EP3159349A4 - Lobaplatin crystal, preparation method and pharmaceutical application - Google Patents

Lobaplatin crystal, preparation method and pharmaceutical application Download PDF

Info

Publication number
EP3159349A4
EP3159349A4 EP14894886.2A EP14894886A EP3159349A4 EP 3159349 A4 EP3159349 A4 EP 3159349A4 EP 14894886 A EP14894886 A EP 14894886A EP 3159349 A4 EP3159349 A4 EP 3159349A4
Authority
EP
European Patent Office
Prior art keywords
preparation
pharmaceutical application
lobaplatin crystal
lobaplatin
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14894886.2A
Other languages
German (de)
French (fr)
Other versions
EP3159349A1 (en
EP3159349B1 (en
Inventor
Qiling DOU
Donghu SUI
Shenggui ZHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guizhou Yibai Pharmaceutical Co Ltd
Original Assignee
Guizhou Yibai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201410279331.3A external-priority patent/CN105440082B/en
Priority claimed from CN201410279879.8A external-priority patent/CN105440083B/en
Priority claimed from CN201410279369.0A external-priority patent/CN105198932B/en
Application filed by Guizhou Yibai Pharmaceutical Co Ltd filed Critical Guizhou Yibai Pharmaceutical Co Ltd
Publication of EP3159349A1 publication Critical patent/EP3159349A1/en
Publication of EP3159349A4 publication Critical patent/EP3159349A4/en
Application granted granted Critical
Publication of EP3159349B1 publication Critical patent/EP3159349B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0013—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
EP14894886.2A 2014-06-20 2014-11-28 Lobaplatin crystal, preparation method and pharmaceutical application Active EP3159349B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201410279331.3A CN105440082B (en) 2014-06-20 2014-06-20 A kind of lobaplatin crystal, preparation method and medicinal application
CN201410279879.8A CN105440083B (en) 2014-06-20 2014-06-20 A kind of lobaplatin crystal, preparation method and medicinal application
CN201410279369.0A CN105198932B (en) 2014-06-20 2014-06-20 Lobaplatin dihydrate, preparation method and medicinal application
PCT/CN2014/092571 WO2015192606A1 (en) 2014-06-20 2014-11-28 Lobaplatin crystal, preparation method and pharmaceutical application

Publications (3)

Publication Number Publication Date
EP3159349A1 EP3159349A1 (en) 2017-04-26
EP3159349A4 true EP3159349A4 (en) 2017-10-25
EP3159349B1 EP3159349B1 (en) 2020-08-05

Family

ID=54934818

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14894886.2A Active EP3159349B1 (en) 2014-06-20 2014-11-28 Lobaplatin crystal, preparation method and pharmaceutical application

Country Status (8)

Country Link
US (1) US9889112B2 (en)
EP (1) EP3159349B1 (en)
JP (1) JP6404461B2 (en)
KR (1) KR20170018822A (en)
PH (1) PH12016502359A1 (en)
RU (1) RU2648990C1 (en)
SG (1) SG11201609948YA (en)
WO (1) WO2015192606A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020043144A1 (en) 2018-09-01 2020-03-05 北京硕佰医药科技有限责任公司 Phosphate of platinum compound and preparation method therefor
CN111721841B (en) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 Detection of lobaplatin-related substances
CN111721840B (en) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 Detection of related substances in lobaplatin
CN113173953B (en) * 2021-04-12 2022-06-10 昆明贵研药业有限公司 Purification method of high-purity lobaplatin trihydrate for preparing antitumor drugs
CN115032297B (en) * 2022-05-27 2023-11-14 四川汇宇制药股份有限公司 Separation detection method of trans-1, 2-diaminomethyl cyclobutane and cis isomer thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324154A2 (en) * 1988-01-09 1989-07-19 ASTA Medica Aktiengesellschaft 1,2 Bis(aminomethyl)cyclobutane-platinum-complexes
WO1995028407A1 (en) * 1994-04-15 1995-10-26 Asta Medica Aktiengesellschaft Lobaplatinum trihydrate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102020679B (en) * 2010-11-24 2013-12-25 贵州益佰制药股份有限公司 Method for preparing lobaplatin trihydrate by usingoxalate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324154A2 (en) * 1988-01-09 1989-07-19 ASTA Medica Aktiengesellschaft 1,2 Bis(aminomethyl)cyclobutane-platinum-complexes
WO1995028407A1 (en) * 1994-04-15 1995-10-26 Asta Medica Aktiengesellschaft Lobaplatinum trihydrate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015192606A1 *

Also Published As

Publication number Publication date
KR20170018822A (en) 2017-02-20
EP3159349A1 (en) 2017-04-26
US9889112B2 (en) 2018-02-13
PH12016502359B1 (en) 2017-02-13
PH12016502359A1 (en) 2017-02-13
JP6404461B2 (en) 2018-10-10
WO2015192606A1 (en) 2015-12-23
RU2648990C1 (en) 2018-03-29
EP3159349B1 (en) 2020-08-05
SG11201609948YA (en) 2017-01-27
US20170189367A1 (en) 2017-07-06
JP2017517572A (en) 2017-06-29

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