EP3230755A1 - Cable loop detection mechanism for improved mri safety - Google Patents

Cable loop detection mechanism for improved mri safety

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Publication number
EP3230755A1
EP3230755A1 EP15813108.6A EP15813108A EP3230755A1 EP 3230755 A1 EP3230755 A1 EP 3230755A1 EP 15813108 A EP15813108 A EP 15813108A EP 3230755 A1 EP3230755 A1 EP 3230755A1
Authority
EP
European Patent Office
Prior art keywords
cable
electrically conductive
optical fiber
shape
core optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15813108.6A
Other languages
German (de)
French (fr)
Other versions
EP3230755B1 (en
Inventor
Francis Patrick O'NEILL
Ronald Paul CONSIGLIO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
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Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of EP3230755A1 publication Critical patent/EP3230755A1/en
Application granted granted Critical
Publication of EP3230755B1 publication Critical patent/EP3230755B1/en
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0816Measuring devices for examining respiratory frequency
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/16Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165Evaluating the state of mind, e.g. depression, anxiety
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4821Determining level or depth of anaesthesia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/288Provisions within MR facilities for enhancing safety during MR, e.g. reduction of the specific absorption rate [SAR], detection of ferromagnetic objects in the scanner room
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36Electrical details, e.g. matching or coupling of the coil to the receiver
    • G01R33/3692Electrical details, e.g. matching or coupling of the coil to the receiver involving signal transmission without using electrically conductive connections, e.g. wireless communication or optical communication of the MR signal or an auxiliary signal other than the MR signal
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4808Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56509Correction of image distortions, e.g. due to magnetic field inhomogeneities due to motion, displacement or flow, e.g. gradient moment nulling
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/567Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution gated by physiological signals, i.e. synchronization of acquired MR data with periodical motion of an object of interest, e.g. monitoring or triggering system for cardiac or respiratory gating
    • G01R33/5673Gating or triggering based on a physiological signal other than an MR signal, e.g. ECG gating or motion monitoring using optical systems for monitoring the motion of a fiducial marker
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36Electrical details, e.g. matching or coupling of the coil to the receiver

Definitions

  • the following relates generally to Magnetic Resonance Imaging (MRI) and to ancillary components such as local radio frequency (RF) coils, MR-compliant electrocardiographic instrumentation, and so forth.
  • MRI Magnetic Resonance Imaging
  • RF radio frequency
  • Magnetic resonance (MR) systems use radio frequency (RF) pulses to create the MR signal. This RF energy is transmitted through free space from the transmit RF coil to the patient. When conducting materials are placed within the RF field, a concentration of electrical currents sufficient to cause excessive heating and tissue damage may occur. The patient may be burned, for example, at the point where an electrocardiography (ECG) electrode attaches to the patient.
  • ECG electrocardiography
  • ECG electrode wires can form loops, which may be resonant at the MR resonance frequency depending upon loop size (e.g. circumference or perimeter length) and orientation respective to the RF electric field vector. If a resonant loop is so formed, high electrical current can be induced in the ECG electrode wire, and since this wire contacts the imaging subject a burn can result. Similar issues can arise with surface RF coils placed onto or in close proximity to the imaging subject.
  • the electrically conductive cable is located inside the MR bore, it is not readily visible to the MR technician so that potentially resonant loops are not readily detected by visual observation. Even if the technician looks for such a problem during the imaging session preparation, patient movement can result in formation of a resonant loop during the imaging session. Moreover, there is typically no way for the technician to visually identify whether a given loop will be resonant at the MR frequency.
  • a magnetic resonance imaging (MRI) system including: a cable bundle including an electrically conductive cable and a multi-core optical fiber bundled together with the electrically conductive cable to form the cable bundle; an electrical component connected with the electrically conducive cable of the cable bundle; a fiber shape readout device optically coupled with the multi core optical fiber of the cable bundle and configured to measure reflectance of light injected into the multi core optical fiber and to compute the shape of the cable bundle based on the reflectance measurements; and a processor configured to detect a portion of the electrically conductive cable that is potentially resonant at a magnetic resonance frequency based on the shape computed for the multi core optical fiber bundled with the electrically conductive cable.
  • MRI magnetic resonance imaging
  • the fiber shape readout device may compute the shape of the cable bundle by performing a method comprising: detecting changes in optical length in cores in the multi-core optical fiber based on the reflectance measurements; and determining an angle or direction at a point on the multi-core fiber based on the detected changes in optical length.
  • the processor may be configured to detect a loop in the electrically conductive cable that is potentially resonant at the magnetic resonance frequency. A loop may, be detected by, for example, detecting a crossing point of the shape computed for the multi-core optical fiber bundled with the electrically conductive cable.
  • the MRI system may further comprise a magnetic resonance scanner with at least a portion of the cable bundle being disposed in an examination region of the magnetic resonance scanner.
  • the electrical component may be connected with the electrically conducive cable of the cable bundle comprises a radio frequency (RF) coil.
  • An alarm may be connected to be activated by the processor upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency.
  • the MRI system may further comprise: a radio frequency excitation coil; and a radio frequency amplifier operatively connected to cause the radio frequency excitation coil to output radio frequency pulses; wherein the processor may be further configured to interlock the radio frequency amplifier upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency.
  • a system may include: a magnetic resonance scanner configured to operate at a magnetic resonance frequency to acquire a magnetic resonance image of a subject disposed in an examination region of the magnetic resonance scanner; a cable bundle disposed at least partially in the examination region of the magnetic resonance scanner, the cable bundle including an electrically conductive cable and a multi- core optical fiber bundled together with the electrically conductive cable to form the cable bundle; a fiber shape readout device configured to measure reflectance of light injected into the multi core optical fiber and to determine the shape of the cable bundle disposed inside the examination region of the magnetic resonance scanner based on the reflectance measurements; and a processor programmed to detect a loop in the electrically conductive cable based on the shape of the cable bundle.
  • the fiber shape readout device may include an electronic data processing device optionally programmed to: compute a change in optical length in cores in the multi-core optical fiber up to a point on the multi-core optical fiber based on the measured reflectance; and determine a location or direction at the point on the multi-core optical fiber based on the computed changes in optical length.
  • the processor may further be programmed to analyze a detected loop in the electrically conductive cable with respect to resonance at a magnetic resonance frequency.
  • the system may further include a radio frequency coil or electrocardiographic electrode connected to an end of the electrically conductive cable disposed inside the examination region of the magnetic resonance scanner.
  • the system may further include an alarm.
  • the processor may further be configured to interrupt current in a radio frequency excitation coil upon detection of a loop in the electrically conductive cable.
  • the system may further include an alarm or radio frequency excitation interlock, wherein the processor is further configured to analyze a detected loop in the electrically conductive cable and to activate the alarm or radio frequency excitation interlock if the analysis indicates the detected loop is potentially resonant at the magnetic resonance frequency.
  • a method including: applying a radio frequency (RF) pulse generated by an RF coil to an imaging subject; determining, with a shape sensor, a shape of a multi-core optical fiber bundled with an electrically conductive cable and exposed to the applied RF pulse; and determining if a portion of an electrically conductive cable is resonant at the frequency of the RF pulse based on the shape of the multi- core optical fiber.
  • RF radio frequency
  • the shape sensor may compute the shape of the multi core optical fiber by operations including: measuring reflectance of light injected into the multi-core optical fiber; detecting a change in optical length in cores in the multi-core optical fiber at successive points along the multi-core optical fiber based on the measured reflectance; and determining a location or a direction of the multi core optical fiber at successive points along the multi- core optical fiber based on the detected changes in optical length.
  • the multi core optical fiber may be in contact with the imaging subject and the method may further include determining a motion of the imaging subject based on change in time of the shape of the multi core optical fiber.
  • the method may further include determining a motion signal of a patient based on information gathered by the shape sensor; and determining a depth of sedation or patient distress level based on the motion signal.
  • One advantage resides in monitoring in real-time the shape of a flexible electrically conductive cable disposed in the examination region of an MR scanner.
  • Another advantage resides in preventing patient burns before they occur. For example, once it is detected that the shape of an electrically conductive cable may cause resonance in the cable, the MRI system may be shut down (or the RF emission turned off) before such a patient burn occurs.
  • the invention may take form in various components and arrangements of components, and in various steps and arrangements of steps.
  • the drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention.
  • FIGURE 1 diagrammatically shows an MRI system in an embodiment.
  • FIGURE 2 shows a flow chart in accordance with an embodiment.
  • a diagrammatically illustrated MRI system 10 includes an MRI scanner 12 including a scanner housing 1 (cylindrical in the illustrative embodiment, and shown in side- sectional view to reveal selected internal components) defining a scanner bore 2 (or, more generally, scanner examination region 2, which in an open bore MR scanner may not be a fully enclosed bore).
  • Magnetic field gradient coils 4 superimpose magnetic field gradients on the static field in the examination region 2 in order to spatially encode magnetic resonance, spoil magnetic resonance, or perform other functions.
  • One or more radio frequency (RF) coils 5, 6 provide magnetic resonance excitation and detect excited magnetic resonance.
  • a whole body RF coil 5 mounted in the scanner housing 1 serves as the RF excitation coil while a local coil 6 (or, in some instances, an array of local coils) receives the magnetic resonance excitation.
  • the excitation coil 5 is driven by an RF amplifier 7 while an RF receiver 8 is connected with the receive coil 6 to receive, demodulate, and further process the received MR signal.
  • the main magnet 3 is typically a superconducting magnet (although some MR scanners employ a resistive main magnet) and is typically kept on except during scanner shutdown/maintenance in order to minimize power-up transients.
  • An imaging subject such as a human medical patient, animal veterinary subject, inanimate subject (e.g. an archaeological mummy), or so forth is loaded into the examination region 2 via a suitable subject support couch 9 or the like.
  • the RF amplifier 7 applies an RF pulse (or pulse packet) to the excitation coil 5 at the magnetic resonance frequency to excite magnetic resonance.
  • Magnetic field gradients are applied by the gradient coils 4 in the x, y, z or other direction(s) at predefined times before, during, or after the RF pulse is applied in order to spatially limit and/or frequency-and/or phase-encode the excited magnetic resonance, and the RF receive coil 6 and RF receiver 8 receive, demodulate and further process the MR signals.
  • diagrammatic FIGURE 1 omits numerous conventional MR system components such as magnetic field gradient amplifiers, an MR controller, cryogenic systems (if the magnet 3 is superconducting), optional patient physiology monitoring components such as an electrocardiographic (ECG) instrument and associated electrode leads extending into the bore 2 to contact the patient, and so forth.
  • ECG electrocardiographic
  • the MR scanner 12 is merely an illustrative example, and that more generally the MR scanner may be a horizontal closed-bore MR scanner (as shown), or an open bore scanner (horizontal or vertical), or so forth.
  • the MR scanner may, for example, be a Philips IngeniaTM, AchievaTM, MultivaTM, SonalleveTM, or other MR scanner (available from Koninklijke Philips N.V., Eindhoven, the Netherlands).
  • an illustrative resonant loop detector is provided for each cable that could pose a threat to the subject (or possibly to equipment) if the cable were to pick up an induced electric current due to the formation of a resonant loop.
  • an illustrative resonant loop detector comprises fiber optic cables 14 (or a multi-core fiber optic cable 14) bundled with an electrically conductive cable 22 that connects with the illustrative receive coil 6.
  • the multi- core optical fiber 14 and the flexible electrically conductive cable 22 are bundled together, for example by cable ties (not shown), so that the multi-core optical fiber 14 and the flexible electrically conductive cable 22 maintain (for practical purposes) the same shape as the cable bundle moves.
  • an illustrative cable loop 23 is present in both the optical fiber 14 and the electrically conductive cable 22 because the two are bundled together.
  • the fiber optical cable 14 is illustrated as a dashed line whereas the electrically conductive cable 22 is illustrated as a solid line.
  • the fiber optical cable 14 and the electrically conductive cable 22 need only be bundled together over the portion of the electrically conductive cable 22 that is located inside the examination region 2 of the MR scanner 12, as only that portion of the electrically conductive cable 22 is susceptible to RF- induced electric current formation. Thus, the portion of the electrically conductive cable 22 extending outside of the examination region 2 and running to the RF receiver 8 is not bundled with the optical fiber 14.
  • Certain shapes and/or lengths of cables exhibit the phenomenon of "resonance" that increases their propensity to concentrate RF currents.
  • conducting loops of tens of centimeters in size can create problems and, therefore, should be avoided, even if high impedance techniques are used to limit the RF current.
  • Even loops that include small gaps separated by insulation may still conduct current and lead to burns.
  • cables and transmit RF coils can capacitively-couple (without any contact or crossover) when placed close together to form a resonant loop.
  • Approaches described herein enable the detection and prevention of such contact or close proximity, and thus makes monitoring in the MR environment safer by eliminating the risk of cable loops inducing burns.
  • one such approach to protect a patient is to determine a shape of a fiber optic cable and, based on the determined shape, determine if resonance potentially may occur in an electrically conductive cable; and generate an alarm if resonance may potentially occur.
  • MRI systems once it is determined that resonance will occur, it is also useful to stop pulses in the RF coil or to stop current flowing into the electrically conductive cable.
  • this cable monitoring system can additionally be used to monitor patient movement. This is possible if the optical fiber 14 bundled with the electrically conductive cable 22 is disposed on the patient such that respiration, breath hold, or other motion causes corresponding movement of the optical fiber 14 that can be tracked without additional physiological sensors. Depth of sedation can potentially be derived from these motion signals as can patient distress. Additionally, a respiration rate and breath hold may be determined from these signals. It is also possible to use these functions for motion correction of images.
  • the illustrative cable shape measurement device operates as described in Froggatt et al, U.S. Patent Application Publication No. 2011/0109898 Al published May 12, 2011, which is incorporated by reference herein in its entirety.
  • the illustrative cable shape measurement device includes the multi-core optical fiber 14 and a fiber shape readout device 30.
  • the core-to-core spacing of the cores of the multi-core optical fiber 14 are constant in any cross-section of the multi-core fiber 14, which holds true for (by way of example) a multi-core fiber in which the cores are embedded in a glass or polymeric matrix.
  • any twisting or curvature of the fiber 14 is accommodated by elongation or compression of the cores along their lengths.
  • the core or cores "inside" the bend are compressed, while the cores or cores "outside” the bend are stretched, in order to accommodate the bend.
  • Optical Frequency Domain Reflectometry can be used to measure reflectance of light injected into the multi-core optical fiber and to determine, based on the reflectance measurements, changes in core length for successive small (i.e. quasi-differential) segments along the entire length of each core of the optical fiber 14.
  • the angle or direction of the fiber at any position along the fiber 14 is obtained based on summation of the changes in length of the cores up to that position.
  • the fiber shape readout device 30 may, for example, suitably include a tunable laser or other tunable light source inputting to the multi- core optical fiber 14 and an optical interferometer to perform the OFDR measurements, along with an electronic data processing device programmed to compute and sum fiber core length changes and associated fiber angle or direction changes to generate the fiber shape.
  • the fiber shape output from the readout device 30 may, for example, be formatted as a table of entries in which each entry includes the fields (di, Xi, yi, zi), where di denotes a location along the optical fiber 14 measured as a distance di from a reference point (such as the point at which the fiber 14 connects with the readout device 30) and the coordinates (xi, yi, Zi) are the spatial coordinates of that position along the fiber 14.
  • a cable loop detector 40 identifies any loops that may be present along the optical fiber 14 (and hence also along the bundled electrically conductive cable 22). For example, the cable loop detector 40 detects the illustrative loop 23.
  • a resonance analyzer 42 analyzes any detected loop to determine loop circumference or length and/or diameter, and assesses whether the loop in the electrically conductive cable 22 is resonant at the magnetic resonance frequency.
  • the shape of the fiber optic cable 14 may be used to compute the shape of the bundled electrically conductive cable because the fiber optic and electrically conductive cables are bundled together.
  • the cable loop detector 40 and optional resonance analyzer 42 are suitably implemented by a computer 46 programmed to process the fiber shape output from the readout device 30 of the shape measurement device 14, 30 to detect loops.
  • the computer 46 may also be programmed to implement the MR controller that controls the MR scanner 12.
  • any data processing component(s) of the fiber shape readout device 30 may optionally be implemented by the computer 46 as well.
  • the alarm 44 may be variously embodied, for example as warning text displayed on the display component 48 of the computer 46 (possibly in a highlighted fashion, e.g. flashing, in boldface red font, or so forth), an audible alarm (preferably in conjunction with displayed alarm text) or so forth. Since the cable shape is available from the shape detector 14, 30, it is contemplated in some embodiments to display a three-dimensional rendering of the cable shape on the display component 48.
  • the interlock 44 if provided, may be implemented as a digital or analog control signal transmitted from the computer 46 to the RF amplifier 7 (e.g. via a digital cable, dedicated analog line, or so forth).
  • the cable loop detector 40 can detect a cable loop. For example, one such way would be to gather the set of points on the cable ranging from di to d n . Each two neighboring points di, di+i are spaced apart by a distance di+i-di, and each point will have an associated set of coordinates, namely (xi, yi, zi) for the point di and (x i+lj y i+lj Zi+i) for the point di+i . If the cable has formed a loop, then the cable will have to "cross" itself.
  • This crossing point can be recognized as two points d a and d b for which the distance d b -d a is large enough to define a possibly resonant loop and for which the respective coordinates are close enough together, e.g. the separationj(x b — x a ) 2 + (y b — y a ) 2 + (3 ⁇ 4— z a ) 2 is smaller than a designated threshold T chosen to account for loop formation by inductive coupling across insulation or a small air gap.
  • a suitable process performed by the cable loop detector 40 and optional resonance analyzer 42 is described.
  • the process operates on a detected cable shape 50 output by the shape detector 14, 30.
  • an operation SI starting at location d a along the cable each point d b for which d b -d a is greater than some minimum threshold is searched for a crossing ⁇ x b — x a ) 2 + (y b — y a ) 2 + (z b — z a ) 2 ⁇ T.
  • the minimum threshold is at least chosen so that dt,-d a >T (otherwise a straight cable portion would be erroneously detected as a "loop.” In some embodiments the minimum threshold is chosen to be larger, so as to avoid detecting small cable loops that are too small to be resonant at the magnetic resonance frequency.
  • the operation S 1 is suitably performed by the cable loop detector 40 of FIGURE 1.
  • the resonance analyzer 42 determines its perimeter length as dt,-d a , and in a decision S3 the resonance analyzer 42 determines whether the cable loop is resonant. In general, the resonance condition is satisfied if the loop perimeter length is such that it can support a standing wave at the magnetic resonance frequency 52. If a resonant loop is determined, then in an operation S4 the alarm or interlock 44 is activated. If the loop is determined not to be resonant, then processing passes to S5 where the next loop is identified.
  • the resonance analyzer 42 and corresponding operations S2, S3 are optionally omitted. In general, determining whether a given cable loop is likely to be resonant at the magnetic resonance frequency can be difficult. If the crossing is not exact
  • the gap introduces a capacitive element into the loop, and the resonance condition depends on both the loop perimeter length and the value of this capacitance.
  • the capacitance also depends on the dielectric constant of the gap material (which may be air and/or insulation in various fractions). Still further, the precise resonance frequency may depend on the applied magnetic field gradients.
  • the resonance analyzer 42 is omitted and instead the cable loop detector 40 operates over an interval L m i n ⁇ (d b -d a ) ⁇ L max where the limits Lmm and Lma X are chosen to detect loops of any perimeter length that is possibly resonance (e.g. if the resonance condition is expected for loops on the order of tens of centimeters, Lmin-lO cm and Lma X ⁇ 100 cm may be appropriate).
  • This approach is likely to be overinclusive (that is, may detect cable loops relatively far away from the resonance condition) but such overinclusiveness may be useful to provide added safety, and also because once a loop is formed its size can rapidly change due to subject motion.
  • a fiber optic position monitoring bundle (e.g. the multi-core optical fiber 14) can be attached to any flexible electrically conductive cable for use in the MR environment.
  • This cable bundle is preferably made from MR compatible and biocompatible materials.
  • the multi-core optical fiber can be connected with a local RF coil cable (as shown), or with an ECG electrode wire, or so forth.
  • the optical fiber/electrically conductive cable bundle it is also contemplated to form the bundle more integrally, for example by providing a cable conduit containing both the optical fiber and the electrically conductive cable or by providing a common sheath for the optical fiber and electrically conductive cable.
  • Bundling of patient cable into an umbilical using a single position detection system is possible. If the shapes of two (or more) electrically conductive cables are monitored using respective bundled multi-core optical fibers, then potentially resonant loops formed between different cables can also be detected, again by detecting crossing points and determining perimeter lengths.
  • the patient protection techniques disclosed herein may be embodied by a non-transitory storage medium storing instructions readable and executable by an electronic data processing device (such as the computer 46) to perform the disclosed techniques.
  • a non-transitory storage medium may comprise a hard drive or other magnetic storage medium, an optical disk or other optical storage medium, a cloud- based storage medium such as a RAID disk array, flash memory or other non-volatile electronic storage medium, or so forth.

Abstract

The following relates generally to ensuring patient safety while operating a Magnetic Resonance Imaging (MRI) machine. Many MRI systems operate using: fiber optic cables to carry signals, electrically conductive cables to carry other signals,and radio frequency (RF) coils to create an electromagnetic field. Typically, the electrically conductive cables and RF coils do not interact in a way that causes harm to a patient. However, certain shapes and/or lengths of cables exhibit the phenomenon of "resonance" that increases their propensity to concentrate RF currents induced by the RF coils. This may increase the temperature of the cable or other component in the MRI system leading to patient harm. The methods disclosed herein provide a solution to this by sensing a shape of the fiber optic cable and determining if the fiber optic cable will exhibit resonance. If it is determined that resonance may potentially occur, an alarm may be generated or a radio frequency amplifier may be interlocked.

Description

CABLE LOOP DETECTION MECHANISM FOR IMPROVED MRI SAFETY
BACKGROUND
The following relates generally to Magnetic Resonance Imaging (MRI) and to ancillary components such as local radio frequency (RF) coils, MR-compliant electrocardiographic instrumentation, and so forth.
Magnetic resonance (MR) systems use radio frequency (RF) pulses to create the MR signal. This RF energy is transmitted through free space from the transmit RF coil to the patient. When conducting materials are placed within the RF field, a concentration of electrical currents sufficient to cause excessive heating and tissue damage may occur. The patient may be burned, for example, at the point where an electrocardiography (ECG) electrode attaches to the patient.
The nature of high frequency electromagnetic fields is such that the energy can be transmitted across open space and through insulators. Therefore, only devices with carefully designed current paths can be made safe for use during MR procedures. Simply insulating conductive material (e.g., wire or lead) or separating it from the patient may not be sufficient to prevent excessive heating or burns from occurring for some devices.
Flexible electrically conductive cables present a special problem, because RF- resonant loops can be formed depending upon how the cable happens to lay out. For example, electrocardiograph (ECG) electrode wires can form loops, which may be resonant at the MR resonance frequency depending upon loop size (e.g. circumference or perimeter length) and orientation respective to the RF electric field vector. If a resonant loop is so formed, high electrical current can be induced in the ECG electrode wire, and since this wire contacts the imaging subject a burn can result. Similar issues can arise with surface RF coils placed onto or in close proximity to the imaging subject.
Because the electrically conductive cable is located inside the MR bore, it is not readily visible to the MR technician so that potentially resonant loops are not readily detected by visual observation. Even if the technician looks for such a problem during the imaging session preparation, patient movement can result in formation of a resonant loop during the imaging session. Moreover, there is typically no way for the technician to visually identify whether a given loop will be resonant at the MR frequency.
SUMMARY In accordance with one aspect, a magnetic resonance imaging (MRI) system including: a cable bundle including an electrically conductive cable and a multi-core optical fiber bundled together with the electrically conductive cable to form the cable bundle; an electrical component connected with the electrically conducive cable of the cable bundle; a fiber shape readout device optically coupled with the multi core optical fiber of the cable bundle and configured to measure reflectance of light injected into the multi core optical fiber and to compute the shape of the cable bundle based on the reflectance measurements; and a processor configured to detect a portion of the electrically conductive cable that is potentially resonant at a magnetic resonance frequency based on the shape computed for the multi core optical fiber bundled with the electrically conductive cable. The fiber shape readout device may compute the shape of the cable bundle by performing a method comprising: detecting changes in optical length in cores in the multi-core optical fiber based on the reflectance measurements; and determining an angle or direction at a point on the multi-core fiber based on the detected changes in optical length. The processor may be configured to detect a loop in the electrically conductive cable that is potentially resonant at the magnetic resonance frequency. A loop may, be detected by, for example, detecting a crossing point of the shape computed for the multi-core optical fiber bundled with the electrically conductive cable. The MRI system may further comprise a magnetic resonance scanner with at least a portion of the cable bundle being disposed in an examination region of the magnetic resonance scanner. The electrical component may be connected with the electrically conducive cable of the cable bundle comprises a radio frequency (RF) coil. An alarm may be connected to be activated by the processor upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency. The MRI system may further comprise: a radio frequency excitation coil; and a radio frequency amplifier operatively connected to cause the radio frequency excitation coil to output radio frequency pulses; wherein the processor may be further configured to interlock the radio frequency amplifier upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency.
In accordance with another aspect, a system may include: a magnetic resonance scanner configured to operate at a magnetic resonance frequency to acquire a magnetic resonance image of a subject disposed in an examination region of the magnetic resonance scanner; a cable bundle disposed at least partially in the examination region of the magnetic resonance scanner, the cable bundle including an electrically conductive cable and a multi- core optical fiber bundled together with the electrically conductive cable to form the cable bundle; a fiber shape readout device configured to measure reflectance of light injected into the multi core optical fiber and to determine the shape of the cable bundle disposed inside the examination region of the magnetic resonance scanner based on the reflectance measurements; and a processor programmed to detect a loop in the electrically conductive cable based on the shape of the cable bundle.
In accordance with another aspect, in a system as set forth in the immediately preceding paragraph, the fiber shape readout device may include an electronic data processing device optionally programmed to: compute a change in optical length in cores in the multi-core optical fiber up to a point on the multi-core optical fiber based on the measured reflectance; and determine a location or direction at the point on the multi-core optical fiber based on the computed changes in optical length. The processor may further be programmed to analyze a detected loop in the electrically conductive cable with respect to resonance at a magnetic resonance frequency. The system may further include a radio frequency coil or electrocardiographic electrode connected to an end of the electrically conductive cable disposed inside the examination region of the magnetic resonance scanner. The system may further include an alarm. The processor may further be configured to interrupt current in a radio frequency excitation coil upon detection of a loop in the electrically conductive cable. The system may further include an alarm or radio frequency excitation interlock, wherein the processor is further configured to analyze a detected loop in the electrically conductive cable and to activate the alarm or radio frequency excitation interlock if the analysis indicates the detected loop is potentially resonant at the magnetic resonance frequency.
In accordance with another aspect, a method is provided including: applying a radio frequency (RF) pulse generated by an RF coil to an imaging subject; determining, with a shape sensor, a shape of a multi-core optical fiber bundled with an electrically conductive cable and exposed to the applied RF pulse; and determining if a portion of an electrically conductive cable is resonant at the frequency of the RF pulse based on the shape of the multi- core optical fiber. The shape sensor may compute the shape of the multi core optical fiber by operations including: measuring reflectance of light injected into the multi-core optical fiber; detecting a change in optical length in cores in the multi-core optical fiber at successive points along the multi-core optical fiber based on the measured reflectance; and determining a location or a direction of the multi core optical fiber at successive points along the multi- core optical fiber based on the detected changes in optical length. The multi core optical fiber may be in contact with the imaging subject and the method may further include determining a motion of the imaging subject based on change in time of the shape of the multi core optical fiber. The method may further include determining a motion signal of a patient based on information gathered by the shape sensor; and determining a depth of sedation or patient distress level based on the motion signal.
One advantage resides in monitoring in real-time the shape of a flexible electrically conductive cable disposed in the examination region of an MR scanner.
Another advantage resides in preventing patient burns before they occur. For example, once it is detected that the shape of an electrically conductive cable may cause resonance in the cable, the MRI system may be shut down (or the RF emission turned off) before such a patient burn occurs.
Other advantages will become apparent to one of ordinary skill in the art upon reading and understanding this disclosure.
The invention may take form in various components and arrangements of components, and in various steps and arrangements of steps. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention.
FIGURE 1 diagrammatically shows an MRI system in an embodiment.
FIGURE 2 shows a flow chart in accordance with an embodiment. DETAILED DESCRIPTION
With reference to FIGURE 1, a diagrammatically illustrated MRI system 10 includes an MRI scanner 12 including a scanner housing 1 (cylindrical in the illustrative embodiment, and shown in side- sectional view to reveal selected internal components) defining a scanner bore 2 (or, more generally, scanner examination region 2, which in an open bore MR scanner may not be a fully enclosed bore). The scanner housing 1 contains a main magnet 3 generating a static magnetic field typically denoted B0, for example B0 = 3T in the case of a 3-Tesla MR scanner. Magnetic field gradient coils 4 superimpose magnetic field gradients on the static field in the examination region 2 in order to spatially encode magnetic resonance, spoil magnetic resonance, or perform other functions. One or more radio frequency (RF) coils 5, 6 provide magnetic resonance excitation and detect excited magnetic resonance. In the illustrative embodiment, a whole body RF coil 5 mounted in the scanner housing 1 serves as the RF excitation coil while a local coil 6 (or, in some instances, an array of local coils) receives the magnetic resonance excitation. The excitation coil 5 is driven by an RF amplifier 7 while an RF receiver 8 is connected with the receive coil 6 to receive, demodulate, and further process the received MR signal. The main magnet 3 is typically a superconducting magnet (although some MR scanners employ a resistive main magnet) and is typically kept on except during scanner shutdown/maintenance in order to minimize power-up transients. An imaging subject, such as a human medical patient, animal veterinary subject, inanimate subject (e.g. an archaeological mummy), or so forth is loaded into the examination region 2 via a suitable subject support couch 9 or the like. During an imaging scan, the RF amplifier 7 applies an RF pulse (or pulse packet) to the excitation coil 5 at the magnetic resonance frequency to excite magnetic resonance. Magnetic field gradients are applied by the gradient coils 4 in the x, y, z or other direction(s) at predefined times before, during, or after the RF pulse is applied in order to spatially limit and/or frequency-and/or phase-encode the excited magnetic resonance, and the RF receive coil 6 and RF receiver 8 receive, demodulate and further process the MR signals. It will be appreciated that diagrammatic FIGURE 1 omits numerous conventional MR system components such as magnetic field gradient amplifiers, an MR controller, cryogenic systems (if the magnet 3 is superconducting), optional patient physiology monitoring components such as an electrocardiographic (ECG) instrument and associated electrode leads extending into the bore 2 to contact the patient, and so forth. It is to be further appreciated that the MR scanner 12 is merely an illustrative example, and that more generally the MR scanner may be a horizontal closed-bore MR scanner (as shown), or an open bore scanner (horizontal or vertical), or so forth. For further illustrative purposes, the MR scanner may, for example, be a Philips Ingenia™, Achieva™, Multiva™, Sonalleve™, or other MR scanner (available from Koninklijke Philips N.V., Eindhoven, the Netherlands).
Various flexible electrically conductive cables may extend into the examination region 2 of the MR scanner 12 for various purposes. As disclosed herein, a resonant loop detector is provided for each cable that could pose a threat to the subject (or possibly to equipment) if the cable were to pick up an induced electric current due to the formation of a resonant loop. In the illustrative example, an illustrative resonant loop detector comprises fiber optic cables 14 (or a multi-core fiber optic cable 14) bundled with an electrically conductive cable 22 that connects with the illustrative receive coil 6. The multi- core optical fiber 14 and the flexible electrically conductive cable 22 are bundled together, for example by cable ties (not shown), so that the multi-core optical fiber 14 and the flexible electrically conductive cable 22 maintain (for practical purposes) the same shape as the cable bundle moves. For example, an illustrative cable loop 23 is present in both the optical fiber 14 and the electrically conductive cable 22 because the two are bundled together. For illustrative purposes, the fiber optical cable 14 is illustrated as a dashed line whereas the electrically conductive cable 22 is illustrated as a solid line. The fiber optical cable 14 and the electrically conductive cable 22 need only be bundled together over the portion of the electrically conductive cable 22 that is located inside the examination region 2 of the MR scanner 12, as only that portion of the electrically conductive cable 22 is susceptible to RF- induced electric current formation. Thus, the portion of the electrically conductive cable 22 extending outside of the examination region 2 and running to the RF receiver 8 is not bundled with the optical fiber 14.
Certain shapes and/or lengths of cables exhibit the phenomenon of "resonance" that increases their propensity to concentrate RF currents. At the operating frequencies of typical MRI systems, conducting loops of tens of centimeters in size can create problems and, therefore, should be avoided, even if high impedance techniques are used to limit the RF current. Even loops that include small gaps separated by insulation may still conduct current and lead to burns. Thus, even the close proximity of conductive materials with each other should be avoided because cables and transmit RF coils can capacitively-couple (without any contact or crossover) when placed close together to form a resonant loop. Approaches described herein enable the detection and prevention of such contact or close proximity, and thus makes monitoring in the MR environment safer by eliminating the risk of cable loops inducing burns.
With continuing reference to FIGURE 1, one such approach to protect a patient is to determine a shape of a fiber optic cable and, based on the determined shape, determine if resonance potentially may occur in an electrically conductive cable; and generate an alarm if resonance may potentially occur. In MRI systems, once it is determined that resonance will occur, it is also useful to stop pulses in the RF coil or to stop current flowing into the electrically conductive cable.
Optionally, this cable monitoring system can additionally be used to monitor patient movement. This is possible if the optical fiber 14 bundled with the electrically conductive cable 22 is disposed on the patient such that respiration, breath hold, or other motion causes corresponding movement of the optical fiber 14 that can be tracked without additional physiological sensors. Depth of sedation can potentially be derived from these motion signals as can patient distress. Additionally, a respiration rate and breath hold may be determined from these signals. It is also possible to use these functions for motion correction of images. The illustrative cable shape measurement device operates as described in Froggatt et al, U.S. Patent Application Publication No. 2011/0109898 Al published May 12, 2011, which is incorporated by reference herein in its entirety. The illustrative cable shape measurement device includes the multi-core optical fiber 14 and a fiber shape readout device 30. In this approach, it is assumed that the core-to-core spacing of the cores of the multi-core optical fiber 14 are constant in any cross-section of the multi-core fiber 14, which holds true for (by way of example) a multi-core fiber in which the cores are embedded in a glass or polymeric matrix. As a consequence, any twisting or curvature of the fiber 14 is accommodated by elongation or compression of the cores along their lengths. For example, in a bend of the fiber 14, the core or cores "inside" the bend are compressed, while the cores or cores "outside" the bend are stretched, in order to accommodate the bend. As described in U.S. Pub. No. 2011/0109898 Al, a technique such as Optical Frequency Domain Reflectometry (OFDR) can be used to measure reflectance of light injected into the multi-core optical fiber and to determine, based on the reflectance measurements, changes in core length for successive small (i.e. quasi-differential) segments along the entire length of each core of the optical fiber 14. The angle or direction of the fiber at any position along the fiber 14 is obtained based on summation of the changes in length of the cores up to that position. To implement this shape measurement, the fiber shape readout device 30 may, for example, suitably include a tunable laser or other tunable light source inputting to the multi- core optical fiber 14 and an optical interferometer to perform the OFDR measurements, along with an electronic data processing device programmed to compute and sum fiber core length changes and associated fiber angle or direction changes to generate the fiber shape. The fiber shape output from the readout device 30 may, for example, be formatted as a table of entries in which each entry includes the fields (di, Xi, yi, zi), where di denotes a location along the optical fiber 14 measured as a distance di from a reference point (such as the point at which the fiber 14 connects with the readout device 30) and the coordinates (xi, yi, Zi) are the spatial coordinates of that position along the fiber 14.
With continuing reference to FIGURE 1, from the information obtained from the shape sensor 14, 30, a cable loop detector 40 identifies any loops that may be present along the optical fiber 14 (and hence also along the bundled electrically conductive cable 22). For example, the cable loop detector 40 detects the illustrative loop 23. Optionally, a resonance analyzer 42 analyzes any detected loop to determine loop circumference or length and/or diameter, and assesses whether the loop in the electrically conductive cable 22 is resonant at the magnetic resonance frequency. The shape of the fiber optic cable 14 may be used to compute the shape of the bundled electrically conductive cable because the fiber optic and electrically conductive cables are bundled together. If a potentially resonant loop is detected, then a safety alarm and/or interlock 44 is triggered to inform the MR technician of the potential problem and/or to automatically shut off the RF excitation, for example by interlocking the RF amplifier 7. As illustrated in FIGURE 1, the cable loop detector 40 and optional resonance analyzer 42 are suitably implemented by a computer 46 programmed to process the fiber shape output from the readout device 30 of the shape measurement device 14, 30 to detect loops. In some embodiments the computer 46 may also be programmed to implement the MR controller that controls the MR scanner 12. In some embodiments any data processing component(s) of the fiber shape readout device 30 may optionally be implemented by the computer 46 as well. The alarm 44, if provided, may be variously embodied, for example as warning text displayed on the display component 48 of the computer 46 (possibly in a highlighted fashion, e.g. flashing, in boldface red font, or so forth), an audible alarm (preferably in conjunction with displayed alarm text) or so forth. Since the cable shape is available from the shape detector 14, 30, it is contemplated in some embodiments to display a three-dimensional rendering of the cable shape on the display component 48. The interlock 44, if provided, may be implemented as a digital or analog control signal transmitted from the computer 46 to the RF amplifier 7 (e.g. via a digital cable, dedicated analog line, or so forth).
There are various ways by which the cable loop detector 40 can detect a cable loop. For example, one such way would be to gather the set of points on the cable ranging from di to dn. Each two neighboring points di, di+i are spaced apart by a distance di+i-di, and each point will have an associated set of coordinates, namely (xi, yi, zi) for the point di and (xi+lj yi+lj Zi+i) for the point di+i . If the cable has formed a loop, then the cable will have to "cross" itself. This crossing point can be recognized as two points da and db for which the distance db-da is large enough to define a possibly resonant loop and for which the respective coordinates are close enough together, e.g. the separationj(xb— xa)2 + (yb— ya)2 + (¾— za)2 is smaller than a designated threshold T chosen to account for loop formation by inductive coupling across insulation or a small air gap.
With reference to FIGURE 2, a suitable process performed by the cable loop detector 40 and optional resonance analyzer 42 is described. The process operates on a detected cable shape 50 output by the shape detector 14, 30. In an operation SI, starting at location da along the cable each point db for which db-da is greater than some minimum threshold is searched for a crossing ^{xb— xa)2 + (yb— ya)2 + (zb— za)2 < T. The minimum threshold is at least chosen so that dt,-da>T (otherwise a straight cable portion would be erroneously detected as a "loop." In some embodiments the minimum threshold is chosen to be larger, so as to avoid detecting small cable loops that are too small to be resonant at the magnetic resonance frequency. The operation S 1 is suitably performed by the cable loop detector 40 of FIGURE 1.
In an operation S2 of FIGURE 2, if a cable loop is detected then the resonance analyzer 42 determines its perimeter length as dt,-da, and in a decision S3 the resonance analyzer 42 determines whether the cable loop is resonant. In general, the resonance condition is satisfied if the loop perimeter length is such that it can support a standing wave at the magnetic resonance frequency 52. If a resonant loop is determined, then in an operation S4 the alarm or interlock 44 is activated. If the loop is determined not to be resonant, then processing passes to S5 where the next loop is identified.
As previously noted, the resonance analyzer 42 and corresponding operations S2, S3 are optionally omitted. In general, determining whether a given cable loop is likely to be resonant at the magnetic resonance frequency can be difficult. If the crossing is not exact
(that is, y/ .xb— xa)2 + (jb ~ J a)2 + (¾ — za)2 is less than the threshold T but is not exactly zero because there is some finite gap due to insulation or an air gap), then the gap introduces a capacitive element into the loop, and the resonance condition depends on both the loop perimeter length and the value of this capacitance. The capacitance, however, also depends on the dielectric constant of the gap material (which may be air and/or insulation in various fractions). Still further, the precise resonance frequency may depend on the applied magnetic field gradients. Accordingly, in some embodiments the resonance analyzer 42 is omitted and instead the cable loop detector 40 operates over an interval Lmin<(db-da)<Lmax where the limits Lmm and LmaX are chosen to detect loops of any perimeter length that is possibly resonance (e.g. if the resonance condition is expected for loops on the order of tens of centimeters, Lmin-lO cm and LmaX~100 cm may be appropriate). This approach is likely to be overinclusive (that is, may detect cable loops relatively far away from the resonance condition) but such overinclusiveness may be useful to provide added safety, and also because once a loop is formed its size can rapidly change due to subject motion.
Any cable loop that is located well outside of the examination region 2, that is, outside of the space within which the excitation coil 5 applies the RF pulses, cannot be a source of induced electric current. Accordingly, in a variant embodiment the coordinates of the cable shape output by the cable shape detector 14, 30 are registered with the coordinate system of the MR scanner 12, and the cable loop detector 40 only processes the portion of the cable that is located inside the RF excitation region. As a further benefit, the MR image of the subject can be spatially registered with the cable shape in the common coordinate system, and this can be used to identify potentially resonant loops formed between the cable 22 and the imaging subject.
In general, a fiber optic position monitoring bundle (e.g. the multi-core optical fiber 14) can be attached to any flexible electrically conductive cable for use in the MR environment. This cable bundle is preferably made from MR compatible and biocompatible materials. For example, the multi-core optical fiber can be connected with a local RF coil cable (as shown), or with an ECG electrode wire, or so forth. Instead of forming the optical fiber/electrically conductive cable bundle by cable ties or the like, it is also contemplated to form the bundle more integrally, for example by providing a cable conduit containing both the optical fiber and the electrically conductive cable or by providing a common sheath for the optical fiber and electrically conductive cable.
Bundling of patient cable into an umbilical using a single position detection system is possible. If the shapes of two (or more) electrically conductive cables are monitored using respective bundled multi-core optical fibers, then potentially resonant loops formed between different cables can also be detected, again by detecting crossing points and determining perimeter lengths.
It will be further appreciated that the patient protection techniques disclosed herein may be embodied by a non-transitory storage medium storing instructions readable and executable by an electronic data processing device (such as the computer 46) to perform the disclosed techniques. Such a non-transitory storage medium may comprise a hard drive or other magnetic storage medium, an optical disk or other optical storage medium, a cloud- based storage medium such as a RAID disk array, flash memory or other non-volatile electronic storage medium, or so forth.
Of course, modifications and alterations will occur to others upon reading and understanding the preceding description. It is intended that the invention be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Claims

CLAIMS:
1. A magnetic resonance imaging (MRI) system (10) comprising:
a cable bundle including an electrically conductive cable (22) and a multi-core optical fiber (14) bundled together with the electrically conductive cable (22) to form the cable bundle;
an electrical component (6) connected with the electrically conducive cable (22) of the cable bundle;
a fiber shape readout device (30) optically coupled with the multi-core optical fiber of the cable bundle and configured to measure reflectance of light injected into the multi-core optical fiber and to compute the shape of the cable bundle based on the reflectance measurements; and
a processor (46) configured to detect a portion of the electrically conductive cable that is potentially resonant at a magnetic resonance frequency based on the shape computed for the multi-core optical fiber bundled with the electrically conductive cable.
2. The MRI system (10) of claim 1 wherein the fiber shape readout device (30) computes the shape of the cable bundle by a method comprising:
detecting changes in optical length in cores in the multi-core optical fiber (14) based on the reflectance measurements; and
determining an angle or direction at a point on the multi-core fiber (14) based on the detected changes in optical length.
3. The MRI system (10) as in any one of claims 1-2 wherein the processor (46) is configured to detect a loop in the electrically conductive cable (22) that is potentially resonant at the magnetic resonance frequency.
4. The MRI system (10) as in claim 3 wherein the processor (46) is configured to detect said loop in the electrically conductive cable (22) by detecting a crossing point of the shape computed for the multi-core optical fiber bundled with the electrically conductive cable.
5. The MRI system (10) as in any one of claims 1-4 further comprising:
a magnetic resonance scanner (12), at least a portion of the cable bundle being disposed in an examination region (2) of the magnetic resonance scanner (12).
6. The MRI system (10) as in any one of claims 1-4 wherein the electrical component (6) connected with the electrically conducive cable (22) of the cable bundle comprises a radio frequency (RF) coil (6).
7. The MRI system (10) as in any one of claims 1-6 further comprising:
an alarm (44) connected to be activated by the processor (46) upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency.
8. The MRI system (10) as in any one of claims 1-6 further comprising:
a radio frequency excitation coil (5); and
a radio frequency amplifier (7) operatively connected to cause the radio frequency excitation coil to output radio frequency pulses;
wherein the processor (46) is further configured to interlock the radio frequency amplifier upon detection of a portion of the electrically conductive cable that is potentially resonant at the magnetic resonance frequency.
9. A system comprising:
a magnetic resonance scanner (12) configured to operate at a magnetic resonance frequency to acquire a magnetic resonance image of a subject disposed in an examination region (2) of the magnetic resonance scanner;
a cable bundle disposed at least partially in the examination region of the magnetic resonance scanner, the cable bundle including an electrically conductive cable (22) and a multi-core optical fiber (14) bundled together with the electrically conductive cable (22) to form the cable bundle;
a fiber shape readout device (30) configured to measure reflectance of light injected into the multi-core optical fiber and to determine the shape of the cable bundle disposed inside the examination region of the magnetic resonance scanner based on the reflectance measurements; and
a processor (46) programmed to detect a loop in the electrically conductive cable (22) based on the shape of the cable bundle.
10. The system of claim 9 wherein the fiber shape readout device (30) includes an electronic data processing device programmed to:
compute a change in optical length in cores in the multi-core optical fiber (14) up to a point on the multi-core optical fiber (14) based on the measured reflectance; and
determine a location or direction at the point on the multi-core optical fiber (14) based on the computed changes in optical length.
11. The system as in any one of claims 9-10 wherein the processor (46) is further programmed to analyze a detected loop in the electrically conductive cable (22) with respect to resonance at a magnetic resonance frequency.
12. The system as in any one of claims 9-11 further comprising:
a radio frequency coil (6) or electrocardiographic electrode connected to an end of the electrically conductive cable (22) disposed inside the examination region (2) of the magnetic resonance scanner (12).
13. The system as in any one of claims 9-12 further comprising:
an alarm (44), wherein if the processor (46) detects a loop in the electrically conductive cable (22), an alarm is generated.
14. The system as in any one of claims 9-13 wherein the processor (46) is further configured to interrupt current in a radio frequency excitation coil (5) upon detection of a loop in the electrically conductive cable (22).
15. The system as in any one of claims 9-14 further comprising:
an alarm or radio frequency excitation interlock (44), wherein the processor (46) is further configured to analyze a detected loop in the electrically conductive cable (22) and to activate the alarm or radio frequency excitation interlock if the analysis indicates the detected loop is potentially resonant at the magnetic resonance frequency.
16. A method comprising:
applying a radio frequency (RF) pulse generated by an RF coil (20) to an imaging subject; determining, with a shape sensor, a shape of a multi-core optical fiber (14) bundled with an electrically conductive cable (22) and exposed to the applied RF pulse; and
determining if a portion of an electrically conductive cable (22) is resonant at the frequency of the RF pulse based on the shape of the multi-core optical fiber (14).
17. The method of claim 16 wherein the shape sensor computes the shape of the multi-core optical fiber (14) by operations including:
measuring reflectance of light injected into the multi-core optical fiber (14);
detecting a change in optical length in cores in the multi-core optical fiber (14) at successive points along the multi-core optical fiber based on the measured reflectance; and determining a location or a direction of the multi-core optical fiber at successive points along the multi-core optical fiber (14) based on the detected changes in optical length.
18. The method as in any one of claims 16-17 wherein the multi-core optical fiber (14) is in contact with the imaging subject and the method further comprises:
determining a motion of the imaging subject based on change in time of the shape of the multi-core optical fiber (14).
19. The method as in any one of claims 16-18 further comprising:
determining a motion signal of a patient based on information gathered by the shape sensor; and
determining a depth of sedation based on the motion signal.
20. The method as in any one of claims 16-18 further comprising:
determining a motion signal of a patient based on information gathered by the shape sensor; and
determining a patient distress level based on the motion signal.
21. The method as in any one of claims 16-18 further comprising:
determining a motion signal of a patient based on information gathered by the shape sensor; and
determining a respiration rate based on the motion signal.
22. The method as in any one of claims 16-18 further compri determining a motion signal of a patient based on information gathered by the shape sensor; and
detecting a breath hold based on the motion signal.
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3227700B1 (en) * 2014-12-04 2023-10-04 Koninklijke Philips N.V. Light data communication link device for use in magnetic resonance examination systems
WO2016092409A1 (en) * 2014-12-11 2016-06-16 Koninklijke Philips N.V. Cable loop detection mechanism for improved mri safety
WO2018100030A1 (en) * 2016-11-30 2018-06-07 Tracinnovations Aps Medical scanner accessory system and medical scanner
EP4001942A1 (en) * 2020-11-13 2022-05-25 Koninklijke Philips N.V. Magnetic resonance imaging system with protection from overheating
JP2022124633A (en) * 2021-02-16 2022-08-26 キヤノンメディカルシステムズ株式会社 Image processing device

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935082C1 (en) * 1989-10-20 1991-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen, De
WO2002081011A1 (en) 2001-04-03 2002-10-17 Medrad, Inc. Encoding and sensing of syringe information
US7772541B2 (en) * 2004-07-16 2010-08-10 Luna Innnovations Incorporated Fiber optic position and/or shape sensing based on rayleigh scatter
DE102004045495B4 (en) 2004-09-20 2015-06-18 Siemens Aktiengesellschaft Method and system for generating images of an organ
US7123015B2 (en) * 2004-09-29 2006-10-17 General Electric Company Magnetic resonance system and method
DE102004058943B4 (en) 2004-12-07 2011-12-08 Siemens Ag Magnetic resonance system and method for checking the positioning of an examination object
JP2009511105A (en) * 2005-10-06 2009-03-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Cable-free MR coil
JP2008018190A (en) * 2006-07-14 2008-01-31 Ge Medical Systems Global Technology Co Llc Magnetic resonance imaging apparatus
JP2008070357A (en) * 2006-08-15 2008-03-27 Suncall Corp Optical pressure sensor
RU2491567C2 (en) * 2007-10-05 2013-08-27 Конинклейке Филипс Электроникс Н.В. Magnetic resonance imaging apparatus and method
JP4934067B2 (en) 2008-01-24 2012-05-16 株式会社日立製作所 Superconducting magnet apparatus and magnetic resonance imaging apparatus
CA2839071C (en) 2009-03-04 2017-10-17 Imricor Medical Systems, Inc. Mri compatible medical device temperature monitoring system and method
EP2412310A4 (en) 2009-03-25 2013-04-24 Seiko Mitachi Optical fiber sheet and body motion sensor
US20120086449A1 (en) * 2009-04-01 2012-04-12 Koninklijke Philips Electronics N.V. Magnetic resonance system and method for comprehensive implantable device safety tests and patient safety monitoring
US8773650B2 (en) * 2009-09-18 2014-07-08 Intuitive Surgical Operations, Inc. Optical position and/or shape sensing
US8183520B2 (en) * 2009-11-13 2012-05-22 Intuitive Surgical Operations, Inc. Optical fiber shape sensor calibration
CN102655808A (en) * 2009-12-16 2012-09-05 皇家飞利浦电子股份有限公司 Optical respiration status sensor
BR112012019616A2 (en) * 2010-02-09 2020-05-26 Koninklijke Philips Electronics N.V. APPARATUS FOR DETERMINING A POSITION, ORIENTATION AND \ OR FORM AND SYSTEM FOR TRACKING A PORTION OF AN IMAGE GENERATION DEVICE OR THERAPY
KR101204047B1 (en) * 2011-01-07 2012-11-22 건국대학교 산학협력단 Thermochromic pigment-based fiber-optic respiration sensor for respiratory monitoring during clinical procedures using MRI system or radiation devices
US9625254B2 (en) * 2011-01-27 2017-04-18 Koninklijke Philips N.V. Integration of fiber optic shape sensing within an interventional environment
EP2747590A1 (en) * 2011-10-21 2014-07-02 Koninklijke Philips N.V. Body surface feedback for medical interventions
DE102011086561B4 (en) * 2011-11-17 2013-06-13 Siemens Aktiengesellschaft MRI system, receiving device for an MRI system and method for obtaining an MR signal in an MRI system
EP2614769A1 (en) * 2012-01-10 2013-07-17 Koninklijke Philips Electronics N.V. Electro-cardiograph sensor mat
CN104169678B (en) * 2012-03-16 2017-10-24 皇家飞利浦有限公司 For determining the position of associated objects and/or the optical sensing system of shape
BR112015005602A2 (en) * 2012-09-18 2017-07-04 Koninklijke Philips Nv medical instrument and computer program product
JP6366597B2 (en) * 2012-11-15 2018-08-01 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. MRI for distributed sensors that monitor coil cable and trap temperature and / or strain
CN203117412U (en) 2013-01-17 2013-08-07 上海辰光医疗科技股份有限公司 An onsite detecting device of a coil cable common-mode suppressor
RU2015138916A (en) * 2013-02-14 2017-03-20 Конинклейке Филипс Н.В. INTERVENTIONAL SYSTEM
US20160228200A1 (en) * 2013-10-02 2016-08-11 Koninklijke Philips N.V. Device tracking using longitudinal encoding
GB2540071B (en) * 2014-06-16 2020-12-16 Halliburton Energy Services Inc Distributed nondestructive structural defects detection in slickline cables
JP5755783B2 (en) * 2014-06-19 2015-07-29 大日精化工業株式会社 End-face proximity multicore optical fiber manufacturing equipment
EP3218747B1 (en) * 2014-11-11 2020-10-14 Luna Innovations Incorporated Optical fiber and method and apparatus for accurate fiber optic sensing under multiple stimuli
WO2016092409A1 (en) * 2014-12-11 2016-06-16 Koninklijke Philips N.V. Cable loop detection mechanism for improved mri safety

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RU2702943C2 (en) 2019-10-14
JP6820848B2 (en) 2021-01-27
CN107003366A (en) 2017-08-01
RU2017124347A (en) 2019-01-11
RU2017124347A3 (en) 2019-04-23
JP2018500984A (en) 2018-01-18
US20180259601A1 (en) 2018-09-13
BR112017012039A2 (en) 2018-01-16
WO2016092409A1 (en) 2016-06-16
CN107003366B (en) 2021-07-30
US11193991B2 (en) 2021-12-07

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