EP3168301A4 - Oxidase, polynucleotide encoding same, and use of these - Google Patents

Oxidase, polynucleotide encoding same, and use of these Download PDF

Info

Publication number
EP3168301A4
EP3168301A4 EP15818623.9A EP15818623A EP3168301A4 EP 3168301 A4 EP3168301 A4 EP 3168301A4 EP 15818623 A EP15818623 A EP 15818623A EP 3168301 A4 EP3168301 A4 EP 3168301A4
Authority
EP
European Patent Office
Prior art keywords
oxidase
polynucleotide encoding
encoding same
same
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15818623.9A
Other languages
German (de)
French (fr)
Other versions
EP3168301A1 (en
EP3168301B1 (en
Inventor
Hiroyuki Asako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of EP3168301A1 publication Critical patent/EP3168301A1/en
Publication of EP3168301A4 publication Critical patent/EP3168301A4/en
Application granted granted Critical
Publication of EP3168301B1 publication Critical patent/EP3168301B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/12Methionine; Cysteine; Cystine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00Preparation of sulfur-containing organic compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01002Formate dehydrogenase (1.2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y104/00Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01009Leucine dehydrogenase (1.4.1.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y111/00Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01Peroxidases (1.11.1)
    • C12Y111/01006Catalase (1.11.1.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
EP15818623.9A 2014-07-11 2015-07-02 Oxidase, polynucleotide encoding same, and use of these Active EP3168301B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014143021 2014-07-11
PCT/JP2015/069105 WO2016006521A1 (en) 2014-07-11 2015-07-02 Oxidase, polynucleotide encoding same, and use of these

Publications (3)

Publication Number Publication Date
EP3168301A1 EP3168301A1 (en) 2017-05-17
EP3168301A4 true EP3168301A4 (en) 2018-01-17
EP3168301B1 EP3168301B1 (en) 2019-11-20

Family

ID=55064157

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15818623.9A Active EP3168301B1 (en) 2014-07-11 2015-07-02 Oxidase, polynucleotide encoding same, and use of these

Country Status (6)

Country Link
US (1) US10364448B2 (en)
EP (1) EP3168301B1 (en)
JP (1) JP6551407B2 (en)
CN (1) CN106795511B (en)
SG (1) SG11201700099PA (en)
WO (1) WO2016006521A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3330380A1 (en) * 2016-12-05 2018-06-06 Evonik Degussa GmbH Process for producing l-methionine from methional
EP3875590A4 (en) * 2018-10-30 2023-02-15 Green Earth Institute Co., Ltd. Method for producing organic compound and coryneform bacterium

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063238A1 (en) * 2004-02-19 2006-03-23 Werner Hummel Method for the preparation of L-amino acids from D-amino acids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60345B2 (en) 1979-01-30 1985-01-07 住友化学工業株式会社 Method for recovering active ingredients from methionine synthesis exhaust gas
DE3307094A1 (en) * 1983-03-01 1984-09-06 Degussa Ag, 6000 Frankfurt METHOD FOR THE CONTINUOUS ENCYMATIC CONVERSION OF (ALPHA) -HYDROXYCARBONIC ACIDS TO APPROPRIATE OPTICALLY ACTIVE (ALPHA) -AMINOCARBONIC ACIDS
DE3536662A1 (en) 1985-10-15 1987-05-27 Degussa MICROBIOLOGICALLY PRODUCED D (-) - MANDELATE DEHYDROGENASE, METHOD FOR THEIR PRODUCTION AND THEIR USE
JPWO2008047656A1 (en) * 2006-10-12 2010-02-25 株式会社カネカ Method for producing L-amino acid
WO2010067578A1 (en) * 2008-12-09 2010-06-17 株式会社カネカ Novel amino acid dehydrogenase, and process for producing l-amino acid, 2-oxo acid or d-amino acid
JP2012080878A (en) 2010-09-15 2012-04-26 Sumitomo Chemical Co Ltd Method for producing vinyl glycine derivative or salt of the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063238A1 (en) * 2004-02-19 2006-03-23 Werner Hummel Method for the preparation of L-amino acids from D-amino acids

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AHMED BELMOUDEN ET AL: "The Role of a beta Barrel Loop 4 Extension in Modulating the Physical and Functional Properties of Long-Chain 2-Hydroxy-Acid Oxidase Isozymes", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 238, no. 3, 15 June 1996 (1996-06-15), GB, pages 790 - 798, XP055425554, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1996.0790w.x *
ANNE FERJANCIC-BIAGINI ET AL: "Inhibitory effects of anions and active site amino acid sequence of chicken liver L-2-hydroxyacid oxidase A, a member of the FMN-dependent [alpha]-hydroxyacid oxidizing enzyme family", BIOCHIMIE, vol. 80, no. 12, 1 December 1998 (1998-12-01), FR, pages 1047 - 1054, XP055425556, ISSN: 0300-9084, DOI: 10.1016/S0300-9084(99)80011-X *
DATABASE EMBL [online] 31 October 2010 (2010-10-31), "Achromobacter xylosoxidans A8 FMN-dependent dehydrogenase family protein 2", XP002775689, retrieved from EBI Database accession no. ADP16608 *
DATABASE ENA [online] 13 August 2012 (2012-08-13), "Achromobacter piechaudii HLE FMN-dependent dehydrogenase family protein 1", XP002775691, retrieved from EBI Database accession no. EJO31882 *
DATABASE ENA [online] 13 August 2012 (2012-08-13), "Achromobacter piechaudii HLE FMN-dependent dehydrogenase family protein 2", XP002775693, retrieved from EBI Database accession no. EJO33561 *
DATABASE ENA [online] 22 March 2015 (2015-03-22), "Achromobacter xylosoxidans (S)-mandelate dehydrogenase", XP002775690, retrieved from EBI Database accession no. CKH41207 *
DATABASE ENA [online] 31 October 2010 (2010-10-31), "Achromobacter xylosoxidans A8 FMN-dependent dehydrogenase family protein 1", XP002775695, retrieved from EBI Database accession no. ADP14612 *
DATABASE ENA [online] 6 December 2011 (2011-12-06), "Achromobacter arsenitoxydans SY8 FMN-dependent dehydrogenase family protein 1", XP002775692, retrieved from EBI Database accession no. EHK66600 *
DATABASE ENA [online] 6 December 2011 (2011-12-06), "FMN-dependent dehydrogenase family protein 2", XP002775694, retrieved from EBI Database accession no. EHK64408 *
See also references of WO2016006521A1 *

Also Published As

Publication number Publication date
US10364448B2 (en) 2019-07-30
EP3168301A1 (en) 2017-05-17
SG11201700099PA (en) 2017-02-27
CN106795511B (en) 2020-02-11
CN106795511A (en) 2017-05-31
US20170191097A1 (en) 2017-07-06
WO2016006521A1 (en) 2016-01-14
EP3168301B1 (en) 2019-11-20
JPWO2016006521A1 (en) 2017-04-27
JP6551407B2 (en) 2019-07-31

Similar Documents

Publication Publication Date Title
HK1232140A1 (en) Micro-organoids, and methods of making and using the same
EP3200915A4 (en) Biochars and biochar treatment processes
EP3161124A4 (en) Endophytes, associated compositions, and methods of use thereof
EP3161135A4 (en) Plant-endophyte combinations and uses therefor
EP3245291A4 (en) Novel micro-dystrophins and related methods of use
EP3125960A4 (en) Click-crosslinked hydrogels and methods of use
EP3095027A4 (en) Software application and zones
EP3110820A4 (en) Tyk2 inhibitors and uses thereof
EP3015526A4 (en) Halo-olefin composition and use therefor
EP3218005A4 (en) Glycan-interacting compounds and methods of use
EP3104948A4 (en) Parent-infant-interactive, sensory-stimulation toy and methods of use
EP3110729A4 (en) Backfill, methods of making, and use thereof
EP3137168A4 (en) Substituted 4-phenylpiperidines, their preparation and use
EP3133152A4 (en) Novel bacteriophage, and composition containing same
EP3438256A4 (en) 3-epimerase and polynucleotide encoding same
EP3133153A4 (en) Novel bacteriophage and composition comprising same
EP3124569A4 (en) Polishing composition, and polishing method using same
EP3130669A4 (en) Novel bacteriophage and composition containing same
EP3133151A4 (en) Novel bacteriophage and composition comprising same
EP3384921A4 (en) New use of thiopeptin
EP3099783A4 (en) Recombinant microorganisms and methods of use thereof
EP3110902A4 (en) Well treatment methods and fluids
EP3124572A4 (en) Phosphor and use thereof
SG11201705085UA (en) Polymer composition, its method of preparation, its use and composition comprising it
EP3166945A4 (en) Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170208

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12P 9/00 20060101ALI20171128BHEP

Ipc: C12N 1/19 20060101ALI20171128BHEP

Ipc: C12N 5/10 20060101ALI20171128BHEP

Ipc: C12N 1/15 20060101ALI20171128BHEP

Ipc: C12N 1/21 20060101ALI20171128BHEP

Ipc: C12N 15/09 20060101AFI20171128BHEP

Ipc: C12P 13/04 20060101ALI20171128BHEP

Ipc: C12P 7/40 20060101ALI20171128BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20171219

RIC1 Information provided on ipc code assigned before grant

Ipc: C12P 9/00 20060101ALI20171212BHEP

Ipc: C12N 1/15 20060101ALI20171212BHEP

Ipc: C12N 1/21 20060101ALI20171212BHEP

Ipc: C12N 15/09 20060101AFI20171212BHEP

Ipc: C12N 5/10 20060101ALI20171212BHEP

Ipc: C12P 7/40 20060101ALI20171212BHEP

Ipc: C12P 13/04 20060101ALI20171212BHEP

Ipc: C12N 1/19 20060101ALI20171212BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20190125

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602015042212

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: C12N0015090000

Ipc: C12P0011000000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 9/06 20060101ALI20190506BHEP

Ipc: C12P 7/40 20060101ALI20190506BHEP

Ipc: C12P 13/12 20060101ALI20190506BHEP

Ipc: C12P 9/00 20060101ALI20190506BHEP

Ipc: C12N 15/09 20060101ALI20190506BHEP

Ipc: C12P 13/04 20060101ALI20190506BHEP

Ipc: C12P 11/00 20060101AFI20190506BHEP

Ipc: C12N 5/10 20060101ALI20190506BHEP

INTG Intention to grant announced

Effective date: 20190531

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602015042212

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1204235

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191215

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20191120

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200220

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200220

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200221

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200320

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200412

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1204235

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191120

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602015042212

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20200821

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602015042212

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20200702

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20200731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200731

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200702

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200731

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200702

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200702

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200731

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191120