EP2821138B8 - Flusszelle mit integrierter Trockensubstanz - Google Patents

Flusszelle mit integrierter Trockensubstanz Download PDF

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Publication number
EP2821138B8
EP2821138B8 EP13175335.2A EP13175335A EP2821138B8 EP 2821138 B8 EP2821138 B8 EP 2821138B8 EP 13175335 A EP13175335 A EP 13175335A EP 2821138 B8 EP2821138 B8 EP 2821138B8
Authority
EP
European Patent Office
Prior art keywords
flow cell
dry substance
integrated dry
integrated
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP13175335.2A
Other languages
English (en)
French (fr)
Other versions
EP2821138B1 (de
EP2821138B2 (de
EP2821138A1 (de
Inventor
Weber Lutz
Tina Röser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thinxxs Microtechnology GmbH
Original Assignee
Thinxxs Microtechnology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48745809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2821138(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES13175335T priority Critical patent/ES2704424T5/es
Priority to DK13175335.2T priority patent/DK2821138T4/da
Priority to EP13175335.2A priority patent/EP2821138B2/de
Application filed by Thinxxs Microtechnology GmbH filed Critical Thinxxs Microtechnology GmbH
Priority to CN201480046983.0A priority patent/CN105517710B/zh
Priority to US14/902,787 priority patent/US10232367B2/en
Priority to PCT/EP2014/064290 priority patent/WO2015001070A1/de
Publication of EP2821138A1 publication Critical patent/EP2821138A1/de
Publication of EP2821138B1 publication Critical patent/EP2821138B1/de
Priority to US16/265,127 priority patent/US10946376B2/en
Publication of EP2821138B8 publication Critical patent/EP2821138B8/de
Publication of EP2821138B2 publication Critical patent/EP2821138B2/de
Application granted granted Critical
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Secondary Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP13175335.2A 2013-07-05 2013-07-05 Flusszelle mit integrierter Trockensubstanz Active EP2821138B2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES13175335T ES2704424T5 (es) 2013-07-05 2013-07-05 Célula de flujo con sustancia seca integrada
DK13175335.2T DK2821138T4 (da) 2013-07-05 2013-07-05 Flydecelle med integreret tørstof
EP13175335.2A EP2821138B2 (de) 2013-07-05 2013-07-05 Flusszelle mit integrierter Trockensubstanz
CN201480046983.0A CN105517710B (zh) 2013-07-05 2014-07-04 具有整合的干燥物质的液流电池
US14/902,787 US10232367B2 (en) 2013-07-05 2014-07-04 Flow cell with an integrated dry substance
PCT/EP2014/064290 WO2015001070A1 (de) 2013-07-05 2014-07-04 Flusszelle mit integrierter trockensubstanz
US16/265,127 US10946376B2 (en) 2013-07-05 2019-02-01 Carrier element for introducing a dry substance into a flow cell

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13175335.2A EP2821138B2 (de) 2013-07-05 2013-07-05 Flusszelle mit integrierter Trockensubstanz

Publications (4)

Publication Number Publication Date
EP2821138A1 EP2821138A1 (de) 2015-01-07
EP2821138B1 EP2821138B1 (de) 2018-10-24
EP2821138B8 true EP2821138B8 (de) 2019-03-06
EP2821138B2 EP2821138B2 (de) 2022-02-09

Family

ID=48745809

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13175335.2A Active EP2821138B2 (de) 2013-07-05 2013-07-05 Flusszelle mit integrierter Trockensubstanz

Country Status (6)

Country Link
US (1) US10232367B2 (de)
EP (1) EP2821138B2 (de)
CN (1) CN105517710B (de)
DK (1) DK2821138T4 (de)
ES (1) ES2704424T5 (de)
WO (1) WO2015001070A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2516669B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
GB2516672B (en) 2013-07-29 2015-05-20 Atlas Genetics Ltd A system and method for expelling liquid from a fluidic cartridge
GB2516667A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd An improved cartridge, cartridge reader and method for preventing reuse
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
CN105980058A (zh) 2014-01-07 2016-09-28 达克雷诊断器材有限公司 流体输送装置、系统和方法
CA2962861A1 (en) 2014-09-29 2016-04-07 Chipcare Corporation Methods and devices for cell detection
CN107209095A (zh) 2014-11-28 2017-09-26 奇普凯尔公司 多重珠阵列测定
EP3108962B1 (de) 2015-06-22 2024-10-16 thinXXS Microtechnology GmbH Probenträger
EP3199240A1 (de) * 2016-01-26 2017-08-02 ThinXXS Microtechnology AG Mikrofluidische flusszelle mit integrierter elektrode und verfahren zu ihrer herstellung
EP3263215B1 (de) * 2016-06-30 2021-04-28 ThinXXS Microtechnology AG Vorrichtung mit einer flusszelle mit reagenzspeicher
WO2018065107A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Cartridge for testing a sample and method for producing a cartridge of this kind
KR20190104041A (ko) 2016-12-29 2019-09-05 아도르 디아그노스틱스 에스.알.엘. 전기 영동 애플리케이션을 위한 전기 영동 칩
EP3342485B1 (de) 2017-01-02 2020-07-08 Thinxxs Microtechnology Ag Halterung für reagenzträgerelemente
EP3444034A1 (de) * 2017-08-18 2019-02-20 XanTec bioanalytics GmbH Fliesszelle für die selektive anreicherung von partikeln oder zellen
US10046322B1 (en) 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
WO2020008463A2 (en) 2018-07-04 2020-01-09 Ador Diagnostics Ltd. System, apparatus and method for computerized automatic diagnosis
GB201819415D0 (en) 2018-11-29 2019-01-16 Quantumdx Group Ltd Microfluidic apparatus and method
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
GB201917832D0 (en) 2019-12-05 2020-01-22 Oxford Nanopore Tech Ltd Microfluidic device for preparing and analysing a test liquid
JP7808851B2 (ja) * 2020-02-25 2026-01-30 ヘリックスバインド・インコーポレイテッド 流体システムのための試薬キャリア
EP4173708A1 (de) 2021-10-28 2023-05-03 thinXXS Microtechnology GmbH Mikrofluidelement, insbesondere flusszelle, mit integriertem trockenreagenz
EP4572889A1 (de) * 2022-08-17 2025-06-25 thinXXS Microtechnology GmbH Mikrofluidische flusszelle, herstellungsverfahren, verwendung und analyseeinrichtung

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725831A (en) * 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
JP4013671B2 (ja) * 2002-07-05 2007-11-28 松下電器産業株式会社 ポリメラーゼ連鎖反応容器及びその製造方法
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
DE102004021780B4 (de) * 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
EP1796838B1 (de) * 2004-10-15 2014-10-08 Boehringer Ingelheim Vetmedica GmbH Verfahren zur durchführung einer elektrochemischen messung an einer flüssigen messprobe in einer über leitungen zugänglichen messkammer
MX383382B (es) * 2005-12-21 2025-03-13 Meso Scale Technologies Llc Modulos de ensayo que tienen reactivos de ensayo y metodos para hacer y utilizar los mismos
US8835157B2 (en) † 2007-04-25 2014-09-16 3M Innovative Properties Company Supported reagents, methods, and devices
DE102008021364A1 (de) 2008-04-29 2009-06-25 Siemens Aktiengesellschaft Verfahren zum Einbringen von Trockenreagenzien in eine Analyseeinheit und Kit
KR101102532B1 (ko) 2008-07-10 2012-01-03 삼성전자주식회사 시약 카트리지, 시약 카트리지를 구비하는 미세유동장치, 그 제조방법, 및 이를 이용한 시료분석방법
EP2198964B8 (de) 2008-11-06 2013-04-24 F. Hoffmann-La Roche AG Verfahren zum Bereitstellen eines getrockneten Reagenz in einem mikrofluidischen System
GB0919159D0 (en) † 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
GB2483077A (en) * 2010-08-25 2012-02-29 Concateno Uk Ltd Sample testing assay apparatus and method
EP3425396A3 (de) * 2011-04-13 2019-05-01 Akonni Biosystems, Inc. Probendetektionssystem auf mikroarraybasis
EP2705374A4 (de) * 2011-05-02 2014-11-12 Advanced Liquid Logic Inc Molekulare diagnoseplattform
WO2012154306A1 (en) * 2011-05-12 2012-11-15 William Marsh Rice University Bio-nano-chips for on-site drug screening
EP2610009A1 (de) 2011-12-29 2013-07-03 Samsung Electronics Co., Ltd Festreagenzienauflösungsvorrichtung und Verfahren zur Auflösung von Festreagenzien durch Verwendung davon
CN104937390B (zh) * 2012-09-26 2018-09-21 艾比斯生物科学公司 用于微流体装置的拭子接口

Also Published As

Publication number Publication date
US10232367B2 (en) 2019-03-19
DK2821138T3 (en) 2019-02-11
DK2821138T4 (da) 2022-05-16
WO2015001070A1 (de) 2015-01-08
CN105517710B (zh) 2017-04-05
US20160167047A1 (en) 2016-06-16
ES2704424T5 (es) 2022-05-20
ES2704424T3 (es) 2019-03-18
CN105517710A (zh) 2016-04-20
EP2821138B1 (de) 2018-10-24
EP2821138B2 (de) 2022-02-09
EP2821138A1 (de) 2015-01-07

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