EP2861522A1 - Appareil et procédé permettant de fournir des liquides bénéfiques à une vitesse régulière - Google Patents

Appareil et procédé permettant de fournir des liquides bénéfiques à une vitesse régulière

Info

Publication number
EP2861522A1
EP2861522A1 EP13804772.5A EP13804772A EP2861522A1 EP 2861522 A1 EP2861522 A1 EP 2861522A1 EP 13804772 A EP13804772 A EP 13804772A EP 2861522 A1 EP2861522 A1 EP 2861522A1
Authority
EP
European Patent Office
Prior art keywords
water
chamber
membrane
filter
extraction chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13804772.5A
Other languages
German (de)
English (en)
Inventor
John Gordon
Ashok Joshi
Truman Wold
Sai Bhavaraju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ceramatec Inc
Original Assignee
Ceramatec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/523,015 external-priority patent/US20120267389A1/en
Application filed by Ceramatec Inc filed Critical Ceramatec Inc
Publication of EP2861522A1 publication Critical patent/EP2861522A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12—Apparatus, e.g. holders, therefor
    • A61L9/127—Apparatus, e.g. holders, therefor comprising a wick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/10—Apparatus features
    • A61L2209/11—Apparatus for controlling air treatment

Definitions

  • This invention relates to apparatus and methods for delivering beneficial liquids such as fragrances, deodorizers, sanitizers, pesticides and pest repellants at a steady rate for extended time periods using an osmotic pump and where the source of water for the osmosis typically is not continuously refreshed.
  • beneficial liquids such as fragrances, deodorizers, sanitizers, pesticides and pest repellants
  • an osmagent is contained in a variable volume container that in part includes a semipermeable membrane and also communicates with a container containing a beneficial agent through a flexible diaphragm, piston, or such.
  • a semipermeable membrane Upon activation, the semipermeable membrane is exposed to a source of water. Water flows through the semipermeable membrane into the osmagent container, expanding the volume, which in turn forces the beneficial agent to be expelled.
  • the devices are implanted into the body of an animal or human where the body is the source of water. In other cases, the water is supplied from a reservoir contained in the device.
  • Herbig et al. in U.S. Patent No. 5,798,119 disclosed a device used for delivering fluids such as fragrances and insecticides. They use a hydrophobic microporous separator to separate an osmagent from liquid water. Water vapor passes through the hydrophobic membrane from the liquid water to the osmagent, increasing the volume where the osmagent is located. The volume increase drives the delivery of the beneficial agent.
  • a disadvantage of this approach is that water vapor pressure is very temperature dependant. For example, water vapor pressure is 20X higher at 50°C compared to 0°C.
  • the vapor pressure at 10°C is 56 percent lower than at 23°C and at 44°C the vapor pressure is 326 percent higher than at 23 °C.
  • temperature variations will have a very large impact on the dispense rate with this type of system which is very undesirable in most cases.
  • a disadvantage of these membranes is that while they are substantially semipermeable, they still have permeability to many potential osmagents. As a result, the osmagent can permeate into the water container as well as water diffusing into the osmagent container. While the diffusion of osmagent is small, the effect over time can be very large when the volume of water contained is near the same amount of liquid to be dispensed and especially if the time scale of delivery is long. As osmagent diffuses into the water container, the driving force for diffusion of water across the semipermeable membrane is reduced and the delivery rate declines over time.
  • Chen et al. in U.S Patent No. 6,923,800 disclose osmotically driven devices where the devices are implanted into the body of an animal or man where the water is supplied by the body and where the concentration of the water near the semipermeable membrane remains nearly the same over time due to the active nature of the body. Wong et al. describe the use of "cellulosic polymers such as cellulose acetate, ethyl cellulose, methylcellulose, cellulose acetate butyrate, cellulose acetate propionate, blends of impermeable material and hydrophilic polymer or a molecular weight water soluble enhancer to render the material semipermeable.” Chen et al. on the other hand disclose using polyurethane materials which are somewhat permeable to water for low rate devices.
  • the invention has been developed in response to the present state of the art and, in particular, in response to the problems and needs in the art that have not yet been fully solved by currently available apparatus and methods. Accordingly, the invention has been developed to provide apparatus and methods to provide controlled delivery of beneficial agents at a consistent rate. The features and advantages of the invention will become more fully apparent from the following description and appended claims, or may be learned by practice of the invention as set forth hereinafter.
  • an apparatus for providing controlled delivery of a beneficial agent includes a water chamber and a filter to produce filtered water by removing impurities from water introduced into the water chamber.
  • a water-transporting membrane transports filtered water from the water chamber to an extraction chamber, thereby expanding the extraction chamber.
  • the extraction chamber contains an osmagent that provides the driving force to pull the filtered water through the water-transporting membrane.
  • a dispensing chamber containing a beneficial agent contracts. This causes the beneficial agent to be expelled through a port in communication with the dispensing chamber.
  • a method for providing controlled delivery of a beneficial agent includes receiving water into a water chamber and filtering the water to produce filtered water.
  • the filtered water may then be transported through a water- transporting membrane into an extraction chamber.
  • the extraction chamber contains an osmagent that provides the driving force to pull the filtered water through the water-transporting membrane.
  • the method further comprises contracting a dispensing chamber in response to expanding the extraction chamber. Contracting the dispensing chamber causes a beneficial agent to be dispensed from the dispensing chamber.
  • Figure 1 is a cutaway view of one embodiment of an apparatus in accordance with the invention.
  • Figure 1A is a cutaway view of a portion of the housing of Figure 1;
  • Figure IB is a cutaway view of a portion of the diaphragm of Figure 1;
  • Figure 2 is a top view of a first component of the rate adjustment mechanism of Figure 1;
  • Figure 3 is a top view of a second component of the rate adjustment mechanism of Figure 1;
  • Figure 4 is a graph showing an amount of liquid dispensed over a twenty day period for six devices in accordance with the invention with different membrane areas exposed;
  • Figure 5 is a graph showing the same data illustrated in Figure 4 expressed in terms of an incremental delivery rate over time
  • Figure 6 is a graph showing the delivery rate of three devices in accordance with the invention, where each device was operated at a different temperature
  • Figure 7 is a cutaway view showing one example of a filter incorporated into an apparatus in accordance with the invention.
  • Figure 8 is a cutaway view showing another example of a filter incorporated into an apparatus in accordance with the invention.
  • Figure 9 is a graph showing an amount of liquid dispensed over a twenty-eight day period for three devices using filtered (distilled) water;
  • Figure 10 is a graph showing the same data illustrated in Figure 9 expressed in terms of an incremental delivery rate over time;
  • Figure 11 is a graph showing an amount of liquid dispensed over a twenty-eight day period for three devices using filtered (distilled) water compared to three devices using non-filtered (tap) water;
  • Figure 12 is a graph showing the same data illustrated in Figure 11 expressed in terms of an incremental delivery rate over time.
  • the invention has been developed in response to the present state of the art and, in particular, in response to the problems and needs in the art that have not yet been fully solved by currently available devices for delivering liquid beneficial agents such as fragrances, deodorizers, sanitizers, pesticides, and pest repellants.
  • Such devices either suffer from a decline in delivery performance over time to the point that the benefits are no longer rendered or when the devices are active and have acceptable performance, the devices are complex in nature which results in high cost.
  • the invention has been developed to provide novel apparatus and methods for delivering liquid beneficial agents to target areas in a controlled and predictable manner and where impact of temperature variation is minimal.
  • FIG. 1 schematically shows one embodiment of a device 1 for delivering a beneficial agent 2.
  • the beneficial agent 2 is in container 3 of substantially rigid walls with the exception of a flexible bellows 4 or diaphragm 4 that enables the volume of the container 3 to contract.
  • An ion exchange membrane 5 separates the flexible bellows 4 from the water 9 containing chamber 8.
  • a first adjustment member 6a has openings 7 (not shown).
  • the membrane 5 may be obscured or an increasingly greater area of the membrane 5 may be exposed to the water 9 upon activation.
  • a mass of osmagent (not shown), is located between the flexible bellows 4 and the membrane 5.
  • the bellows 4 preferably comprises or is coated by materials of low water permeability such as metal or barrier polymer such as metalized PET (polyethylene terephthalate), Halar, PCTFE (polychlorotrifluoroethylene).
  • metal or barrier polymer such as metalized PET (polyethylene terephthalate), Halar, PCTFE (polychlorotrifluoroethylene).
  • Other polymers with relatively low water permeability include HDPE (high density polyethylene), PP (polypropylene), PEEK (polyetheretherketone), PET and FEP (fluorinated ethylene propylene).
  • a wick may transport the beneficial agent 2 away from the port 10 and up the side walls of the device 1 so the beneficial agent 2 may more readily evaporate.
  • the device is housed in a structure with a base 14 and a hanger 13 to provide multiple sites where the device can be located in a space such as a room.
  • the water container 8 has a vent 12 with a hydrophobic microporous film that allows air to enter the water container 8 as water 9 transports across the membrane 5.
  • the water container 8 could have a flexible wall or a piston such that the volume diminishes as the water 9 transports out of the container 8.
  • Figure 1 shows just one embodiment of the invention.
  • the apparatus 1 could also be constructed such that the beneficial agent 2 is contained within a pouch or flexible bag that becomes compressed as water 9 transports into the zone between the membrane 5 and the flexible bellows 4.
  • the bellows 4 could be replaced with a flexible diaphragm or piston such that an expansion zone containing the osmagent receives the water 9 transporting across the membrane 5 and mechanically forces the beneficial agent 2 to be expelled from the apparatus 1.
  • an apparatus to provide controlled delivery of a beneficial agent includes a water chamber, a water-transporting membrane in communication with the water collection chamber, an extraction chamber to receive water through the water-transporting membrane and into the extraction chamber, thereby expanding the extraction chamber, an osmagent in the extraction chamber, a dispensing chamber containing a beneficial agent and contracting in response to expanding the extraction chamber, and a port in communication with the dispensing chamber to deliver the beneficial agent.
  • an apparatus to provide controlled delivery of a beneficial agent includes a water chamber, a water-transporting membrane in communication with the water collection chamber where the membrane has a membrane feature that repels one or more osmagent constituents, an extraction chamber to receive water through the water-transporting membrane and into the extraction chamber, thereby expanding the extraction chamber, an osmagent in the extraction chamber, a dispensing chamber containing a beneficial agent and contracting in response to expanding the extraction chamber, and a port in communication with the dispensing chamber to deliver the beneficial agent.
  • the osmagent repelling feature or structure of the membrane may be a functional group on the surface of the membrane, and may be of the class including a quaternary ammonium group or a sulfonate group, or a combination thereof.
  • the osmagent repelling feature or structure of the membrane in one embodiment is a charged functional group within the membrane.
  • the charged functional group within the membrane may be of the class including a sulfonate or a quaternary ammonium, or combinations thereof.
  • the membrane of the apparatus may be an ion exchange membrane.
  • the ion exchange membrane in one embodiment may be chosen from the class consisting of an anion exchange membrane or a cation exchange membrane.
  • the ion exchange membrane has a polymer structure.
  • the ion exchange membrane polymer structure may be one fluoropolymer or styrene divinyl benzene, or combinations thereof.
  • the ion exchange membrane may be chosen from the class consisting of Nafion by Dupont; Neosepta CMX, AMX, QMS, CMB, AHA, ACM, ACS, AFN, AFX by ASTOM Corporation; Selemion by Asahi Glass, or combinations thereof.
  • the osmagent may be a salt. In one embodiment, the osmagent comprises at least one of ammonium and phosphate.
  • the apparatus includes an extraction chamber and a dispensing chamber that may be separated by a flexible diaphragm, piston, or other displacement member.
  • the flexible diaphragm comprises or is coated with a low water permeable material.
  • the low water permeable material may be a metal, a metal coated polymer such as metalized PET (polyethylene terephthalate), Halar, PCTFE (polychlorotrifluoroethylene), HDPE (high density polyethylene), PP (polypropylene), PEEK (polyetheretherketone), PET, FEP (fluorinated ethylene propylene) or combinations thereof.
  • the apparatus in one embodiment may be configured such that at least one of the extraction chamber and the dispensing chamber is at least partially contained within a pouch.
  • the pouch may comprise or be coated with a low or negligible water-permeable material.
  • the low or negligible water permeable material may be a metal, a metal-coated polymer such as metalized PET (polyethylene terephthalate), Halar, PCTFE (polychlorotrifluoroethylene), HDPE (high density polyethylene), PP (polypropylene), PEEK (polyetheretherketone), PET, FEP (fluorinated ethylene propylene) or combinations thereof.
  • the beneficial agent includes a fragrance.
  • the apparatus may further comprise a circuit to regulate electrical current flowing through the water-transporting membrane, thereby regulating water flowing through the water-transporting membrane into the extraction chamber.
  • the apparatus may further comprise a rate adjustment mechanism to control the rate at which water is received through the water-transporting membrane.
  • the rate adjustment mechanism may be a blind which obscures the water chamber from the water transporting membrane with varying degree.
  • the apparatus may include a water container that comprises a flexible wall such that the volume changes as water transports across the membrane.
  • the water container may include a vent to allow gas to enter the container as water transports across the membrane.
  • the water container comprises a moveable wall.
  • a method for delivering a beneficial agent is also disclosed.
  • the method may include the steps of collecting water into a water chamber, transporting the water through a water-transporting membrane into an extraction chamber containing an osmagent, thereby expanding the extraction chamber, dispensing a beneficial agent from a dispensing chamber in response to expanding the extraction chamber, and delivering the beneficial agent.
  • Expanding the extraction chamber may include deflecting a flexible diaphragm or moving a piston or other displacement member.
  • the flexible diaphragm may comprise or be coated with a material with low or negligible water permeability.
  • the material with low or negligible water permeability may be a metal, a metal coated polymer such as metalized PET (polyethylene terephthalate), Halar, PCTFE (polychlorotrifluoroethylene), HDPE (high density polyethylene), PP (polypropylene), PEEK (polyetheretherketone), PET, FEP (fluorinated ethylene propylene) or combinations thereof.
  • the water-transporting membrane may be in communication with the water chamber and the membrane may have a membrane feature that repels one or more osmagent constituents.
  • FIG. 1A a close up view of the container 8 is shown having a wicking layer 11 that extends down an outside surface of the container 8 to the port 10 of the device 1.
  • the wicking layer 11 or wick 11 may transport the beneficial agent 2 away from the port 10 and up the side walls of the device 1 so the beneficial agent 2 may more readily evaporate.
  • a flexible bellows 4 or diaphragm 4 that enables the volume of the container 3 to contract as fluid passes through the membrane 5.
  • the bellows 4 preferably comprises or is coated by materials of low water permeability such as metal or barrier polymer such as metalized PET (polyethylene terephthalate), Halar, or PCTFE (polychlorotrifluoroethylene).
  • a first adjustment member 6a includes openings 7 radially extending from a midpoint of the first adjustment member 6a.
  • a second adjustment member 6b includes an opening 27.
  • the openings 7 and 27 in respective members 6a and 6b are placed adjacent to each other in the device 1 such that as adjustment member 6a is rotated relative to adjustment member 6b, more or less of the openings 7 and 27 overlap to allow water 9 to access the membrane 5 in different quantities. This in turn affects the rate at which the beneficial agent 2 is dispensed from the device 1.
  • FIG. 4 Six devices in accordance with the invention were constructed using Neosepta CMB ion exchange membrane from Astom Corporation. Two of the devices had 0.342 square centimeters of membrane exposed between an osmagent consisting of saturated ammonium phosphate dibasic and water. Two other devices had 0.519 square centimeters of membrane exposed between an osmagent consisting of saturated ammonium phosphate dibasic and water. Two additional devices had 1.026 square centimeters of membrane exposed between an osmagent consisting of saturated ammonium phosphate dibasic and water. Upon activation, the devices delivered beneficial agent approximately in proportion to the area of membrane exposed and at a steady rate as shown.
  • FIG. 6 Three devices where constructed according to the teachings of the present invention with a Neosepta CMB membrane and ammonium phosphate dibasic osmagent.
  • the exposed membrane area in each of the devices was approximately 10 square centimeters.
  • One device was operated at 10°C, another at
  • the delivery rate over time is shown in Figure 6.
  • the rate of the device operated at 44°C was approximately 83 percent of the rate of the device operated at 24°C while the rate of the device operated at 10°C was approximately 52 percent of the rate of the device operated at 24°C.
  • filtered water may significantly improve the operation of the device 1. This is because unfiltered water may contain impurities that may impair the operation of the device over time. For example, over time, impurities (particulate matter, dissolved matter, etc.) may become lodged in or deposited on the membrane 5 to restrict the flow of water therethrough. Thus, even if a desired concentration gradient is maintained across the membrane 5, the flow of water across the membrane 5 may diminish over time. This, in turn, will change the rate that the beneficial agent 2 is dispensed from the device 1 over time. If the device 1 is dispensing a fragrance, for example, the fragrance will be dispensed in diminishing amounts, thereby decreasing the effectiveness of the device 1 over time.
  • impurities particle matter, dissolved matter, etc.
  • filtered water within the device 1 to provide a more consistent release rate over time.
  • requiring use of filtered water may be disadvantageous since filtered water may not always be readily available, or may incur additional expense to acquire.
  • tap water or other unfiltered water is readily available at little or no cost.
  • FIG. 7 shows one embodiment of a device 1 incorporating a filter 30.
  • the filter 30 includes a perforated structural member 34 and filter media 32.
  • the perforated structural member 34 provides physical support to the filter media 32, while the filter media 32 provides most if not all of the filtering capability.
  • the perforated structural member 34 retains the filter media 32 within the device 1 as opposed to physically supporting the filter media 32.
  • the perforated structural member 34 provides both a physical support and a retention function.
  • the filter media 32 may filter water added to the device 1 using various different filtering mechanisms, including but not limited to physical straining, chemical absorption, and ion-exchanging.
  • the filter media 32 contains activated carbon to remove contaminants and impurities by way of chemical absorption.
  • the carbon may be activated with a positive charge in order to attract negatively charged impurities.
  • Activated carbon may be effective to remove organics and non-polar molecules from water, in addition to absorbing chemicals such as chlorine, although it is less effective at removing minerals, salts, and dissolved inorganic compounds.
  • other filtering layers or constituents may be added to the filter 30 to aid in removing minerals, salts, and dissolved inorganic compounds from the water.
  • the perforated structural member 34 also performs a filtering function.
  • the perforated structural member 34 is a microporous structure that physically strains the water.
  • the perforated structural member 34 is a microporous ceramic structure that physically strains the water in addition to providing a structural support to and/or retention of the filter media 32.
  • the perforated structural member 34 is used to provide mechanical support to or retain a microporous membrane such as a microporous ceramic membrane.
  • the perforated structural member 34 and filter media 32 are combined into a single layer.
  • the filter media 32 could be incorporated into a composite of sufficient mechanical strength that no additional support or retention mechanism is needed.
  • the filter media 32 includes multiple layers. For example, certain layers could remove impurities using chemical absorption, while other layers could remove particulate matter by physical sieving. Other layers could remove unwanted impurities using an ion-exchange process.
  • all or part of the filter 30 is replaceable.
  • one or more of the perforated structural member 34 and the filter media 32 may be replaceable.
  • the filter 30 is permanently affixed within the device 1. In such embodiments, the filter 30 may be intended to last the lifetime of the device 1 and be discarded with the device 1 when the lifetime has expired.
  • the placement of the filter 30 within the device 1 may vary.
  • the filter 30 is placed adjacent to the water-transporting membrane 5.
  • the water chamber 8 contains mostly unfiltered water.
  • the filter 30 is provided at or near an inlet 12 (in this embodiment, the vent 12 previously described may also function as an inlet 12 to fill the device 1 with water).
  • tap water may be poured through a filter 30 separate from the device 1 , and then added to the device 1.
  • Other locations for the filter 30 are possible and within the scope of the invention.
  • Figure 9 is graph showing an amount of liquid dispensed over a twenty-eight day period for three devices in accordance with the invention using filtered (distilled) water. As shown, the amount of fluid transferred stayed remarkably consistent over time for each of the devices (as indicated by the linearity of the graphs).
  • Figure 10 is a graph showing the same data illustrated in Figure 9 expressed in terms of incremental delivery rate over time. As can be observed from Figure 10, the fluid transfer rate was remarkably consistent over the twenty-eight day period for each of the devices when filtered water was used.
  • Figure 11 is a graph showing an amount of liquid dispensed over a twenty-eight day period for three devices using filtered (distilled) water, and three devices using non- filtered (tap) water.
  • the solid lines represent the devices using filtered water and the dashed lines represent the devices using unfiltered water.
  • the amount of fluid dispensed by the devices using unfiltered water was significantly less than the amount of fluid dispensed by the devices using filtered water, most likely due to the clogging of the water-transporting membranes over time.
  • Figure 12 is a graph showing the same data illustrated in Figure 11 expressed in terms of incremental delivery rate over time. As can be observed from Figure 12, the fluid transfer rate diminished over time for each of the devices using unfiltered water, whereas the fluid transfer rate stayed remarkably consistent for each of the devices using filtered water.

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

La présente invention a trait à un appareil (1) permettant de procéder à une fourniture contrôlée d'un agent bénéfique (2). Selon un mode de réalisation, cet appareil (1) inclut une chambre à eau (8) et un filtre permettant de produire de l'eau filtrée grâce au retrait des impuretés de l'eau qui est introduite dans la chambre à eau. Une membrane de transport d'eau transporte l'eau filtrée de la chambre à eau (8) jusqu'à une chambre d'extraction, ce qui permet de la sorte de développer la chambre d'extraction. La chambre d'extraction contient un agent osmotique qui offre la poussée permettant d'amener l'eau filtrée à travers la membrane de transport d'eau. A mesure que la chambre d'extraction se développe, une chambre de délivrance contenant un agent bénéfique (2) se contracte. Ceci permet à l'agent bénéfique d'être expulsé par l'intermédiaire d'un orifice (10) qui est en communication avec la chambre de délivrance. La présente invention a également trait à un procédé correspondant.
EP13804772.5A 2012-06-14 2013-06-06 Appareil et procédé permettant de fournir des liquides bénéfiques à une vitesse régulière Withdrawn EP2861522A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/523,015 US20120267389A1 (en) 2008-04-10 2012-06-14 Apparatus and method for delivering beneficial liquids at a consistent rate
PCT/US2013/044417 WO2013188199A1 (fr) 2012-06-14 2013-06-06 Appareil et procédé permettant de fournir des liquides bénéfiques à une vitesse régulière

Publications (1)

Publication Number Publication Date
EP2861522A1 true EP2861522A1 (fr) 2015-04-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP13804772.5A Withdrawn EP2861522A1 (fr) 2012-06-14 2013-06-06 Appareil et procédé permettant de fournir des liquides bénéfiques à une vitesse régulière

Country Status (2)

Country Link
EP (1) EP2861522A1 (fr)
WO (1) WO2013188199A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
ES2378675T3 (es) * 1997-12-30 2012-04-16 Intarcia Therapeutics, Inc Sistema de suministro de un agente beneficioso con una membrana obturadora
US7378015B2 (en) * 2003-12-18 2008-05-27 The Clorox Company Filtered water enhancements
US7658156B2 (en) * 2008-04-10 2010-02-09 Microlin, Llc, A Utah Limited Liability Company Apparatus and method for delivering beneficial agents to subterranean locations
JP2012501233A (ja) * 2008-08-28 2012-01-19 ミクロリン・エルエルシー 有益薬剤を一定速度で送出するための装置および方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2013188199A1 *

Also Published As

Publication number Publication date
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