EP3137628A4 - Verfahren zur vorhersage von medizinisch refraktiver colitis ulcerosa (mruc) mit erforderlicher kolektomie - Google Patents

Verfahren zur vorhersage von medizinisch refraktiver colitis ulcerosa (mruc) mit erforderlicher kolektomie Download PDF

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Publication number
EP3137628A4
EP3137628A4 EP15785256.7A EP15785256A EP3137628A4 EP 3137628 A4 EP3137628 A4 EP 3137628A4 EP 15785256 A EP15785256 A EP 15785256A EP 3137628 A4 EP3137628 A4 EP 3137628A4
Authority
EP
European Patent Office
Prior art keywords
mruc
predicting
methods
ulcerative colitis
medically refractive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15785256.7A
Other languages
English (en)
French (fr)
Other versions
EP3137628A1 (de
Inventor
Dermot P. Mcgovern
Talin Haritunians
Stephan Targan
Philip FLESHNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of EP3137628A1 publication Critical patent/EP3137628A1/de
Publication of EP3137628A4 publication Critical patent/EP3137628A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15785256.7A 2014-05-02 2015-05-04 Verfahren zur vorhersage von medizinisch refraktiver colitis ulcerosa (mruc) mit erforderlicher kolektomie Withdrawn EP3137628A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461988078P 2014-05-02 2014-05-02
PCT/US2015/029101 WO2015168699A1 (en) 2014-05-02 2015-05-04 Methods of predicting medically refractive ulcerative colitis (mruc) requiring colectomy

Publications (2)

Publication Number Publication Date
EP3137628A1 EP3137628A1 (de) 2017-03-08
EP3137628A4 true EP3137628A4 (de) 2018-03-21

Family

ID=54359430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15785256.7A Withdrawn EP3137628A4 (de) 2014-05-02 2015-05-04 Verfahren zur vorhersage von medizinisch refraktiver colitis ulcerosa (mruc) mit erforderlicher kolektomie

Country Status (3)

Country Link
EP (1) EP3137628A4 (de)
CA (1) CA2946317A1 (de)
WO (1) WO2015168699A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
BR112015024752A2 (pt) 2013-03-27 2017-07-18 Cedars Sinai Medical Center mitigação e reversão da fibrose e inflamação através da inibição da função de tl1a e vias de sinalização relacionadas
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120053131A1 (en) * 2008-12-24 2012-03-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
CN103149371A (zh) * 2013-02-26 2013-06-12 哈药慈航制药股份有限公司 生物标记物在制备预测5-氨基水杨酸治疗溃疡性结肠炎的反馈响应药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100015156A1 (en) * 2007-03-06 2010-01-21 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children
EP2757160A3 (de) * 2009-07-20 2014-07-30 Genentech, Inc. Genexpressionsmarker für Morbus Crohn
WO2012071436A1 (en) * 2010-11-24 2012-05-31 Genentech, Inc. Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120053131A1 (en) * 2008-12-24 2012-03-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
CN103149371A (zh) * 2013-02-26 2013-06-12 哈药慈航制药股份有限公司 生物标记物在制备预测5-氨基水杨酸治疗溃疡性结肠炎的反馈响应药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015168699A1 *
TALIN HARITUNIANS ET AL: "Genetic predictors of medically refractory ulcerative colitis :", INFLAMMATORY BOWEL DISEASES, vol. 16, no. 11, 1 November 2010 (2010-11-01), US, pages 1830 - 1840, XP055419882, ISSN: 1078-0998, DOI: 10.1002/ibd.21293 *

Also Published As

Publication number Publication date
EP3137628A1 (de) 2017-03-08
WO2015168699A1 (en) 2015-11-05
CA2946317A1 (en) 2015-11-05

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Inventor name: TARGAN, STEPHAN

Inventor name: MCGOVERN, DERMOT P.

Inventor name: FLESHNER, PHILIP

Inventor name: HARITUNIANS, TALIN

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Inventor name: HARITUNIANS, TALIN

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Inventor name: FLESHNER, PHILIP

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