EP2817324A4 - Nemo binding domain fusion proteins - Google Patents

Nemo binding domain fusion proteins

Info

Publication number
EP2817324A4
EP2817324A4 EP13751500.3A EP13751500A EP2817324A4 EP 2817324 A4 EP2817324 A4 EP 2817324A4 EP 13751500 A EP13751500 A EP 13751500A EP 2817324 A4 EP2817324 A4 EP 2817324A4
Authority
EP
European Patent Office
Prior art keywords
binding domain
fusion proteins
domain fusion
nemo binding
nemo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13751500.3A
Other languages
German (de)
French (fr)
Other versions
EP2817324A1 (en
Inventor
Nima Shiva
Mark Nowak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ENCODE BIO Inc
Original Assignee
ENCODE BIO Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ENCODE BIO Inc filed Critical ENCODE BIO Inc
Publication of EP2817324A1 publication Critical patent/EP2817324A1/en
Publication of EP2817324A4 publication Critical patent/EP2817324A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP13751500.3A 2012-02-23 2013-02-25 Nemo binding domain fusion proteins Withdrawn EP2817324A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261602264P 2012-02-23 2012-02-23
PCT/US2013/027702 WO2013126919A1 (en) 2012-02-23 2013-02-25 Nemo binding domain fusion proteins

Publications (2)

Publication Number Publication Date
EP2817324A1 EP2817324A1 (en) 2014-12-31
EP2817324A4 true EP2817324A4 (en) 2015-11-11

Family

ID=49006315

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13751500.3A Withdrawn EP2817324A4 (en) 2012-02-23 2013-02-25 Nemo binding domain fusion proteins

Country Status (3)

Country Link
EP (1) EP2817324A4 (en)
JP (1) JP2015509949A (en)
WO (1) WO2013126919A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864355B1 (en) * 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOANN STRNAD ET AL: "NEMO binding domain of IKK-2 encompasses amino acids 735-745", JOURNAL OF MOLECULAR RECOGNITION, vol. 19, no. 3, 1 May 2006 (2006-05-01), pages 227 - 233, XP055194088, ISSN: 0952-3499, DOI: 10.1002/jmr.766 *
KATHRYN GREENWOOD: "The development of the cyclotide MCoTI-II as a molecular engineering framework in drug design", INTERNET CITATION, 1 October 2008 (2008-10-01), XP009184742, Retrieved from the Internet <URL:http://espace.library.uq.edu.au/view/UQ:183997> [retrieved on 20150120] *
See also references of WO2013126919A1 *

Also Published As

Publication number Publication date
EP2817324A1 (en) 2014-12-31
WO2013126919A1 (en) 2013-08-29
JP2015509949A (en) 2015-04-02

Similar Documents

Publication Publication Date Title
IL282226A (en) St2 antigen binding proteins
HK1211297A1 (en) Binding proteins comprising at least two repeat domains against her2 her2
HK1208707A1 (en) Cd3 binding polypeptides cd3
HK1203528A1 (en) Fusion proteins comprising igg2 hinge domains igg2
IL240838A0 (en) Anti-lag-3 binding proteins
EP2877854A4 (en) Fusion proteins and methods thereof
HK1207656A1 (en) Albumin binding polypeptide
SG10202100341XA (en) Npp1 fusion proteins
PL2912054T3 (en) Albumin binding polypeptide
EP2683742A4 (en) Npp1 fusion proteins
GB201418608D0 (en) Peridinin-chlorophyll binding proteins
EP2817324A4 (en) Nemo binding domain fusion proteins
GB201213672D0 (en) Protein
GB201203944D0 (en) Binding polypeptides
GB201215901D0 (en) Protein modification
GB201200743D0 (en) Protein bridges
GB201007955D0 (en) Somatosatin fusion proteins
GB201214293D0 (en) Binding surfaces
GB201114701D0 (en) Fusion proteins
GB201107189D0 (en) Fusion proteins

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20140922

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/09 20060101ALI20150616BHEP

Ipc: A61P 21/00 20060101ALI20150616BHEP

Ipc: C07K 14/00 20060101AFI20150616BHEP

Ipc: A61P 29/00 20060101ALI20150616BHEP

Ipc: A61K 38/00 20060101ALI20150616BHEP

Ipc: A61P 37/00 20060101ALI20150616BHEP

Ipc: A61K 9/10 20060101ALI20150616BHEP

Ipc: C12N 9/12 20060101ALI20150616BHEP

Ipc: A61K 35/00 20060101ALI20150616BHEP

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20151009

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 37/00 20060101ALI20151005BHEP

Ipc: C12N 15/09 20060101ALI20151005BHEP

Ipc: A61P 21/00 20060101ALI20151005BHEP

Ipc: A61P 29/00 20060101ALI20151005BHEP

Ipc: A61K 35/00 20060101ALI20151005BHEP

Ipc: A61K 9/10 20060101ALI20151005BHEP

Ipc: C12N 9/12 20060101ALI20151005BHEP

Ipc: A61K 38/00 20060101ALI20151005BHEP

Ipc: C07K 14/00 20060101AFI20151005BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20160507