EP2823798A1 - Device for combining substances, in particular for reconstituting injection solutions - Google Patents

Abstract

The device (1) has a housing (2) and a flexible bag arranged in the housing for receiving a liquid. In the housing, a dispensing device, in particular a syringe (5) is also arranged such that it can be removed from the housing. A transfer channel (6) serves for the direct or indirect transfer of the liquid from the bag into the dispenser. In addition, at least one pressable against the bag pressure plate (7) for squeezing the bag is provided. The pressure plate is preferably activated via a spring mechanism (16), which serves as an energy store. The device according to the invention makes it possible to prepare an injection liquid with little manipulation and to supply it to the injection syringe, wherein the combining of the substances proceeds largely automatically.

Description

The invention relates to a device for combining substances, in particular for the reconstitution of injection solutions. Such devices are needed, for example, for injection solutions whose ingredients are not storable in a mixed form, so that, for example, a lyophilized drug is mixed with a solvent before administration and then drawn into a syringe.

Numerous devices are already known and used in the state of the art in order to prepare such injection solutions. By the EP 2 559 414 An adapter for a transfer device for a fluid has become known. This adapter is used to first supply a container with a lyophilizate a solvent liquid and then raise the thus prepared injection liquid into a syringe. The WO 2013/003951 describes a reconstitution device with two different chambers, which can be arranged in a common cylinder and connected to each other via piston movements.

A disadvantage of the known systems is that in some cases up to 20 working steps have to be carried out until the injection solution is drawn up in the syringe and ready for injection. It also requires a degree of care and skill, with frequent misuse. Finally, in many systems, different components must be stored separately, which increases the overall cost.

It is therefore an object of the invention to provide a device of the type mentioned, with the help of which the reconstitution of the substances can be simplified and automated. The handling should be as simple and safe as possible.

This object is achieved according to the invention with a device having the features in claim 1. The arranged in a housing, flexible bag serves to receive a liquid, which is usually a solvent. In the same housing and removable therefrom, a dispensing device is arranged, which is usually an injection syringe. Other dispensers such as e.g. Dropper, Sprühgefässe or the like would be conceivable without further ado. By housing in a common housing, the bag and the dispenser are protected against contamination and damage. A transfer channel for the direct or indirect transfer of the liquid leads from the bag into the delivery device. The hydraulic pressure for the transfer of the liquid is applied by at least one pressable against the bag pressure plate for squeezing the bag. These at least one pressure plate is housed in the mentioned housing, so that the device forms a compact unit, which can be easily stored and transported.

Particularly advantageously, the device is equipped with two printing plates, between which the bag is arranged. In this way, the bag can be squeezed out so that it always remains approximately in the same plane, each of the two pressure plates must perform a smaller movement, as with a single pressure plate.

Further advantages can be achieved if each pressure plate has two articulated sections which are movable from an angled rest position to an extended squish position. In this way, the pressure plates do not act plane-parallel to the flexible bag, but there is squeezing out from the outer edge towards the center of the bag. The two sections can be connected to each other, for example via a film hinge. The printing plates may be made of plastic material and be produced for example by injection molding. It is also possible that the printing plates are structured on the side facing away from the bag and functional elements such. Reinforcing ribs, cams or the like.

The housing may have a connecting piece for connecting a container containing a second substance, wherein the connecting piece communicates via a valve device with the transfer channel and / or with the flexible bag. This connection piece can be provided with coupling means for holding a container mouth as well as with a hollow needle for penetrating the closure element on the container. In this way, a container with an arbitrary substance can be connected to the device.

Alternatively or additionally, it is also possible that in the housing an additional container, preferably also a flexible bag, is arranged, which communicates via a valve device with the transfer channel. In this way it is possible to store the second substance already in the additional container within the housing. The second substance could also be a liquid.

Further advantages can be achieved if a valve device for shutting off the fluid connection between the flexible bag and the dispensing device is arranged in the transfer channel, wherein the valve device can be brought into the open position by a lifting movement. An activatable by means of stroke movement valve device can be controlled very easily. Alternatively, however, other valve functions would be conceivable such. a flap valve or a tap.

A particularly advantageous function can be achieved if a mechanical energy store, in particular a spring mechanism is arranged as a drive in the housing, with which the pressure plate can be pressed against the bag. Such an energy storage causes the pressure plate is almost always applied position-independent with the same force, wherein the transfer of the liquid always takes place in the same time. A spring mechanism is particularly advantageous for this purpose, because it can be applied safely and lossless sufficient forces. Alternative energy storage such as e.g. Compressed air storage or batteries for driving a micromotor would be conceivable. A magnetic actuation of the printing plate would be possible in principle.

Preferably, the lifting movement on the valve device and the pressure plate are activated with the same drive. By appropriate control means, these movements can be performed sequentially. Of course, it would also be conceivable that, for example, the lifting movement or another movement for valve actuation is performed manually and that with the help of the drive, only the pressure plate is activated.

Particularly advantageously, a spring mechanism with at least one coil spring is arranged in the housing. Such a spring mechanism is simple and inexpensive to produce and depending on the design of the coil spring is sufficient energy for various functions available. Spring mechanisms of this type are also well known and common in other fields of technology. The drive axle of the spring mechanism can be connected to a cam disk for forming the rotational movement into at least one linear force component. By means of the cam can be converted into a linear force in a relatively simple manner, the torque of the spring mechanism. Of course, this would also be possible by means of a gear transmission or with another type of transmission.

The at least one pressure plate can be mounted linearly displaceable together with the bag in the housing and in particular relative to the cam. In this way, there is a lifting movement with which a valve device can be activated. In the case of using a cam, this can cooperate with engagement members on the pressure plate such that it initially performs a linear movement and is then pressed while maintaining the reached end position against the bag. This results in a composite movement, with the help of which the valve is first actuated, in order subsequently to effect the transfer of the liquid.

Of course, the squeezing of the bag could also be done with other mechanical means, for example via a linkage or over against the pressure plate pressable rollers or pins or directly via a spring which presses directly against the pressure plate.

The housing may have a lid, wherein the drive can be activated by opening the lid. With the help of the lid, in particular the removable from the housing dispenser is protected and held in position. Activation of the drive by means of the lid movement has the advantage that the transfer of the liquid from the flexible bag takes place automatically, without the need for activating further actuating means. Activation of the drive would of course also be conceivable via a pushbutton or the like.

A particularly advantageous transfer of the liquid into an injection syringe with a filling opening mounted in the housing can take place in that the injection syringe has a needle holder which communicates with the transfer channel, wherein the filling opening can be closed during removal of the injection syringe from a syringe holder. When the injection syringe is mounted in the housing in the syringe holder, the piston is retracted. The solution for injection is taken up via the filling opening by actuation of the piston and when removing it from the syringe holder, the filling opening closes automatically so that the solution for injection can only be dispensed via the needle. Such mechanisms are already known per se and, for example, in the EP 2 559 414 described.

In principle, it is also conceivable that a hypodermic syringe or another type of dispensing device is stored in the housing, which already contains a second substance. In this way, the reconstitution of the liquid to be dispensed would take place directly in the dispenser itself.

The flexible bag is advantageously arranged between two printing plates, which can be activated either via a common drive or individually assigned to the printing plates drives. For example, each pressure plate can be associated with a spring mechanism with its own cam. These two cams can also have such differently shaped curve sections that the printing plates can be pressed in an asymmetrical movement against the bag. This will ensure that the bag is squeezed in such a way that no pockets of fluid remain.

Fig. 1:

eine perspektivische Darstellung einer Vorrichtung mit teilweise entferntem Gehäuse und mit geöffnetem Deckel,

Fig. 2:

die Vorrichtung gemäss Fig. 1 vor dem Öffnen des Deckels,

Fig. 3:

eine Seitenansicht der Vorrichtung gemäss Fig. 1,

Fig. 4:

ein Schnitt durch die Ebene A-A gemäss Fig. 3,

Fig. 5:

eine Draufsicht auf die Vorrichtung gemäss Fig. 3,

Fig. 6:

das Detail x gemäss Fig. 5,

Fig. 7:

eine Seitenansicht entsprechend Fig. 3 nach dem Auspressen des Beutels,

Fig. 8:

ein Schnitt durch die Ebene B-B gemäss Fig. 4 nach dem Auspressen des Beutels,

Fig 9:

eine Draufsicht auf die Vorrichtung gemäss Fig. 7,

Fig. 10:

eine perspektivische Darstellung auf ein Federwerk vor der Aktivierung,

Fig. 11:

das Federwerk gemäss Fig. 10 nach der Aktivierung,

Fig. 12:

ein Querschnitt durch die Vorrichtung gemäss Fig. 1 in der Ebene des flexiblen Beutels,

Fig. 13:

das Detail x gemäss Fig. 12,

Fig. 14:

die Vorrichtung gemäss Fig. 12 nach dem Öffnen des Deckels,

Fig. 15:

das Detail y gemäss Fig. 14,

Fig. 16:

ein Längsschnitt durch eine Vorrichtung durch den flexiblen Beutel,

Fig. 17:

das Detail y gemäss Fig. 16,

Fig. 18:

eine Seitenansicht auf ein geschlossenes Gehäuse mit ausgefahrenem Spritzenkolben,

Fig. 19:

ein vergrösserter Querschnitt durch die Ebene A-A gemäss Fig. 18,

Fig. 20a - 20e:

die Darstellung der Funktion einer Vorrichtung in fünf verschiedenen Schritten,

Fig. 21:

eine perspektivische Darstellung der Vorrichtung gemäss Fig. 1 mit entferntem Gehäuse und entferntem Antrieb,

Fig. 22:

die Vorrichtung gemäss Fig. 21 mit geschlossenen Druckplatten,

Fig. 23:

ein alternatives Ausführungsbeispiel einer Vorrichtung mit einem Zahnradantrieb,

Fig. 24:

eine Draufsicht auf die Vorrichtung gemäss Fig. 23,

Fig. 25:

ein Querschnitt durch die Vorrichtung gemäss Fig. 23,

Fig. 26:

das Detail x gemäss Fig. 25,

Fig. 27a - 27e:

die Funktion der Vorrichtung gemäss Fig. 23 in fünf verschiedenen Schritten,

Fig. 28:

ein weiteres Ausführungsbeispiel der Vorrichtung mit einem zweiten Behälter innerhalb des Gehäuses,

Fig. 29:

die Vorrichtung gemäss Fig. 28 nach dem Auspressen des flexiblen Beutels,

Fig. 30:

ein Querschnitt durch die Vorrichtung gemäss Fig. 28,

Fig. 31:

das Detail x gemäss Fig. 30,

Fig. 32:

die Vorrichtung gemäss Fig. 30 nach dem Öffnen der Ventilvorrichtung,

Fig. 33:

das Detail y gemäss Fig. 32,

Fig. 34:

die Vorrichtung gemäss Fig. 32 nach dem Füllen des zweiten Beutels und,

Fig. 35:

die Vorrichtung gemäss Fig. 34 nach dem Aufziehen der Flüssigkeit in die Spritze.

Further advantages and individual features of the invention will become apparent from the following description of exemplary embodiments and from the drawings. Show it:

Fig. 1:

a perspective view of a device with partially removed housing and with the lid open,

Fig. 2:

the device according to Fig. 1 before opening the lid,

3:

a side view of the device according to Fig. 1 .

4:

a section through the plane AA according to Fig. 3 .

Fig. 5:

a plan view of the device according to Fig. 3 .

Fig. 6:

the detail x according to Fig. 5 .

Fig. 7:

a side view accordingly Fig. 3 after squeezing the bag,

Fig. 8:

a section through the plane BB according to Fig. 4 after squeezing the bag,

Fig. 9:

a plan view of the device according to Fig. 7 .

Fig. 10:

a perspective view of a spring mechanism before activation,

Fig. 11:

the spring mechanism according to Fig. 10 after activation,

Fig. 12:

a cross section through the device according to Fig. 1 in the plane of the flexible bag,

Fig. 13:

the detail x according to Fig. 12 .

Fig. 14:

the device according to Fig. 12 after opening the lid,

Fig. 15:

the detail y according to Fig. 14 .

Fig. 16:

a longitudinal section through a device through the flexible bag,

Fig. 17:

the detail y according to Fig. 16 .

Fig. 18:

a side view of a closed housing with extended syringe plunger,

Fig. 19:

an enlarged cross section through the plane AA according to Fig. 18 .

FIGS. 20a-20e:

the representation of the function of a device in five different steps,

Fig. 21:

a perspective view of the device according to Fig. 1 with the housing removed and the drive removed,

Fig. 22:

the device according to Fig. 21 with closed pressure plates,

Fig. 23:

an alternative embodiment of a device with a gear drive,

Fig. 24:

a plan view of the device according to Fig. 23 .

Fig. 25:

a cross section through the device according to Fig. 23 .

Fig. 26:

the detail x according to Fig. 25 .

FIGS. 27a-27e:

the function of the device according to Fig. 23 in five different steps,

Fig. 28:

Another embodiment of the device with a second container within the housing,

Fig. 29:

the device according to Fig. 28 after squeezing the flexible bag,

Fig. 30:

a cross section through the device according to Fig. 28 .

Fig. 31:

the detail x according to Fig. 30 .

Fig. 32:

the device according to Fig. 30 after opening the valve device,

Fig. 33:

the detail y according to Fig. 32 .

Fig. 34:

the device according to Fig. 32 after filling the second bag and,

Fig. 35:

the device according to Fig. 34 after drawing the liquid into the syringe.

According to the Figures 1 and 2 There is a designated 1 device essentially of a housing 2, with a lid 24. This is mounted on a cover joint 36 pivotally mounted on the housing. Within the housing, a syringe holder 29 is formed, which receives a syringe designated 5 play. Parallel to the syringe holder two congruent pressure plates are arranged, of which only the one pressure plate 7 is visible here. About this pressure plate, a spring mechanism 16 is fixedly mounted in the housing, whose function will be described in more detail below. Below the two pressure plates protrudes a connection piece 9 from the housing 2, in which a container 10 can be inserted. The syringe 5 has a piston 25, which, however, in the starting position according to FIG. 2 retracted. The needle of the injection syringe, which is not visible here, rests in a quiver 37, which runs approximately parallel to the connecting piece 9.

The FIGS. 3 to 6 show further structural details, according to the FIGS. 3 and 4 the device is rotated such that the cover 24 is below and the connecting piece 9 above. In FIG. 4 is visible between the two pressure plates 7, 7 'a flexible bag 3, in which a liquid, such as a solvent is filled. The two printing plates are present in a starting position the squeezing out of the bag 3. How out FIG. 3 it can be seen, each of the two pressure plates consists of two separate sections 8a, 8b, which are hinged together along a film hinge 38. Each pressure plate 7 and 7 'is assigned its own spring mechanism 16 and 16', wherein each spring mechanism has a spiral spring 17. In FIG. 6 is still a piercing mandrel 34 visible in the center of the connecting piece, with the aid of a closure element of the container 10 can be pierced.

The FIGS. 7 and 8 show the device according to the FIGS. 3 and 4 However, after the squeezing of the bag 3. This is now flat between the two pressure plates 7 and 7 ', which are moved together plane-parallel under the action of the two spring mechanisms 16 and 16'. The originally slightly angled plate sections 8a, 8b, are now stretched flat.

Based on Figures 10 and 11 the function of the spring mechanism and the control of the printing plates is described in more detail. The coil spring 17 of a spring mechanism 16 surrounds in several turns a drive axle 18 which is formed in the present case as a hollow hub and which is mounted in the side wall of the housing. The free end 39 of the coil spring is laterally supported on a spring stop 40. The spring mechanism can be mounted from the outside, so that the coil spring exerts a torque on the drive axle 18. A locking gear 32 ensures that a cam 19 is rotatable only in the drive direction, while it is prevented from rotating when mounting the spring mechanism by a stop 30. The cam 19 further has a press wedge segment 21, which is curved in the circumferential direction, as well as a lifting cam 20 which bears against a stroke stop 22 of the pressure plate 7. The printing plate also has a support shoulder 33 with a corresponding to the press wedge segment 21 curvature.

At the symmetrical rear pressure plate a similar spring mechanism is arranged, which is also associated with a press wedge segment 21 '. The latter, however, has a somewhat flatter wedge inclination, so that the two pressure plates are acted upon by force unbalanced.

The two pressure plates with the flexible bag arranged therebetween are linearly displaceable relative to the two spring mechanisms, wherein they can cover a stroke of, for example, about 2 to 3 mm.

FIG. 11 shows the situation after activation of the spring mechanism and thus after the squeezing of the bag. The lifting cam 20 ( FIG. 10 ) has the stroke stop 22 in the course of the rotational movement of the cam 19 is shifted upward, so that the entire unit consisting of the two pressure plates 7, 7 'and the flexible bag has made a lifting movement. After completion of the lifting movement, the press wedge segment 21 engages under the support shoulder 33, so that reversing of the lifting movement is no longer possible. The locking gear 32 continues to rotate when relaxing the coil spring 17, the cam 19, wherein the press wedge segment 21 exerts a pressing force on the pressure plate 7. Exactly the same process takes place on the opposite side. Over the stroke h returned by the linear displacement of the press plates, the flexible bag is short-circuited to the transfer channel.

The valve functions and the fluid connections are in the FIGS. 12 to 15 shown. According to the FIGS. 12 and 13 the device is in the starting position, in which the bag 3 is shut off from a fluid channel 6 via the valve device 12. This shut-off relates both to the connection to the piercing spike 34 on the connecting piece 9 and to a filling opening 28 on a needle holder 27 of the injection syringe 5. The injection needle 26 is held by the needle holder 27. Out FIG. 12 is also apparent that the lid 24, a hold-down element 41 is arranged, with which the pressure plate assembly is held with the bag 3 in the starting position.

The filling of the liquid in the flexible bag 3 is carried out in the fully assembled state via a filling channel 44. This is then inextricably closed by means of a plug 46. The connection of the flexible bag 3 to the valve device 12 via a discharge channel 45th

The FIGS. 14 and 15 show the state after opening the lid, for reasons of clarity, no container is shown in the connection piece 9. After the release of the pressure plate assembly by the hold-down element 41, the spring mechanism relaxes and this arrangement sets the stroke h ( FIG. 11 ) back. In this case, the valve device 12 is opened and the pressure plates press the flexible bag 3 together, wherein the contents of which are emptied into the container connected to the connecting piece 9, so that the injection liquid is processed. The dashed line F1 shows the flow of fluid through the discharge channel 45 out of the flexible bag through the open valve device 12 and through the connecting posts 9 into the connected container. The transfer channel 6 and the filling opening 28 are opened in this process, so that the liquid can also expand against the injection syringe, as far as the piston 25 and the compressed air below it allows.

After this process, the piston 25 of the syringe can be pulled out, so that via the transfer channel 6 and the filling opening 28, the contents of the container is sucked into the syringe. A ventilation opening 42 ensures that no vacuum builds up in the container. By removing the injection syringe from the syringe holder 29 is a rotational movement in the region of the needle holder 27, whereby the filling opening 28 is shut off from the outside atmosphere and the contents of the syringe can be emptied via the needle 26. With the dot-dash line F2, the fluid flow is shown when drawing the liquid from the container into the syringe. The dotted line L indicates the air flow through the ventilation opening 42. This consists of a filter that lets through air, but no liquid.

In the FIGS. 16 and 17 is shown in an alternative sectional view, the connection between the bag 3 and the connecting piece 9, wherein the position 35 shows the bag connection. Since the cutting plane is not in the central axis of the connecting piece 9, this is shown only as a sub-segment.

FIG. 18 shows the outside of a device (without lid) with inserted container 10 and drawn-out piston 25 of the syringe. The lateral housing walls have a bearing opening 43, in which the hollow drive axle 18 of the spring mechanism 16 is mounted. This storage is in FIG. 19 shown. Through the opening 43, the spring mechanism is mounted after assembly of the device and after closing the lid.

According to FIG. 20 the preparation of an injection solution takes place as follows:

According to a, a device 1 according to the invention and a sealed container 10 with a lyophilisate 11 are provided. The container 10 is pressed into the connecting piece 9, so that the centrally arranged piercing spike penetrates the closure of the container and the container is held firmly in the device (illustration b). According to c, the lid 24 can now be opened, wherein the previously described Auspressvorgang takes place. After complete squeezing of the bag according to d, the entire liquid 4 is in the container 10 and the lyophilisate has dissolved in the liquid. Now, according to e, the injection solution can be transferred out of the container 10 by pulling the piston 25 into the injection syringe 5 in any position, but preferably in an overhead position. The injection syringe is then removed from the housing 2, wherein the empty syringe after application for safety reasons, in turn, can be pushed back into the housing. Subsequently, the entire unit can be disposed of.

The FIGS. 21 and 22 show by way of illustration again the positions of the pressure plate sections 8a and 8b and 8a 'and 8b' before pressing ( FIG. 21 ) and after pressing ( FIG. 22 ). Well visible here are the pressing tracks 23a, 23b, against which the press wedge segments of the cam press in the course of the rotational movement. The outsides of the press plate sections are also provided with reinforcing ribs.

In the FIGS. 23 to 26 an alternative embodiment is shown, in which the Auspressmechanismus differs from that of the aforementioned embodiment. A common spring mechanism 50 with a locking gear 51 here serves to activate both printing plates. For this purpose, a first gear segment 52 is driven via the locking gear, which meshes with a second gear segment 53. The axes of rotation of the two gear segments lie on both sides of the pressure plate assembly. The gear segments move in opposite directions and they are provided with pressing elements 55 which are pressed against the pressure plates 54 ( FIG. 25 ). The pressure plates 54 and 54 'are made for example as injection molded parts and integrally connected to each other via material films. Evidently, the opposite movement of the two gear segments 52 and 53 causes a squeezing of the bag 3. As out FIG. 26 It can be seen here is also a transfer of the liquid first in the docked to the connection piece 9 container and then via the transfer channel 6 to the injection syringe. The lifting movement of the pressure plate assembly and thus the opening of the valve device 56 ( FIG. 26 ) is controlled by the two gear segments 52 and 53. These have control cam 57 which act on a stop 58 and thus cause a linear displacement.

Analogous to FIG. 20 shows FIG. 27 the flow of liquid transfer in the alternative embodiment. Again, according to a and b, the container 10 is first connected to the connecting piece 9 and then the lid 24 is opened. As a result, the spring mechanism is activated (c) after which the squeezing process begins. After the complete Reconstitution of the solution for injection in the container 10, its contents can be included in the syringe.

The FIGS. 28 to 35 show a further embodiment in which no connection piece 9 is provided for connecting a container. For this purpose, an additional container 13 is arranged in the form of another bag within the housing and approximately at right angles to the first bag between the two pressure plates 7. However, the function of the pressure plate assembly after the release of the spring mechanism is the same as in the first embodiment, ie the pressure plate assembly with the first bag first returns a lifting movement, so that the lift valve 15 ( FIG. 31 and 33 ) is opened. The liquid then passes via the transfer channel 6 and via a valve device 14 first into the additional tank 13. This is likewise a lifting valve analogous to the lifting valve 15 on the first bag. After filling the additional container, as in FIG. 34 represented, the treated injection liquid enters the injection syringe 5 as described above. The additional container 13 may be associated with a second substance, which may be either solid or liquid.

Claims (15)

Device (1) for combining substances, in particular for the reconstitution of injection solutions, comprising a housing (2), a flexible bag (3) arranged in the housing for receiving a liquid (4), a dispensing device arranged in the housing and removable from the housing, in particular a hypodermic syringe (4), a transfer channel (6) for the direct or indirect transfer of the liquid from the bag into the delivery device, - And at least one against the bag (3) pressable pressure plate (7) for squeezing the bag. Apparatus according to claim 1, characterized in that it comprises two pressure plates (7, 7 '), between which the bag (3) is arranged. Apparatus according to claim 1 or 2, characterized in that the pressure plate (7) has two hingedly interconnected portions (8a, 8b) which are movable from an angled rest position to an extended squish position. Device according to one of claims 1 to 3, characterized in that the housing (2) has a connecting piece (9) for connecting a second substance (11) containing container (10), wherein the connecting piece via a valve device (12) with the Transfer channel (6) and / or with the flexible bag (3) communicates. Device according to one of claims 1 to 4, characterized in that in the housing (2) an additional container (15), preferably also a flexible bag, is arranged, which communicates via a valve device (14) with the transfer channel (6). Device according to one of claims 1 to 5, characterized in that in the transfer channel (6) a valve device (15) for shutting off the fluid connection between the flexible bag (3) and the dispensing device is arranged, wherein the valve device can be brought by a lifting movement in the open position is. Device according to one of claims 1 to 6, characterized in that in the housing (2) a mechanical energy storage, in particular a spring mechanism (16) is arranged as a drive, with which the pressure plate (7) against the bag (3) can be pressed. Apparatus according to claim 6 and claim 7, characterized in that with the same drive, the lifting movement of the valve device (15) and the pressure plate (7) can be activated. Apparatus according to claim 7 or 8, characterized in that in the housing (2) a spring mechanism (16) with at least one coil spring (17) is arranged, wherein the drive axle (18) of the spring mechanism with a cam disc (19) for forming the rotational movement in at least one linear one Force component is connected. Apparatus according to claim 9, characterized in that the pressure plate (7) is mounted linearly displaceable together with the bag (3) in the housing (2) and relative to the cam and that the cam plate (19) with engaging members (20, 21) the pressure plate (7) cooperates, that this initially performs a linear movement and then while maintaining the reached end position against the bag (3) is pressed. Device according to one of claims 7 to 10, characterized in that the housing (2) has a cover (24) and that the drive can be activated by opening the lid. Device according to one of claims 1 to 11, characterized in that in the housing an injection syringe (5) is mounted with retracted piston (25) in a syringe holder (29), and that the injection tip a needle holder (27) having a filling opening (28). has, which communicates with the transfer channel (6), wherein the filling opening is closable during removal of the injection syringe from the syringe holder. Device according to one of claims 1 to 12, characterized in that in the housing (2) an injection syringe (5) is mounted, which contains a second substance. Apparatus according to claim 9 or 10, characterized in that the bag (3) between two pressure plates 7, 7 ') is arranged and that each pressure plate is a spring mechanism (16, 16') with a cam assigned. Apparatus according to claim 14, characterized in that the two cams have curved sections of different shape such that the pressure plates (7, 7 ') can be pressed against the bag in an asymmetrical movement.

Images