EP2753641A4 - Neuroprotective cell-penetrating peptides - Google Patents

Neuroprotective cell-penetrating peptides

Info

Publication number
EP2753641A4
EP2753641A4 EP12830062.1A EP12830062A EP2753641A4 EP 2753641 A4 EP2753641 A4 EP 2753641A4 EP 12830062 A EP12830062 A EP 12830062A EP 2753641 A4 EP2753641 A4 EP 2753641A4
Authority
EP
European Patent Office
Prior art keywords
penetrating peptides
neuroprotective cell
neuroprotective
cell
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12830062.1A
Other languages
German (de)
French (fr)
Other versions
EP2753641A1 (en
Inventor
Urmas Arumäe
Mart Saarma
Pia Runeberg-Roos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2753641A1 publication Critical patent/EP2753641A1/en
Publication of EP2753641A4 publication Critical patent/EP2753641A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
EP12830062.1A 2011-09-05 2012-09-05 Neuroprotective cell-penetrating peptides Withdrawn EP2753641A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20115870A FI20115870A0 (en) 2011-09-05 2011-09-05 Neuroprotective cell penetrating peptides
PCT/FI2012/050859 WO2013034805A1 (en) 2011-09-05 2012-09-05 Neuroprotective cell-penetrating peptides

Publications (2)

Publication Number Publication Date
EP2753641A1 EP2753641A1 (en) 2014-07-16
EP2753641A4 true EP2753641A4 (en) 2015-06-24

Family

ID=44718780

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12830062.1A Withdrawn EP2753641A4 (en) 2011-09-05 2012-09-05 Neuroprotective cell-penetrating peptides

Country Status (3)

Country Link
EP (1) EP2753641A4 (en)
FI (1) FI20115870A0 (en)
WO (1) WO2013034805A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9891231B2 (en) * 2012-01-24 2018-02-13 University Of Massachusetts Soluble MANF in pancreatic β-cell disorders
WO2014191630A2 (en) * 2013-05-28 2014-12-04 Helsingin Yliopisto Non-human animal model encoding a non-functional manf gene
US10265380B2 (en) 2014-03-05 2019-04-23 Amarantus Bioscience Holdings, Inc. Method of administering MANF for the protection of sensory cells
WO2015149005A1 (en) * 2014-03-28 2015-10-01 Buck Institute For Research On Aging Methods and compositions for modulating the immune system
WO2015200469A1 (en) * 2014-06-24 2015-12-30 University Of Massachusetts Manf as a regulator of immune system function
WO2017085362A1 (en) 2015-11-18 2017-05-26 Herantis Pharma Plc Compositions comprising cdnf or manf for use in the intranasal treatment of central nervous system diseases
EP3619227A1 (en) 2017-05-04 2020-03-11 Helsingin Yliopisto C-terminal cdnf and manf fragments, pharmaceutical compositions comprising same and uses thereof
KR20200138798A (en) * 2018-03-29 2020-12-10 헬싱인 일리오피스토 C-terminal CDNF fragment, pharmaceutical composition comprising same, and use thereof
EP3838912A1 (en) 2019-12-20 2021-06-23 Herantis Pharma Oyj Retro-inverso peptides
EP3838345A1 (en) 2019-12-20 2021-06-23 Herantis Pharma Oyj Macrocyclic peptides

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043693A1 (en) * 1998-02-26 1999-09-02 Human Genome Sciences, Inc. 36 human secreted proteins
WO2002074956A2 (en) * 2001-03-20 2002-09-26 Prescient Neuropharma Inc. Dopaminergic neuronal survival-promoting factors and uses thereof
WO2002079246A2 (en) * 2001-03-30 2002-10-10 Geneprot, Inc. Human arginine-rich protein-related compositions
US20030109690A1 (en) * 1999-09-29 2003-06-12 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
US20030109457A1 (en) * 2001-10-25 2003-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress
WO2004050688A1 (en) * 2002-12-02 2004-06-17 Xenome Ltd NOVEL χ-CONOTOXIN PEPTIDES (-II)
WO2009133247A1 (en) * 2008-04-30 2009-11-05 Licentia Oy Neurotrophic factor manf and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005023550D1 (en) * 2005-12-14 2010-10-21 Licentia Ltd Uses of a neurotrophic factor

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043693A1 (en) * 1998-02-26 1999-09-02 Human Genome Sciences, Inc. 36 human secreted proteins
US20030109690A1 (en) * 1999-09-29 2003-06-12 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
WO2002074956A2 (en) * 2001-03-20 2002-09-26 Prescient Neuropharma Inc. Dopaminergic neuronal survival-promoting factors and uses thereof
WO2002079246A2 (en) * 2001-03-30 2002-10-10 Geneprot, Inc. Human arginine-rich protein-related compositions
US20030109457A1 (en) * 2001-10-25 2003-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress
WO2004050688A1 (en) * 2002-12-02 2004-06-17 Xenome Ltd NOVEL χ-CONOTOXIN PEPTIDES (-II)
WO2009133247A1 (en) * 2008-04-30 2009-11-05 Licentia Oy Neurotrophic factor manf and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 June 2003 (2003-06-12), Database accession no. 536071-66-6 *
JORDAN M. FLETCHER ET AL: "Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor", JOURNAL OF PEPTIDE SCIENCE, vol. 12, no. 8, 1 January 2006 (2006-01-01), pages 515 - 524, XP055145298, ISSN: 1075-2617, DOI: 10.1002/psc.760 *
M. HELLMAN: "Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons", J. BIOL. CHEM., vol. 286, no. 4, 1 January 2011 (2011-01-01), pages 2675 - 2680, XP055145300 *
PÄIVI LINDHOLM ET AL: "Novel CDNF/MANF family of neurotrophic factors", DEVELOPMENTAL NEUROBIOLOGY, 1 January 2010 (2010-01-01), pages NA - NA, XP055145301, ISSN: 1932-8451, DOI: 10.1002/dneu.20760 *
See also references of WO2013034805A1 *
VICTOR J. HRUBY: "Designing peptide receptor agonists and antagonists", NATURE REVIEWS DRUG DISCOVERY, vol. 1, no. 11, 1 November 2002 (2002-11-01), pages 847 - 858, XP055034286, ISSN: 1474-1776, DOI: 10.1038/nrd939 *

Also Published As

Publication number Publication date
EP2753641A1 (en) 2014-07-16
WO2013034805A1 (en) 2013-03-14
FI20115870A0 (en) 2011-09-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20140317

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DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150526

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/28 20060101ALI20150519BHEP

Ipc: A61K 38/18 20060101ALI20150519BHEP

Ipc: C07K 14/475 20060101AFI20150519BHEP

Ipc: A61P 5/00 20060101ALI20150519BHEP

Ipc: A61P 25/00 20060101ALI20150519BHEP

Ipc: A61P 25/30 20060101ALI20150519BHEP

Ipc: C07K 5/103 20060101ALI20150519BHEP

Ipc: A61P 25/16 20060101ALI20150519BHEP

Ipc: A61K 38/07 20060101ALI20150519BHEP

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Effective date: 20151223