EP3215047A1 - Procédé de fabrication d'un appareil de repositionnement dentaire précontraint - Google Patents

Procédé de fabrication d'un appareil de repositionnement dentaire précontraint

Info

Publication number
EP3215047A1
EP3215047A1 EP15800734.4A EP15800734A EP3215047A1 EP 3215047 A1 EP3215047 A1 EP 3215047A1 EP 15800734 A EP15800734 A EP 15800734A EP 3215047 A1 EP3215047 A1 EP 3215047A1
Authority
EP
European Patent Office
Prior art keywords
tooth
jaw
real
digital
attachment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15800734.4A
Other languages
German (de)
English (en)
Inventor
Wajeeh Khan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Caps GmbH
Original Assignee
Ortho Caps GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Caps GmbH filed Critical Ortho Caps GmbH
Publication of EP3215047A1 publication Critical patent/EP3215047A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/08—Mouthpiece-type retainers or positioners, e.g. for both the lower and upper arch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/007—Dental splints; teeth or jaw immobilisation devices; stabilizing retainers bonded to teeth after orthodontic treatments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/002—Orthodontic computer assisted systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/14—Brackets; Fixing brackets to teeth
    • A61C7/146—Positioning or placement of brackets; Tools therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/28—Securing arch wire to bracket

Definitions

  • the invention relates to methods for producing a prestressed tooth repositioning device.
  • the orthodontist seeks to achieve the therapeutic goal successively by retightening the archwire element in a m-v / vo situation on the patient. But he has not the certainty that the measures taken on the teeth individually actually lead to the desired result.
  • a method for producing a pre-loaded tooth repositioning device which method has the following steps: a) Generation of a real or digital model of a jaw or jaw section of a patient with at least one tooth that has failed ("actual state”) )
  • step b) generating a real or digital model of a jaw or jaw section of a patient in which the position of at least one tooth is changed in comparison to the model named in step a) ("desired state"),
  • step b) Digital or real positioning of a real or digital tooth repositioning device on the real or digital model mentioned in step b)
  • step d) transfer of the real or digital tooth repositioning device according to step c) to the real or digital model with at least one faulty tooth according to step a), wherein the real or digital tooth repositioning device is biased, and
  • step e) optionally, generating a real preloaded tooth repositioning device based on the digital preloaded tooth repositioning device according to step d) by means of a CAM method.
  • Real models ie models that can be touched and processed with real tools, but can be transferred to the digital domain by means of suitable methods (3D scan, stereoscopy or video copy), or
  • the device Upon transmission of the tooth repositioning device according to the model with at least one faulty tooth, the device is forced to deform and thus be biased.
  • pre-stressed refers to the condition of a repositioning device that, due to imposed deformation, tends to return to its original position, thereby transferring all six degrees of freedom to teeth in terms of tilting and torquing.
  • the method further comprises the step f) transfer of the real preloaded tooth repositioning device by means of a tension-preserving transfer template on the jaw or jaw portion of a patient with at least one faulty tooth
  • a tension-preserving transfer template may comprise, for example, a curable liquid plastic which, after transfer of the tooth repositioning device according to the model with at least one faulty tooth, is applied to the tooth-repositioning device pretensioned in this way and then cured.
  • the tooth repositioning device After subsequent detachment of the tooth repositioning device, it rests in the hardened tension-retaining transfer template and can then be transferred to the jaw or jaw section of the patient.
  • the therapy goal can be achieved with significantly greater probability of success, as is the case with conventional methods, in which the orthodontist successively seeks to achieve the therapy goal by tightening the arch element in an in vivo situation on the patient, but it does not have the certainty that the individual measures taken on the teeth actually lead to the desired result.
  • the tooth repositioning device has at least one archwire element and at least two attachments.
  • attachments disposed on the surface of a tooth, are capable of transmitting the tilting and torques exerted by an archwire element to said tooth.
  • these are, for example, attachments that consist of a hardenable plastic and are applied in situ directly on the teeth using a suitable template.
  • a wire or silicone tube may be incorporated, which has the same cross-section as the arched element, and is pulled out after curing of the plastic.
  • the said attachments may be brackets.
  • Brackets are common in orthodontics fasteners in fixed appliances. They are bonded to the surface of the tooth by special bonding techniques and thus form a starting point for the movement of teeth in fixed appliances.
  • Characteristic of a bracket is the device for receiving arch wire elements. This is, for example, a horizontal slot. Brackets can be distinguished according to where they are attached to the tooth. If they are attached to the cheek, they are called buccal brackets. If they are located on the inner surface, towards the tongue, they are called lingual brackets. Brackets are often made of stainless steel, but can also be made of gold, ceramic, composite and titanium. An important feature that can be crucial for the choice of bracket and sheet material is friction. Both the material combination of bracket and bow, as well as the type of ligatures used can increase or decrease the friction.
  • archwire element refers to devices which are arranged on the attachments and transmit corrective forces to them.
  • wire arch members are wires that can be inserted into the receptacles of the attachments and thereby necessarily deformed. They can be made of steel and comparable materials, but also consist of shape memory materials such as Nitinol or NiTiCu.
  • the elastic recovery tendency of the archwire element now exerts a force on the teeth by means of the attachments, which causes the tissue in the periodontal space to be compressed in places (pressure zone) and stretched at the respectively opposite points (tensile zone). This stimulates remodeling processes in which osteoclasts in the pressure zone grow bone and osteoblasts grow in the tensile zone of bone.
  • the prestressing produced may also eliminate the sliding mechanics that occur in conventional methods, which are made possible by the fact that the archwire element is attached in a sliding manner to the attachments, which can therefore move relative to one another This may also allow arrangements using only two attachments, one on the tooth to be corrected and one on an adjacent tooth serving as an anchorage.
  • said archwire element is a spring element, an archwire or a partial wire (which does not surround the entire jaw, but only sections thereof, as is not shown in greater detail below)
  • the wire arch element consists of a wire with a polygonal cross section.
  • at least one attachment has a polygonal bore or recess.
  • the archwire element can be inserted in a form-fitting manner into the bore or recess of the attachments. In this way, attachments and archwire element can transmit to each other tilting and turning momentarily all six degrees of freedom.
  • At least one attachment has a ligature with a lock into which the archwire element can be inserted.
  • the digital or real positioning of a real or digital tooth repositioning device takes place on the real or digital model mentioned in step b), by
  • An attachment is created in situ on at least one tooth of the model, which has a bore or recess for the archwire element, and then a wire arch element is inserted into correspondingly shaped holes or recesses of the attachment, or
  • this can be made directly on the dental models using a suitable template, for example made of a hardenable plastic.
  • a wire or silicone tube may be incorporated, which has the same cross-section as the arched element, and is pulled out after curing of the plastic.
  • the real model of the jaw or jaw section with at least one faulty tooth is produced by taking an impression in dental impression material and then pouring it out with dental casting compound.
  • dental impression material has a high alginate content and serves to produce a negative model of a jaw or jaw section.
  • Dental casting compound for example, has a high proportion of gypsum and is used to generate a positive model of a jaw or jaw section by pouring out the previously generated negative model
  • the digital model of the jaw or jaw section with at least one faulty tooth is generated by a three-dimensional imaging method. This can be accomplished, for example, by 3D scanning, stereoscopy or probe-based scanning of the real model of the jaw or jaw section with at least one faulty tooth, or by in vivo video copy or intraoral scanning of the jaw or jaw section with at least one faulty tooth.
  • a real model of the jaw or jaw section with at least one faulty tooth can subsequently also be produced based on this step by means of the described CAM method.
  • stereolithography CNC milling or 3D plotting can be used as a method.
  • the real model of the jaw or jaw section in which the position of at least one tooth is changed ("target state"), by sawing said tooth and placing it on a base of a deformable material, and subsequent manual manipulation of Position of the said tooth is generated.
  • the digital model of the jaw or jaw section in which the position of at least one tooth is changed (“desired state") is generated by digital manipulation of the image or data set representing the jaw or jaw section.
  • a real model of the jaw or jaw section with at least one faulty tooth can subsequently also be produced based on this step by means of the described CAM method. Furthermore, fiction, according to a biased tooth repositioning device, prepared by a method according to the above description.
  • said tooth repositioning device has at least two attachments and a wire arch element.
  • a voltage-preserving transmission template for the transmission of a prestressed tooth repositioning device to the jaw or jaw section of a patient is provided with at least one faulty tooth.
  • a kit for correcting dental malocclusions comprising a) a combination of at least two attachments with a wire arch element already arranged therein, said combination is arranged in the region of a jaw portion of a patient having at least one faulty tooth ("actual state"), and
  • toothed rail made of a resilient material, wherein said toothed rail is arranged at least in a region of the jaw section of the patient which lies outside the area mentioned under a).
  • resilient material refers to an elastically deformable material that, however, builds up restoring forces when deformed, preferably using acrylate materials.
  • the combination of at least two attachments and a wire arch element is produced by the method described above.
  • the toothed rail made of a resilient material is an aligner, retainer or positioner.
  • aligner, retainer and positioner are used interchangeably herein and refer to removable tooth correcting devices that are used in the context of orthodontic treatment and have recordings for at least one tooth. They are able to stabilize the position of teeth (for example after orthodontic treatment with a combination of attachments and archwire element) or to actively correct the position of teeth. They are made of resilient material, and are often transparent.
  • the combination of attachment and archwire element on the one hand and the dental splint on the other hand support synergistically.
  • the at least one toothed rail has a recess in the region of the combination of attachment and archwire element.
  • the dental splint serves to stabilize the further teeth in the jaw of the patient and may possibly also act repositioning on individual teeth, wherein the correction requirement may be lower than with respect to the tooth corrected by the combination of attachment and archwire element.
  • the dental splint also serves to stabilize the teeth surrounding the tooth to be corrected, to which the combination of attachment and archwire element is fastened and to which these teeth serve as an abutment.
  • the dental splint thus prevents the teeth surrounding the tooth to be corrected from being displaced in position, thereby ensuring sufficient differential movement of the tooth to be corrected.
  • attachment and archwire element on the one hand and dental splint on the other hand allows by the stabilization of the teeth, which serve the tooth to be corrected as an abutment, a reduction in the number of said, serving as an abutment teeth.
  • the at least one toothed rail has an extension in the region of the combination of attachment and archwire element.
  • the dental splint serves to stabilize the other teeth in the patient's jaw and, if necessary, can also act repositioning on individual teeth, the correction requirement being smaller than with respect to the tooth corrected by the combination of attachment and archwire element.
  • the toothed rail can also consist of a series of incremental toothed rails, which act successively repositioning on other teeth in the patient's jaw.
  • the volume of expansion in the area of the tooth corrected by the combination of attachment and archwire element decreases successively.
  • the one or more dental splints may be configured to assist the correction path of the tooth to be corrected by the combination of attachment and archwire element.
  • the at least one toothed rail in the region of at least one attachment has a receptacle in which the bracket can come to lie in a form-fitting manner.
  • the attachments can also serve as anchoring and force transmission points for the dental splint.
  • said kit comprises a plurality of toothed rails made of a resilient material, wherein at least A dental splint has a geometry which is chosen to support the repositioning of at least one failed tooth from the actual state into a transitional state effected by the combination of attachment and archwire element,
  • a dental splint has a geometry selected to assist in repositioning the at least one failed tooth from the transient state to a desired state effected by the attachment and archwire element combination.
  • further incremental toothed rails may be provided which have a geometry which is selected in order to support the repositioning of at least one tooth from a first transitional state to a second transitional state (and optionally further transitional states) effected by the combination of attachment and archwire element
  • kits as described above for the treatment of dental malocclusions in patients are provided.
  • a dental splint has a geometry which is chosen to support the repositioning of at least one failed tooth from the actual state into a transitional state effected by the combination of attachment and archwire element,
  • a dental splint has a geometry selected to reposition the attachment caused by the combination of attachment and archwire element To support at least one faulty tooth from the transient state to a desired state.
  • further incremental toothed rails may be provided which have a geometry which is selected in order to support the repositioning of at least one tooth from a first transitional state to a second transitional state (and optionally further transitional states) effected by the combination of attachment and archwire element
  • FIG. 1A shows a dental arch of a patient with dislocated teeth 11, 12, 13 as well as the tongue 14.
  • FIG. 1B shows a reproduction 15 of this dental arch in plaster, for example produced by producing an impression of the mandibular arch according to FIG. 1A in a dental impression material and pouring it with a plaster material.
  • the reproduction of the mandibular arch can also be made with an alveolar ridge model as disclosed in WO2014096341 of the present applicant, the contents of which are fully incorporated herein by reference, and the contents of which are incorporated by reference into the disclosure of the present application.
  • FIG. 1C shows a setup 16, which is generated on the basis of the reproduction of the mandibular arch with the teeth according to FIG. 1B and shows the clinically generated final state of the tooth configuration - or a transition state thereof.
  • the setup in FIG. 1C may be created by exposing the failed tooth models from the reproduction of the mandibular arch of FIG. 1B Wax socket placed, reinserted into the mandibular arch and then manually manipulated in position after warming the wax.
  • this setup can also be generated by a so-called CAD / CAM method.
  • the reproduction of the mandibular arch is scanned using a 3-D scanner as shown in FIG. 1B.
  • the subsequent manipulation steps to reposition the faulty tooth models are performed digitally using appropriate software, followed by a CAM procedure, such as a 3-D printer or milling machine, to set up with the repositioned tooth models.
  • a CAM procedure such as a 3-D printer or milling machine
  • this setup can also be generated by a so-called CAD / CAM method.
  • the reproduction of the mandibular arch is scanned using a 3-D scanner as shown in FIG. 1B.
  • the subsequent manipulation steps to reposition the faulty tooth models are performed digitally using appropriate software, followed by a CAM procedure, such as a 3-D printer or milling machine, to set up with the repositioned tooth models.
  • a CAM procedure such as a 3-D printer or milling machine
  • this setup can also be made with an alveolar ridge model as disclosed in WO2014096341 of the present applicant, the contents of which are hereby fully referenced and the contents of which are incorporated by reference into the disclosure of the present application.
  • FIG. 2A shows the setup according to FIG. 1C with attachments 21, 22, 23 placed thereon and an archwire element 24 to be fastened to these attachments.
  • the archwire element consists, for example, of a wire with a square cross-section which is cut into correspondingly shaped bores or recesses in FIG Attachments is introduced positively. In this way, attachments and archwire element can transmit to each other tilting and torques all six degrees of freedom.
  • the attachments - unlike conventional attachments - must have no forward open lock with associated ligature, since the arch wire element does not necessarily have to be inserted from the front into the already glued attachments, but laterally into the Attachments or the provided therein holes can be introduced.
  • an already prefabricated combination of attachments with an archwire element already inserted therein can also be glued onto the teeth.
  • Fig. 2B the archwire element is shown positioned on the attachments.
  • this configuration which corresponds to the clinically generated final state of the tooth configuration - or a transient state thereof - the archwire element is without tension.
  • Fig. 2C shows the combination 25 of attachments and archwire element after detachment of the attachments from the setup.
  • Fig. 3A shows how the untensioned attachment 25 and archwire element combination 25 is now applied to the false tooth jaw reproduction 15 shown in Fig. 1B. This is done by adhering the attachments to the dental models. In this case, the archwire element is put under tension, since the attachments are tilted or rotated relative to the archwire element and thus build up tilting and torques.
  • the biassed combination of attachments and archwire element 25 is fixed with the aid of a transfer template 31 and detached from the tooth models of the reproduction of the dental arch 15 with false teeth.
  • the biassed combination of attachments and archwire element 25 is transferred by means of the transfer template 31 to the malformed patient's mandibular arch shown in FIG. 1a. The attachments are glued to the teeth.
  • the combination of attachments and archwire element is biased, and the archwire element is endeavored to return to its configuration shown in FIG. 2B. In doing so, it applies tilting and torques to the teeth to be corrected in their position by means of the attachments and thus effects a change of the tooth configuration towards the clinically generated final state of the tooth configuration shown in FIG. 4C - or a transition state thereof.
  • Fig. 5 shows a with the in Figs. 1 to 4, and only one part of the patient's jaw ("partial braces"). In the example shown, the position of one tooth 52 must be significantly corrected while the positions of the other teeth are not or only insignificantly corrected
  • Figs. Figures 5A-C show the incremental correction path traveled by the tooth to be corrected due to the tilting and torques applied by the pretensioned archwire element.
  • Fig. 6 also shows a with the in Figs. 1 to 4, and only one part of the patient's jaw ("partial braces").
  • partial aligner 63 which has a recess in the region of the attachment 61 and the archwire element 61.
  • the aligner serves to stabilize the further teeth in the patient's jaw and, if necessary, can also act repositioning on individual teeth, the correction requirement being smaller than in relation to one another on tooth 62.
  • the aligner also serves to stabilize the teeth surrounding the tooth 62 to be corrected, to which the prestressed combination 61 of attachments and Arch wire element is attached and which serve these teeth as abutment.
  • the aligner thus prevents the teeth surrounding the tooth 62 to be corrected from being displaced in position.
  • Figs. Figures 6A-C show the incremental correction path traveled by the tooth to be corrected due to the tilting and torques applied by the pretensioned archwire element.
  • the Aligner can also consist of a series of incremental aligners, which act successively repositioning on other teeth in the patient's jaw.
  • Such incremental aligners are disclosed, for example, in EP patent EP2263598 B1 and EP patent EP 1369091 B1, to the contents of which reference is hereby made in full and the content of which is incorporated by reference into the disclosure of the present application.
  • Fig. 7 also shows a with the in Figs. 1 to 4, and only one part of the patient's jaw ("partial braces") is produced in the example shown, and only the position of a tooth 72 needs to be corrected
  • Aligner 73 which has an extension in the area of attachments 71 and archwire element combination.
  • the aligner serves to stabilize the other teeth in the patient's jaw and may possibly also be repositioning on individual teeth, the correction requirement being lower than with respect to Tooth 72.
  • the aligner also serves to stabilize the teeth surrounding the tooth 72 to be corrected, to which the prestressed attachment 71 and archwire element combination is attached and which serve as abutment for these teeth.
  • the Aigner thus prevents the teeth surrounding the tooth 62 to be corrected from being displaced in position.
  • Figs. Figures 7A-C show the incremental correction path traveled by the tooth to be corrected due to the tilting and torques applied by the pretensioned archwire element.
  • the Aligner can also consist of a series of incremental aligners, which act successively repositioning on other teeth in the patient's jaw. The volume of expansion in the region of the tooth 72 decreases successively.
  • Such incremental aligners are for example in the EP patent EP2263598 Bl and EP patent EP 1369091 Bl, the contents of which are hereby fully referenced and the contents of which are incorporated by reference into the disclosure of the present application.
  • FIG. 8 shows that a combination 81 of attachments 82 and possibly pretensioned archwire element 83 is also capable of extracting a tooth 84 out of the jaw. A correction regarding this degree of freedom is difficult to achieve with conventional Alignern.
  • FIG. 9 shows a combination 91 of attachments 92 and archwire element 93, in which only two teeth 95 arranged on one side of the tooth 94 to be corrected serve as abutments. In extreme cases, only one adjacent tooth can serve as an abutment.
  • This refinement is possible in particular because the preload symbolized symbolically by reference symbol 96 may possibly also eliminate the "sliding mechanics" occurring in conventional methods, so that the archwire element is fixedly arranged on the attachments in FIG.
  • This configuration is optionally supported by the combination with a rack as described above.
  • the latter allows by the stabilization of the teeth serving as the abutment to the tooth to be corrected, a reduction in the number of said, serving as abutment teeth.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

Procédé de fabrication d'un appareil de repositionnement dentaire précontraint, comprenant les étapes suivantes : a) réalisation d'un modèle réel ou numérique d'une mâchoire ou d'une partie de mâchoire d'un patient présentant au moins une dent mal positionnée, b) réalisation d'un modèle réel ou numérique d'une mâchoire ou d'une partie de mâchoire d'un patient dans lequel la position d'au moins une dent est changée par rapport au modèle de l'étape a), c) positionnement numérique ou réel d'un appareil de repositionnement dentaire réel ou numérique sur le modèle réel ou numérique de l'étape b), d) transfert de l'appareil de repositionnement dentaire réel ou numérique de l'étape c) sur le modèle réel ou numérique de l'étape a) présentant au moins une dent mal positionnée, l'appareil de repositionnement dentaire réel ou numérique étant placé sous précontrainte, et e) réalisation éventuelle d'un appareil de repositionnement dentaire précontraint réel sur la base de l'appareil de repositionnement dentaire précontraint numérique de l'étape d) par un procédé de fabrication assistée par ordinateur.
EP15800734.4A 2014-11-07 2015-11-06 Procédé de fabrication d'un appareil de repositionnement dentaire précontraint Withdrawn EP3215047A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014116247 2014-11-07
PCT/EP2015/075962 WO2016071508A1 (fr) 2014-11-07 2015-11-06 Procédé de fabrication d'un appareil de repositionnement dentaire précontraint

Publications (1)

Publication Number Publication Date
EP3215047A1 true EP3215047A1 (fr) 2017-09-13

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Country Status (3)

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US (1) US20180021106A1 (fr)
EP (1) EP3215047A1 (fr)
WO (1) WO2016071508A1 (fr)

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