EP2841148A1 - Piercing-like refillable drug feeding device - Google Patents
Piercing-like refillable drug feeding deviceInfo
- Publication number
- EP2841148A1 EP2841148A1 EP13720237.0A EP13720237A EP2841148A1 EP 2841148 A1 EP2841148 A1 EP 2841148A1 EP 13720237 A EP13720237 A EP 13720237A EP 2841148 A1 EP2841148 A1 EP 2841148A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- hollow body
- closure
- feeding device
- tissue
- longitudinal end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/41—Devices for promoting penis erection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/04—Access sites having pierceable self-sealing members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
- A61M5/3291—Shafts with additional lateral openings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M2039/0036—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use characterised by a septum having particular features, e.g. having venting channels or being made from antimicrobial or self-lubricating elastomer
- A61M2039/0081—Means for facilitating introduction of a needle in the septum, e.g. guides, special construction of septum
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0261—Means for anchoring port to the body, or ports having a special shape or being made of a specific material to allow easy implantation/integration in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0264—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body with multiple inlets or multiple outlets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/027—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body having a particular valve, seal or septum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0276—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body for introducing or removing fluids into or out of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0282—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body with implanted tubes connected to the port
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0288—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body protectors, caps or covers therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0291—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body method or device for implanting it in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/16—Male reproductive, genital organs
- A61M2210/167—Penis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2250/00—Specially adapted for animals
Definitions
- the invention relates to a device for delivering an active substance, in particular into the tissue of a living human or animal, comprising an elongated hollow body having a first longitudinal end and a second longitudinal end, wherein the hollow body comprises a radially outer circumferential conversion, which surrounds a radially inner, elongated cavity ,
- Such devices for delivering a drug into the body of a living human or animal are already known in the art.
- these are devices whose hollow body is tube-like, wherein the cavity extends continuously from the first to the second longitudinal end of the hollow body.
- Such hollow bodies are, for example, as a hollow needle, also called “cannula”, formed and are usually used to inject by means of a hollow cylinder and a piston syringe containing an active ingredient in the tissue to be treated or directly into the bloodstream of the human or animal.
- cannula also called “cannula”
- Another example are so-called “catheters”.
- These are tubes or tubes of various diameters, with which hollow organs, such as bladder, vessels, etc., can be probed, emptied, filled or rinsed.
- catheters that are suitable for a longer residence time in the body, with a longer residence time of a stay of several days or even longer is to be understood, but such catheters have several disadvantages in practice.
- the permanently secure fixation without restricting the freedom of movement of the person concerned, often an unsolved problem.
- the elongate hollow body of such a catheter is adhered to the skin around the puncture site with a suitable adhesive.
- a suitable adhesive there is a risk that germs remain under the splice and can multiply there. This in turn, if the germs then penetrate the puncture site in the body, lead to serious infections.
- a particular field of application of drug delivery devices, with which the present invention is particularly concerned, relates to the treatment of erectile dysfunction in men.
- potentiators such as Sildenafil, better known under the trade name Viagra ® of the US company Pfizer, which can be taken to produce an erection orally, but there are persons in which such orally administered Potency - for whatever reason - do not achieve the desired effect or cause unwanted side effects. These persons are then often dependent to inject a corresponding drug directly into the penis, in particular directly into at least one erectile tissue of the same.
- the aforementioned device for supplying an active ingredient wherein the peripheral wall of the hollow body between the two longitudinal ends has at least one active substance outlet opening.
- the at least one active substance outlet opening makes it possible to place the delivery device in the body of the human or animal to be treated such that both the first longitudinal end and the second longitudinal end of the hollow body are arranged extracorporeally, whereas a section of the hollow body arranged between these two longitudinal ends, which has the at least one active substance outlet opening, is arranged intracorporeally.
- the feeder can easily remain permanently, at least in sections, in the body. An always again to be performed puncturing of the skin is not necessary. Rather, the active ingredient may be repeatedly supplied to the human or animal body via the delivery device.
- a material failure of the delivery device at an intracorporeal point is largely unproblematic in the delivery device according to the invention, since both longitudinal ends outside the body are placed and thus can be pulled out individually in different directions when breaking the hollow body.
- the at least one active substance outlet opening preferably passes through the circumferential wall of the hollow body between the two longitudinal ends of the hollow body in the radial direction.
- the at least one active substance outlet opening can be designed, for example, as a substantially circular or oval or slot-shaped through hole in the circumferential wall of the hollow body of the feeding device.
- the hollow body may have substantially the shape of a straight circular hollow cylinder. This is particularly advantageous when the Hohlzyl indians is made of a metal or other relatively solid material, which is to be performed in a straight line through the corresponding body part, for example.
- the penis it is also possible for me that the hollow body has a different shape. It may for example be made of a relatively flexible, elastic material, such as a correspondingly soft plastic, so that it is elastically deformable.
- the hollow space extends continuously from the first to the second longitudinal end of the hollow body.
- the elongated cavity starting from one of the two longitudinal ends of the hollow body, although extending into the hollow body, but ends before reaching the opposite longitudinal end of the hollow body, similar to a blind hole.
- the second longitudinal end of the hollow body can be made correspondingly more stable, for example as a solid profile.
- the feeding device according to the invention is tube-like, wherein the cavity extends continuously from the first to the second longitudinal end of the hollow body.
- the active ingredient can optionally be supplied to the human or animal body via the first longitudinal end or the second longitudinal end of the hollow body.
- this embodiment has the advantage that for the placement of the hollow body in human or animal tissue, a puncture needle can be used, which is passed through the lumen of the hollow body, and the hollow body when piercing the human or animal tissue, eg. The penis, with takes itself and leads through the tissue.
- the piercing needle can at the same time give the hollow body stability during the placement process, which is particularly important when the hollow body is made of a relatively soft material, for example a flexible plastic.
- the hollow body has a plurality of active substance outlet openings. This can also be achieved that the active ingredient in human or animal tissue better distributed, so that the desired effect can be achieved faster or more efficient.
- the hollow body has at least two active substance outlet openings, namely one for each of the two penile erectile tissue.
- the hollow body has four active substance outlet openings, namely two for each penile swelling body, since in this case there is redundancy for each penile swelling body.
- each active substance outlet opening reduces the structural stability of the peripheral wall of the hollow body to some extent.
- the hollow body has a plurality of active substance outlet openings
- the Feeding device further comprises at least one closure assembly, preferably two closure assemblies, which is attached to a respective longitudinal end of the hollow body and / or attachable or are to seal the cavity at the respective longitudinal end of the hollow body.
- the at least one closure arrangement should be suitable for allowing the delivery of an active substance from outside the delivery device into the cavity. In order to ensure this, it may be necessary in the short term to forego the aforementioned tightness to prevent the ingress of bacteria or other pathogens.
- At least one of the at least one closure assembly is releasably connected, or connectable, in particular by means of a screw connection to the hollow body.
- “releasable” means that the connection can be made and removed repeatedly without destroying a material cohesion that can only be restored with the aid of ancillary means
- the said closure arrangement can be repeatedly screwed onto the hollow body in a simple manner and removed again for the delivery of the active substance from the hollow body.
- At least one, preferably both, of the at least one closure arrangement may be insoluble, in particular by means of a gluing device. Connection, is connected to the hollow body or are.
- "Undetachable" in this context means that in order to release the connection of the closure arrangement from the hollow body, a material cohesion must be irreversibly separated, which can only be restored with auxiliary means, such as by re-application of an adhesive agent, however, since it is generally unpractical, after each intended use of the drug delivery device according to the invention, the closure assembly using aids again to connect to the hollow body, in particular in those cases in which the closure assembly is permanently connected to the hollow body, proposed that the corresponding closure assembly is suitable, the supply of an active ingredient allow, even if the closure assembly remains connected to the hollow body.
- At least one of the at least one closure arrangement may comprise a closure means suitable for opening and reclosing.
- This closure means may e.g. be formed in the form of a closure cap, which may be formed either integrally with the remaining closure assembly, for example by means of a hinge, in particular a hinge joint, in particular a film hinge joint, or as a separate component thereof.
- a portion of the closure assembly may include an external thread and a separately formed closure cap a complementarily shaped female threaded portion, similar to the valve closure of a bicycle tire.
- At least one of the at least one closure assembly comprises an elastic body, for example grafting, which is suitable to be pierced with a pointed needle in order to insert an active substance into the interior of the body Hollow body to introduce, and which is suitable, due to its elastic properties, to close the cavity at the corresponding longitudinal end of the hollow body again when the needle is pulled out.
- an elastic body for example grafting
- a pointed needle in order to insert an active substance into the interior of the body Hollow body to introduce, and which is suitable, due to its elastic properties, to close the cavity at the corresponding longitudinal end of the hollow body again when the needle is pulled out.
- the elastic body may, at least in sections, be surrounded by a metallic ring, which gives it structural support and provides the hypodermic needle with a certain guidance It is particularly advantageous in this case if the metallic ring is funnel-shaped and tapers toward the hollow space of the hollow body in order to move the tip of the injection needle, with which the active substance can be introduced into the cavity of the supply device, toward the cavity of the supply device.
- the user of the feed device according to the invention has a surface area for applying the injection needle available, which can be formed significantly larger than the cross-sectional area orthogonal to the longitudinal extension direction of the elongated hollow body cavity.
- a connecting piece could be provided on at least one closure arrangement which can be coupled to a correspondingly complementary counterpart fitting of an applicator containing the active substance, for example in the manner of a bayonet closure.
- a pipette instead of a syringe with an injection needle, similar to when taking nasal drops, in particular when the delivery device according to the invention has a correspondingly large funnel for receiving the pipette end.
- the feed device according to the invention comprises a pointed or sharp-edged projection, which is preferably concealed, as long as the access to the interior of the hollow body is closed by a closure arrangement at one of the longitudinal ends of the hollow body.
- a projection could be used to intentionally destroy the shell of a suitably designed drug reservoir locally, so that a quantity, preferably a precisely predetermined amount, of active ingredient can escape from the reservoir into the interior of the hollow body.
- a closure arrangement could comprise or receive a rubber ball or the like serving as a drug reservoir, or else be formed essentially of itself.
- the rubber ball or the like can then be pressed, for example, by a firm pressure against a sharp or sharp-edged projection of the device in order to allow a predetermined amount of active substance to escape in a targeted manner into the interior of the hollow body.
- a man who uses the delivery device according to the invention in potency problems in the region of its member bring the drug inconspicuous and uncomplicated when needed for use, without having to handle syringe and injection needle. Replacing the destroyed drug reservoir with a new, intact drug reservoir may then occur at a later time in preparation for the next sexual act.
- closure arrangements are in this case to be designed so that they allow, preferably by the targeted application of pressure, to reliably open the drug reservoirs, for example by being bursted.
- the active substance reservoirs it would also be possible for the active substance reservoirs to have a predetermined breaking point which is designed such that the active substance reservoirs open solely by applying a correspondingly dimensioned pressure, without it being necessary to provide a pointed or sharp-edged projection on the feeding device according to the invention for this purpose the drug reservoir is to be pressed.
- the delivery device according to the invention is used to supply a male enhancer drug, for example alprostadil or prostaglandin E1 or a mixture comprising papaverine HCL, phentolamine mesilate, and prostavasin
- a male enhancer drug for example alprostadil or prostaglandin E1 or a mixture comprising papaverine HCL, phentolamine mesilate, and prostavasin
- an overreaction may occur in which the erected limb no longer swells in an acceptable time. This is for the person concerned on the one hand very unpleasant and on the other hand can also lead to serious damage to the vessels, if no timely countermeasures are taken.
- the addition of a corresponding antidote or antidote comes into consideration as a countermeasure.
- the delivery device according to the invention can thus comprise a plurality of different active substances in spatially separate reservoirs.
- At least one, preferably all, of the at least one closure arrangement in the radial direction of the hollow body further extends radially outward or extend than the hollow body, in particular as a located between the two longitudinal ends of the hollow body portion of the hollow body.
- each having a longitudinal end of the hollow body associated closure assemblies have a corresponding radial dimension, it can be reliably ensured that the feeder can slip out of the pierced body part neither in one direction, nor in the other direction.
- the peripheral wall has a minimum, or substantially constant over the entire length, outer diameter in the radial direction which is> 0.26 mm, preferably between 0.26 mm and 0.9 mm, for example 0.4 mm.
- Catheters or cannulas which are already known in medical technology are generally normalized in terms of their size, in particular with regard to their outer diameter, the size being frequently indicated in gauge (G).
- G 20 corresponds to an outer diameter of 0.9 mm
- G 27 corresponds to an outer diameter. diameter of 0.4mm
- G 33 an outer diameter of 0.26mm.
- the outside diameter of the hollow body to be guided through the corresponding body part of the human or animal should be as small as possible in order to allow the simplest possible and painless passage.
- the outer diameter should be sufficiently large to give the hollow body sufficient structural stability and / or to allow the flow of the required minimum amount of active ingredient in a given period of time.
- peripheral walls having an outer diameter of between 0.26 mm and 0.9 mm are generally preferred, in particular if the delivery device is intended for use in the treatment of potency problems in the area of the male member in humans.
- the circumferential conversion may of course also have a different outer diameter, in particular a significantly larger outer diameter.
- the outer diameter of the hollow body is up to 2 cm in size, or even greater in exceptional cases.
- the at least one active substance outlet opening at least at the transition to the outer surface of the peripheral wall, be rounded and / or provided with a chamfer. The smoother this region is, the fewer injuries are to be expected in the case of a relative movement of the delivery device to the tissue into which it is introduced.
- the feeding device when used as intended, comprise a hollow body whose length is at least as great as the width of the erected member at the location where the feeding device has been made by it.
- the length of the hollow body should not be excessively larger, since the overhanging portions could otherwise be disturbing. Since the diameter of the erected member may be different, it may be considered to provide the delivery device with hollow bodies of different, predetermined lengths.
- the hollow body has a maximum length of ⁇ 200 mm, preferably of ⁇ 90 mm, more preferably of ⁇ 70 mm, even more preferably of ⁇ 50 mm.
- a length of the hollow body of up to 200mm is more important in the field of veterinary medicine. It should be pointed out again at this point that the possible field of application of the delivery device according to the invention is not limited to the treatment of potency problems.
- the length of the hollow body of the delivery device individually to the physical conditions of the patient.
- the hollow body for example, formed from a suitably flexible material, it could be thought to store this rolled up on a roll and, depending on the desired length pieces to separate if necessary. Care should be taken in the determination of the length of the hollow body in any case that even with maximum displacement of the hollow body relative to the penetrated by the hollow body part exit of the at least one active substance outlet opening from the body part does not take place to minimize the risk of infection.
- biocompatible materials can be selected, for example, from: niobium, palladium and titanium.
- the active ingredient delivery device according to the invention is used in the field of animal husbandry and / or veterinary medicine
- the present invention also has the advantage that a re-injection or repeated introduction of drugs or hormones is also possible by personnel who are not specially trained in medical practice. This can be saved to a considerable extent costs that otherwise a veterinarian and possibly additionally, for example, for holding the animal, required auxiliary staff for repeated injections into account.
- the animal to be treated may not need to be anesthetized several times, thus resulting in a reduction in the supply of narcotic drugs and a reduction in the risk of side effects.
- the invention relates to a method for arranging the delivery device according to the invention in the tissue of a human or an animal in order to inject an active substance into the tissue, comprising the following step: a) puncturing the tissue with a puncture needle, wherein at the same time the hollow body of the Feeding device is guided through the tissue, so that both Longitudinal ends of the hollow body are arranged outside the tissue, whereas a lying between the two longitudinal ends of the hollow body portion, which preferably has at least one active substance outlet opening, is arranged in the tissue.
- the piercing needle when the hollow body is formed like a tube, wherein the cavity extends continuously from the first to the second longitudinal end of the hollow body, are performed through the cavity of the hollow body, so that a tip of the piercing needle from the one Longitudinal end of the hollow body protrudes before the piercing needle is guided together with the hollow body through the tissue of the human or animal.
- the delivery device according to the invention is designed to be durable, i. Over months, if not years, to dwell in the body of the human or animal without further punctures being necessary during this time, it is not disproportionate effort to have the unique arrangement of the delivery device according to the invention carried out by medically trained personnel.
- an imaging method in particular an ultrasound imaging method, be used during step a) to ensure the correct arrangement of the hollow body, and in particular of the at least one active substance outlet opening, in the tissue ,
- the cavity extends continuously from the first to the second longitudinal end of the hollow body, which is tubular, wherein before step a) the piercing needle has been guided through the tubular hollow body, so that a pointed longitudinal end of the piercing needle protrudes at a longitudinal end of the hollow body.
- step a) further comprises the following step: b) withdrawing the piercing needle from the hollow body, without substantially changing the position of the hollow body relative to the tissue.
- the surrounding of the peripheral wall of the hollow body lumen is free again and allows the delivery of the drug from an extracorporeal source to the intracorporeally arranged drug outlet opening.
- step a) If the tissue is a male member, with the arrangement of the delivery device preferably taking place near the root of the limb, it is proposed for the purpose of the above-mentioned individual adaptation of the length of the hollow body to the anatomical conditions of the patient that the method according to step a), and optionally after step b), further comprising the following steps:
- step a), and optionally after step b), and preferably also after step c) and d), also the following step includes:
- the invention relates to a method for delivering a drug into the tissue of a human or animal using the method of the invention Feeding device according to the invention, which has preferably been arranged in tissue according to the previously described arrangement method, comprising the following step:
- the delivery method may include the following steps:
- closure assembly is a previously described releasable closure assembly:
- Fig. 1 is a cross-sectional view through a male member through which a drug delivery device of the present invention is performed;
- Figure 2a a cross-sectional view of a first embodiment of a on a
- FIG. 2b shows a cross-sectional view of a variant of the first embodiment according to FIG.
- Figure 2a wherein the variant comprises a receptacle for a drug reservoir and a sharp-edged projection for selectively destroying the drug reservoir;
- Figure 3 a cross-sectional view of a second embodiment of a on a
- Figure 4 a cross-sectional view of a third embodiment of a on a
- Figure 5 a cross-sectional view of a fourth embodiment of a on a
- Figure 6 a cross-sectional view of a fifth embodiment of a on a
- FIG. 7 shows a cross-sectional view of an active substance outlet opening
- Figure 1 shows a non-scale, schematic cross-sectional view of a male member G, wherein the sectional plane is substantially orthogonal to the longitudinal direction of the member G and in the region of the root.
- an outer skin H of the member G can be seen, which includes two penile erectile tissue PSK1 and PSK2, as well as a urethra Schwelk I body HSK surrounds.
- the urethral swelling body HSK in turn surrounds a urethra HR.
- a septum S is arranged between the two Penisschwell stressesn PSK1 and PSK2 .
- An embodiment of the feeding device 10 according to the invention extends through the member G.
- this comprises an elongated hollow body 12 having a first longitudinal end 14 and a second longitudinal end 1 6.
- the hollow body in turn comprises a radially outer axis X with respect to the longitudinal extension axis X.
- the hollow body 12 is formed substantially tubular, wherein the elongated cavity 20 extends continuously from the first longitudinal end 14 to the second longitudinal end 16.
- the circumferential wall 18 in this exemplary embodiment has a plurality of active ingredient outlet openings 22.
- the peripheral wall 18 of the hollow body 12 has four active substance outlet openings 22 which are arranged in such a way that two active substance delivery openings 10 are placed in the first membered penile body PSK1 in the limb-placed state of the active ingredient delivery apparatus 10, whereas the other two Outlet openings 22 are arranged in the second penile swelling body PSK2.
- a single active substance outlet opening 22 would be sufficient in one of the two penile body PSK 1 and PSK 2, there Starting from the one active substance outlet opening 22, the active substance would be distributed independently in both penile cavernous bodies PSK1 and PSK2.
- the Providing a plurality of active substance outlet openings 22, however, has the advantage that the distribution is accelerated ungsrea and thus faster the desired effect can be caused.
- the provision of a plurality of active substance outlet openings 22 offers the advantage that the failure safety of the active ingredient delivery device according to the invention can be increased since the device 10 is still functional even if one or more active substance outlet openings 22 have been added over time, as long as at least one active substance outlet opening 22, starting from one of the two longitudinal ends 14, 16 of the hollow body 12 is accessible.
- the feeding device 10 according to the invention is intended in particular for permanent use, ie for use over several months, if not even years or decades, high reliability is of increased importance.
- the feed device 10 shown in FIG. 1 comprises at both longitudinal ends 14, 16 of the hollow body 12 a closure arrangement 30 shown only extremely schematically, wherein different embodiments of the closure arrangement 30 will be explained in more detail below with reference to FIGS.
- the two closure arrangements 30 are arranged at the two longitudinal ends 14, 16 of the hollow body 12 in such a way that they allow germs, bacteria or other pathogens to penetrate from outside the delivery device 10 into the cavity 20, and thus into the skin H of the limb G surrounding tissues, can prevent.
- the closure arrangements 30, as will be explained in more detail below are designed such that they allow a delivery of an active substance, in the present application in particular a liquid power means, from an extracorporeally stored active substance source into the cavity 20 of the device 10.
- a syringe provided with an injection needle can be used to introduce the active ingredient into the cavity 20 of the delivery device 10, from where the active ingredient is then passed to the drug outlet openings 22 and from there into the tissue can penetrate, ie in the present application in the two penile bodies PSK1 and PSK2.
- the two closure arrangements 30 have a diameter, ie a radial dimension with respect to the longitudinal extension axis X of the hollow body 12 of the feed device 10, which is significantly larger than the corresponding radial dimension of the hollow body 12 , or its peripheral wall 18, is formed in the present case substantially in the form of a straight circular hollow cylinder.
- the placement of the hollow body 12 in the tissue, ie in the present case in the member G, preferably takes place in a state in which at least one, preferably both, closure arrangements 30 are not yet connected to the hollow body 12.
- a long, pointed piercing needle is guided through the elongated cavity 20 of the hollow body 12, so that the tip of the piercing needle at one of the two longitudinal ends 14, 16 of the hollow body 12th protrudes.
- the piercing needle possibly using a suitable auxiliary means, together with the hollow body 12 through the tissue, ie in the present case the member G, are stung, the hollow body 12 is placed in the tissue such that its two longitudinal ends 14, the first 6 protrude from the tissue, while a disposed between the two longitudinal ends 14, 1 6 section, which has the at least one active substance outlet opening 22, is disposed within the tissue.
- the piercing needle can be pulled out of the hollow body to free the cavity 20 again. It is important to ensure that the relative position of the hollow body 12 does not change substantially in relation to the tissue.
- a respective closure arrangement 30 can be arranged at the two longitudinal ends 14, 16 of the hollow body.
- the closure arrangements 30, as described above have a larger radial dimension than the hollow body 12, they prevent the hollow body 12 from slipping unintentionally out of the tissue, ie in the present case the limb G.
- This provision is for the continuous use of the feeding device according to the invention of great advantage, as in other similar devices, such as so-called. Venous indwelling, there is always the risk of slipping out, especially if the person concerned moves a lot.
- the feeding device 10 according to the invention can, similar to a Intimate piercing, reliably permanently in the tissue to which an active ingredient is to be supplied, are kept.
- the diameter of the limb G can vary depending on the person concerned. Therefore either drug delivery devices can be used with hollow bodies of different clothing size, or it can be thought to customize the length of the hollow body 12 depending on the anatomical conditions. The latter can either be done before the placement of the hollow body 1 2 in the limb G, or the adaptation can, preferably by medically trained staff, which makes the placement, take place only after the placement.
- the hollow body 12 has a length in the axial direction X, which is significantly greater than the required length, which measures according to the diameter of the member G at the corresponding point in the excited state. In such a case, it is possible to shorten the hollow body 12 after placement in the member G either on one side or on both sides to the required length.
- the hollow body 12 when the hollow body 12 is substantially formed of a metallic material, it can be visualized well with conventional imaging techniques, such as ultrasonics. Such an imaging method may be used during placement of the hollow body 1 2 in the member G in particular to ensure that the at least one active substance outlet opening 22 is placed optimally with respect to the penile erectile tissue PSK1 and PSK2.
- the at least one active substance outlet opening 22 should be spaced from the longitudinal ends 14, 16 of the hollow body 1 2 in such a way that, even with a maximum displacement along the extension direction X of the hollow body 12 relative to the limb in the slackened state, the at least one active substance Outlet opening 22 from the member G, preferably also from the respective penile swelling body PSK 1 and PSK2, is reliably prevented in order to prevent penetration of germs or the like via the at least one active substance outlet opening 22.
- the schematic cross-sectional view shown in Figure 1 shows the male member G in a moderately erected state, in which the arranged at the two longitudinal ends 14, 16 of the hollow body 12 closure arrangements are still significantly spaced from the skin H of the member G.
- these closure arrangements may also abut the skin H, but they should exert substantially no pressure on the limb G.
- the delivery device is preferably arranged in the region of the root of the limb G in order not to disturb the sexual intercourse.
- the hollow body 12 when the hollow body 12 is made substantially of a metallic material, it is advantageous if the dimensions of the hollow body 12 in the radial direction are relatively small, ie of preferably ⁇ 0.9 mm, so that the hollow body 12 in a simple manner, eg ., with the help of pliers, can be cut, similar to a protruding wire of a dental bracket.
- the outer diameter of the hollow body should be at least 0.26 mm.
- the hollow body 12 of the delivery device 10 should preferably be made of a biocompatible, suitable for continuous use in the appropriate tissue material. In particular materials come into consideration, as they are known, for example, from the piercing area.
- FIG. 2 a shows a schematic cross-sectional view of a first embodiment of a closure arrangement 30 a arranged at a longitudinal end of the hollow body 12.
- the closure arrangement 30 a comprises a ball-like closure body 32, in which a blind hole 34 is provided.
- the blind hole 34 includes an internally threaded portion 36 which is complementary to an outer threaded portion 38 provided at the corresponding longitudinal end of the hollow body 12.
- the closure body 32 in a simple manner repeatedly connected to the hollow body 12, or be solved by this, to introduce an active ingredient in the cavity 20 of the hollow body 12, or otherwise to prevent pathogens in the cavity 20th can penetrate.
- the hollow body 12 is closed in order to prevent the active substance from emerging at this longitudinal end and thus to ensure that the active ingredient has at least one active substance -Eritts- opening 22 passes into the tissue to be treated.
- the round shape of the ball-like closure body 32 reduces the risk of injury or the risk that the wearer of the delivery device 10 has an unpleasant feeling. Furthermore, it is conceivable to design the closure body 32 similar to a piece of jewelry, so that the delivery device 10 according to the invention is similar to a piercing.
- closure arrangement 30b provides the illustrated in Figure 3 second embodiment of a closure assembly 30b.
- the closure arrangement 30 further comprises a hollow-cylindrical sleeve element 42 whose inner diameter substantially corresponds to the outer diameter of the circumferential wall 18 at the corresponding longitudinal end of the hollow body 12, so that the sleeve element 42 is pushed over the longitudinal end of the hollow body 12, at least in sections can.
- the sleeve element 42 can then be permanently connected to the circumferential wall 18 of the hollow body 12, preferably with the aid of a bond K.
- the sleeve element 42 can be connected to the tissue, in particular the member G, only after the corresponding longitudinal end of the hollow body 12 has been made .
- the closure element 40 has an internally threaded portion 44, which is designed to be complementary to an externally threaded portion 46 provided on the sleeve element 42.
- the closure member 40 can be repeatedly connected to the sleeve member 42 - and thus with the hollow body 12 - or be released therefrom to allow the delivery of an active ingredient in the cavity 20 of the hollow body 12, and otherwise the ingress of pathogens reliably prevent.
- sealing means between the sleeve member 42 and the closure member 40 may be provided, such as, for example, a sealing ring or the like.
- the two previously described embodiments 30a, 30b of the closure arrangement are characterized in that the corresponding closure element 32 or 40 can be completely separated from the hollow body 12.
- this entails the risk that the closing element 32, 40 released from the hollow body during the delivery of the active substance may be lost or accidentally dropped and thereby contaminated.
- a third embodiment of a closure arrangement 30c shown in FIG. 4 it is proposed to permanently connect a corresponding closure element 50 to a corresponding sleeve element 48 by means of a hinge device 52.
- the closure member 50 can be opened and closed like a cap without being lost.
- the sleeve element 48 shown in the embodiment 30c substantially corresponds to the sleeve element 42 shown in FIG.
- the hinge or hinge 52 may, for example, be designed as a film hinge, in particular if the sleeve element 48 and the closure element 50 are made of plastic.
- the sleeve member 48, the closure member 50 and the hinge point 52 may be made integral.
- the embodiment of the closure arrangement 30c shown in FIG. 4 furthermore has an annular sealing element 54, which reliably prevents the penetration of germs or others Pathogens in the cavity 20 of the hollow body 12 prevented when the cap-like closure member 50 is closed.
- FIG. 30d A fourth embodiment of a closure arrangement 30d is shown in FIG.
- a sleeve member 56 which may be connected to the peripheral wall 18 of the hollow body 12 as in the two previously described embodiments, widens in a funnel shape towards its free longitudinal end.
- the funnel-shaped portion of the sleeve member 56 is thereby blocked with an elastic closure element 58, preferably in the form of a rubber stopper.
- the rubber stopper prevents the penetration of germs or other pathogens into the cavity 20 of the hollow body 12.
- the rubber stopper 58 allows the penetration or penetration of a pointed cannula of a syringe, with the aid of an active ingredient in the cavity 20 of the hollow body 12 can be injected , Due to the elastic properties of the closure element 58, this self-closing again as soon as the cannula is pulled out.
- the handling of such a closure arrangement 30d is thus very simple.
- the funnel-shaped widening portion of the sleeve member 56 facilitates the insertion of the cannula, since the surface into which can be inserted, is significantly larger than the cross-sectional area - orthogonal to the longitudinal direction X - of the cavity 20 of the hollow body 12th
- FIG. 6 shows another embodiment of a closure assembly 30e similar to that of FIG.
- the funnel-shaped widening section is formed integrally with the circumferential wall 18 of the hollow body 12.
- this funnel-shaped widening section is closed by means of an elastic closure element 62, which may be formed as an elastic rubber stopper.
- a feeding device 10 can only have a closure arrangement 30e shown in FIG. 6 at one of the two longitudinal ends 14, 16 of the hollow body 12, since, due to its large radial diameter, it is not suitable for being guided through the fabric, in particular a limb G.
- At the opposite longitudinal end of the hollow body 12 can after the placement of the hollow body 12 in the tissue, for example, one of the darg Congressen in Figures 3 to 5 closure arrangements 30b, 30c, 30d.
- Figure 7 shows a schematic, also greatly enlarged cross-sectional view of a located between the two longitudinal ends 14, 16 of the hollow body portion having an active substance outlet opening 22.
- the active substance outlet opening 22 passes through the circumferential wall 18 of the hollow body 12 in a substantially radial direction.
- the transition region 64 of the active substance outlet opening 22 to the outer surface of the peripheral wall 18 of the hollow body 12 is rounded, i. free of sharp corners and edges.
- the peripheral wall 18 could also have a chamfer at this point. This has the advantage that, when the hollow body 12 is passed through the tissue to be treated of a human or animal, for example a limb, there are no or fewer injuries.
- the feeding device 10 is characterized in particular by the fact that it is suitable for long-term or long-term use, so that in cases in which repeatedly at more or less regular intervals, a supply of active ingredients is necessary, the skin is not always again to puncture to deliver the drug from an extracorporeal source to an intracorporeal destination.
- FIG. 2b shows a variant of the first embodiment shown in FIG. 2a.
- Functionally identical or similar components or component sections have the same reference numerals in FIG. 2b as in FIG. 2a; It is therefore with regard to these components or component sections referred to the above description of Figure 2a.
- the substantially spherical closure body 32 of the closure arrangement 30a has a blind hole 34 which is longer than the blind hole 34 of the first embodiment shown in FIG. 2a and which is thus suitable as a receptacle 34 (only dashed in FIG. 2b) which is indicated)
- the drug reservoir 80 may be, for example, a substantially elastically formed sheath (similar to an air balloon) that is filled with the drug to be administered, for example a sexual enhancer, or a corresponding antidote.
- the drug reservoir 80 may have, for example, the basic shape of a ball which adapts to the cylindrical contour of the receptacle 34 when it is inserted into the drug reservoir receptacle 34, or the drug reservoir 80 may already have a substantially cylindrical basic shape that corresponds to the contour of the Recording 34 is tuned. In the latter case, the elasticity of the drug reservoir 80 is only of minor importance.
- a groove 1 3 is provided radially inwardly on the illustrated longitudinal end of the hollow body 12.
- a plate 70 is inserted and preferably fixedly connected to the hollow body 12, for example by gluing.
- the plate 70 has at least one through-hole 72.
- the plate 70 may have four through holes 72 evenly distributed around a center of the substantially circular plate 70.
- the through-holes 72 serve to pass the active substance to be applied from an extracorporeal source, namely the active substance reservoir 80, to the active substance outlet openings 22 provided in the hollow body 12.
- the plate 70 includes a sharp-edged projection 74.
- this pointed projection 74 is formed in the form of a spike extending from the center of the plate 70 toward the drug reservoir 80. It should be noted, however, that the pointed or sharp-edged projection could also be designed differently, e.g. It is only important that the projection extends towards the drug reservoir 80 to achieve the following desired effect:
- the sharp projection 74 comes into contact the drug reservoir 80 and destroys this purposefully.
- the precisely predetermined amount of active substance contained in the drug reservoir 80 escape from this and through the through ⁇ holes 72 in the plate 70, the cavity 20 of the hollow body 12 and provided in the hollow body 12 drug outlet openings 22 to the Schwel I stressesn PSK1, PSK2 of the limb G arrive there and develop the desired effect.
- the plate 70 prevents that the destroyed shell of the deflated drug reservoir 80 can also get into the cavity 20 of the hollow body 12. Rather, the shell remains in the receptacle 34 of the closure body 32 and can be easily removed by the user and, if necessary, be replaced by an intact drug reservoir 80.
- a drug reservoir receptacle and a sharp-edged projection can also be provided in the previously described devices according to FIGS. 3 and 4.
- the closure body may, for example, be designed similar to the proximal end of a typical nose drop pipette.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Nursing (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13720237.0A EP2841148A1 (en) | 2012-04-24 | 2013-04-19 | Piercing-like refillable drug feeding device |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12002873 | 2012-04-24 | ||
PCT/EP2013/001170 WO2013159889A1 (en) | 2012-04-24 | 2013-04-19 | Piercing-like refillable drug feeding device |
EP13720237.0A EP2841148A1 (en) | 2012-04-24 | 2013-04-19 | Piercing-like refillable drug feeding device |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2841148A1 true EP2841148A1 (en) | 2015-03-04 |
Family
ID=48289011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13720237.0A Withdrawn EP2841148A1 (en) | 2012-04-24 | 2013-04-19 | Piercing-like refillable drug feeding device |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150126868A1 (en) |
EP (1) | EP2841148A1 (en) |
CN (1) | CN104334228A (en) |
HK (1) | HK1207999A1 (en) |
WO (1) | WO2013159889A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110404144B (en) * | 2019-07-16 | 2023-10-31 | 中山大学附属第五医院 | Positioning device for penile drug injection |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5370613A (en) * | 1993-02-11 | 1994-12-06 | Helmy; Ali M. | Catheter apparatus for delivering drugs to the penis |
US6773428B2 (en) * | 2000-05-12 | 2004-08-10 | Stephen M. Zappala | Implantable delivery system and method for the pharmacologic management of erectile dysfunction |
DE10243917A1 (en) * | 2002-09-20 | 2004-04-01 | Udo Dr. Auweiler | Device for subcutaneous delivery of a pharmaceutical product is introducible through the skin so that its subcutaneous part contains a system for controlled release of the product |
US9750874B2 (en) * | 2008-10-10 | 2017-09-05 | Peter Forsell | Stimulation of penis erection |
-
2013
- 2013-04-19 EP EP13720237.0A patent/EP2841148A1/en not_active Withdrawn
- 2013-04-19 WO PCT/EP2013/001170 patent/WO2013159889A1/en active Application Filing
- 2013-04-19 US US14/394,283 patent/US20150126868A1/en not_active Abandoned
- 2013-04-19 CN CN201380021413.1A patent/CN104334228A/en active Pending
-
2015
- 2015-09-04 HK HK15108644.6A patent/HK1207999A1/en unknown
Non-Patent Citations (1)
Title |
---|
See references of WO2013159889A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN104334228A (en) | 2015-02-04 |
US20150126868A1 (en) | 2015-05-07 |
HK1207999A1 (en) | 2016-02-19 |
WO2013159889A1 (en) | 2013-10-31 |
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