EP3143379A4 - Microfluidic flow cell assemblies for imaging and method of use - Google Patents

Microfluidic flow cell assemblies for imaging and method of use Download PDF

Info

Publication number
EP3143379A4
EP3143379A4 EP15792752.6A EP15792752A EP3143379A4 EP 3143379 A4 EP3143379 A4 EP 3143379A4 EP 15792752 A EP15792752 A EP 15792752A EP 3143379 A4 EP3143379 A4 EP 3143379A4
Authority
EP
European Patent Office
Prior art keywords
imaging
flow cell
cell assemblies
microfluidic flow
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15792752.6A
Other languages
German (de)
French (fr)
Other versions
EP3143379A1 (en
Inventor
Kashan Ali Shaikh
Mengli Wang
Adriana Ines Larriera Moreno
Jessica Godin Karp
Christine Lynne Pitner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/277,503 external-priority patent/US9080941B2/en
Application filed by General Electric Co filed Critical General Electric Co
Publication of EP3143379A1 publication Critical patent/EP3143379A1/en
Publication of EP3143379A4 publication Critical patent/EP3143379A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
EP15792752.6A 2014-05-14 2015-04-24 Microfluidic flow cell assemblies for imaging and method of use Ceased EP3143379A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/277,503 US9080941B2 (en) 2012-04-27 2014-05-14 Microfluidic flow cell assemblies for imaging and method of use
PCT/US2015/027549 WO2015175188A1 (en) 2014-05-14 2015-04-24 Microfluidic flow cell assemblies for imaging and method of use

Publications (2)

Publication Number Publication Date
EP3143379A1 EP3143379A1 (en) 2017-03-22
EP3143379A4 true EP3143379A4 (en) 2017-05-31

Family

ID=54480428

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15792752.6A Ceased EP3143379A4 (en) 2014-05-14 2015-04-24 Microfluidic flow cell assemblies for imaging and method of use

Country Status (3)

Country Link
EP (1) EP3143379A4 (en)
JP (1) JP6723541B2 (en)
WO (1) WO2015175188A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150166956A1 (en) * 2013-12-16 2015-06-18 General Electric Company Devices for separation of particulates, associated methods and systems
FR3063990A1 (en) * 2017-03-17 2018-09-21 Commissariat A L'energie Atomique Et Aux Energies Alternatives MICRO-FLUIDIC DEVICE
AU2018257203B2 (en) 2017-04-27 2022-05-26 Mochida Pharmaceutical Co., Ltd. Novel tetrahydronaphthyl urea derivatives
US11326989B2 (en) * 2017-10-26 2022-05-10 Essenlix Corporation Devices and methods for tissue and cell staining
WO2020197993A1 (en) 2019-03-26 2020-10-01 Siemens Healthcare Diagnostics Inc. Methods and apparatus for performing sample measurements using visible light on samples manipulated with acoustic waves

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020185184A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic synthesis devices and methods
WO2003015922A1 (en) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Laminated microarray interface device
US20100179068A1 (en) * 2007-05-03 2010-07-15 Clondiag Gmbh Assays
EP2388500A1 (en) * 2010-05-18 2011-11-23 Samsung Electronics Co., Ltd. Microvalve device and method of manufacturing the same
US20120128548A1 (en) * 2007-08-14 2012-05-24 Arcxis Biotechnologies Polymer microfluidic biochip fabrication
WO2013106458A2 (en) * 2012-01-09 2013-07-18 Micronics, Inc. Microfluidic reactor system
US20130287645A1 (en) * 2012-04-27 2013-10-31 General Electric Company Microfluidic chamber device and fabrication

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147606A (en) * 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5872582A (en) * 1996-07-02 1999-02-16 Hewlett-Packard Company Microfluid valve for modulating fluid flow within an ink-jet printer
JP3777112B2 (en) * 2001-11-02 2006-05-24 財団法人川村理化学研究所 Microfluidic device and manufacturing method thereof
EP1636017A2 (en) * 2003-05-20 2006-03-22 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
JP2007322284A (en) * 2006-06-01 2007-12-13 Konica Minolta Medical & Graphic Inc Microchip and filling method of reagent in microchip
US9494500B2 (en) * 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020185184A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic synthesis devices and methods
WO2003015922A1 (en) * 2001-08-20 2003-02-27 Biomicro Systems, Inc. Laminated microarray interface device
US20100179068A1 (en) * 2007-05-03 2010-07-15 Clondiag Gmbh Assays
US20120128548A1 (en) * 2007-08-14 2012-05-24 Arcxis Biotechnologies Polymer microfluidic biochip fabrication
EP2388500A1 (en) * 2010-05-18 2011-11-23 Samsung Electronics Co., Ltd. Microvalve device and method of manufacturing the same
WO2013106458A2 (en) * 2012-01-09 2013-07-18 Micronics, Inc. Microfluidic reactor system
US20130287645A1 (en) * 2012-04-27 2013-10-31 General Electric Company Microfluidic chamber device and fabrication

Also Published As

Publication number Publication date
JP2017516099A (en) 2017-06-15
EP3143379A1 (en) 2017-03-22
JP6723541B2 (en) 2020-07-15
WO2015175188A1 (en) 2015-11-19

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