EP3003557A1 - Carte fluidique comportant un canal fluidique pourvu d'une ouverture refermable par un film souple - Google Patents
Carte fluidique comportant un canal fluidique pourvu d'une ouverture refermable par un film soupleInfo
- Publication number
- EP3003557A1 EP3003557A1 EP14732827.2A EP14732827A EP3003557A1 EP 3003557 A1 EP3003557 A1 EP 3003557A1 EP 14732827 A EP14732827 A EP 14732827A EP 3003557 A1 EP3003557 A1 EP 3003557A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fluidic
- card
- flexible film
- opening
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
Definitions
- FLUID CARD COMPRISING A FLUIDIC CHANNEL WITH AN OPENING
- the present invention relates to the field of fluidic cards, intended in particular to be connected to instrumented supports for in vitro diagnostics. It also relates to the field of techniques relating to the control of valves present on such fluidic boards.
- the invention has applications in many fields, such as, among others, the fields of medical research, biology and pharmaceuticals.
- the invention thus proposes a fluidic card comprising a fluidic valve, an assembly comprising such a fluidic card and a card holder for controlling the fluidic valve, as well as a method for controlling at least one valve of a card. fluidic implemented by means of such a set.
- Such a fluidic card 300 is shown in FIG. 1.
- the card 300 comprises at least one fluidic (or microfluidic) channel 302 at its surface and / or in its thickness.
- the thickness of the card 300 is defined along the axis k 'of an orthogonal reference
- the fluidic channel 302 is connected to two openings or mouths 304 opening into a face 306 of the board, called the connecting face 306, parallel to another face 308, called the face of a pipe 308.
- the mouths 304 are located on the part of the connecting face 306 closest to a front face 314, located in a plane parallel to the plane i'k 'in Figure 1.
- This front face 314 is parallel to a rear face 310 of the card 300.
- a film for example plastic, preferably biocompatible, can cover the mouths 304 of the fluid channel 302 , and protects the mouths to prevent the intrusion of material in the fluid channel 304, before connection of the card 300 to a connection device.
- the card 300 can then be used in various environments, without particular conditions of cleanliness.
- FIGS. 2A and 2B show such an example of a connection device for a fluidic card 300 such as that represented in FIG. 1, respectively without and with the presence of the card 300.
- the connection device comprises a base or soleplate 10 which itself comprises a lower surface or bearing surface of the entire device 12, and an upper surface or first surface 14, on which the fluidic card 300 can come to rest during use of the device.
- the device is further delimited at its ends by two front and rear walls 30 arranged substantially perpendicular to each of the surfaces 12 and 14.
- the surface 22 of the front wall 20, turned towards the inside of the device, is called the front stop 22.
- the surface 32 of the rear wall, adjacent to the first surface 14, is called the rear stop 32.
- At the upper part of the front stop 22, is connected an upper wall or upper side plate 40, substantially parallel to the surface of the 12, the first surface 14 and the bottom surface 16, and which comprises at least one channel 44 for connection between a mouth 304 of the card 300 and a fluid treatment or analysis instrument (not shown) in Figures 2A and 2B).
- the card 300 is thus intended to be placed on the first surface 14, as shown in FIG.
- Holding means 60 exert a force on the card 300 when it is connected to the device, and then keep it pressed against the first surface 14 of the device, which, by leveraging, allows a support of the card against channels 44.
- the first surface 14 may be traversed by one or more mobile pads 80 at orifices 82 (see Figure 2A).
- Displacement means 84 allow the stud 80 to have a translation movement perpendicular to the first surface 14 and / or the bottom surface 16 so as to exert or release a localized pressure on a flexible surface of the card 300, by for example a tube or a membrane forming a valve. This deformation then makes it possible to narrow the section 88 of the fluidic channel 302, or even to obstruct this channel 302 (see FIG. 2B).
- the translational movement can be controlled by an operator and / or means such as an automaton interacting with an interface 86.
- the object of the invention is to remedy at least partially the needs mentioned above and the drawbacks relating to the embodiments of the prior art.
- the invention aims in particular to propose an alternative solution for designing and enabling the control of the operation of at least one valve of a fluidic card.
- the invention thus has, according to one of its aspects, a fluidic card comprising a rigid support and a fluidic channel formed at least partially in the rigid support, characterized in that the fluidic channel comprises an opening opening on the surface.
- the fluidic card further comprises a flexible film disposed on the outer surface of the rigid support, at least at the opening of the fluidic channel, the flexible film being able to be deformed between a position in which it allows the closure of the fluidic channel so as to prevent a fluid flow of the fluidic channel through the opening and an open position in which it allows the presence of a fluid flow space of the fluidic channel at the through the opening.
- the outer surface of the rigid support thus constitutes an external surface of the fluidic card.
- the fluidic card may also be called a microfluidic or consumable card.
- the assembly formed by the flexible film disposed on the opening of the fluidic channel constitutes a valve of the fluidic card.
- the deformation of the flexible film between the open and closed positions allows the regulation of this valve.
- the valve of the fluidic card is therefore included therein, the assembly being consumable (i.e. disposable).
- the deformation of the flexible film can be done under the action of an external means, in particular pneumatic, to reach the closed position. This deformation is advantageously reversible to allow the flexible film to return to the open position.
- the activation or control of the valve of the fluidic card can thus be done by actuation and release on the flexible film of the valve.
- the invention it is possible to obtain control of the operation of a valve of a fluidic card with great reliability and simplicity.
- the size is reduced to a minimum, especially at the card holder (described later), and the absence of movement between mechanical parts avoids wear and therefore any maintenance.
- the alignment between the fluidic card and the card holder, to then allow the deformation of the flexible film and the passage from one position (closed or open) to the other does not require great precision.
- the fluidic card according to the invention may further comprise one or more of the following characteristics taken separately or in any possible technical combinations.
- the fluidic card may include a plurality of fluidic channels together forming a fluid circuit of the card.
- Such fluidic channels may, all or at least some, have a fluidic channel opening on which is disposed a flexible film to form a fluidic card valve as in the invention.
- open position must be understood in a broad sense. Thus, it designates any position in which fluid of the fluidic channel can flow through the opening.
- the expression “open position” may therefore correspond to different degrees of opening, for example a semi-opening position, that is to say a median deformation of the flexible film or a median pressure exerted on the flexible film, or a position of total opening, that is to say a zero deformation of the flexible film or a lack of pressure exerted on the flexible film.
- the total open position allows a maximum fluid flow of the fluidic channel through the opening of the fluidic channel.
- the total open position also corresponds to the rest (or equilibrium) position of the flexible film.
- the opening degree of the open position can be adjusted depending on the deformability (i.e. pressure) applied to the flexible film.
- the movement of the flexible film can be minute.
- the flexible film can move a distance less than or equal to 100 ⁇ .
- the opening of the fluidic channel may extend along its largest dimension substantially parallel to the flexible film.
- the opening of the fluidic channel may have any shape, for example an annular shape.
- the fluidic card may further comprise a closure seal disposed between the flexible film and the opening of the fluidic channel.
- the closure seal may facilitate the closure of the opening of the fluidic channel during the deformation of the flexible film from the open position to the closed position.
- closure seal is secured to the flexible film, being in particular bonded to the flexible film.
- the closure seal is a flat seal.
- the closure seal may be an annular or a ring seal, particularly in the case of a large sizing of the opening of the fluidic channel.
- the opening of the fluidic channel may comprise a boss, in particular formed all around the fluidic channel.
- the boss can be annular.
- the boss advantageously constitutes a relief in the opening of the fluidic channel, on which the closure seal can come to rest in the closed position of the flexible film.
- the closure seal may therefore be fixed, in particular by gluing, on the flexible film so as to face the boss formed in the opening of the fluidic channel.
- the boss may be a relief formed on the rigid support of the fluidic card, or may be constituted by an insert element on the rigid support of the fluidic card.
- the opening may comprise a channel for fluid flow of the fluidic channel allowing the flow of the fluid leaving the fluidic channel in the open position of the flexible film.
- the flow channel may be formed in the rigid support of the fluidic card, in particular by machining.
- the flow channel may be made in juxtaposition with the boss of the opening of the fluidic channel.
- the machining of the flow channel may allow the formation of the boss in the rigid support of the fluidic card.
- the flow channel may be located all around the boss of the opening.
- the flow channel may further lead to another fluidic channel of the fluidic card, for example formed on the rigid support of the card so as to extend along its largest dimension substantially parallel to the flexible film.
- the rigid support of the fluidic card can be made in one piece.
- the fluidic channel may extend substantially from one edge to the other of the rigid support of the fluidic card, in particular according to the thickness of the rigid support.
- the fluidic card can be connected to at least one instrument, in particular for carrying out in vitro diagnostics, such as, for example, a measuring device, a heating element, a mechanical actuator or a pump.
- the fluidic card according to the invention may for example be used in association with a connection device as described in the international application WO 2012/136943 A1, previously commented on.
- the fluidic card may comprise complex means, for example a biochip or a reaction chamber.
- the fluidic card may have dimensions similar or similar to the dimensions of a credit card. Its thickness may be sufficient to contain at least one fluidic channel, and possibly a fluidic network (comprising several fluidic channels).
- the length and / or the width of the fluidic card may be between a few centimeters and a few decimetres, for example between 1 cm and 10 cm, or even 20 cm.
- the thickness of the fluidic card may be between a few millimeters and a few centimeters, for example between, on the one hand, 1 mm or 5 mm and, on the other hand, 1 cm or 2 cm.
- the subject of the invention is, according to another of its aspects, an assembly, characterized in that it comprises a fluidic card as defined above and a card support, able to allow the deformation of the flexible film and on which the fluidic card is intended to be plated.
- the fluidic card can thus be placed on the card support, and the card support can constitute an external means for controlling the valve of the card fluidic, and in particular the deformation of the flexible film placed on the opening of the fluidic channel of the fluidic card.
- the fluidic card has an outer surface and that the flexible film is disposed on this outer surface can allow the actuation of the flexible film by the card holder, separate from the card, when the fluidic card is disposed on the outer surface of the card holder.
- the card holder is then adapted to receive a plurality of similar fluidic cards, each card being placed on the card holder, and then removed when the operation is performed.
- the external surfaces of the fluidic card and the card support are substantially parallel to each other.
- the flexible film may be disposed on the surface of the fluidic card after etching of fluidic channels in the card, the latter opening to the outer surface of the card.
- the flexible film then constitutes a wall of these fluidic channels formed in the card. It also allows the closing or opening of a fluid channel when it is deformed by an external actuating means.
- the card support may comprise means for actuating the valve of the fluidic card, in particular a fluidic control channel opening on the surface of the card support in which a pressure fluid, in particular a gas, is able to circulate in order to allow the deformation of the flexible film of the fluidic card.
- a pressure fluid in particular a gas
- the fluidic card in order to enable the control of the valve of the fluidic card, or in other words the deformation of the flexible film covering the opening of the fluidic channel of the fluidic card, the fluidic card must be placed on the card support so as to allow a substantial alignment of the fluidic channel with the fluidic channel for controlling the card support.
- a fluid, in particular a gas, flowing in the fluidic control channel can exert a pressure, more or less strong depending on the desired opening intensity of the valve, on the flexible film in order to control the opening of the the valve. It is thus possible to manage via the fluid projected on the flexible film the passage from the open position to the closed position of the flexible film, and vice versa.
- a fluid can prevent damage to the flexible film, and can help limit the disadvantages described above in connection with the use of mechanical parts for actuating the valve.
- pressurized fluid especially pressurized gas
- the flexible film remains in its rest position (i.e. without deformation) and the valve is fully open.
- the card support may include a groove formed on the surface of the card support, and a pressure seal placed in the groove.
- the throat may be annular.
- the pressure seal may be annular (or toric).
- the pressure seal can locate the pressure applied to the flexible film facing the fluidic channel of the fluidic card.
- the seal may facilitate the alignment of the fluidic control channel vis-à-vis the fluidic channel of the fluidic card and may facilitate the plating of the fluidic card on the card support.
- the pressure seal may extend outwardly of the fluid flow channel of the fluidic channel opening when the fluidic card is in place on the card carrier.
- the subject of the invention is also a method for controlling at least one valve of a fluidic card implemented by means of an assembly as defined above, the valve consisting of association of the flexible film and the opening of the fluidic channel of the fluidic card of the assembly, in which the control of the valve is achieved by varying the pressure of the fluid flowing in the fluidic pressure channel of the card support which comes into contact with the flexible film to allow deformation.
- control method according to the invention may comprise any of the previously mentioned characteristics, taken separately or in any technically possible combination with other characteristics.
- FIG. 1 represents, in perspective, an example of a fluidic card
- FIGS. 2A and 2B show, in perspective, an exemplary device according to the prior art for connecting a fluidic card to one or more instruments, respectively without and with the presence of the fluidic card,
- FIG. 3 represents, in partial section, an example of a fluidic card according to the invention
- FIG. 4 represents, in perspective and partially, a detail of a variant of a fluidic card according to the invention.
- FIG. 5 shows, in partial section, an exemplary assembly according to the invention comprising a fluidic card and a card holder.
- FIGS. 1, 2A and 2B have already been described previously in the part relating to the prior art.
- FIGS. 3 and 4 show exemplary embodiments of fluidic card 1 according to the invention
- FIG. 5 an exemplary embodiment of an assembly according to the invention comprising a fluidic card 1 and a card holder 2. .
- the fluidic card 1 comprises a rigid support 105 made in a single block and a fluidic channel 103 formed in the thickness of the rigid support 105.
- the fluidic channel 103 has an opening 102 formed on the outer surface S of the rigid support 105, and the fluidic card 1 further comprises a flexible film
- outer surface refers to the fact that the surface constitutes a boundary delimiting the inside of the map from the outside.
- the fluidic card 1 is substantially parallelepipedal. It then comprises two parallel outer surfaces, a lower surface and an outer surface, distant from a distance generally less than 5 cm, and most often 1 cm. These external surfaces are connected by a curved perpendicular surface constituting the edge of the card.
- the opening 102 has for example a round shape and extends along its largest dimension corresponding to its width L substantially parallel to the flexible film 100.
- the flexible film 100 may extend over the entire outer surface S of the rigid support 105, or only partially. In any case, the flexible film 100 extends at least over the opening 102 of the fluidic channel 103.
- the flexible film 100 is intended to be deformed between a closed position in which it allows the closing of the fluidic channel 103 so as to prevent a fluid flow from the fluidic channel 103 through the opening 102 and an open position in which it allows the presence of a flow space E, visible in FIG. 5, of the fluid of the fluidic channel 103 through the opening 102.
- the combination of the flexible film 100 and the opening 102 of the fluidic channel 103 constitutes a valve of the fluidic card 1.
- the deformation of the flexible film 100 in particular by means of external means, in particular pneumatic, as described herein. - after referring to Figure 5, can allow the control of this valve.
- the fluidic card 1 comprises a closure seal 101 which is disposed between the flexible film 100 and the opening 102 of the fluidic channel 103.
- the closure seal 101 is for example a flat seal, and it allows a support on the opening of the fluid channel 103 during the deformation of the flexible film 100 to the closed position.
- closure seal 101 and the flexible film 100 have not been shown in a juxtaposed manner for the sake of clarity. Nevertheless, advantageously, the closure seal 101 is fixed to the flexible film 100, especially by gluing. In particular, the fixing of the closure seal 101 to the flexible film 100 is carried out so that the closure seal 101 is placed opposite the fluidic channel 103.
- the opening 102 of the fluid duct 103 may comprise a boss 106 formed all around the fluidic channel 103.
- the boss 106 thus produced may serve as support for the closure seal 101 during the deformation of the flexible film 100 to the closed position.
- the opening 102 may further comprise a flow channel 107 of the fluidic channel 103 fluid allowing the flow of the fluid leaving the fluidic channel 103 in the open position of the flexible film 100.
- the boss 106 and the flow channel 107 may be made by machining the rigid support 105 of the fluidic card 1.
- the boss 106 may thus constitute an annular relief around the fluidic channel 103, and the flow channel 107 of the outgoing fluid of the fluidic channel 103 may be constituted by a bowl extending all around the boss 106.
- FIG. 4 shows an exemplary embodiment of a fluidic card 1 according to the invention (without the presence of the flexible film 100 or the closure seal 101), which illustrates the possibility of having another fluidic channel 103 'of the fluidic card 1 into which the flow channel 107 opens.
- This other fluid channel 103' can be formed on the rigid support 105, for example by machining, so as to extend along its largest dimension substantially parallel to the flexible film 100.
- the flexible film 100 is a wall of the longitudinal fluid channel 103 ', the term "longitudinal" designating that the channel extends parallel to the outer surface S.
- the fluidic card 1 may comprise at least one longitudinal fluid channel 103 ', produced by etching or molding, or by any other method, opening on the external surface S of the card.
- the flexible film 100, deposited on said outer surface S then constitutes a wall of the fluidic channel 103 ', while allowing, during its deformation, the opening and closing of a transverse fluidic channel 103.
- transverse designates the fact that the axis of the channel is according to the thickness of the card 1, that is to say whose axis is not parallel to the external surfaces S, S '.
- the flexible film 100 serves as a wall for a longitudinal channel 103 ', and a valve for a transverse channel 103.
- FIG. 5 shows an exemplary assembly according to the invention comprising a fluidic card 1 and a card support 2, able to allow the deformation of the flexible film 100 and on which the fluidic card 1 is intended to be plated. .
- the fluidic card 1 of the assembly of FIG. 5 may for example be such as that represented in FIG. 3 or that represented in FIG. 4.
- the card support 2 comprises a control fluid channel 104 which opens on the surface S 'of the card support 2 in which a pressure fluid, and in particular a pressure gas, is able to circulate to allow the deformation of the flexible film 100 of the fluidic card 1.
- the sending of a pressurized gas in the fluidic control channel 104 to make contact with the flexible film 100 allows the control of the valve of the fluidic card 1, and allows, by variation of the intensity of the the pressure exerted by the gas on the film 100, the transition from an open position to the closed position of the flexible film 100, and vice versa.
- the card support 2 further comprises a groove 108, in particular an annular groove, formed on the surface S 'of the card support 2.
- a pressure seal 109 is placed in this groove 108.
- the pressure seal 109 can make it easier to position the fluidic card 1 with respect to the card support 2 so that an alignment is made between the fluidic channel 103 and the control fluid channel 104.
- the method of controlling the valve of the fluidic card 1 by means of the assembly described with reference to FIG. 5, consists in varying the pressure of the gas flowing in the fluidic pressure channel 104 of the card support 2 this gas comes into contact with the flexible film 100 so as to allow the deformation of the flexible film 100 and the closure or a variation of the degree of opening of the fluidic channel 103.
- the flexible film 100 being disposed on the outer surface of the card, this makes it possible to control the deformation of the film 100 by actuating means carried on the card support 2, and not inside the card 1.
- the same card holder 2 can drive different cards of the same type, in turn applied to the support 2.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1354950A FR3006207A1 (fr) | 2013-05-30 | 2013-05-30 | Carte fluidique comportant un canal fluidique pourvu d'une ouverture refermable par un film souple |
PCT/EP2014/061179 WO2014191519A1 (fr) | 2013-05-30 | 2014-05-28 | Carte fluidique comportant un canal fluidique pourvu d'une ouverture refermable par un film souple |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3003557A1 true EP3003557A1 (fr) | 2016-04-13 |
Family
ID=48980087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14732827.2A Ceased EP3003557A1 (fr) | 2013-05-30 | 2014-05-28 | Carte fluidique comportant un canal fluidique pourvu d'une ouverture refermable par un film souple |
Country Status (4)
Country | Link |
---|---|
US (1) | US10086371B2 (fr) |
EP (1) | EP3003557A1 (fr) |
FR (1) | FR3006207A1 (fr) |
WO (1) | WO2014191519A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3040141B1 (fr) | 2015-08-20 | 2020-02-14 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Carte fluidique comportant au moins une vanne fluidique |
WO2018104516A1 (fr) * | 2016-12-08 | 2018-06-14 | Danmarks Tekniske Universitet | Soupape microfluidique |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010073020A1 (fr) * | 2008-12-24 | 2010-07-01 | Heriot-Watt University | Système et procédé microfluidiques |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5628411A (en) * | 1994-12-01 | 1997-05-13 | Sortex Limited | Valve devices for use in sorting apparatus ejectors |
US5863502A (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US20020015959A1 (en) * | 2000-06-23 | 2002-02-07 | Bardell Ronald L. | Fluid mixing in microfluidic structures |
GB0028647D0 (en) | 2000-11-24 | 2001-01-10 | Nextgen Sciences Ltd | Apparatus for chemical assays |
DE10202996A1 (de) * | 2002-01-26 | 2003-08-14 | Eppendorf Ag | Piezoelektrisch steuerbare Mikrofluidaktorik |
WO2004061085A2 (fr) * | 2002-12-30 | 2004-07-22 | The Regents Of The University Of California | Procedes et appareil pour la detection et l'analyse d'agents pathogenes |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
NL1031465C2 (nl) * | 2006-03-30 | 2007-10-03 | C2V B V | Werkwijze voor het opbouwen van een inrichting met fluïdische en elektrische functies. |
FR2973720B1 (fr) | 2011-04-08 | 2016-02-26 | Commissariat Energie Atomique | Dispositif de connexion d'une carte microfluidique |
-
2013
- 2013-05-30 FR FR1354950A patent/FR3006207A1/fr active Pending
-
2014
- 2014-05-28 US US14/893,209 patent/US10086371B2/en active Active
- 2014-05-28 EP EP14732827.2A patent/EP3003557A1/fr not_active Ceased
- 2014-05-28 WO PCT/EP2014/061179 patent/WO2014191519A1/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010073020A1 (fr) * | 2008-12-24 | 2010-07-01 | Heriot-Watt University | Système et procédé microfluidiques |
Non-Patent Citations (1)
Title |
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See also references of WO2014191519A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014191519A1 (fr) | 2014-12-04 |
US10086371B2 (en) | 2018-10-02 |
FR3006207A1 (fr) | 2014-12-05 |
US20160121328A1 (en) | 2016-05-05 |
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