-lymphocytes and epithelial cells as a model of mucosal immune system", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 380, no. 3, 13 March 2009 (2009-03-13), pages 575 - 580, XP026422257, ISSN: 0006-291X, [retrieved on 20090131], DOI: 10.1016/J.BBRC.2009.01.164 * |
VÉRONIQUE LECAULT ET AL: "Microfluidic cell culture arrays for clonal expansion and characterization of mammalian cells", 1 January 2012 (2012-01-01), XP055487736, Retrieved from the Internet <URL:http://dataaccess-p.internal.epo.org/dal/data/documents/nonpatent> * |
Also Published As
Publication number | Publication date |
---|---|
CA2972846A1 (en) | 2016-07-14 |
EP3242671A1 (de) | 2017-11-15 |
WO2016112245A1 (en) | 2016-07-14 |
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