EP3094380A4 - Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists - Google Patents

Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists Download PDF

Info

Publication number
EP3094380A4
EP3094380A4 EP15737537.9A EP15737537A EP3094380A4 EP 3094380 A4 EP3094380 A4 EP 3094380A4 EP 15737537 A EP15737537 A EP 15737537A EP 3094380 A4 EP3094380 A4 EP 3094380A4
Authority
EP
European Patent Office
Prior art keywords
methods
retinoic acid
metabolic syndrome
receptor agonists
related conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15737537.9A
Other languages
German (de)
French (fr)
Other versions
EP3094380B1 (en
EP3094380A1 (en
Inventor
Lorraine J GUDAS
Yannick Benoit
Ronald Perez
Xiao-Han TANG
Steven TRASINO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell University
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/012083 external-priority patent/WO2014113695A1/en
Application filed by Cornell University filed Critical Cornell University
Publication of EP3094380A1 publication Critical patent/EP3094380A1/en
Publication of EP3094380A4 publication Critical patent/EP3094380A4/en
Application granted granted Critical
Publication of EP3094380B1 publication Critical patent/EP3094380B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP15737537.9A 2014-01-17 2015-01-16 Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists Active EP3094380B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2014/012083 WO2014113695A1 (en) 2013-01-18 2014-01-17 Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists
US201461990808P 2014-05-09 2014-05-09
PCT/US2015/011820 WO2015109231A1 (en) 2014-01-17 2015-01-16 Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists

Publications (3)

Publication Number Publication Date
EP3094380A1 EP3094380A1 (en) 2016-11-23
EP3094380A4 true EP3094380A4 (en) 2017-10-25
EP3094380B1 EP3094380B1 (en) 2021-04-28

Family

ID=53543499

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15737537.9A Active EP3094380B1 (en) 2014-01-17 2015-01-16 Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists

Country Status (5)

Country Link
US (2) US11160769B2 (en)
EP (1) EP3094380B1 (en)
CN (1) CN106211757B (en)
CA (1) CA2937107C (en)
WO (1) WO2015109231A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109231A1 (en) 2014-01-17 2015-07-23 Cornell University Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists
EP3806839A4 (en) * 2018-06-14 2022-03-30 Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") Compositions and methods for providing cardioprotective effects
CN109359833B (en) * 2018-09-27 2022-05-27 中国石油大学(华东) Ocean platform blasting risk analysis method based on ABC-BRANN model
WO2023044355A1 (en) * 2021-09-15 2023-03-23 Cornell University Compositions and methods for mitigating alcohol liver disease
CN114392266B (en) * 2022-01-22 2022-11-15 暨南大学附属第一医院（广州华侨医院） Pharmaceutical composition containing PPAR gamma inhibitor and application thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698392A1 (en) * 1994-08-02 1996-02-28 L'oreal Compositions containing a RAR alpha specific ligand and at least one fatty acid
WO1998042340A1 (en) * 1997-03-24 1998-10-01 Galderma Research & Development, S.N.C. Retinoid related molecules for the treatment of non-insulin dependent diabetes mellitus
WO1998048055A1 (en) * 1997-04-24 1998-10-29 Institut National De La Sante Et De La Recherche Medicale Methods and compositions for use in modulating expression of matrix metalloproteinase genes
WO2007009083A2 (en) * 2005-07-12 2007-01-18 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
US20080139842A1 (en) * 2006-09-27 2008-06-12 R&R Inc. Medicament for preventive and/or therapeutic treatment of diseases with secretory disorder
US20090137671A1 (en) * 2007-05-17 2009-05-28 Noy Noa Methods of treating metabolic disorders
WO2012162698A1 (en) * 2011-05-26 2012-11-29 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the treatment of immune disorders
WO2014113695A1 (en) * 2013-01-18 2014-07-24 Cornell University Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110298A (en) 1993-07-13 1999-04-11 Brann Mark Robert Identification of ligands by selective amplification of cells transfected with receptors
TW558554B (en) * 1999-10-29 2003-10-21 Takeda Chemical Industries Ltd Crystals of oxyiminoalkanoic acid derivative
BRPI0509374A (en) * 2004-03-29 2007-09-11 Wyeth Corp multivitamin and mineral nutritional supplements
PT1868454E (en) 2005-04-06 2013-04-03 Nestec Sa Composition for nutritionally improving glucose control and insulin action
WO2008064136A2 (en) 2006-11-17 2008-05-29 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
EP2397039A1 (en) * 2010-06-21 2011-12-21 Abbott Laboratories Compositions for delaying progression of diabetes using Salacia oblonga extract
DK2723347T3 (en) * 2011-06-24 2019-11-18 Gri Bio Inc Prevention and treatment of inflammatory conditions
US11191755B2 (en) 2014-01-17 2021-12-07 Cornell University Compositions and methods for providing cardioprotective effects
WO2015109231A1 (en) 2014-01-17 2015-07-23 Cornell University Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698392A1 (en) * 1994-08-02 1996-02-28 L'oreal Compositions containing a RAR alpha specific ligand and at least one fatty acid
WO1998042340A1 (en) * 1997-03-24 1998-10-01 Galderma Research & Development, S.N.C. Retinoid related molecules for the treatment of non-insulin dependent diabetes mellitus
WO1998048055A1 (en) * 1997-04-24 1998-10-29 Institut National De La Sante Et De La Recherche Medicale Methods and compositions for use in modulating expression of matrix metalloproteinase genes
WO2007009083A2 (en) * 2005-07-12 2007-01-18 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
US20080139842A1 (en) * 2006-09-27 2008-06-12 R&R Inc. Medicament for preventive and/or therapeutic treatment of diseases with secretory disorder
US20090137671A1 (en) * 2007-05-17 2009-05-28 Noy Noa Methods of treating metabolic disorders
WO2012162698A1 (en) * 2011-05-26 2012-11-29 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the treatment of immune disorders
WO2014113695A1 (en) * 2013-01-18 2014-07-24 Cornell University Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DOUGUET D ET AL: "QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF RAR ALPHA,BETA,GAMMA RETINOID AGONISTS", QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, VCH PUBLISHERS, DEERFIELD BEACH, FL, US, vol. 18, no. 2, 1 January 1999 (1999-01-01), pages 107 - 123, XP000957375, ISSN: 0931-8771, DOI: 10.1002/(SICI)1521-3838(199906)18:2<107::AID-QSAR107>3.0.CO;2-3 *
LUND B W ET AL: "Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 48, no. 24, 11 April 2005 (2005-04-11), pages 7517 - 7519, XP002411145, ISSN: 0022-2623, DOI: 10.1021/JM050891R *
MIWAKO ISHIDO ET AL: "Oral administration of synthetic retinoid Am80 inhibits the development of type 1 diabetes in non-obese diabetic (NOD) mice.", BIOLOGICAL & PHARMACEUTICAL BULLETIN JAN 2009, vol. 32, no. 1, January 2009 (2009-01-01), pages 157 - 159, XP002773750, ISSN: 0918-6158 *
See also references of WO2015109231A1 *

Also Published As

Publication number Publication date
US20220304945A1 (en) 2022-09-29
CA2937107C (en) 2020-12-22
WO2015109231A1 (en) 2015-07-23
US11160769B2 (en) 2021-11-02
EP3094380B1 (en) 2021-04-28
EP3094380A1 (en) 2016-11-23
US20180263924A1 (en) 2018-09-20
CA2937107A1 (en) 2015-07-23
CN106211757A (en) 2016-12-07
CN106211757B (en) 2022-06-07

Similar Documents

Publication Publication Date Title
EP3212226A4 (en) Compositions and methods of use for treating metabolic disorders
EP3137169A4 (en) Inhibitors of lysine specific demethylase-1
EP3102576B8 (en) Dihydropyrrolopyridine inhibitors of ror-gamma
EP3335134A4 (en) Computing system with structure vertical-tier mechanism and method of operation thereof
EP3223823A4 (en) Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
EP3189038A4 (en) Inhibitors of lysine specific demethylase-1
EP3174894A4 (en) Compositions and methods of use for treating metabolic disorders
EP3092782B8 (en) Mechanisms for conserving resources of wearable devices
EP3160956A4 (en) Inhibitors of lysine specific demethylase-1
EP3232781A4 (en) Methods for forming peroxyformic acid and uses thereof
EP3291765A4 (en) Methods of delivering an agent to the eye
EP3125895A4 (en) Substituted spirocydic inhibitors of autotaxin
EP3164380A4 (en) Inhibitors of lysine specific demethylase-1
EP3068783A4 (en) Methods of treating heart failure with agonists of hypocretin receptor 2
EP3142709A4 (en) Solution target for cyclotron production of radiometals
EP3164509A4 (en) Inhibitors of lysine specific demethylase-1
EP3201361A4 (en) Methods of quantifying cell-free dna
EP3186230A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3186229A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3183238A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3191455A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3174856A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
ZA201703112B (en) Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
IL252882A0 (en) Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (rarbeta) agonists
EP3166931A4 (en) An improved process for the preparation of enzalutamide

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20160721

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: TRASINO, STEVEN

Inventor name: TANG, XIAO-HAN

Inventor name: GUDAS, LORRAINE J

Inventor name: PEREZ, RONALD

Inventor name: BENOIT, YANNICK

A4 Supplementary search report drawn up and despatched

Effective date: 20170925

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/426 20060101ALI20170918BHEP

Ipc: A61K 31/192 20060101ALI20170918BHEP

Ipc: A61P 3/10 20060101AFI20170918BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20190821

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20201113

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CORNELL UNIVERSITY

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TANG, XIAO-HAN

Inventor name: GUDAS, LORRAINE J

Inventor name: BENOIT, YANNICK

Inventor name: PEREZ, RONALD

Inventor name: TRASINO, STEVEN

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1386441

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210515

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602015068638

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1386441

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210728

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210728

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210830

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210828

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210729

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602015068638

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20220131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210828

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220116

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20230127

Year of fee payment: 9

Ref country code: FR

Payment date: 20230125

Year of fee payment: 9

Ref country code: CH

Payment date: 20230130

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230127

Year of fee payment: 9

Ref country code: DE

Payment date: 20230127

Year of fee payment: 9

Ref country code: BE

Payment date: 20230127

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240126

Year of fee payment: 10

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20150116

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20240129

Year of fee payment: 10

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210428

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240129

Year of fee payment: 10

Ref country code: GB

Payment date: 20240129

Year of fee payment: 10

Ref country code: CH

Payment date: 20240202

Year of fee payment: 10