EP3065549A4 - Methods for inhibiting tie2 kinase useful in the treatment of cancer - Google Patents

Methods for inhibiting tie2 kinase useful in the treatment of cancer Download PDF

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Publication number
EP3065549A4
EP3065549A4 EP13896951.4A EP13896951A EP3065549A4 EP 3065549 A4 EP3065549 A4 EP 3065549A4 EP 13896951 A EP13896951 A EP 13896951A EP 3065549 A4 EP3065549 A4 EP 3065549A4
Authority
EP
European Patent Office
Prior art keywords
cancer
treatment
methods
tie2 kinase
kinase useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13896951.4A
Other languages
German (de)
French (fr)
Other versions
EP3065549A1 (en
Inventor
Daniel L. Flynn
Michael D. Kaufman
Bryan Smith
Marc S. RUDOLTZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deciphera Pharmaceuticals LLC
Original Assignee
Deciphera Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals LLC filed Critical Deciphera Pharmaceuticals LLC
Publication of EP3065549A1 publication Critical patent/EP3065549A1/en
Publication of EP3065549A4 publication Critical patent/EP3065549A4/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP13896951.4A 2013-11-07 2013-11-07 Methods for inhibiting tie2 kinase useful in the treatment of cancer Ceased EP3065549A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/069005 WO2015069266A1 (en) 2013-11-07 2013-11-07 Methods for inhibiting tie2 kinase useful in the treatment of cancer

Publications (2)

Publication Number Publication Date
EP3065549A1 EP3065549A1 (en) 2016-09-14
EP3065549A4 true EP3065549A4 (en) 2017-05-24

Family

ID=53041876

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13896951.4A Ceased EP3065549A4 (en) 2013-11-07 2013-11-07 Methods for inhibiting tie2 kinase useful in the treatment of cancer

Country Status (7)

Country Link
EP (1) EP3065549A4 (en)
JP (1) JP6568093B2 (en)
KR (2) KR20210063475A (en)
CN (2) CN108464981B (en)
AU (3) AU2013404949B2 (en)
CA (1) CA2929715A1 (en)
WO (1) WO2015069266A1 (en)

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
JP6568093B2 (en) * 2013-11-07 2019-08-28 デシフェラ ファーマシューティカルズ，エルエルシー Method of inhibiting TIE2 kinase useful for cancer treatment
DK3102605T3 (en) 2014-02-04 2019-02-25 Pfizer COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR INHIBITOR FOR TREATMENT OF CANCER
AU2016222928B2 (en) 2015-02-26 2021-05-13 Merck Patent Gmbh PD-1 / PD-L1 inhibitors for the treatment of cancer
WO2016191401A1 (en) * 2015-05-27 2016-12-01 Albert Einstein College Of Medicine, Inc. Tmem active test and uses thereof in diagnosis, prognosis and treatment of tumors
CN107750166B (en) 2015-06-16 2022-02-11 默克专利股份有限公司 PD-L1 antagonist combination therapy
RU2021125492A (en) 2016-03-02 2022-04-05 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF APPLICATION
WO2017172734A1 (en) 2016-03-29 2017-10-05 Mayo Foundation For Medical Education And Research Treating cancer metastasis
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
IL265762B2 (en) 2016-10-06 2024-04-01 Merck Patent Gmbh Dosing regimen of avelumab for the treatment of cancer
ES2928773T3 (en) 2017-01-17 2022-11-22 Heparegenix Gmbh Protein kinase inhibitors to promote liver regeneration or reduce or prevent hepatocyte death
CN106822128A (en) * 2017-02-24 2017-06-13 南华大学附属第医院 The new opplication of tyrosine kinase inhibitor DCC 2036
AU2019216351B2 (en) 2018-01-31 2024-07-25 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
CN118557737A (en) 2018-01-31 2024-08-30 德西费拉制药有限责任公司 Combination therapy for the treatment of gastrointestinal stromal tumors
CN110003181B (en) * 2019-05-22 2020-08-28 北京凯恩梅格医药科技有限公司 c-Met/HDAC double-target inhibitor based on crizotinib structure and synthetic method and application thereof
BR112022002609A2 (en) 2019-08-12 2022-08-09 Deciphera Pharmaceuticals Llc METHODS OF TREATMENT OF GASTROINTESTINAL STROMAL TUMORS
TW202122082A (en) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 Methods of treating gastrointestinal stromal tumors
EP4013417A1 (en) * 2019-08-12 2022-06-22 Deciphera Pharmaceuticals, LLC Methods and compositions for treating vascular malformations
CN112812109B (en) * 2019-11-18 2022-06-21 中国科学院微生物研究所 Compound DaP-01 and preparation method and application thereof
CN115135308A (en) 2019-12-30 2022-09-30 德西费拉制药有限责任公司 Amorphous kinase inhibitor formulations and methods of use thereof
MX2022008097A (en) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-d ihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea.
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011123788A1 (en) * 2010-04-01 2011-10-06 Duke University Compositions and methods for the treatment of cancer
US9296722B2 (en) * 2010-05-27 2016-03-29 Ambit Biosciences Corporation Azolyl urea compounds and methods of use thereof
CN103298345B (en) * 2011-01-11 2016-12-14 诺瓦蒂斯公司 Combination
CA2843417C (en) * 2011-07-29 2018-08-21 Medivation Prostate Therapeutics, Inc. Treatment of breast cancer
WO2013036232A2 (en) * 2011-09-08 2013-03-14 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
AU2013201121A1 (en) * 2011-09-20 2013-04-04 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
JP6568093B2 (en) * 2013-11-07 2019-08-28 デシフェラ ファーマシューティカルズ，エルエルシー Method of inhibiting TIE2 kinase useful for cancer treatment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRYAN D SMITH ET AL: "Abstract B78: Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model", February 2013 (2013-02-01), XP002769061, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/73/3_Supplement/B78> [retrieved on 20170410] *
JAVIER CORTES ET AL: "Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study", THE LANCET, vol. 377, no. 9769, 1 March 2011 (2011-03-01), pages 914 - 923, XP055030961, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60070-6 *
KARLAN BETH Y. ET AL: "Randomized, Double-Blind, Placebo-Controlled Phase II Study of AMG 386 Combined With Weekly Paclitaxel in Patients With Recurrent Ovarian Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 30, no. 4, 1 February 2012 (2012-02-01), US, pages 362 - 371, XP055890024, ISSN: 0732-183X, DOI: 10.1200/JCO.2010.34.3178 *
See also references of WO2015069266A1 *

Also Published As

Publication number Publication date
JP6568093B2 (en) 2019-08-28
CN105873440A (en) 2016-08-17
CN108464981A (en) 2018-08-31
EP3065549A1 (en) 2016-09-14
AU2021200113A1 (en) 2021-03-04
KR20160070188A (en) 2016-06-17
CN108464981B (en) 2022-06-24
JP2017500371A (en) 2017-01-05
CN105873440B (en) 2018-06-01
KR20210063475A (en) 2021-06-01
AU2019200261A1 (en) 2019-01-31
AU2013404949A1 (en) 2016-05-26
WO2015069266A1 (en) 2015-05-14
AU2013404949B2 (en) 2018-10-18
CA2929715A1 (en) 2015-05-14

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