EP2820028A4 - A process for preparing pure citicoline (cdp-choline) - Google Patents

A process for preparing pure citicoline (cdp-choline)

Info

Publication number
EP2820028A4
EP2820028A4 EP13755755.9A EP13755755A EP2820028A4 EP 2820028 A4 EP2820028 A4 EP 2820028A4 EP 13755755 A EP13755755 A EP 13755755A EP 2820028 A4 EP2820028 A4 EP 2820028A4
Authority
EP
European Patent Office
Prior art keywords
citicoline
cdp
choline
preparing pure
pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13755755.9A
Other languages
German (de)
French (fr)
Other versions
EP2820028A1 (en
Inventor
Rajiv Kumar
Yogendra Chauhan
Vilas Dhake
Vijay Tambe
Atul Wagh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FRICHEM PRIVATE Ltd
Original Assignee
FRICHEM PRIVATE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRICHEM PRIVATE Ltd filed Critical FRICHEM PRIVATE Ltd
Publication of EP2820028A1 publication Critical patent/EP2820028A1/en
Publication of EP2820028A4 publication Critical patent/EP2820028A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP13755755.9A 2012-02-28 2013-02-28 A process for preparing pure citicoline (cdp-choline) Withdrawn EP2820028A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN540MU2012 2012-02-28
PCT/IB2013/051585 WO2013128393A1 (en) 2012-02-28 2013-02-28 A process for preparing pure citicoline (cdp-choline)

Publications (2)

Publication Number Publication Date
EP2820028A1 EP2820028A1 (en) 2015-01-07
EP2820028A4 true EP2820028A4 (en) 2015-08-26

Family

ID=49081721

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13755755.9A Withdrawn EP2820028A4 (en) 2012-02-28 2013-02-28 A process for preparing pure citicoline (cdp-choline)

Country Status (2)

Country Link
EP (1) EP2820028A4 (en)
WO (1) WO2013128393A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104031105B (en) * 2014-06-06 2015-07-15 回音必集团(江西)东亚制药有限公司 Method for preparing citicoline sodium
CN105732752A (en) * 2016-03-18 2016-07-06 新乡学院 Citicoline and synthetic method thereof
CN106146590A (en) * 2016-06-29 2016-11-23 陈建峰 A kind of preparation method of C14H25N4NaO11P2
CN110684066B (en) * 2019-05-22 2020-12-08 广东金城金素制药有限公司 Cytophosphocholine medicinal preparation and new application thereof in cerebral infarction acute-stage disturbance of consciousness
CN113563377A (en) * 2021-07-15 2021-10-29 浙江蓝波新材料科技有限公司 Novel phosphorylcholine synthesis process technical method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3787392A (en) * 1970-12-02 1974-01-22 Boehringer Mannheim Gmbh Process for the preparation of nucleoside diphosphate esters
CN102010454A (en) * 2010-12-02 2011-04-13 胡建荣 Citicoline sodium compound and new method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666748A (en) * 1967-12-18 1972-05-30 Takeda Chemical Industries Ltd Method for production of cytidine (or deoxycytidine)-5{40 -diphosphate choline and intermediates therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3787392A (en) * 1970-12-02 1974-01-22 Boehringer Mannheim Gmbh Process for the preparation of nucleoside diphosphate esters
CN102010454A (en) * 2010-12-02 2011-04-13 胡建荣 Citicoline sodium compound and new method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2013128393A1 *

Also Published As

Publication number Publication date
EP2820028A1 (en) 2015-01-07
WO2013128393A1 (en) 2013-09-06

Similar Documents

Publication Publication Date Title
IL274500A (en) Glycoconjugation process
HK1210784A1 (en) Process for preparing nucleoside prodrugs
HK1245798A1 (en) Methods for preparing anti-viral nucleotide analogs
SG11201503371PA (en) A process for producing dimethyl sulfoxide
EP2699534A4 (en) PROCESS FOR PRODUCING TRANS-1233zd
ZA201503644B (en) Antiviral phosphonate analogues and process for preparation thereof
IL236711B (en) Process for preparing 3-methoxy-6-oxo-7,8-didehydro-14-hydroxy-17-substituted-morphinan sulfates
IL236710B (en) Process for preparing 3-oxy-6-oxo-7,8-didehydro-14-hydroxy-17-substituted-morphinan sulfates
SG10201505540SA (en) Process for preparing antiviral compounds
LT2940030T (en) Method for producing p1,p4-di(uridine 5`-)tetraphosphate
IL227872A0 (en) Process for preparing substituted n-phenylhydroxylamines
ZA201500937B (en) Process for preparing olefins by thermal steamcracking
IL245649A0 (en) A process for the preparation of regadenoson
EP2887941A4 (en) Process for preparing antiviral compounds
EP2820028A4 (en) A process for preparing pure citicoline (cdp-choline)
EP2857528A4 (en) Process for producing sugar solution
EP2740719A4 (en) Process for producing a-fluoroaldehydes
ZA201406356B (en) Process for producing maltitol from starch
EP2819995A4 (en) Process for preparing 3-methylsulfonylpropionitrile
EP2868657A4 (en) Method for preparing high purity scutellarin aglycone
GB201104313D0 (en) Process for preparing glatiramer
EP2831054A4 (en) Improved process for producing (s)-equol
IL232311A0 (en) Process for producing 4-hydroxytmethyl-2,3,5,6-tetrafluorotoluene
GB201208483D0 (en) High pressure crystallisation process

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20140822

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150728

RIC1 Information provided on ipc code assigned before grant

Ipc: C07H 1/00 20060101ALI20150722BHEP

Ipc: C07H 19/10 20060101AFI20150722BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20160225