EP3240541A4 - Synthetische rigidin-analoga als antikrebsmittel, salze, solvate und prodrugs davon und verfahren zur herstellung davon - Google Patents

Synthetische rigidin-analoga als antikrebsmittel, salze, solvate und prodrugs davon und verfahren zur herstellung davon Download PDF

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Publication number
EP3240541A4
EP3240541A4 EP15876018.1A EP15876018A EP3240541A4 EP 3240541 A4 EP3240541 A4 EP 3240541A4 EP 15876018 A EP15876018 A EP 15876018A EP 3240541 A4 EP3240541 A4 EP 3240541A4
Authority
EP
European Patent Office
Prior art keywords
rigidin
prodrugs
solvates
analogues
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15876018.1A
Other languages
English (en)
French (fr)
Other versions
EP3240541A1 (de
Inventor
Igor MAGEDOV
Snezna Rogelj
Liliya V. FROLOVA
Alexander V. KORNIENKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New Mexico Tech Research Foundation
Original Assignee
New Mexico Tech Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/584,929 external-priority patent/US9334280B2/en
Application filed by New Mexico Tech Research Foundation filed Critical New Mexico Tech Research Foundation
Publication of EP3240541A1 publication Critical patent/EP3240541A1/de
Publication of EP3240541A4 publication Critical patent/EP3240541A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP15876018.1A 2014-12-29 2015-12-21 Synthetische rigidin-analoga als antikrebsmittel, salze, solvate und prodrugs davon und verfahren zur herstellung davon Withdrawn EP3240541A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/584,929 US9334280B2 (en) 2012-11-16 2014-12-29 Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and method of producing same
PCT/US2015/067136 WO2016109292A1 (en) 2014-12-29 2015-12-21 Synthetic rigidin analogues as anti-cancer agents, salts, solvates and prodrugs thereof, and method of producing same

Publications (2)

Publication Number Publication Date
EP3240541A1 EP3240541A1 (de) 2017-11-08
EP3240541A4 true EP3240541A4 (de) 2018-07-25

Family

ID=56284926

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15876018.1A Withdrawn EP3240541A4 (de) 2014-12-29 2015-12-21 Synthetische rigidin-analoga als antikrebsmittel, salze, solvate und prodrugs davon und verfahren zur herstellung davon

Country Status (10)

Country Link
EP (1) EP3240541A4 (de)
JP (1) JP2018503633A (de)
KR (1) KR20170105033A (de)
CN (1) CN107530351A (de)
AU (1) AU2015374367A1 (de)
BR (1) BR112017014264A2 (de)
CA (1) CA2972787A1 (de)
IL (1) IL253245A0 (de)
MX (1) MX2017008744A (de)
WO (1) WO2016109292A1 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140142125A1 (en) * 2012-11-16 2014-05-22 New Mexico Technical Research Foundation Synthetic Rigidin Analogues as Anticancer Agents, Salts, Solvates and Prodrugs Thereof, and Method of Producing Same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345046B2 (en) * 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140142125A1 (en) * 2012-11-16 2014-05-22 New Mexico Technical Research Foundation Synthetic Rigidin Analogues as Anticancer Agents, Salts, Solvates and Prodrugs Thereof, and Method of Producing Same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROBERT SCOTT ET AL.: "Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins", CHEMMEDCHEM, vol. 9, 18 March 2014 (2014-03-18), pages 1428 - 1435, XP002781927, DOI: 10.1002/cmdc.201300532 *
See also references of WO2016109292A1 *

Also Published As

Publication number Publication date
MX2017008744A (es) 2018-06-06
BR112017014264A2 (pt) 2018-03-06
IL253245A0 (en) 2017-08-31
CA2972787A1 (en) 2016-07-07
CN107530351A (zh) 2018-01-02
AU2015374367A1 (en) 2017-07-20
AU2015374367A8 (en) 2017-07-27
JP2018503633A (ja) 2018-02-08
WO2016109292A1 (en) 2016-07-07
KR20170105033A (ko) 2017-09-18
EP3240541A1 (de) 2017-11-08

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Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MAGEDOV, IGOR

Inventor name: ROGELJ, SNEZNA

Inventor name: FROLOVA, LILIYA V.

Inventor name: KORNIENKO, ALEXANDER V.

DAV Request for validation of the european patent (deleted)
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A4 Supplementary search report drawn up and despatched

Effective date: 20180622

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 487/04 20060101AFI20180615BHEP

Ipc: A61K 31/535 20060101ALI20180615BHEP

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