EP3151822A4 - Fixed dose combination for pain relief without edema - Google Patents

Fixed dose combination for pain relief without edema Download PDF

Info

Publication number
EP3151822A4
EP3151822A4 EP15806490.7A EP15806490A EP3151822A4 EP 3151822 A4 EP3151822 A4 EP 3151822A4 EP 15806490 A EP15806490 A EP 15806490A EP 3151822 A4 EP3151822 A4 EP 3151822A4
Authority
EP
European Patent Office
Prior art keywords
edema
pain relief
fixed dose
dose combination
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15806490.7A
Other languages
German (de)
French (fr)
Other versions
EP3151822A1 (en
Inventor
Vuong Trieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autotelic LLC
Original Assignee
Autotelic LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/011148 external-priority patent/WO2016114761A1/en
Application filed by Autotelic LLC filed Critical Autotelic LLC
Publication of EP3151822A1 publication Critical patent/EP3151822A1/en
Publication of EP3151822A4 publication Critical patent/EP3151822A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP15806490.7A 2014-06-08 2015-06-08 Fixed dose combination for pain relief without edema Withdrawn EP3151822A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462009300P 2014-06-08 2014-06-08
US201462023962P 2014-07-14 2014-07-14
PCT/US2015/011148 WO2016114761A1 (en) 2015-01-13 2015-01-13 Method for individualized drug therapy
PCT/US2015/034706 WO2015191460A1 (en) 2014-06-08 2015-06-08 Fixed dose combination for pain relief without edema

Publications (2)

Publication Number Publication Date
EP3151822A1 EP3151822A1 (en) 2017-04-12
EP3151822A4 true EP3151822A4 (en) 2017-11-22

Family

ID=54834151

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15806490.7A Withdrawn EP3151822A4 (en) 2014-06-08 2015-06-08 Fixed dose combination for pain relief without edema
EP15807276.9A Withdrawn EP3151823A4 (en) 2014-06-08 2015-06-08 Fixed dose combination for pain relief without edema

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP15807276.9A Withdrawn EP3151823A4 (en) 2014-06-08 2015-06-08 Fixed dose combination for pain relief without edema

Country Status (8)

Country Link
EP (2) EP3151822A4 (en)
JP (2) JP2017517529A (en)
KR (2) KR20160091349A (en)
CN (2) CN106572985A (en)
AU (2) AU2015274895A1 (en)
CA (2) CA2956899A1 (en)
TW (2) TW201642854A (en)
WO (2) WO2015191473A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115057A1 (en) * 2015-01-13 2016-07-21 Autotelic Llc Fixed dose combination for pain relief without edema
EP3384282A1 (en) * 2015-11-30 2018-10-10 Pharnext Method for adapting doses of combination therapies
KR20220113436A (en) * 2019-12-04 2022-08-12 레스큐 파마슈티컬스 엘엘씨 Methods and compositions for treating edema refractory to oral diuretics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058073A2 (en) * 2004-11-23 2006-06-01 Transform Pharmaceuticals, Inc. Pharmaceutical compositions comprising a selective cox-2 inhibitor and a diuretic
WO2009154944A2 (en) * 2008-05-28 2009-12-23 Hoyle Peter C Pharmaceutical formulations and methods of use which combine non-steroidal anti-inflammatory compounds with anti-hypertensive compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1299122A2 (en) * 2000-07-13 2003-04-09 Pharmacia Corporation Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain
EP1990049A3 (en) * 2005-03-21 2008-11-26 Vicus Therapeutics SPE 1, LLC Combination therapy of beta-blockers and non-steroidal anti-inflammatory drugs (NSAID)
EP2014284A1 (en) * 2007-06-15 2009-01-14 Novartis AG Pharmaceutical compositions and uses
EP2715359A4 (en) * 2011-05-30 2015-01-21 String Therapeutics Inc Methods and compositions for therapeutic drug monitoring and dosing by point-of-care pharmacokinetic profiling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058073A2 (en) * 2004-11-23 2006-06-01 Transform Pharmaceuticals, Inc. Pharmaceutical compositions comprising a selective cox-2 inhibitor and a diuretic
WO2009154944A2 (en) * 2008-05-28 2009-12-23 Hoyle Peter C Pharmaceutical formulations and methods of use which combine non-steroidal anti-inflammatory compounds with anti-hypertensive compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MOORE R ANDREW ET AL: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports", ARTHRITIS RESEARCH, CURRENT SCIENCE, LONDON, GB, vol. 7, no. 3, 24 March 2005 (2005-03-24), pages R644 - R665, XP021011594, ISSN: 1465-9905, DOI: 10.1186/AR1704 *
SANJIVE QAZI ET AL: "Abstract 2597: Celecoxib fixed dose combinations - patient level data analyses", CANCER RESEARCH, vol. 77, no. 13 Supplement, 1 July 2017 (2017-07-01), US, pages 2597 - 2597, XP055416583, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2017-2597 *
See also references of WO2015191460A1 *
W WANG ET AL: "Poster Number 110: Patient-level Data Analysis Revealed the Real Incidence and Impact of Celecoxib on Edema", CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, vol. 6, no. Suppl 1, 1 September 2017 (2017-09-01), pages 69 - 70, XP055416585, DOI: 10.1002/cpdd.385 *

Also Published As

Publication number Publication date
CA2956899A1 (en) 2015-12-17
TW201642906A (en) 2016-12-16
CN106572984A (en) 2017-04-19
AU2015274908A1 (en) 2017-01-19
WO2015191473A1 (en) 2015-12-17
JP2017517575A (en) 2017-06-29
CA2956897A1 (en) 2015-12-17
JP2017517529A (en) 2017-06-29
TW201642854A (en) 2016-12-16
WO2015191473A9 (en) 2016-03-24
KR20160091348A (en) 2016-08-02
EP3151822A1 (en) 2017-04-12
AU2015274895A1 (en) 2017-02-02
WO2015191460A1 (en) 2015-12-17
KR20160091349A (en) 2016-08-02
CN106572985A (en) 2017-04-19
EP3151823A1 (en) 2017-04-12
EP3151823A4 (en) 2017-11-22

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/549 20060101ALI20171019BHEP

Ipc: A61K 45/06 20060101ALI20171019BHEP

Ipc: A61P 7/10 20060101ALI20171019BHEP

Ipc: A61K 9/00 20060101AFI20171019BHEP

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