EP2797889A4 - Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators - Google Patents

Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators

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Publication number
EP2797889A4
EP2797889A4 EP12863580.2A EP12863580A EP2797889A4 EP 2797889 A4 EP2797889 A4 EP 2797889A4 EP 12863580 A EP12863580 A EP 12863580A EP 2797889 A4 EP2797889 A4 EP 2797889A4
Authority
EP
European Patent Office
Prior art keywords
novel
estrogen receptor
receptor modulators
selective estrogen
arylalkene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12863580.2A
Other languages
German (de)
French (fr)
Other versions
EP2797889A1 (en
Inventor
Dengming Xiao
Li Zhu
Yuandong Hu
Rong Yu
Wei Hu
Na Zhao
Yong Peng
Hong Luo
Yongxin Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centaurus Biopharma Co Ltd
Original Assignee
Centaurus Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN2011104578981A external-priority patent/CN102584687A/en
Priority claimed from CN2011104561181A external-priority patent/CN102532073A/en
Application filed by Centaurus Biopharma Co Ltd filed Critical Centaurus Biopharma Co Ltd
Publication of EP2797889A1 publication Critical patent/EP2797889A1/en
Publication of EP2797889A4 publication Critical patent/EP2797889A4/en
Withdrawn legal-status Critical Current

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    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
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    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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EP12863580.2A 2011-12-30 2012-12-28 Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators Withdrawn EP2797889A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2011104578981A CN102584687A (en) 2011-12-30 2011-12-30 Ethylene derivatives used as selective estrogen receptor modulators
CN2011104561181A CN102532073A (en) 2011-12-30 2011-12-30 Ethylene derivative serving as selective estrogen receptor modulators (SERMs)
US201261646628P 2012-05-14 2012-05-14
US201261646668P 2012-05-14 2012-05-14
PCT/CN2012/087884 WO2013097773A1 (en) 2011-12-30 2012-12-28 Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators

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US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
DE102015222031A1 (en) * 2015-11-10 2017-05-11 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Synthesis of (Z) -endoxifene hydrochloride
SG11201806829TA (en) * 2016-02-15 2018-09-27 Sanofi Sa 6,7-dihydro-5h-benzo[7]annulene derivatives as estrogen receptor modulators
RU2742278C2 (en) 2016-11-17 2021-02-04 Санофи Novel compounds of substituted n-(3-fluoropropyl)pyrrolidine, methods for production thereof and therapeutic application thereof
CN108333349A (en) * 2017-01-19 2018-07-27 浙江东方基因生物制品股份有限公司 A kind of 4- methyl methcathinone artificial antigen and preparation method and utilization
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
CN107674051B (en) * 2017-09-20 2021-01-08 南京医科大学 4-hydroxy tamoxifen cyclic derivative hypoxia activated prodrug and pharmaceutical application thereof
MX2020005525A (en) 2017-11-30 2020-10-28 Landos Biopharma Inc Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith.
CN108514539B (en) * 2018-07-11 2021-07-27 广州市腾宇化妆品有限公司 Antiseptic composition for cosmetics based on mild effect and preparation method of cosmetics
WO2020025574A1 (en) * 2018-08-03 2020-02-06 Bayer Aktiengesellschaft Process for the preparation of 6-(haloalkyl)-2-halo-5-acylpyridines and intermediates for this process
AR116300A1 (en) 2018-09-07 2021-04-21 Sanofi Sa PROCESS FOR THE PREPARATION OF 6- (2,4-DICHLOROPHENIL) -5- [4 - [(3S) -1- (3-FLUOROPROPYL) PYRROLIDIN-3-IL] OXIFENIL] -8,9-DIHIDRO-7H-BENZO [7] ANULENE-2-METHYL CARBOXYLATE
AU2019384807A1 (en) 2018-11-21 2021-05-20 Accutar Biotechnology Inc. Novel compounds having estrogen receptor alpha degradation activity and uses thereof
CA3135502C (en) 2019-12-20 2024-01-09 Josep Bassaganya-Riera Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same
JP2023508357A (en) 2019-12-23 2023-03-02 アキュター バイオテクノロジー インコーポレイテッド Cancer therapeutic combinations of estrogen receptor degrading agents and cyclin dependent kinase inhibitors
AU2021283577A1 (en) * 2020-06-02 2023-01-19 Chengdu Kanghong Pharmaceutical Co., Ltd. Novel thyroid hormone β receptor agonist

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