EP3149190A4 - Identification of novel anti-persister activity for borrelia burgdorferi - Google Patents

Identification of novel anti-persister activity for borrelia burgdorferi Download PDF

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Publication number
EP3149190A4
EP3149190A4 EP15788973.4A EP15788973A EP3149190A4 EP 3149190 A4 EP3149190 A4 EP 3149190A4 EP 15788973 A EP15788973 A EP 15788973A EP 3149190 A4 EP3149190 A4 EP 3149190A4
Authority
EP
European Patent Office
Prior art keywords
identification
novel anti
borrelia burgdorferi
persister
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15788973.4A
Other languages
German (de)
French (fr)
Other versions
EP3149190A1 (en
Inventor
Ying Zhang
Jie Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP3149190A1 publication Critical patent/EP3149190A1/en
Publication of EP3149190A4 publication Critical patent/EP3149190A4/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP15788973.4A 2014-05-09 2015-04-02 Identification of novel anti-persister activity for borrelia burgdorferi Withdrawn EP3149190A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461990759P 2014-05-09 2014-05-09
US201461990766P 2014-05-09 2014-05-09
US201462073605P 2014-10-31 2014-10-31
US201562136678P 2015-03-23 2015-03-23
PCT/US2015/024122 WO2015171225A1 (en) 2014-05-09 2015-04-02 Identification of novel anti-persister activity for borrelia burgdorferi

Publications (2)

Publication Number Publication Date
EP3149190A1 EP3149190A1 (en) 2017-04-05
EP3149190A4 true EP3149190A4 (en) 2018-04-18

Family

ID=54392835

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15788973.4A Withdrawn EP3149190A4 (en) 2014-05-09 2015-04-02 Identification of novel anti-persister activity for borrelia burgdorferi

Country Status (3)

Country Link
EP (1) EP3149190A4 (en)
CN (1) CN107148480A (en)
WO (1) WO2015171225A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017031216A1 (en) * 2015-08-19 2017-02-23 The Johns Hopkins University Compositions and methods for diagnosing and treating lyme disease
EP3252470B1 (en) 2016-06-03 2020-07-29 Te?ted Oy A method and a solid support for detecting tick-borne microbes in a biological sample
CN108570032B (en) * 2017-03-09 2021-04-02 华东理工大学 Novel rhodamine dye and application thereof in resisting pathogenic bacteria
WO2020019289A1 (en) * 2018-07-27 2020-01-30 华东理工大学 Novel rhodamine dye and application thereof against pathogenic bacteria
CN109620979B (en) * 2018-12-29 2020-09-01 福建师范大学 Method for improving efficiency of aminoglycoside antibiotics in killing and retaining bacteria by low ion shock
GB202118957D0 (en) * 2021-12-23 2022-02-09 Univ Liverpool Dyes and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070042453A1 (en) * 2005-08-22 2007-02-22 Novak John S High throughput screening method for antimicrobial formulations
US20100130437A1 (en) * 2007-07-25 2010-05-27 Gustave Huber Topical antibiotic composition for the prevention of lyme disease
US20130084625A1 (en) * 2011-09-30 2013-04-04 Advanced Laboratory Services, Inc. Compositions and methods for culturing spirochetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932437A (en) * 1998-04-13 1999-08-03 Genesis Laboratories, Inc. Control of lyme disease spirochete
CN101568262A (en) * 2005-07-20 2009-10-28 斯克利普斯研究院 Compositions and methods for treating Gram positive bacterial infection in a mammalian subject
CN101365455A (en) * 2005-12-15 2009-02-11 活跃生物药物学有限公司 Uses of rifamycins
CN101762684A (en) * 2008-12-24 2010-06-30 上海市计划生育科学研究所 Method for extracorporeally detecting survival rate of sperms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070042453A1 (en) * 2005-08-22 2007-02-22 Novak John S High throughput screening method for antimicrobial formulations
US20100130437A1 (en) * 2007-07-25 2010-05-27 Gustave Huber Topical antibiotic composition for the prevention of lyme disease
US20130084625A1 (en) * 2011-09-30 2013-04-04 Advanced Laboratory Services, Inc. Compositions and methods for culturing spirochetes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARBESTI S ET AL: "TWO AND THREE-COLOR FLUOROESCENCE FLOW CYTOMETRIC ANALYSIS OF IMMUNOIDENTIFIED VIABLE BACTERIA", CYTOM, ALAN LISS, NEW YORK, US, vol. 40, no. 3, 1 July 2000 (2000-07-01), pages 214 - 218, XP009042629, ISSN: 0196-4763, DOI: 10.1002/1097-0320(20000701)40:3<214::AID-CYTO6>3.0.CO;2-M *
LAKOS A ET AL: "[Effect of an antibiotic combination on the propagation of Borrelia burgdorferi, causative agent of Lyme disease].", ORVOSI HETILAP 04 JUL 1999, vol. 140, no. 27, 4 July 1999 (1999-07-04), pages 1529 - 1532, XP009501949, ISSN: 0030-6002 *
MARC RÜGER ET AL: "A flow cytometric method for viability assessment of Staphylococcus aureus and Burkholderia cepacia in mixed culture", CYTOMETRY. PART A, vol. 81A, no. 12, 18 October 2012 (2012-10-18), US, pages 1055 - 1066, XP055429410, ISSN: 1552-4922, DOI: 10.1002/cyto.a.22219 *
RAPHAEL STRICKER ET AL: "Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi", INFECTION AND DRUG RESISTANCE, 1 May 2011 (2011-05-01), pages 97, XP055080660, DOI: 10.2147/IDR.S19201 *
See also references of WO2015171225A1 *
THOMAS C A ET AL: "FLUOROMETRIC ASSESSMENTS OF ACROSOMAL INTEGRITY AND VIABILITY IN CRYOPRESERVED BOVINE SPERMATOZOA", BIOLOGY OF REPRODUCTION, NEW YORK, NY [U.A.] : ACADEM. PRESS, US, vol. 56, 1 January 1997 (1997-01-01), pages 991 - 998, XP002924037, ISSN: 0006-3363, DOI: 10.1095/BIOLREPROD56.4.991 *

Also Published As

Publication number Publication date
CN107148480A (en) 2017-09-08
EP3149190A1 (en) 2017-04-05
WO2015171225A1 (en) 2015-11-12

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