EP2793025A4 - Disk-type microfluid system and method for checking blood status - Google Patents

Disk-type microfluid system and method for checking blood status

Info

Publication number
EP2793025A4
EP2793025A4 EP12858051.1A EP12858051A EP2793025A4 EP 2793025 A4 EP2793025 A4 EP 2793025A4 EP 12858051 A EP12858051 A EP 12858051A EP 2793025 A4 EP2793025 A4 EP 2793025A4
Authority
EP
European Patent Office
Prior art keywords
disk
microfluid system
blood status
checking blood
type microfluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12858051.1A
Other languages
German (de)
French (fr)
Other versions
EP2793025A1 (en
Inventor
Dong Sung Kim
Moonwoo La
Sangmin Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Academy Industry Foundation of POSTECH
Original Assignee
Academy Industry Foundation of POSTECH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academy Industry Foundation of POSTECH filed Critical Academy Industry Foundation of POSTECH
Publication of EP2793025A1 publication Critical patent/EP2793025A1/en
Publication of EP2793025A4 publication Critical patent/EP2793025A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
    • G01N2011/008—Determining flow properties indirectly by measuring other parameters of the system optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • G01N2015/055—Investigating sedimentation of particle suspensions in blood for hematocrite determination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Centrifugal Separators (AREA)
EP12858051.1A 2011-12-12 2012-12-12 Disk-type microfluid system and method for checking blood status Withdrawn EP2793025A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110133258A KR101252259B1 (en) 2011-12-12 2011-12-12 Microfluidic disc system and method for identifying state of blood
PCT/KR2012/010797 WO2013089433A1 (en) 2011-12-12 2012-12-12 Disk-type microfluid system and method for checking blood status

Publications (2)

Publication Number Publication Date
EP2793025A1 EP2793025A1 (en) 2014-10-22
EP2793025A4 true EP2793025A4 (en) 2015-09-16

Family

ID=48442656

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12858051.1A Withdrawn EP2793025A4 (en) 2011-12-12 2012-12-12 Disk-type microfluid system and method for checking blood status

Country Status (6)

Country Link
US (1) US9012228B2 (en)
EP (1) EP2793025A4 (en)
JP (1) JP5770388B2 (en)
KR (1) KR101252259B1 (en)
CN (1) CN103998928B (en)
WO (1) WO2013089433A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3151963B1 (en) 2014-06-06 2018-03-14 Roche Diagnostics GmbH Rotatable cartridge with a metering chamber for analyzing a biological sample
EP2952258A1 (en) * 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for analyzing a biological sample
EP2952257A1 (en) 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for processing and analyzing a biological sample
EP2957890A1 (en) * 2014-06-16 2015-12-23 Roche Diagnostics GmbH Cartridge with a rotatable lid
CN108463708B (en) 2015-11-06 2021-10-08 密歇根大学董事会 Micro-droplet-based microfluidic rheometer system
TWI664413B (en) * 2018-04-27 2019-07-01 Feng Chia University Apparatus and method for viscosity measurement of fluids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403328B1 (en) * 1998-03-05 2002-06-11 Roger Clampitt Method of measuring erythrocyte sedimentation rate (ESR) or plasma fibrinogen of a blood sample
WO2010104292A2 (en) * 2009-03-09 2010-09-16 Samsung Electronics Co., Ltd., Strobo thin film chemical analysis apparatus and assay method using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6472064A (en) * 1987-09-10 1989-03-16 Den Kuo Chien Automatically monitoring/recording system for blood sedimentation rate
US6506606B1 (en) * 1995-06-06 2003-01-14 Brigham And Women's Hospital Method and apparatus for determining erythrocyte sedimentation rate and hematocrit
CA2239613A1 (en) * 1995-12-05 1997-06-12 Alec Mian Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) * 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
CN1184929C (en) * 1995-12-27 2005-01-19 希森美康株式会社 Noninvasive blood examination apparatus
KR20030061746A (en) * 2003-06-23 2003-07-22 신세현 Blood cell rheometer
CN103454191B (en) * 2003-07-02 2016-01-06 泰尔茂比司特公司 For the method utilizing predicted data analytical algorithm to control blood processing centrifugation machine
JP4665902B2 (en) * 2004-07-29 2011-04-06 パナソニック株式会社 Analysis device, analysis disk, and analysis system including them
KR101335727B1 (en) * 2007-08-22 2013-12-04 삼성전자주식회사 Centrifugal force-based disk type microfluidic device for blood chemistry analysis
KR100915195B1 (en) * 2008-02-29 2009-09-04 고려대학교 산학협력단 Apparatus and method for measuring blood cell deformability using rotating disc
WO2010137470A1 (en) * 2009-05-29 2010-12-02 コニカミノルタオプト株式会社 Device for measuring deformability and method for measuring deformability
KR20120061551A (en) * 2010-12-03 2012-06-13 경북대학교 산학협력단 micro fluidic chip and particle imaging system in isotacho-electrophoresis using thereof
US9347867B2 (en) * 2012-07-18 2016-05-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403328B1 (en) * 1998-03-05 2002-06-11 Roger Clampitt Method of measuring erythrocyte sedimentation rate (ESR) or plasma fibrinogen of a blood sample
WO2010104292A2 (en) * 2009-03-09 2010-09-16 Samsung Electronics Co., Ltd., Strobo thin film chemical analysis apparatus and assay method using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUTCHINSON R M ET AL: "A COMPARISON OF THE ERYTHROCYTE SEDIMENTATION RATE AND PLASMA VISCOSITY IN DETECTING CHANGES IN PLASMA PROTEINS", JOURNAL OF CLINICAL PATHOLOGY, BMJ PUBLISHING GROUP, GB, vol. 30, no. 4, 1 April 1977 (1977-04-01), pages 345 - 349, XP002702831, ISSN: 0021-9746 *
See also references of WO2013089433A1 *

Also Published As

Publication number Publication date
KR101252259B1 (en) 2013-04-08
US9012228B2 (en) 2015-04-21
JP5770388B2 (en) 2015-08-26
WO2013089433A1 (en) 2013-06-20
CN103998928A (en) 2014-08-20
US20140315317A1 (en) 2014-10-23
JP2015501925A (en) 2015-01-19
CN103998928B (en) 2015-12-23
EP2793025A1 (en) 2014-10-22

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