EP2807216A4 - Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo - Google Patents

Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo

Info

Publication number
EP2807216A4
EP2807216A4 EP12827106.1A EP12827106A EP2807216A4 EP 2807216 A4 EP2807216 A4 EP 2807216A4 EP 12827106 A EP12827106 A EP 12827106A EP 2807216 A4 EP2807216 A4 EP 2807216A4
Authority
EP
European Patent Office
Prior art keywords
poly
polymers
nucleic acid
vinyl ester
acid delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12827106.1A
Other languages
German (de)
English (en)
Other versions
EP2807216A1 (fr
Inventor
Darren H Wakefield
Nicholas Rossi
Dan Sheik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arrowhead Pharmaceuticals Inc
Original Assignee
Arrowhead Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Research Corp filed Critical Arrowhead Research Corp
Priority claimed from PCT/US2012/051968 external-priority patent/WO2013032829A1/fr
Publication of EP2807216A1 publication Critical patent/EP2807216A1/fr
Publication of EP2807216A4 publication Critical patent/EP2807216A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/22—Esters containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP12827106.1A 2011-08-26 2012-08-23 Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo Withdrawn EP2807216A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161527703P 2011-08-26 2011-08-26
PCT/US2012/051968 WO2013032829A1 (fr) 2011-08-26 2012-08-23 Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo

Publications (2)

Publication Number Publication Date
EP2807216A1 EP2807216A1 (fr) 2014-12-03
EP2807216A4 true EP2807216A4 (fr) 2015-10-28

Family

ID=51795158

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12827106.1A Withdrawn EP2807216A4 (fr) 2011-08-26 2012-08-23 Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo

Country Status (1)

Country Link
EP (1) EP2807216A4 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048410A1 (en) * 2002-03-11 2009-02-19 Wakefield Darren H Membrane Active Heteropolymers
US20110207799A1 (en) * 2010-02-24 2011-08-25 Roche Madison Inc. Compositions for Targeted Delivery of siRNA

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048410A1 (en) * 2002-03-11 2009-02-19 Wakefield Darren H Membrane Active Heteropolymers
US20110207799A1 (en) * 2010-02-24 2011-08-25 Roche Madison Inc. Compositions for Targeted Delivery of siRNA

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2013032829A1 *

Also Published As

Publication number Publication date
EP2807216A1 (fr) 2014-12-03

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20140324

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150929

RIC1 Information provided on ipc code assigned before grant

Ipc: C08L 33/06 20060101AFI20150923BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ARROWHEAD PHARMACEUTICALS, INC.

17Q First examination report despatched

Effective date: 20170220

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20191105