EP2892510A4 - Bolaamphiphilic compounds, compositions and uses thereof - Google Patents
Bolaamphiphilic compounds, compositions and uses thereofInfo
- Publication number
- EP2892510A4 EP2892510A4 EP13834981.6A EP13834981A EP2892510A4 EP 2892510 A4 EP2892510 A4 EP 2892510A4 EP 13834981 A EP13834981 A EP 13834981A EP 2892510 A4 EP2892510 A4 EP 2892510A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- bolaamphiphilic compounds
- bolaamphiphilic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261696789P | 2012-09-04 | 2012-09-04 | |
PCT/US2013/057956 WO2014039501A1 (en) | 2012-09-04 | 2013-09-04 | Bolaamphiphilic compounds, compositions and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2892510A1 EP2892510A1 (en) | 2015-07-15 |
EP2892510A4 true EP2892510A4 (en) | 2016-06-01 |
Family
ID=50237566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13834981.6A Pending EP2892510A4 (en) | 2012-09-04 | 2013-09-04 | Bolaamphiphilic compounds, compositions and uses thereof |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2892510A4 (en) |
AU (4) | AU2013312908A1 (en) |
CA (2) | CA2883784C (en) |
IL (3) | IL237541B (en) |
WO (1) | WO2014039501A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3283060A4 (en) * | 2015-04-16 | 2018-12-19 | Lauren Sciences LLC | Bolaamphiphilic compounds, compositions and uses thereof |
KR20220044816A (en) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | Lipids for charge mass transfer, formulations thereof, and methods for preparing the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005521645A (en) * | 2001-12-04 | 2005-07-21 | ベン グリオン ユニバーシティ オブ ザ ネジェブ リサーチ アンド ディベラップメント オーソリティ | Amphiphilic compounds and vesicles / liposomes for organ-specific drug targeting |
EP1845943A2 (en) * | 2005-01-03 | 2007-10-24 | Ben Gurion University of the Negev Research and Development Autority | Nano- and mesosized particles comprising an inorganic core, process and applications thereof |
CA3056405C (en) | 2009-05-04 | 2021-11-09 | Bengurion University Of The Negev Research And De | Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery |
-
2013
- 2013-09-04 WO PCT/US2013/057956 patent/WO2014039501A1/en active Application Filing
- 2013-09-04 AU AU2013312908A patent/AU2013312908A1/en not_active Abandoned
- 2013-09-04 CA CA2883784A patent/CA2883784C/en active Active
- 2013-09-04 EP EP13834981.6A patent/EP2892510A4/en active Pending
- 2013-09-04 CA CA3233929A patent/CA3233929A1/en active Pending
-
2015
- 2015-03-03 IL IL237541A patent/IL237541B/en active IP Right Grant
-
2018
- 2018-06-06 AU AU2018203992A patent/AU2018203992B2/en active Active
-
2019
- 2019-07-07 IL IL267888A patent/IL267888B/en active IP Right Grant
-
2020
- 2020-05-27 AU AU2020203496A patent/AU2020203496B2/en active Active
-
2021
- 2021-01-20 IL IL280316A patent/IL280316B/en unknown
-
2022
- 2022-01-27 AU AU2022200494A patent/AU2022200494A1/en active Pending
Non-Patent Citations (2)
Title |
---|
PAOLINO ET AL: "Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 353, no. 1-2, 28 November 2007 (2007-11-28), pages 233 - 242, XP022513723, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2007.11.037 * |
POPOV MARY ET AL: "Site-directed decapsulation of bolaamphiphilic vesicles with enzymatic cleavable surface groups", JOURNAL OF CONTROLLED RELEASE, vol. 160, no. 2, 29 December 2011 (2011-12-29), pages 306 - 314, XP028926636, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2011.12.022 * |
Also Published As
Publication number | Publication date |
---|---|
AU2022200494A1 (en) | 2022-02-24 |
CA3233929A1 (en) | 2014-03-13 |
IL237541B (en) | 2019-07-31 |
AU2018203992A1 (en) | 2018-06-21 |
AU2013312908A1 (en) | 2015-03-26 |
CA2883784C (en) | 2024-05-14 |
WO2014039501A1 (en) | 2014-03-13 |
IL280316B (en) | 2021-08-31 |
IL267888A (en) | 2019-09-26 |
AU2020203496B2 (en) | 2021-10-28 |
EP2892510A1 (en) | 2015-07-15 |
AU2018203992B2 (en) | 2020-02-27 |
IL280316A (en) | 2021-03-01 |
AU2020203496A1 (en) | 2020-06-18 |
IL237541A0 (en) | 2015-04-30 |
IL267888B (en) | 2021-02-28 |
CA2883784A1 (en) | 2014-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20150407 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20160504 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 9/51 20060101AFI20160428BHEP Ipc: A61K 38/18 20060101ALI20160428BHEP Ipc: A61K 9/133 20060101ALI20160428BHEP Ipc: A61P 25/28 20060101ALI20160428BHEP Ipc: A61P 25/16 20060101ALI20160428BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20180125 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |