EP3179501A3 - Procédé et appareil de dissociation cellules tandems induite par collision - Google Patents

Procédé et appareil de dissociation cellules tandems induite par collision Download PDF

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Publication number
EP3179501A3
EP3179501A3 EP16202435.0A EP16202435A EP3179501A3 EP 3179501 A3 EP3179501 A3 EP 3179501A3 EP 16202435 A EP16202435 A EP 16202435A EP 3179501 A3 EP3179501 A3 EP 3179501A3
Authority
EP
European Patent Office
Prior art keywords
collison
tandem
induced dissociation
mass spectrometer
dissociation cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16202435.0A
Other languages
German (de)
English (en)
Other versions
EP3179501B1 (fr
EP3179501A2 (fr
Inventor
Alan E. Schoen
Harald Oser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Finnigan LLC
Original Assignee
Thermo Finnigan LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Finnigan LLC filed Critical Thermo Finnigan LLC
Publication of EP3179501A2 publication Critical patent/EP3179501A2/fr
Publication of EP3179501A3 publication Critical patent/EP3179501A3/fr
Application granted granted Critical
Publication of EP3179501B1 publication Critical patent/EP3179501B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP16202435.0A 2015-12-08 2016-12-06 Procédé et appareil de dissociation cellules tandems induite par collision Active EP3179501B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14/963,123 US9842730B2 (en) 2015-12-08 2015-12-08 Methods for tandem collision-induced dissociation cells

Publications (3)

Publication Number Publication Date
EP3179501A2 EP3179501A2 (fr) 2017-06-14
EP3179501A3 true EP3179501A3 (fr) 2017-09-13
EP3179501B1 EP3179501B1 (fr) 2018-10-24

Family

ID=57517739

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16202435.0A Active EP3179501B1 (fr) 2015-12-08 2016-12-06 Procédé et appareil de dissociation cellules tandems induite par collision

Country Status (2)

Country Link
US (2) US9842730B2 (fr)
EP (1) EP3179501B1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201509412D0 (en) * 2015-06-01 2015-07-15 Micromass Ltd Coupling intermediate pressure regions
US10665441B2 (en) 2018-08-08 2020-05-26 Thermo Finnigan Llc Methods and apparatus for improved tandem mass spectrometry duty cycle
US11728153B2 (en) * 2018-12-14 2023-08-15 Thermo Finnigan Llc Collision cell with enhanced ion beam focusing and transmission
GB201904135D0 (en) * 2019-03-26 2019-05-08 Thermo Fisher Scient Bremen Gmbh Interference suppression in mass spectrometers
GB201907171D0 (en) * 2019-05-21 2019-07-03 Thermo Fisher Scient Bremen Gmbh Switchable ion guide
US10892152B1 (en) * 2019-08-27 2021-01-12 Thermo Finnigan Llc Adjustable dwell time for SRM acquisition
CN110767526B (zh) * 2019-11-01 2022-07-05 上海裕达实业有限公司 一种倾斜多极杆导引系统
CN114944321A (zh) * 2022-05-31 2022-08-26 安益谱(苏州)医疗科技有限公司 一种质谱仪碰撞室及其控制方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070138383A1 (en) * 2005-12-20 2007-06-21 Dowell Jerry T Molecular activation for tandem mass spectroscopy
WO2014197341A2 (fr) * 2013-06-02 2014-12-11 Perkinelmer Health Sciences, Inc. Cellules de collision et procédés utilisant ces cellules
US20150136966A1 (en) * 2010-02-26 2015-05-21 Hamid Badiei Systems and methods of suppressing unwanted ions
US20150340212A1 (en) * 2012-11-22 2015-11-26 Shimadzu Corporation Tandem quadrupole mass spectrometer

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214160A (en) 1976-03-04 1980-07-22 Finnigan Corporation Mass spectrometer system and method for control of ion energy for different masses
DE19515271C2 (de) 1995-04-26 1999-09-02 Bruker Daltonik Gmbh Vorrichtung für den gasgeführten Transport von Ionen durch ein Kapillarrohr
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
WO1997007530A1 (fr) 1995-08-11 1997-02-27 Mds Health Group Limited Spectrometre a champ axial
US6163032A (en) 1997-03-12 2000-12-19 Leco Corporation Tapered or tilted electrodes to allow the superposition of independently controllable DC field gradients to RF fields
US6316768B1 (en) 1997-03-14 2001-11-13 Leco Corporation Printed circuit boards as insulated components for a time of flight mass spectrometer
US6753523B1 (en) 1998-01-23 2004-06-22 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
US6259088B1 (en) 1999-06-24 2001-07-10 The United States Of America As Represented By The Secretary Of The Army Image intensifier tube with curved components
US6417511B1 (en) 2000-07-17 2002-07-09 Agilent Technologies, Inc. Ring pole ion guide apparatus, systems and method
US6713757B2 (en) 2001-03-02 2004-03-30 Mds Inc. Controlling the temporal response of mass spectrometers for mass spectrometry
US6800846B2 (en) 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
US7034292B1 (en) * 2002-05-31 2006-04-25 Analytica Of Branford, Inc. Mass spectrometry with segmented RF multiple ion guides in various pressure regions
US7081618B2 (en) 2004-03-24 2006-07-25 Burle Technologies, Inc. Use of conductive glass tubes to create electric fields in ion mobility spectrometers
US6949743B1 (en) * 2004-09-14 2005-09-27 Thermo Finnigan Llc High-Q pulsed fragmentation in ion traps
US7064322B2 (en) 2004-10-01 2006-06-20 Agilent Technologies, Inc. Mass spectrometer multipole device
US7067802B1 (en) 2005-02-11 2006-06-27 Thermo Finnigan Llc Generation of combination of RF and axial DC electric fields in an RF-only multipole
DE102006016259B4 (de) 2006-04-06 2010-11-04 Bruker Daltonik Gmbh HF-Multipol-Ionenleitsysteme für weiten Massenbereich
US7564025B2 (en) 2007-02-28 2009-07-21 Agilent Technologies, Inc. Multipole devices and methods
EP1968100B1 (fr) 2007-03-08 2014-04-30 Tofwerk AG Chambre de guide d'ions
GB0723487D0 (en) * 2007-11-30 2008-01-09 Micromass Ltd Mass spectrometer
EP2124246B1 (fr) 2007-12-20 2017-03-08 Shimadzu Corporation Spectromètre de masse
US7675031B2 (en) * 2008-05-29 2010-03-09 Thermo Finnigan Llc Auxiliary drag field electrodes
US20090326828A1 (en) * 2008-06-27 2009-12-31 Amol Prakash Optimizing Selection of SRM Transitions for Analysis of Biomolecules by Tandem Mass Spectrometry
US20110049360A1 (en) 2009-09-03 2011-03-03 Schoen Alan E Collision/Reaction Cell for a Mass Spectrometer
JP5257334B2 (ja) 2009-11-20 2013-08-07 株式会社島津製作所 質量分析装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070138383A1 (en) * 2005-12-20 2007-06-21 Dowell Jerry T Molecular activation for tandem mass spectroscopy
US20150136966A1 (en) * 2010-02-26 2015-05-21 Hamid Badiei Systems and methods of suppressing unwanted ions
US20150340212A1 (en) * 2012-11-22 2015-11-26 Shimadzu Corporation Tandem quadrupole mass spectrometer
WO2014197341A2 (fr) * 2013-06-02 2014-12-11 Perkinelmer Health Sciences, Inc. Cellules de collision et procédés utilisant ces cellules

Also Published As

Publication number Publication date
EP3179501B1 (fr) 2018-10-24
US20170162371A1 (en) 2017-06-08
EP3179501A2 (fr) 2017-06-14
US20180102239A1 (en) 2018-04-12
US9842730B2 (en) 2017-12-12

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