EP3141846A1 - Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien - Google Patents

Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien Download PDF

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Publication number
EP3141846A1
EP3141846A1 EP15002623.5A EP15002623A EP3141846A1 EP 3141846 A1 EP3141846 A1 EP 3141846A1 EP 15002623 A EP15002623 A EP 15002623A EP 3141846 A1 EP3141846 A1 EP 3141846A1
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EP
European Patent Office
Prior art keywords
compartment
heat exchanger
gaseous phase
cryogen
liquid cryogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15002623.5A
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English (en)
French (fr)
Inventor
Tim Wigfall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Linde GmbH
Original Assignee
Linde GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Linde GmbH filed Critical Linde GmbH
Priority to EP15002623.5A priority Critical patent/EP3141846A1/de
Publication of EP3141846A1 publication Critical patent/EP3141846A1/de
Withdrawn legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D21/00—Defrosting; Preventing frosting; Removing condensed or defrost water

Definitions

  • the invention relates to a method and a system for cooling chemical, pharmaceutical and biological materials.
  • the problem underlying the present invention is to provide a method and a system for cooling the above-stated materials which allows the user to cool said materials in an energy and cost efficient way.
  • a method for cooling one of: a chemical, a pharmaceutical or a biological material wherein a liquid cryogen or a cold gas derived from a liquid cryogen (e.g. a gaseous phase of the liquid cryogen) is passed (e.g. from a container) to a heat exchanger that is arranged in a compartment in which said material is arranged in order to cool said material, wherein liquid cryogen or cold gas removes heat from its surroundings and the resultant warmer gas exiting the heat exchanger is preferably entirely clean and preferably with some further temperature and pressure conditioning is then re-used in the gaseous phase in another application.
  • a liquid cryogen or a cold gas derived from a liquid cryogen e.g. a gaseous phase of the liquid cryogen
  • a heat exchanger that is arranged in a compartment in which said material is arranged in order to cool said material, wherein liquid cryogen or cold gas removes heat from its surroundings and the resultant warmer gas exiting the heat exchanger is preferably entirely clean and preferably with
  • cryogenically cooled storage equipment material samples are particularly preserved in specially designed cryogenically cooled storage equipment.
  • the equipment proposed is preferably to be cooled via indirect heat exchange, most preferably but not necessarily exclusively using a cryogenic liquid such as liquid Nitrogen.
  • a cryogenic liquid such as liquid Nitrogen.
  • the benefit of the invention over and above the advantages of general cryogenic freezing i.e. high levels of cooling capability, the maintenance of a safe breathable atmosphere (or and additional gas modified inerted atmosphere if storage conditions are enhanced and safe access controls are in place), reliability due to few moving parts, potentially very low terminal temperatures, quiet, low power requirement and small footprint - is that in this particular application, the pure cold cryogen exhaust gas is conditioned for re-use, e.g. as an ambient temperature gas supply.
  • the cryogen might be nitrogen - for which there is very often an existing demand for gaseous nitrogen for process uses such as purging and inerting etc.
  • the cryogen could be liquid oxygen, which might be particularly beneficial in hospitals, where biological samples need preservation and gaseous oxygen is required for patient support/respiration (e.g. of human or animal patients).
  • the proposed method or system has significant cost, operational, environmental, quality assurance and power consumption benefits over and above the conventionally refrigerated cold store systems.
  • compartment air may be circulated along the heat exchanger in order to cool said air and therewith said material arranged in said compartment.
  • a circulation may be achieved by means of at least one fan that is configured to move air along the heat exchanger.
  • a system for cooling chemical, pharmaceutical or biological material is provided, which system is particularly used in the method according to the invention.
  • this system comprises a container for storing a liquid cryogen, a compartment for accommodating said material to be cooled, a heat exchanger arranged in said compartment and in fluid connection with said container so that liquid cryogen can be guided (e.g. from said container) into said heat exchanger, a conduit means being in fluid connection with the heat exchanger, which conduit means is configured to guide a gaseous phase of the cryogen (e.g.
  • a further compartment and particularly a component arranged therein the further compartment being in fluid connection with said conduit means so that said gaseous phase can be guided into said further compartment, preferably in order to purge said further compartment or said component arranged therein or in order to render said further compartment or said component arranged therein inert.
  • said further compartment or component is one of or formed by one of an enclosure, a chemical reactor, a product drier (e.g. a centrifuge), or a chemical storage tanks etc.
  • a flammable atmosphere and/or a solvent is present in said further compartment and/or component.
  • a flammable (e.g. organic) solvent or gas may be one of e.g. xylene, toluene, acetone, or hydrogen etc.
  • the system comprises a further heat exchanger arranged in said compartment and in fluid connection with said container so that liquid cryogen or a gaseous phase derived from the liquid cryogen can be guided from said container into said further heat exchanger in order to cool said material.
  • the system then preferably further comprises a further conduit means being in fluid connection with the further heat exchanger, which further conduit means is configured to guide a gaseous phase of the cryogen from the further heat exchanger out of said compartment, the further compartment being in fluid connection with said further conduit means so that said gaseous phase can be guided into said further compartment in order to purge said further compartment or a component arranged in said further compartment or in order to render said further compartment or a component arranged in said further compartment inert
  • the system is configured to alternately defrost the two heat exchangers and to use the heat exchanger that is not being defrosted for cooling said material in said compartment.
  • the preservation/degradation of a material can be greatly influenced by the rate at which it is cooled, and the terminal temperatures at which it is then stored. Due to the daunting cooling capacity of cryogenic liquids, a cryogenic based cooling and storage solution offers greatly enhanced flexibility, controllability and terminal temperatures vs traditional mechanically refrigerated systems. Cryogenic cooling systems also offer very precise temperature control capability and potential terminal storage temperatures of -196 °C vs -40 °C for mechanical systems.
  • cryogenic gases are typically natural, non polluting components derived from air and as such are not polluting when released back into the atmosphere - where as many chemically derived cooling fluids: CFC's, HCFC's etc contain chlorine atoms that become atmospheric ozone depleting radicals.
  • Ammonia is another common refrigerant and is both highly toxic and flammable.
  • Fig. 1 shows a system 1 and method for cooling chemical, pharmaceutical or biological material 6.
  • the system 1 comprises a container 2 for storing a liquid cryogen C such as e.g. nitrogen or oxygen, a compartment 5 for accommodating said material 6 to be cooled, a heat exchanger 4 arranged in said compartment 5 and in fluid connection with said container 2.
  • the system 1 further comprises a conduit means 7 being in fluid connection with the heat exchanger 4, which conduit means 7 is adapted to guide a gaseous phase C" of the cryogen from the heat exchanger 4 out of said compartment 5 where the gaseous cryogen C" can be re-used in another application 9.
  • the pressure and/or temperature of said gaseous phase C" may be adjusted so that it is suitable for the further application 9.
  • the cryogen C may me guided into the heat exchanger 4 (or into the further heat exchanger 4', see below) in the liquid phase, Then, the cryogen C evaporates in the heat exchanger when cooling the material 6/compartment 5 to form the gaseous phase C".
  • the cryogen C may also be guided into the heat exchangers 4 (and optionally heat exchanger 4') in the gaseous phase C' (i.e. as a cold gas) which then takes up heat in the heat exchanger 4 (and optionally heat exchanger 4').
  • the then warmer gaseous phase C" is then re-used in said other application 9.
  • the heat exchangers 4, 4' can be operated with a liquid cryogen C or with a cold gas C" derived from the liquid cryogen C.
  • the gaseous phase C" as generated in the heat exchanger 4 may be used for purging or inerting a further compartment 10, or for purging or inerting a component or material 11, e.g. arranged in said further compartment 10.
  • the gaseous phase C" When used for inerting it preferably forms an inert gas, e.g. such as nitrogen.
  • cryogen C may also be oxygen.
  • the gaseous phase C" may be used in the further compartment 10 for providing respiration, e.g. to a human 11 or animal 11 or for supporting a biological sample 11.
  • cryogen C is piped from the container 2 via conduit 3 into the heat exchanger 4 (or into heat exchanger 4', see below), where the cryogen C takes up heat stored in the compartment 5, particularly in the air or atmosphere therein, and in said material 6.
  • said material 6 is cooled while the cryogen C is evaporated yielding a gaseous phase C" which is then guided via conduit means 7 towards its further use 9 described herein.
  • the cryogen C may be evaporated to form a gold gas C' which is then guided into the heat exchanger 4 (or 4'). Cooling in the compartment 5 can be supported by circulating the air or atmosphere in the compartment 5 using a rotating fan 12 as indicated in Fig. 1
  • the system or method according to the invention may use a further heat exchanger 4' arranged in said compartment 5 and in fluid connection with said container 2 so that liquid cryogen C or a gaseous phase C' derived from the liquid cryogen C can be guided (e.g. from said container 2) into said further heat exchanger 4'.
  • a further conduit means 7' may be in fluid connection with the further heat exchanger 4', which further conduit means 7' is configured to guide a gaseous phase C" of the cryogen C from the further heat exchanger 4' out of said compartment 5 into a further compartment 10 being in fluid connection with said further conduit means 7' so that said gaseous phase C" can be guided into said further compartment 10 in order to purge or render said further compartment 10 or a component 11 or material 11 arranged in said further compartment 10 inert.
  • each heat exchanger 4, 4' is preferably mounted within an (e.g. open) container 4a. 4b when in use (hence allowing cold air to circulate throughout the coldstore or compartment 5).
  • an (e.g. open) container 4a. 4b when in use (hence allowing cold air to circulate throughout the coldstore or compartment 5).
  • cooling to the heat exchanger 4 would be isolated, its container 4a would be closed to isolate it from the general compartment 5 and the temperature raised within the container 4a to melt the ice and remove water.
  • the melting of the ice could be done by: electric heater contained within the enclosure/container 4a, or using heated inert gas passed within the heat exchanger 4, or a combination of both. Whilst one heat exchanger 4 was being de-iced, the second heat exchanger 4' would be used to maintain cooling within the compartment 5 (and vice-versa).

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
EP15002623.5A 2015-09-08 2015-09-08 Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien Withdrawn EP3141846A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15002623.5A EP3141846A1 (de) 2015-09-08 2015-09-08 Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15002623.5A EP3141846A1 (de) 2015-09-08 2015-09-08 Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien

Publications (1)

Publication Number Publication Date
EP3141846A1 true EP3141846A1 (de) 2017-03-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP15002623.5A Withdrawn EP3141846A1 (de) 2015-09-08 2015-09-08 Kryogenes kühllager zur konservierung von chemischen, pharmazeutischen und biologischen materialien

Country Status (1)

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EP (1) EP3141846A1 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1855071A2 (de) * 2006-05-11 2007-11-14 Aisberg Ltd Verfahren zur kontinuierlichen Luftkühlung für Kühltheken mit mittlerer Temperatur von Ladenausstattungen
EP2226595A2 (de) * 2009-03-06 2010-09-08 Linde Aktiengesellschaft Thermoakustischer Kühlschrank zum kryogenen Einfrieren
US20120174600A1 (en) * 2008-08-04 2012-07-12 Boyd Bowdish Flow Control of a Cryogenic Element to Remove Heat

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1855071A2 (de) * 2006-05-11 2007-11-14 Aisberg Ltd Verfahren zur kontinuierlichen Luftkühlung für Kühltheken mit mittlerer Temperatur von Ladenausstattungen
US20120174600A1 (en) * 2008-08-04 2012-07-12 Boyd Bowdish Flow Control of a Cryogenic Element to Remove Heat
EP2226595A2 (de) * 2009-03-06 2010-09-08 Linde Aktiengesellschaft Thermoakustischer Kühlschrank zum kryogenen Einfrieren

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